Kaye and Prisco draw our attention to one of the more obvious difficulties with all versions of the argument from design.

Autobiographical memory (AM) is closely linked to the self-concept, and fulfills directive, identity, social, and adaptive functions. Individuals with autism spectrum disorder (ASD) are now known to have atypical AM, which may be closely associated with social communication difficulties. This may result in qualitatively different autobiographical narratives, notably regarding social identity. In the present study, we sought to investigate this concept and develop a cognitive intervention targeting individuals with ASD. First, 13 adolescents with ASD and 13 typically developing adolescents underwent (...) an AM interview featuring an original coding system designed to analyze the social self. We observed that the narratives produced by the ASD group focused more on the family than on extended social spheres, compared with those of the comparison group. Moreover, participants with ASD did not include themselves in the social groups they mentioned, and produced more references to others, compared with typically developing participants. Second, we designed a cognitive intervention program consisting of individual and group sessions that targeted AM. We conducted a pilot study among three adolescents with ASD aged 12, 16, and 17 years. Preliminary results showed that the program increased extra-family narrative references by the two youngest adolescents, who produced more social integration markers. Our study of autobiographical narratives yielded interesting findings about social positioning in ASD and showed how AM can be targeted in rehabilitation programs as a vector of social interaction. (shrink)

Biobanks are proliferating rapidly worldwide because they are powerful tools and organisational structures for undertaking medical research. By linking samples to data on the health of individuals, it is anticipated that biobanks will be used to explore the relationship between genes, environment and lifestyle for many diseases, as well as the potential of individually-tailored drug treatments based on genetic predisposition. However, they also raise considerable challenges for existing legal frameworks and research governance structures. This book critically examines the current governance (...) structures in place for biobanks in England and Wales. It shows that the technologies, techniques and practices involved in biobanking do not always conform neatly to existing legal principles and frameworks that apply to other areas of medical research. Using a socio-legal approach, including interview data gathered from the scientific community, this book provides unique insights and makes recommendations about appropriate governance mechanisms for biobanking in the future. It also explores the issues around the secondary use of information, such as consent and how to protect privacy, when biobanks are accessed by a number of different third parties. These issues have relevance both within England and Wales and to a wide international audience, as well as for other areas where large datasets are used.--Back cover. (shrink)

As soon as he had observed labour to be ‘first of all, a process between man and nature', Marx turned to conscious determination. ‘Man not only affects a change of form in the materials of nature, he also realises his own purpose in these materials. And this is a purpose he is conscious of. It is purpose which distinguishes labour from the activities of animals. Marx called the purposive character of labour ‘an exclusively human characteristic’ and the term indicates its (...) fundamental importance in his thought. As it is purposive activity, so labour is ‘a specific productive activity appropriate to its purpose, a productive activity that assimilate[s] particular natural materials to a particular human requirement'.3 Since ends are specific by definition, this has to be the case, and neither absence of skill nor indifference effect the issue one way or the other. Work does not cease to be particular because it demands no special capacities - tightening screws and stacking shelves do not stop being different kinds of activity by virtue of the fact that anyone can perform them; or because no store its set by its distinctive qualities. In its accounts, capital may treat different kinds of labour uniformly as a cost of production, but this does not alter the fact that the labour it employs comprises different types of labour: ‘the fact that the production of use-values or goods is carried on under the control of a capitalist and on his behalf does not alter the general character of that production'.4 In which case, we ask, what is labour which is not particular? If labour is always and necessarily a specific productive activity, what is abstract labour — ‘homogenous labour’ which, by definition, is not specific? (shrink)

This paper starts by investigating Ackermann's interpretation of finite set theory in the natural numbers. We give a formal version of this interpretation from Peano arithmetic (PA) to Zermelo-Fraenkel set theory with the infinity axiom negated (ZF−inf) and provide an inverse interpretation going the other way. In particular, we emphasize the precise axiomatization of our set theory that is required and point out the necessity of the axiom of transitive containment or (equivalently) the axiom scheme of ∈-induction. This clarifies the (...) nature of the equivalence of PA and ZF−inf and corrects some errors in the literature. We also survey the restrictions of the Ackermann interpretation and its inverse to subsystems of PA and ZF−inf, where full induction, replacement, or separation is not assumed. The paper concludes with a discussion on the problems one faces when the totality of exponentiation fails, or when the existence of unordered pairs or power sets is not guaranteed. (shrink)

Each book in the series includes six 40-minute studies designed to draw you into God’s Word through basic inductive Bible study.

Ludwig Wittgenstein was a brilliant, intense, complex man, and this novel, a work of historical fiction but based on fact, explores his early thinking, which led him to publish one of the most important works of logic ever written. The story is told by David Pinsent, a student in mathematics who meets Wittgenstein at Trinity College in Cambridge, England, just before World War I. Despite Wittgenstein’s odd mannerisms and difficult personality, David is attracted to him, recognizing his genius immediately and (...) forming a friendship that is as volatile as it is rewarding. Wittgenstein, under the tutelage of the eminent mathematician and philosopher Bernard Russell, has developed a picture theory of meaning to explain human language through the lens of logic, and he is tormented by the idea that he will die before he is able to put it into book form and present it to the world. -/- Both David and Ludwig are welcomed into the elite intellectual circles at Cambridge, which consist of some of the most notable philosophers, mathematicians, and logicians of the day, including not just Russell but also men like John Maynard Keynes and G.E. Moore, as well as the famous Bloomsbury Set. However, David is troubled by the mysteries that surround Wittgenstein. Ludwig, he learns, has developed an innovative propeller that can be used on a flying bomber, and David finds himself caught up in international intrigue as both England and Germany vie for the design to give them an advantage in the impending war. -/- But David and Ludwig have become both emotionally and physically intimate, and as war looms, David is forced to confront the role that their forbidden relationship plays in the escalating risks to Wittgenstein’s safety. Their story is one of tragedy and inspiration, and it aptly illustrates the deeply human core of philosophical ideas. This novel illuminates and clarifies the complex philosophical, linguistic, and mathematical issues that engaged some of the best thinkers of the early twentieth century. -/- There is an accompanying guidebook for this novel. (shrink)

Background Randomized controlled trials are central to generating knowledge about effectiveness of interventions as well as risk, protective and prognostic factors related to diseases in emergency newborn care. Whether prospective participants understand the purpose of research, and what they perceive as the influence of the context on their understanding of the informed consent process for RCTs in emergency obstetric and newborn care are not well documented. Methods Conceptual review. Discussion Research is necessary to identify how the illnesses may be prevented, (...) to explore the causes, and to investigate what medications could be used to manage such illness. Voluntary informed consent requires that prospective participants understand the disclose information about the research, and use this to make autonomous informed decision about participation, in line with their preferences and values. Yet the emergency context affects how information may be disclosed to prospective research participants, how much participants may comprehend, and how participants may express their voluntary decision to participate, all of which pose a threat to the validity of the informed consent. I challenge the claim that the ‘understanding’ of research is always necessary for ethical informed consent for research during emergency care. I argue for reconceptualization of the value of understanding, through recognition of other values that may be equally important. I then present a reflective perspective that frames moral reflection about autonomy, beneficence and justice in research in emergency research. Conclusion While participant ‘understanding’ of research is important, it is neither necessary nor sufficient for a valid informed consent, and may compete with other values with which it needs to be considered. (shrink)

In this paper we present an equivalence between the category of commutative regular rings and the category of Boolean-valued fields, i.e., Boolean-valued sets for which the field axioms are true. The author used this equivalence in [12] to develop a Galois theory for commutative regular rings. Here we apply the equivalence to give an alternative construction of an algebraic closure for any commutative regular ring.Boolean-valued sets were developed in 1965 by Scott and Solovay [10] to simplify independence proofs in set (...) theory. They later were applied by Takeuti [13] to obtain results on Hilbert and Banach spaces. Ellentuck [3] and Weispfenning [14] considered Boolean-valued rings which consisted of rings and associated Boolean-valued relations. To the author's knowledge, the present work is the first to employ the Boolean-valued sets of Scott and Solovay to obtain results in algebra.The idea that commutative regular rings can be studied by examining the properties of related fields is not new. For several years algebraists and logicians have investigated commutative regular rings by representing a commutative regular ring as a subdirect product of fields or as the ring of global sections of a sheaf of fields over a Boolean space. These representations depend, as does the work presented here, on the fact that the set of central idempotents of any ring with identity forms a Boolean algebra. The advantage of the Boolean-valued set approach is that the axioms of classical logic and set theory are true in the Boolean universe. Therefore, if the axioms for a field are true for a Boolean-valued set, then other properties of the set can be deduced immediately from field theory. (shrink)

Current debate on business ethics in Australia continues apace as the excesses of the 1980s are exposed. Codes of Ethics have been a high profile instrument in the American business scene. A survey of Australia''s largest business corporations reveals a different situation. Codes are not as commonly used, tend to refer to legal requirements and do not have as high a profile within the corporation. Given the changing legal framework in Australia a greater role for Codes of Ethics may emerge.

In this paper I take up a critical position in regard to the theme of debility around which this collection is framed. I argue that theorisations of ‘debility’ do little to progress theory and policy in regard to disability and share many of the problems inherent to the social model. I also suggest that the theorisation of debility is rooted in and reinforces ablebodied privilege. I begin with a critical analysis of the social model of disability and explore the dualisms (...) by which it either negates the body altogether or can only conceive the disabled body in negative terms. I then go on to explore how Puar's work on debility continues this negation of the disabled body. From this position I use the work of Inahara to excavate the foundations of ablebodied privilege. In Inahara's work gender is the analytic starting point, but for me white privilege is a much more effective mechanism through which to understand the impact and reproduction of ablebodied privilege— what McRuer refers to as ‘compulsory ablebodiedness'—which I argue underpins Puar's work. I conclude with some reflections upon how a critical analysis of ablebodied privilege might function and I reiterate its importance for a critical theory that goes beyond the mere repetition of binary structures of ablebodiedness and disability. (shrink)

Subjectivists about practical normativity hold that an agent’s favoring and disfavoring attitudes give rise to practical reasons. On this view, an agent’s normative reason to choose vanilla over chocolate ice cream ultimately turns on facts about what appeals to her rather than facts about what her options are like attitude-independently. Objectivists—who ground reasons in the attitude-independent features of the things we aim at—owe us an explanation of why it is rational to choose what we favor, if not because favoring is (...) a source of reasons. My aim in this paper is to supply such a story. The proposal is roughly that when an agent cannot base her choices on her judgments about what she has most reason to do, structural rationality extends to her a license to choose something just because she favors it, without imbuing favoring with the authority of a normative reason. (shrink)

This book is a comprehensive exposition of the Transcendental Deduction of the Categories in both editions of Kant’s Critique of Pure Reason.

Introduction: Thinking, writing, and reading about the real -- Dialectic and the real : Lacan, Hegel, and the alchemy of après-coup -- 'Reality' and the real : culture as anamorphosis -- The real of sexual difference : imagining, thinking, being -- Ethics and the real : the ungodly virtues of psychoanalysis -- Politics, or, the art of the impossible.

Showing key connections between Marx’s oeuvre and Buddhist thought, this book demonstrates connections between Marx and Nishida Kitaro, who many consider the key Japanese philosopher of the Kyoto School of Philosophy, the first modern philosophers in Japan.

We present a comprehensive study of the axiom schemas IΣ - n , BΣ - n (induction and collection schemas for parameter free Σ n formulas) and some closely related schemas.

We show that Matijasevič's Theorem on the diophantine representation of r.e. predicates is provable in the subsystem I ∃ - 1 of Peano Arithmetic formed by restricting the induction scheme to diophantine formulas with no parameters. More specifically, I ∃ - 1 ⊢ IE - 1 + E ⊢ Matijasevič's Theorem where IE - 1 is the scheme of parameter-free bounded existential induction and E is an ∀∃ axiom expressing the existence of a function of exponential growth. We conclude by (...) examining the consequences of these results to the structure of countable nonstandard models of IE - 1. (shrink)

The genetically-modified-organism (GMO) experience has been prominent in motivating science, industry, and regulatory communities to address the social and ethical dimensions of nanotechnology. However, there are some significant problems with the GMO-nanotech analogy. First, it overstates the likelihood of a GMO-like backlash against nanotechnology. Second, it invites misconceptions about the reasons for public engagement and social and ethical issues research as well as their appropriate roles in nanotech research, development, application, commercialization, and regulatory processes. After an explication of the standard (...) GMO-Nanotech analogy, these two problems are discussed in turn. (shrink)

Phosphatidylinositol 3‐phosphate (PtdIns3P) is generated on the cytosolic leaflet of cellular membranes, primarily by phosphorylation of phosphatidylinositol by class II and class III phosphatidylinositol 3‐kinases. The bulk of this lipid is found on the limiting and intraluminal membranes of endosomes, but it can also be detected in domains of phagosomes, autophagosome precursors, cytokinetic bridges, the plasma membrane and the nucleus. PtdIns3P controls cellular functions through recruitment of specific protein effectors, many of which contain FYVE or PX domains. Cellular processes known (...) to be controlled by PtdIns3P and its effectors include endosomal fusion, sorting and motility, autophagy, cytokinesis, regulated exocytosis and signal transduction. Here we discuss how Ptdins3P is generated on specific cellular membranes, how its localizations and functions can be studied, and how its effectors serve to control cellular functions.Editor's suggested further reading in BioEssays:Phosphatidylinositol 4,5‐bisphosphate: Targeted production and signalingAbstractHow does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity?AbstractPhosphatidylinositol‐3,4,5‐trisphosphate: Tool of choice for class I PI 3‐kinasesAbstractPhosphatidylinositol‐4‐phosphate: The Golgi and beyondAbstract. (shrink)

Herr Professor Bohr, der sehr mit Arbeit überlastet ist, hat mich gebeten, Ihnen in seinem Namen für die Zusendung Ihres Aufsatzes über Determinismus und Quantenmechanik zu danken und Ihnen seine Auffassung dieser Fragen mitzuteilen. Ich habe diesen Auftrag nach der Lektüre Ihres Aufsatzes sehr gerne übernommen. Einen Entwurf meiner Antwort habe ich Herrn Prof. Bohr vorgelegt und mit ihm durchgesprochen; ich hoffe daher[,] seine Meinung in der Hauptsache richtig wiedergeben zu können.

Um die Bemühungen unseres Gesprächs vom vorigen Freitag so weit wie möglich auszunutzen und fruchtbar zu machen, will ich versuchen, zunächst noch einmal die Punkte, über die wir einig waren, festzuhalten und zu formulieren. Es liegt mir daran, dass Sie sowohl wie ich eine Kontrolle darüber haben, dass wir nicht – veranlasst durch Unklarheiten im Ausdruck – einander Zugeständnisse machen an Stellen, die in Wahrheit schon die Quellen für das spätere Auseinandergehen unserer Meinungen enthalten. Erst die Aufdeckung dieser Quellen wird (...) zu einer ernsthaften Bereinigung dieser Gegensätze führen können. Ich bitte Sie daher um die Geduld, noch einmal nachzuprüfen, ob bei unserer Besprechung etwas herausgekommen ist, und wenn ja, was. Tun Sie es bitte als Privatmensch und nicht unbedingt als Bohr-Schüler; wir werden in der Klärung unserer Fragen weiter kommen, wenn Sie an Punkten, wo Sie von Bohrs Auffassung abweichen, Ihre eigene Meinung vertreten. (shrink)

Heisenberg sitzt mir stark auf der Pelle. Vielleicht behält er recht. Ich verstehe seine Gedankengänge immer besser, aber überzeugt bin ich noch nicht. Es ist z. Zt. schwierig, anstrengend und schön. – Vorgestern hielt Fritz Hund einen naturphilosophischen Vortrag vor einer phil. Gesellschaft. Das ist auch einer der theoretischen Physiker – jetzt hier Prof. – ich kannte ihn schon in Göttingen als Assistent von Born, hier [habe] ich auch ein paar Mal mit ihm über meine Arbeit disku[tiert.] Es geht lange (...) nicht so gut wie bei Heisenberg. (shrink)

Auf Ihren Brief vom 12. Juni, den ich mit vielem Interesse gelesen habe, sollten Sie schon längst eine Antwort von mir haben. Ein Argument für die Beantwortung hatte ich auch längst bereit. Doch da Sie des Näheren auf den Entwicklungsgang der Kantischen Philosophie zu sprechen kommen, wollte ich mir hierüber erst einiges in der Literatur ansehen. Das aber wurde durch etliche verschiedene Obliegenheiten verzögert, und so komme ich erst jetzt, nach einigen Monate[n] dazu, Ihre Ausführungen zu beantworten.

Durch die Unterstützung der Sächsischen Akademie der Wissenschaften zu Leipzig ist es möglich geworden, drei Arbeiten der Öffentlichkeit zu übergeben, die im Juni 1936 mit dem „Richard Avenarius-Preis“ ausgezeichnet worden sind. Die unterzeichnete Kommission, die stiftungsgemäß von der Akademie eingesetzt wird, hatte im Jahre 1934 eine Preisaufgabe ausgeschrieben, deren Wortlaut folgender war: „Welche Konsequenzen haben die Quantentheorie und die Feldtheorie der modernen Physik für die Theorie der Erkenntnis?“ Nicht weniger als 17 Arbeiten wurden bis zu dem gestellten Termin eingereicht. Sie (...) zeugten nicht nur durch ihren Umfang, sondern zum größeren Teil auch durch ihren Gehalt von dem leidenschaftlichen Ernst, mit dem heute die überraschenden Ergebnisse der exakten Forschung nach ihrer philosophischen Tragweite durchdacht werden. (shrink)

This paper provides an analytical overview of the apostolic networks in Britain. There are several ways to understand the success of the apostolic networks. They can be seen as an extreme answer to an extreme problem an answer to a profound secularisation leading to declining church attendance and influence within society. The apostolic networks appear to fit into post-modern society better than conventional denominational structures. In terms of their organization, despite appearances, these networks are however hierarchical like the denominational structures (...) which they challenge. The difference is in the characteristic informality with which these networks can collaborate with each other even when they grow. (shrink)

A significant share of the U.S. federal R&D budget is devoted to large-scale, complex technological systems commonly referred to as "big science. " Over the last two decades, these systems have continued to grow in size, complexity, development time, and cost. At the same time, political changes in the United States, particularly the concern over government spending and the federal budget deficit, have made it more difficult for proponents to secure and preserve support for these programs over their lifetimes. Using (...) the U.S. space shuttle and space station programs as examples, the article shows that the political requirements for obtaining approval and funding for large and expensive research and development projects create conditions that reduce the likelihood that they will succeed technologically. The problems of technology-based projects like those of the U.S. space program are in fact deeply rooted in the American political process itself. (shrink)

This book develops and defends a new understanding of Kant's account of perceptual representation, showing that it underlies the main doctrines of the Critique of Pure Reason. Intuitions consist of formal unifications by the schematized categories that projectively represent both time and external objects and enable synthetic a priori knowledge.