Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation, has an important role in a variety of diseases and pathological conditions, such as cancer. Targeting ferroptosis is emerging as a promising means of therapeutic intervention in cancer treatment. Polyunsaturated fatty acids, reactive oxygen species, and labile iron constitute the major underlying triggers for ferroptosis. Other regulators of ferroptosis have also been discovered recently, among them the mechanistic target of rapamycin complex 1 (mTORC1), a central controller of cell (...) growth and metabolism. Inhibitors of mTORC1 have been used in treating diverse diseases, including cancer. In this review, we discuss recent findings linking mTORC1 to ferroptosis, dissect mechanisms underlying the establishment of mTORC1 as a key ferroptosis modulator, and highlight the potential of co‐targeting mTORC1 and ferroptosis in cancer treatment. This review will provide valuable insights for future investigations of ferroptosis and mTORC1 in fundamental biology and cancer therapy. (shrink)

The article explores Chinese rural migrants’ perspective on work and their relations with each other and with the Chinese state by drawing upon the ethnographical study of a group of rural home renovators in Beijing in the 1990s. The rural renovators were dubbed “guerrilla” workers because of their physical mobility, irregular employment, and unregistered status. After considering the novelty of guerrilla workfare in China, the article demonstrates the bifurcation of migrants’ social networks along the lines of work and everyday association, (...) locates the politics of worker-state interaction at the place of their everyday living, and explores their understanding of work that is remarkably devoid of nostalgia for state socialism. (shrink)

Post-stroke depression is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced effective connectivity alterations in emotional networks using multivariate Granger causality analysis. Forty-four patients with PSD were equally allocated into an immersive-virtual reality group and a control group. In addition to their usual rehabilitation treatments, the participants in the immersive-virtual reality (...) group participated in an immersive-virtual reality rehabilitation program, while the patients in the control group received 2D virtual reality rehabilitation training. The Hamilton Depression Rating Scale, modified Barthel Index, and resting-state functional magnetic resonance imaging data were collected before and after a 4-week intervention. rsfMRI data were analyzed using multivariate GCA. We found that the immersive virtual reality training was more effective in improving depression in patients with PSD but had no statistically significant improvement in MBI scores compared to the control group. The GCA showed that the following causal connectivities were strengthened after immersive virtual reality training: from the amygdala, insula, middle temporal gyrus, and caudate nucleus to the dorsolateral prefrontal cortex; from the insula to the medial prefrontal cortex; and from the thalamus to the posterior superior temporal sulcus. These causal connectivities were weakened after treatment in the control group. Our results indicated the neurotherapeutic use of immersive virtual reality rehabilitation as an effective non-pharmacological intervention for PSD; the alteration of causal connectivity in emotional networks might constitute the neural mechanisms underlying immersive-virtual reality rehabilitation in PSD. (shrink)

近年來關於賽伯格與後人類主義的論述在西方世界方興未艾，論者紛紛從科學、醫學、宗教、哲學、倫理學、社會學、文學與文化研究等各個不同面向思考人們正在經歷的後人類世界。但對一般中文讀者而言，這兩個新詞彙所指 涉的意義仍相當模糊。本書收錄了國內外關於賽伯格與後人類主義的重要論文，嘗試探討人與科技、身體與環境、精神與物質兩者界線逐漸消弭的後人類社會裡的危機與轉機。本書討論之內容相當廣泛，除了探討大眾文化所透露 出的哲學內涵，也從生態文學談到科幻小說，本身即為一部賽伯格文本，不但充斥著許多有意思的矛盾或裂縫，也跨越了各個不同的學門界線，多元豐富的內容相信能夠給予中文讀者提供一個從文學、文化研究角度思索賽伯格與 後人類的獨特視野。.

Deception is common in the marketplace where individuals pursue self-interests from their perspectives. Extant research suggests that perspective-taking, a cognitive process of putting oneself in other’s situation, increases consumers’ ethical tolerance for marketers’ deceptive behaviors. By contrast, the current research demonstrates that consumers who take the dishonest marketers’ perspective become less tolerant of deception when consumers’ moral self-awareness is high. This effect is driven by moral self-other differentiation as consumers contemplate deception from the marketers’ perspective: high awareness of the “moral (...) self” motivates consumers to distance themselves from the “immoral other.” The findings shed new light on how self-morality can vicariously shape social consideration in ethical judgments. (shrink)

Guang Yangs Arbeit nimmt die zentrale Frage des heideggerschen Denkens nach dem Wesen des Logos und der Sprache wieder auf, verbindet sie aber mit dem Begriff der Dynamis. So erweist sich der Logos als diejenige Kraft, die zwischen Bewegung und Ruhe vermitteln und damit die Bewegtheit des Seins in sich versammeln kann. Mit dieser in sich gesammelten Kraft hängt auch das Phänomen der Ruhe zusammen, welches die Bewegung auffängt und entsprechend aufgewertet werden muss. Dieser in der Heidegger-Forschung selten beachtete (...) Gedanke der Ruhe deutet auf die privative Dimension des Seins hin, die auch bei Phänomenen wie räumlicher Leere und der Stille zum Tragen kommt und dabei nicht negativ zu fassen ist. In dieser Untersuchung wird zudem - mit und gegen Heidegger - der Möglichkeitscharakter des Seins hervorgehoben, der nicht allein in der vollzugshaften Bewegung aufgeht. (shrink)

Recently, Frauchiger and Renner proposed a Gedankenexperiment, which was claimed to be able to prove that quantum theory cannot consistently describe the use of itself. Here we show that the conclusions of Frauchiger and Renner actually came from their incorrect description of some quantum states. With the correct description there will be no inconsistent results, no matter which quantum interpretation theory is used. Especially, the Copenhagen interpretation can satisfy all the three assumptions,, and of Frauchiger and Renner simultaneously, thus it (...) has no problem consistently describing the use of itself. (shrink)

We give a general proof showing that if the evolution from one state to another is not reversible, then the projective measurements on the superposition of these two states are impossible. Applying this no-go result to the Schrödinger’s cat paradox implies that if something is claimed to be a real Schrödinger’s cat, there will be no measurable difference between it and a trivial classical mixture of ordinary cats in any physically implementable process, unless raising the dead becomes reality. Other similar (...) macroscopic quantum superpositions cannot be observed either, due to the lack of non-commuting measurement bases. Our proof does not involve any quantum interpretation theory and hypothesis. (shrink)

The Chinese traditional culture includes three systems of thought: Confucianism, Daoism and Buddhism. The first two are Chinese culture, and Buddhism is a foreign religion introduced from India. Although there had been conflicts among the three systems of thoughts, but integration is the mainstream in the development of Chinese cultural thought. Thus, Chinese culture has developed into a system by uniting the three religions into one with Confucianism at the centre supported by Daoism and Buddhism. For over 2,000 years, Buddhism (...) has interacted with all levels of Chinese culture such as literature, philosophy, morality, arts, architecture and religions. As a result, Buddhism has successfully integrated into the traditional Chinese culture and has become one of the three pillars. In this paper, I will discuss the Buddhist impact on Chinese culture from the following four points: (1) philosophy and moral teaching; (2) religions and popular beliefs; (3) language and literature; and (4) art and architecture. (shrink)

本书包括:系统自然观、演进自然观、生态自然观、科学技术观、历史科学技术观、社会科学技术观等.

本书从生态文艺的基本观念到历史扫描,进而比较宏观地把握中国美学中的生态思想及中国古代艺术中生态性体验的特点,并由此通过对中国古代美学与艺术的生态特点的认识,通过对其理论及审美转换性的把握而引申至现代, 着力挖掘其现代意义及价值。.

As an important branch of applied anthropology, business anthropology has developed well in China in the recent past. This has attracted the attention of not only the academic society but also of industrial and commercial circles. This article illustrates the emergence and the development of business anthropology in China, and affirms the work of Chinese pioneers in this branch of cultural anthropology. It elaborates on what contemporary management and anthropological scholars have contributed to promote business anthropology in that country. Moreover, (...) it expounds, from various perspectives, on the role that business anthropology can play for/in China. China is a large country developing at an astonishing speed. Chinese society is transforming from a traditional agricultural and pre-industrial phase into a post-industrial and commercial phase. Therefore, the development of business anthropology in China is promising. (shrink)

v. 1. Li ze xue -- v. 2. Yu zhou lun xin li xue -- v. 3 Xing shang xue.