BackgroundInnovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accommodate these innovations and comply with ethical, legal and regulatory requirements. This paper explores how Dynamic Consent may provide solutions to address challenges encountered when researchers invite individuals to participate in research and follow them up over time in a continuously changing environment.MethodsAn interdisciplinary workshop jointly organised by the University of Oxford (...) and the COST Action CHIP ME gathered clinicians, researchers, ethicists, lawyers, research participants and patient representatives to discuss experiences of using Dynamic Consent, and how such use may facilitate the conduct of specific research tasks. The data collected during the workshop were analysed using a content analysis approach.ResultsDynamic Consent can provide practical, sustainable and future-proof solutions to challenges related to participant recruitment, the attainment of informed consent, participant retention and consent management, and may bring economic efficiencies.ConclusionsDynamic Consent offers opportunities for ongoing communication between researchers and research participants that can positively impact research. Dynamic Consent supports inter-sector, cross-border approaches and large scale data-sharing. Whilst it is relatively easy to set up and maintain, its implementation will require that researchers re-consider their relationship with research participants and adopt new procedures. (shrink)

Personalized medicine aims to tailor disease prevention, diagnosis, and treatment to individuals on the basis of their genes, lifestyle and environments. Patient and interest organizations may potentially play an important role in the realization of PM. This paper investigates the views and perspectives on PM of a variety of PIOs. Semi-structured telephone interviews were conducted among leading representatives of 13 PIOs located in Europe and North-America. The data collected were analysed using a conventional content analysis approach. The PIO representatives supported (...) the realization of PM but feared that many financial, structural and organizational challenges may delay its realization. They encouraged strategies to modernize drug licencing mechanisms, develop research and data sharing infrastructures, and educate patients and health care professionals in PM. Notably, they emphasized the importance of developing PM in an equitable way and taking into consideration the patients’ needs, values and personal situation. Despite varying levels of awareness regarding PM, the PIO representatives expressed willingness to engage in the PM agenda and recommended that PIOs work closely with policy-makers to design PM in a way that truly addresses the needs and concerns of patients. PIOs have the potential to become central drivers of the PM agenda. Collaborations should be further developed between PIOs, researchers, drug developers and health care authorities. (shrink)

A propositional logic is defined which in addition to propositional language contains a list of probabilistic operators of the form P ≥s (with the intended meaning ‘‘the probability is at least s’’). The axioms and rules syntactically determine that ranges of probabilities in the corresponding models are always finite. The completeness theorem is proved. It is shown that completeness cannot be generalized to arbitrary theories.

The relationship between great statesmen and political parties and what this means for political science and theories of the state; studies of Otto von Bismarck, Woodrow Wilson, Franklin Roosevelt, Mahatma Gandhi and Nikola Pasic and their struggles for the public good and the national interest.

Individual research results from population-based genetic and genomic research are traditionally not disclosed to research participants. Current practices of non-disclosure are, however, being challenged by an increasing number of scientists, ethicists and policy-makers who make arguments in favour of disclosing at least individual results of potential health or lifestyle significance to research participants. Simultaneously, research participants are expressing greater interest in accessing their results. This article first provides an overview of main arguments for and against the disclosure of individual research (...) results to research participants. Next, it discusses the need for a move from the current ethical framework under which researchers operate, which is rather protective of research participants and does not encourage disclosure, to a new ethical framework that would better cope with current developments within the field. Comparative analysis of existing and potential ethical frameworks favours implementation of an ethical framework aimed at enhancing the autonomy of research participants through the disclosure of individual research results. Finally, this article explores practical models of disclosure that could be used under such a new framework. A model of disclosure that takes into account the two key criteria of communicability of research results and the research participant’s preferences to determine which results to disclose is found to comply best with the selected ethical framework. (shrink)

v. 1. Religija Njegoša. Besede pod gorom -- v. 2. Reči o svečoveku. Indijska pisma. Iznad istoka i zapada. Srednji sistem. Niče i Dostojevski. Šekspir--svečovek -- v. 3. Homilogija. Simboli i signali. Rat i biblija. Carev zavet. Vasionik. Rahabilitacija tela. U harmoniji sa beskrajnim. Pravoslavna crkva u uzročost u svetu -- v 4. Omilije -- v. 5. Omilije -- v. 6. Nove besede pod gorom. Iznad greha i smrti. Oče Naš. Rajska piramida. Ljubostinjski stoslov. Misli o dobru i zlu -- (...) v. 7. Tesdul. Kroz tamnički prozor -- v 8. Misionarska pisma -- v. 9. Srpski narod kao Teodul. Divan. Emanuel. Kasijana. Zemlja nedođija -- v. 10. Molitve na jezeru. Pesme molitvene. Molitve. Žetve Gospodnje. Ledini čovekoljubac -- v. 11. Vladika Nikolaj u službi Bogu i rodu. Život svetog Save. Članci, besede i poslanice. Sveri srbi. Blažena Stojna -- v. 12. Kosovo i vidovdan. Dobrovoljci. Mudra igumanija Ljubostinjska. O srpskom patriotizmu. O znamenitim ličstima. Konkordatska borba 1937. godine -- v. 13. Ustanak robova. Srbija u svetlosti i mraku. O istoriji. Duhovni preporod Evrope. O Evropi. Agonija crkve. O zapadnom hrišćanstvu -- v. 14. Biblijske teme. Jevanđelske teme. Egzegeza. O vrlinama. Eseji -- v. 15. Bogomoljački pokret. Duhovne pouke. O ekologiji -- v. 16. Besede -- v. 17. Knjiga o Isusu Hristu. Vera obrazovanih ljudi. Vera svetih. Prvi zakon božji. Molitva gospodnja. Misli o dobru i zlu -- v. 18. knj. 1. Ohridski prolog -- v. 19. knj. 2. Ohridski prolog -- v. 20. knj. 3. Ohridski prolog. (shrink)