Explanations of productivity differences between men and women in science tend to focus on the academic sector and the individual level. This article examines how variation in organizational logic affects sex differences in scientists' commercial productivity, as measured by patenting. Using detailed data from a sample of academic and industrial life scientists working in the United States, the authors present multivariate regression models of scientific patenting. The data show that controlling for education- and career-history variables, women are less likely to (...) patent than men. However, in biotechnology firms—industrial settings characterized by flatter, more flexible, network-based organizational structures— women scientists are more likely to become patent-holding inventors than in more hierarchically arranged organizational settings in industry or academia. The authors discuss how the organization of scientists'work settings may influence enduring disparities between men and women in science and the implications of these findings for future work. (shrink)

In their recent article Consideration and Disclosure of Group Risks in Genomics and Other Data-Centric Research: Does the Common Rule Need Revision? Chapman et al. (2025) thoughtfully explore aspec...

Informed consent is the gateway to research participation. We report on the results of the formative evaluation that follows the electronic informed consent process for the All of Us Research Program. Of the nearly 250,000 participants included in this analysis, more than 95% could correctly answer questions distinguishing the program from medical care, the voluntary nature of participation, and the right to withdraw; comparatively, participants were less sure of privacy risk of the program. We also report on a small mixed-methods (...) study of the experience of persons of very low health literacy with All of Us informed consent materials. Of note, many of the words commonly employed in the consent process were unfamiliar to or differently defined by informants. In combination, these analyses may inform participant-centered development and highlight areas for refinement of informed consent materials for the All of Us Research Program and similar studies. (shrink)

A key feature of unregulated mHealth research is the diversity of participants in this space. Applying an approach drawn from user experience design, we describe a set of archetypal unregulated mHealth researcher “personas,” which range from individuals who seek empowerment or have philanthropic objectives to those who are primarily motivated by financial gain or have misanthropic objectives. These descriptions are useful for evaluating policies applicable to mHealth to understand how they will impact various stakeholders.

The recent cycle of social struggles against precarity in Italy has been characterized by an extensive use of images representing precarious workers. This contribution explores this in the case of the Euro Mayday Parade (EMP) protest campaign. The subversion of existing popular culture traditions was the main objective of the activists’ newly created icons such as San Precario, Serpica Naro and other visual tools. The visual work on gender in the EMP seemed to fill a gap between theoretical work on (...) the feminization of affective and immaterial labour and the less predominant presence of gender. Visual icons seem to have been at least as successful as text messages in publicizing the precarity discourse and their production deserves further attention. (shrink)

Epithelia are the first organized tissues that appear during development. In many animal embryos, early divisions give rise to a polarized monolayer, the primary epithelium, rather than a random aggregate of cells. Here, we review the mechanisms by which cells organize into primary epithelia in various developmental contexts. We discuss how cells acquire polarity while undergoing early divisions. We describe cases where oriented divisions constrain cell arrangement to monolayers including organization on top of yolk surfaces. We finally discuss how epithelia (...) emerge in embryos from animals that branched early during evolution and provide examples of epithelia‐like arrangements encountered in single‐celled eukaryotes. Although divergent and context‐dependent mechanisms give rise to primary epithelia, here we trace the unifying principles underlying their formation. (shrink)

Abstract:Since Homeric times, psychotherapy has been an essential part of the medical act. Initially, the word of physicians had a magical character. Plato rationalizes this in many of his dialogues. In "Charmides," he dives deeper into this matter and proposes to apply it to every disease. Analysing this dialogue has fundamental consequences for psychotherapy: 1) Remedy and epodé (charm) must be applied in every doctor–patient relationship. 2) The body can only be healed if the soul is cured first by a (...) charm. Patients must "offer" their souls to the physician, which implies the need for confidence and the unavoidable asymmetry which characterize doctor–patient relationships. 3) The openness of the patient's soul to the physician and the physician's "beautiful speech" to the patient will enable the latter to reach the state of sophrosyne (temperance), the condition of the possibility of true health. In the discussion of the meaning of sophrosyne, Socrates questions every one of the disciples' propositions and concludes that the only thing one can be sure of is that sophrosyne is a way of searching for virtue (areté). Later, in Theaetetus, Plato adds another element: temperance is a homoiosis theó, that is, the assimilation of patient with God. With this, Plato seals the ethical character of psychotherapy forever. (shrink)

First, I would like to thank Dr. Phillips for his generous words about the potential interest of my work. He speaks about the fact that it is "insightful" and thought-provoking ("it offers us much to think about"). In his comment Dr. Phillips reviews the main moments of the evolution of treatment by words in the Greek world and he focuses on Plato's Dialogue Charmides, whose analysis is the center of my article. He even quotes some parts of the dialogue, which (...) I mention too, although in a different translation. He rightfully underlines the moment in which Socrates tells Charmides: "And the soul... my dear friend, is cured by means of certain charms, and these charms consist of beautiful words. It is a result of... Read More. (shrink)

It is well known how often psychiatric patients report religious experiences. These are especially frequent in schizophrenic and epileptic patients as the subject of their delusions. The question we pose is: are there differences between this kind of religious experiences and those we find in religious texts or in the mythological tradition?

Why do some Ph.D.'s languish in positions with little authority, and what does educational background have to do with it? Hypotheses predicted that life scientists with Ph.D.'s from elite programs would be the most likely, those from middle-ranked programs the next most likely, and those from lower ranked programs the least likely to achieve supervisory positions. A sample of 2,062 life scientists with doctorates from U.S. universities was collected from records archived from 1983 to 1995. In contrast to hypotheses, Ph.D.'s (...) from elite and lower ranked schools did not have a significantly different chance of supervising. Within prestigious organizations, however, Ph.D.'s from top 10 programs did have a greater likelihood of leading. Ph.D.'s from middle-ranked programs were less likely to advance into supervisory positions. Qualitative interviews explored how, in a knowledgeexpanding field such as the life sciences, being stuck on the bottom rung early on can adversely affect a scientist's career. (shrink)

Konstantin Pollok offers the first book-length analysis of Kant's theory of normativity that covers foundational issues in theoretical and practical philosophy as well as aesthetics. Interpreting Kant's 'critical turn' as a normative turn, he argues that Kant's theory of normativity is both original and radical: it departs from the perfectionist ideal of early modern rationalism, and arrives at an unprecedented framework of synthetic a priori principles that determine the validity of our judgments. Pollok examines the hylomorphism in Kant's theory (...) of normativity and relates Kant's idea of our reason's self-legislation to the 'natural right' tradition, revealing Kant's debt to his predecessors as well as his relevance to contemporary debates on normativity. This book will appeal to academic researchers and advanced students of Kant, early modern philosophy and intellectual history. (shrink)

In this paper, we tackle the widely held view that practice-oriented approaches to ethics are conservative, preserving the moral status quo, and, in particular, that they do not promote any (fundamental) change in our dealings with animals or formulate clear principles that help us to achieve such change. We shall challenge this view with reference to Wittgensteinian ethics. As a first step, we show that moral thought and action rest on basic moral certainties like: equals are to be treated equally (...) and unequals unequally. We then explore the relations between this insight and the notion of the difficulty of reality elaborated by Cora Diamond. Our goal is to show that a Wittgensteinian-Diamondian approach to animal ethics is not necessarily morally conservative. Indeed, it offers a profound practice-oriented approach to animal ethics that is capable of promoting change in human dealings with animals because it is compatible with radical critique. (shrink)

This article is a commentary on ChatGPT and LLMs (Large Language Models) in general. It argues that this technology has matured to the point where calling systems such as ChatGPT “stochastic parrots” is no longer warranted. But it also argues that these systems continue to have serious limitations when it comes to reasoning. These limitations are much more severe than commonly thought. A large array of examples are given to support these claims.

Asymmetrical convergence is the increasing overlap between academic and industrial sectors, but with academia moving closer toward for-profit industrial norms than vice versa. Although this concept, developed by Kleinman and Vallas, is useful, processes of asymmetrical convergence in daily laboratory life are largely unexplored. Here, observations of three lab groups of chemical scientists in academic and industry contexts illustrate variation in interactions with ethics-related policies. Findings show more tension for academic science with business-based practices, such as the move toward greater (...) accountability, than for industrial science with academic practices. This asymmetry is evident in the process of purposive decoupling: for example, where academic scientists use humor to distance themselves from the performance of compliance in required reporting and top-down ethics training requirements. This distancing from meaningless requirements contrasts with mentoring around practices of professional behavior that are thought to matter. Convergence is evident in how safety policies seem more engaging than other kinds of policies. Yet, power structures shape engagement. Academic engagement often means rule following, and flows vertically from professor’s authority to student apprenticeship. Industry engagement includes collaborative problem solving and flows along a more horizontal peer structure where informal power is less visible. (shrink)

Konstantin Pollok - Kant's Critical Concepts of Motion - Journal of the History of Philosophy 44:4 Journal of the History of Philosophy 44.4 559-575 Muse Search Journals This Journal Contents Kant's Critical Concepts of Motion Konstantin Pollok There are two significant places in Kant's Critical corpus where he discusses the concept of motion. The first is in the Critique of Pure Reason, where in the "Deduction of the Categories" Kant writes: Motion, as an act of the subject , (...) and therefore the synthesis of the manifold in space, first produces the concept of succession—if we abstract from this manifold and attend solely to the act through which we determine the inner sense according to its form. In this passage Kant simply refers to the concept of motion, and the immediate context in which this reference occurs reveals little about what he means by it. In the Metaphysical Foundations of Natural Science, however, motion plays a more significant role, and, concomitantly, it is in his writings on natural science that Kant most fully expresses his thoughts on the subject. For present purposes, the most relevant passage is paragraph 15 of the Preface of the Metaphysical Foundations, where Kant says that the concept of matter had … to be carried through all four of the indicated functions of the concepts of the understanding , where in each a new determination of this concept was added. The.. (shrink)

Various publications claim that medical AI systems perform as well, or better, than clinical experts. However, there have been very few controlled trials and the quality of existing studies has been called into question. There is growing concern that existing studies overestimate the clinical benefits of AI systems. This has led to calls for more, and higher-quality, randomized controlled trials of medical AI systems. While this a welcome development, AI RCTs raise novel methodological challenges that have seen little discussion. We (...) discuss some of the challenges arising in the context of AI RCTs and make some suggestions for how to meet them. (shrink)

Many graduate programmes in science now require courses in ethics. However, little is known about their reception or use. Using websites and interviews, this essay examines ethics requirements in the field of biosciences in three countries (the United States of America, the United Kingdom, and Italy) between 2000 and 2005. Evidence suggests that current policies may be ineffective, and that scientists who take ethical issues seriously are seen as exceptional.

The original proof of the four-color theorem by Appel and Haken sparked a controversy when Tymoczko used it to argue that the justification provided by unsurveyable proofs carried out by computers cannot be a priori. It also created a lingering impression to the effect that such proofs depend heavily for their soundness on large amounts of computation-intensive custom-built software. Contra Tymoczko, we argue that the justification provided by certain computerized mathematical proofs is not fundamentally different from that provided by surveyable (...) proofs, and can be sensibly regarded as a priori. We also show that the aforementioned impression is mistaken because it fails to distinguish between proof search (the context of discovery) and proof checking (the context of justification). By using mechanized proof assistants capable of producing certificates that can be independently checked, it is possible to carry out complex proofs without the need to trust arbitrary custom-written code. We only need to trust one fixed, small, and simple piece of software: the proof checker. This is not only possible in principle, but is in fact becoming a viable methodology for performing complicated mathematical reasoning. This is evinced by a new proof of the four-color theorem that appeared in 2005, and which was developed and checked in its entirety by a mechanical proof system. (shrink)

In den Kant-Forschungen werden sowohl historisch als auch systematisch orientierte Arbeiten zur Philosophie Immanuel Kants veröffentlicht. Die Bände stellen Funde unbekannter oder verschollen geglaubter Kantischer Autographen und Vorlesungsskripte vor und erörtern Editionsprobleme der Kantischen Vorlesungen und Werke. Sie enthalten darüber hinaus Studien zu Kants Umfeld und zur Kant-Rezeption im 18. Jahrhundert sowie systematisch angelegte Arbeiten zu Architektonik und System der Philosophie Kants.

PA is Peano Arithmetic. Pr(x) is the usual Σ1-formula representing provability in PA. A strong provability predicate is a formula which has the same properties as Pr(·) but is not Σ1. An example: Q is ω-provable if PA + ¬ Q is ω-inconsistent (Boolos [4]). In [5] Dzhaparidze introduced a joint provability logic for iterated ω-provability and obtained its arithmetical completeness. In this paper we prove some further modal properties of Dzhaparidze's logic, e.g., the fixed point property and the Craig (...) interpolation lemma. We also consider other examples of the strong provability predicates and their applications. (shrink)

Synchronic norms of theory choice, a traditional concern in scientific methodology, restrict the theories one can choose in light of given information. Diachronic norms of theory change, as studied in belief revision, restrict how one should change one’s current beliefs in light of new information. Learning norms concern how best to arrive at true beliefs. In this paper, we undertake to forge some rigorous logical relations between the three topics. Concerning, we explicate inductive truth conduciveness in terms of optimally direct (...) convergence to the truth, where optimal directness is explicated in terms of reversals and cycles of opinion prior to convergence. Concerning, we explicate Ockham’s razor and related principles of choice in terms of the information topology of the empirical problem context and show that the principles are necessary for reversal or cycle optimal convergence to the truth. Concerning, we weaken the standard principles of agm belief revision theory in intuitive ways that are also necessary for reversal or cycle optimal convergence. Then we show that some of our weakened principles of change entail corresponding principles of choice, completing the triangle of relations between,, and. (shrink)

In this paper, we identify and explain three kinds of bedrock in moral thought. The term "bedrock," as introduced by Wittgenstein in §217 of the Philosophical Investigations, stands for the end of a chain of reasoning. We affirm that some chains of moral reasoning do indeed end with certainty. However, different kinds of certainties in morality work in different ways. In the course of systematizing the different types of certainties, we argue that present accounts of certainties in morality do not (...) reflect their diversity. Our analysis yields three types of moral certainty: QUASI-UNDOUBTABLE CERTAIN PROPOSITIONS, CERTAIN PROPOSITIONS, and TRANSCENDENTAL CERTAINTIES. We show that the first two types can, at least to some extent, be intelligibly doubted. Therefore, they do not possess the characteristics that would classify them as bedrock in the strictest sense. TRANSCENDENTAL CERTAINTIES cannot likewise be doubted because they are rules that enable moral thinking. Thus, deviating from them is unintelligible. We shall argue that all three types reflect ways in which moral language games come to an end, while only one, TRANSCENDENTAL CERTAINTIES, displays the characteristic of being solid bedrock. (shrink)

By taking into account some texts published between the first and the second edition of the Critique of Pure Reason that have been neglected by most of those who have dealt with the deduction of the categories, I argue that the core of the deduction is to be identified as the ‘almost single inference from the precisely determined definition of a judgment in general’, which Kant adumbrates in the Metaphysical Foundations in order to ‘make up for the deficiency’ of the (...) A-deduction. Whereas the first step of the B-deduction is an attempt to show that the manifold of an intuition belongs to the ‘necessary unity of self-consciousness’ by means of the synthesis of the understanding, the second step has the task of showing that the very same synthesis is responsible for the spatio-temporal unity of the manifold. Thus, Kant's ‘answer to Hume’ is that no spatio-temporal objects of experience at all are merely ‘given’, independently of the conceptual activities of the understanding. Against the established view I substantiate the claim that with this ‘almost single inference’ of the second proof step the distinction between judgments of perception and judgments of experience consequently vanished from Kant's thinking. (shrink)

One of the key ethical debates in Russian religious thought, initiated by Leo Tolstoy, concerned the question of nonresistance to evil by force. The purpose of this article is to assess the influence of Kant’s ethics and philosophy of religion on the course of this debate and to determine the place and significance of the arguments and considerations expressed on this issue by Semyon Frank in the early and late periods (1908 and 1940s) of his work. To this end I (...) reconstruct the general course of the debate, notably the positions and arguments of Leo Tolstoy, Vladimir Solovyov, Ivan Ilyin and Nikolai Berdyaev. Beginning with Tolstoy, Russ­ian thinkers introduced the original ethical content of the idea of nonresistance derived from the Gospel into the ethics of duty borrowed from Kant. The Tolstoy version of this idea was challenged mainly from two directions: from the Kantian grounding of the legitimacy of coercion and attempts to bring in styles of moral thinking other than the ethic of duty. Ilyin’s apolo­gia for the use of force in the struggle against evil prompted Russian émigré thinkers to take a closer look at Tolstoy’s ethical concept and pay attention to its positive content. On this basis Berdyaev and especially Frank create their version of the Christ-centered ethic of salvation which, in the perspective of “protecting the world against evil” includes the ethic of duty and links it with the possibility of using force, always a wrongful act, but one justified “in a situation of extreme need”. (shrink)

Volume 25, Issue 2, February 2025, Page 61-64.

In this paper I discuss the ways in which the early Christian writer Arnobius of Sicca used rhetoric to shape religious identity inAduersus nationes. I raise questions about the reliability of his rhetorical work as a historical source for understanding conflict between Christians and pagans. The paper is intended as an addition to the growing literature in the following current areas of study: the role of local religion and identity in the Roman Empire; the presence of pagan elements in Christian (...) religious practices; the question of how to approach rhetorical works as historical evidence. (shrink)

ArgumentPost-Stalinist reforms resulted in dramatic changes in the ways of operation of Soviet science: one can say that they altered the very understanding of what science was, or should be, in the socialist society. A new vision came about as a result of political and rhetorical efforts of scientists, who pushed forward their various, often conflicting, agendas acting in accordance with specific rules of Soviet polity. The most visible part of the reform came with the 1961 administrative reorganization of the (...) USSR Academy of Sciences. The related series of changes, however, was much broader and comprehensive, modifying the relationships between science and ideology, politicians and academic researchers, and establishing the very division between fundamental and applied research, which had been strongly rejected during the preceding Stalinist period. (shrink)

IMMANUEL KANT GRADUATED IN 1755 from the University of Königsberg on the basis of the dissertation On Fire and with the essay A New Exposition of the First Principles of Metaphysics written specifically for the occasion; he took up a position as lecturer in the same year. In 1756 he wrote a third Latin essay, the Physical Monadology, and applied for a professorship at the Albertina in Königsberg. The application was unsuccessful and, more significantly, the work failed to attract the (...) attention Kant had hoped. He had to wait until 1770—some fourteen years later—for an appointment as full professor in Königsberg, and it was not until the publication of the Critique of Pure Reason in 1781 that he finally established his reputation as a philosopher. (shrink)

Name der Zeitschrift: Kant-Studien Jahrgang: 105 Heft: 4 Seiten: 509-530.

Against the well-established critical rejection of rights a growing literature in the tradition of agonistic democracy asserts their emancipatory role in the struggles for social change. However, agonistic theorists, invested as they are in the idea of democratic innovation as a process of gradual ‘augmentation’ of existing rules, institutions and practices, fail to account for the ruptural capacity, and hence for the full radical potential, of rights. Using the performative approach, I develop a conception of rights claiming as a defiant (...) practice to express the ruptural dimension of certain forms of rights politics. I demonstrate how defiant rights claiming articulates immanent critique by declaring the incapacity of putative duty-bearer institutions and governments to uphold the claimed right due to structural constraints, thereby generating inevitable contradictions within the extant order and creating the necessity for an alternative one. Moreover, in order to fully capture the emancipatory potential and creative capacity of rights, this article argues for understanding certain forms of rights politics both as augmentation and rupture, taking the two to be different dimensions of the same radical democratic practice. I present the creative use of rights discourse by the Landless Workers’ Movement in Brazil and the transnational network of agrarian movements, La Via Campesina, as precisely such a combination of the practice of augmentation and defiant claims, which has led to the transformation of the right to food and land into the right to food sovereignty, demonstration of the structural embeddedness of rights violations in the existing global regime of food production and distribution, and authorisation of an alternative vision of the future. (shrink)

We say that two arithmetical formulas A, B have the Σ1-interpolation property if they have an ‘interpolant’ σ, i.e., a Σ1 formula such that the formulas A→σ and σ→B are provable in Peano Arithmetic PA. The Σ1-interpolability predicate is just a formalization of this property in the language of arithmetic.Using a standard idea of Gödel, we can associate with this predicate its provability logic, which is the set of all formulas that express arithmetically valid principles in the modal language with (...) two modal operators, □ for provability in PA and for Σ1-interpolability. In this paper we determine this provability logic .It turns out that this problem appears to be quite similar to the problem of such modal description of relative interpretability, a problem, solved by Berarducci and Shavrukov. However, the present case is sometimes easier. In particular, we prove in this paper the fixed point property and the Craig interpolation property for our modal system ELH. (shrink)