How eukaryotic genomes are packaged into compact cylindrical chromosomes in preparation for cell divisions has remained one of the major unsolved questions of cell biology. Novel approaches to study the topology of DNA helices inside the nuclei of intact cells, paired with computational modeling and precise biomechanical measurements of isolated chromosomes, have advanced our understanding of mitotic chromosome architecture. In this Review Essay, we discuss – in light of these recent insights – the role of chromatin architecture and the functions (...) and possible mechanisms of SMC protein complexes and other molecular machines in the formation of mitotic chromosomes. Based on the information available, we propose a stepwise model of mitotic chromosome condensation that envisions the sequential generation of intra‐chromosomal linkages by condensin complexes in the context of cohesin‐mediated inter‐chromosomal linkages, assisted by topoisomerase II. The described scenario results in rod‐shaped metaphase chromosomes ready for their segregation to the cell poles. (shrink)

The fifty-seven original essays in this book provide a comprehensive overview of the interdisciplinary field of animal cognition.

This paper is concerned with the problem of selfidentification in the domain of action. We claim that this problem can arise not just for the self as object, but also for the self as subject in the ascription of agency. We discuss and evaluate some proposals concerning the mechanisms involved in selfidentification and in agencyascription, and their possible impairments in pathological cases. We argue in favor of a simulation hypothesis that claims that actions, whether overt or covert, are centrally simulated (...) by the neural network, and that this simulation provides the basis for action recognition and attribution. (shrink)

This paper argues that Rawls’ principles of justice provide a normative foundation for stakeholder theory. The principles articulate (at an abstract level) citizens’ rights; these rights create interests across all aspects of society, including in the space of economic activity; and therefore, stakeholders – as citizens – have legitimate interests in the space of economic activity. This approach to stakeholder theory suggests a political interpretation of Boatright’s Moral Market approach, one that emphasizes the rights/place of citizens. And this approach to (...) stakeholder theory – in terms of citizens – raises a further question, what rights and obligations do economic agents have, beyond those attached to their roles as citizens? Rawls would reject additional rights and obligations of this sort for two reasons, one tied to freedom and one tied to pluralism. Rawls’ work therefore presses us to re-conceptualize the place of ethical claims in the economic context. (shrink)

How do humans discover causal relations when the effect is not immediately observable? Previous experiments have uniformly demonstrated detrimental effects of outcome delays on causal induction. These findings seem to conflict with everyday causal cognition, where humans can apparently identify long-term causal relations with relative ease. Three experiments investigated whether the influence of delay on adult human causal judgements is mediated by experimentally induced assumptions about the timeframe of the causal relation in question, as suggested by Einhorn and Hogarth (1986). (...) Causal judgements generally decreased when a delay separated cause and effect. This decrease was less pronounced when the thematic context of the causal relation induced participants to expect a delay. Experiment 3 ruled out an alternative explanation of the effect based on variations of cue and outcome saliencies, and showed that detrimental effects of delay are reduced even more when instructions explicitly mentioned the timeframe of the causal relation in question. Knowledge thus mediates the impact of delay on human causal judgement. Implications for contemporary theories of human causal induction are discussed. (shrink)

The thesis we develop in this essay is that all humans are endowed with a moral faculty. The moral faculty enables us to produce moral judgments on the basis of the causes and consequences of actions. As an empirical research program, we follow the framework of modern linguistics.1 The spirit of the argument dates back at least to the economist Adam Smith (1759/1976) who argued for something akin to a moral grammar, and more recently, to the political philosopher John Rawls (...) (1971). The logic of the argument, however, comes from Noam Chomsky’s thinking on language specifically and the nature of knowledge more generally (Chomsky, 1986, 1988, 2000; Saporta, 1978). If the nature of moral knowledge is comparable in some way to the nature of linguistic knowledge, as defended recently by Harman (1977), Dwyer (1999, 2004), and Mikhail (2000; in press), then what should we expect to find when we look at the anatomy of our moral faculty? Is there a grammar, and if so, how can the moral grammarian uncover its structure? Are we aware of our moral grammar, its method of operation, and its moment-to-moment functioning in our judgments? Is there a universal moral grammar that allows each child to build a particular moral grammar? Once acquired, are different moral grammars mutually incomprehensible in the same way that a native Chinese speaker finds a native Italian speaker incomprehensible? How does the child acquire a particular moral grammar, especially if her experiences are impoverished relative to the moral judgments she makes? Are there certain forms of brain damage that disrupt moral competence but leave other forms of reasoning intact? And how did this machinery evolve, and for what particular adaptive function? We will have more to say about many of these questions later on, and Hauser (2006) develops others. However, in order to flesh out the key ideas and particular empirical research paths, let us turn to some of the central questions in the study of our language faculty.. (shrink)

Structured around Charles S. Peirce's three-fold categorical scheme, this article proposes a comparative study of Ayn Rand and Peirce's realist views in general metaphysics. Rand's stance is seen as diverging with Peirce's argument from asymptotic representation but converging with arguments from brute relation and neutral category. It is argued that, by dismissing traditional subject-object dualisms, Rand and Peirce both propose iconoclastic construals of what it means to be real, dismissals made all the more noteworthy by the fact each chose to (...) ground them in indissoluble triads of self-evident first principles. (shrink)

"Representation" is one of those Janus-faced terms that seems blatantly obvious when used in a casual or pre-theoretic manner, but which reveals itself far more slippery when attentively studied. Any allusion to "metarepresentation", it would then seem, only compounds these difficulties. Taking the metarepresentationalist framework in its roughest outline as our point of departure, we thus articulate four key "structural" features that appear binding for any such theory.

This paper addresses Prinz's naturalistic theory of conceptual content, which he has defended in several works (Prinz, 2000; 2002; 2006). More precisely, I present in detail and critically assess his account of referential content, which he distinguishes from nominal or cognitive content. The paper argues that Prinz's theory faces four important difficulties, which might have significant consequences for his overall empiricist project.

. I emphasize the importance of broadening behavioral, ecological, and conservation science into a more integrative, interdisciplinary, socially responsible, compassionate, spiritual, and holistic endeavor. I stress the significance of studies of animal behavior, especially ethological research concerned with animal emotions in which individuals are named and recognized for their own personalities, for helping us to learn not only about the nonhuman animal beings with whom we share Earth but also about who we are and our place in nature. We are (...) best understood in relationship with others. To this end I develop the notions of “minding animals” and “deep ethology.” Animals are sources of wisdom, a way of knowing. We are all citizens of Earth, members of a global community in which intimate reciprocal and beneficent peaceful relationships are mandatory. A world without cruelty and with boundless compassion, respect, grace, humility, spirituality, and love would be a better world in which to live. We have compelling responsibilities for making Earth a better and more peaceful habitat for all beings. It is essential that we do better than our ancestors. We must reflect and step lightly as we “redecorate” nature. Time is not on our side. I plead for the development of heartfelt and holistic science that allows for joy and play. Science need not be suspicious of things it cannot fully understand. We must not avert our eyes or other senses from the eyes and voices of other beings who urgently need our uncompromising and unconditional aid and love. We can do much more than we have done for animals and the Earth. (shrink)

Darwin offered an intriguing answer to the species problem. He doubted the existence of the species category as a real category in nature, but he did not doubt the existence of those taxa called ‘‘species’’. And despite his scepticism of the species category, Darwin continued using the word ‘‘species’’. Many have said that Darwin did not understand the nature of species. Yet his answer to the species problem is both theoretically sound and practical. On the theoretical side, DarwinÕs answer is (...) confirmed by contemporary biology, and it offers a more satisfactory answer to the species problem than recent attempts to save the species category. On the practical side, DarwinÕs answer frees us from the search for the correct theoretical definition of ‘‘species’’. But at the same time it does not require that we banish the word ‘‘species’’ from biology as some recent sceptics of the species category advocate. Ó The Willi Hennig Society 2010. (shrink)

Although ‘modern’ mental health care comprises a variety of theoretical approaches and practices, the supposed identification of ‘mental illness’ can be understood as being made on the basis of a specific conception of subjectivity that is characteristic of ‘modernity’. This is to say that any perceived ‘deviation’ from this characteristically ‘modern self’ is seen as a possible ‘sign’ of ‘mental illness’, given a ‘negative determination’, and conceptualized in terms of a ‘deficiency’ or a ‘lack’; accordingly, the ‘ideal’‘therapeutic’ aim of ‘modern’ (...) mental health care can be understood as the ‘rectification’ of that ‘deficiency’ through a ‘re-instatement’ of the ‘modern self’. Although contemporary mental health care is increasingly becoming influenced by the so-called ‘death’ of the ‘modern self’, this paper will suggest that it is the work of the 20th century French philosopher, Gilles Deleuze, that is able to provide mental health care with a coherent determination of a ‘post-modern self’. However, a Deleuzian account of subjectivity stands in stark contrast to ‘modernity’s’ conception of subjectivity and, as such, this paper will attempt to show how this ‘post-modern’ subjectivity challenges many of the assumptions of ‘modern’ mental health care. Moreover, acknowledging the complexity and the perceived difficulty of Deleuze’s work, this paper will provide an account of subjectivity that can be understood as ‘Deleuzian’ in its orientation, rather than ‘Deleuze’s theory of subjectivity’, and therefore, this paper also seeks to stimulate further research and discussion of Deleuze’s work on subjectivity, and how that work may be able to inform, and possibly even reform, the theoretical foundations and associated diagnostic and therapeutic practices of psychiatry, psychotherapy, and mental health nursing. (shrink)

Regularity theories of causation are guided by the idea that causes are collectively sufficient for their effects. Following Mackie [1974], that idea is typically refined to distinguish collections that include redundant members from those that do not. Causes must be collectively sufficient for their effects without redundancy. While Mackie was surely right that the regularity theory must distinguish collections that are in some sense minimally sufficient for an effect from those that include unnecessary hangers-on, I believe that redundancy is the (...) wrong mark of that distinction. I propose a way to develop the regularity theory without it. Instead of distinguishing minimal from mere sufficiency in terms of redundancy, we should look to the influence that events have in the world. Causes, so construed, must have just enough collective influence to ensure that an effect occurs. I argue that such an account provides a uniform solution to the problem of epiphenomena and to a pair of related problems that aris.. (shrink)

Whereas classic work in judgment and decision making has focused on the deviation of intuition from rationality, more recent research has focused on the performance of intuition in real-world environments. Borrowing from both approaches, we investigate to which extent competing models of intuitive probabilistic decision making overlap with choices according to the axioms of probability theory and how accurate those models can be expected to perform in real-world environments. Specifically, we assessed to which extent heuristics, models implementing weighted additive information (...) integration (WADD), and the parallel constraint satisfaction (PCS) network model approximate the Bayesian solution and how often they lead to correct decisions in a probabilistic decision task. PCS and WADD outperform simple heuristics on both criteria with an approximation of 88.8% and a performance of 73.7%. Results are discussed in the light of selection of intuitive processes by reinforcement learning. (shrink)

The French philosopher, Gilles Deleuze, is emerging as one of the most important and influential philosophers of the 20th century, having published widely on philosophy, literature, language, psychoanalysis, art, politics, and cinema. However, because of the ‘experimental’ nature of certain works, combined with the manner in which he draws upon a variety of sources from various disciplines, his work can seem difficult, obscure, and even ‘willfully obstructive’. In an attempt to resist such impressions, this paper will seek to provide an (...) accessible introduction to Deleuze's work, and to begin to discuss how it can be employed to provide a significant critique and reconceptualization of the theoretical foundations and therapeutic practices of psychiatry, psychotherapy, and mental health nursing. In order to do this, the paper will focus upon Deleuze's masterwork, and the cornerstone to his philosophy as a whole, Difference and Repetition; in particular, it will discuss how his innovative and challenging account of time can be employed to provide a conception of human life as a ‘continuity’, rather than as a series of distinct ‘moments’ or ‘events’. As well as discussing the manner in which his work can provide us with an understanding of how life is different and significant for each human being, this paper will also highlight the potential importance of Deleuze's work for logotherapy, for the recent ‘turn’ to ‘narrative’ as a psychotherapeutic approach and for contemporary mental health care's growing interest in ‘social constructionism’. As such, this paper also seeks to stimulate further discussion and research into the importance and the relevance of Deleuze's work for the theory and practice of psychiatry, psychotherapy, and mental health nursing. (shrink)

Intentionality is a central feature of our understanding of the world. We daily attribute intentional states (like beliefs, desires or perceptual states) to explain the behavior of other agents, and many theories appeal to them to understand more complex notions. Nonetheless, intentional states are puzzling entities. This article explains what intentionality is and why it is so important and problematic at the same time. Secondly, it examines various naturalistic theories, which seek to show that intentionality is compatible with a scientific (...) worldview. Finally, given that all extant proposals face significant difficulties, it explores the available options in case no naturalistic theory can succeed. (shrink)

Globalization is a ubiquitousyet highly elusive term. The debate on the cont and meaning of globalization is still waged largely in binary terms; for example, globalization is understood either as increasing standardization or as increasing difference. This article argues that the effects of globalization are best understood in terms of the following three sets of simultaneous contradictions: convergence and divergence, inclusion and exclusion, and centralization and decentralization. These contradictions can be fruitfully “unpacked” and examined through critical stakeholder analysis (CSA). This (...) technique focuses on broader structural commonalties and differences among key stakeholder groups, factors that are not incorporated in mainstream stakeholder theory. The associated normative agenda of CSA promotes a common understanding of key issues within a focal organizational field, the negotiated settlement of zero-sum situations that optimize collective stakeholder interests within that field, and the containment and minimization of negative externalities within as well as between fields. (shrink)

Shaun Gallagher has actively looked into the possibility that psychopathologies involving “thought insertion” might supply a counterexample to the Cartesian principle according to which one can always recognize one’s own thoughts as one’s own. Animated by a general distrust of a priori demonstrations, Gallagher is convinced that pitting clinical cases against philosophical arguments is a worthwhile endeavor. There is no doubt that, if true, a falsification of the immunity to error through misidentification would entail drastic revisions in how we conceive (...) the boundary between self and other. However, I argue that (1) the idea of unearthing an exception to the Cartesian thesis is, on further reflection, not a realistic prospect and that (2) this casts doubt on the attempt to conjoin first-person phenomenology and third-person cognitive science in the service of philosophical debates. (shrink)

The sociology of emotions is a fast-growing disciplinary field. Research on emotions has enabled major advances in medical science, political science, anthropology, psychosociology etc. Turner and Smets have shown that social relations feature a kernel of phenomena with an emotional substrate ranging from face-to-face encounters to the emergence of social movements. The social arena is shaped by emotions, which are powerful agents of change. In this paper, we focus on the links between emotions, happiness and well-being apprehended as a polymorphic (...) state culturally determined by an emotional substrate. Finally, through the lenses of emotions, we sketch out the features of the structural crisis of neoliberalism and the lessons for a renewed understanding of the underlying socio-economic phenomena. (shrink)

Published in 1972, Anti‐Oedipus was the first of a number of collaborative works between the French philosopher, Gilles Deleuze, and the French psychoanalyst and political activist, Felix Guattari. As the first of a two‐volume body of work that bears the subtitle, Capitalism and Schizophrenia, Anti‐Oedipus is, to say the least, an unconventional work that should be understood, in part, as a product of its time – created as it was among the political and revolutionary fervour engendered by the events of (...) ‘May 1968’. However, this paper will suggest that Anti‐Oedipus – as a critique of psychoanalysis and the Oedipus complex, as well as being a study of the relationship between capitalism and schizophrenia – should also be understood in a less ‘time‐bound’ fashion. In particular, the paper will examine Deleuze and Guattari’s formulation of a concept of ‘desire’ and its employment in relation to subjectivity, time, capitalism, representation, and the radical ‘therapeutic’ practice that they refer to as ‘schizoanalysis’. Moreover, nearly 40 years after the events of May 1968 and against possible doubts concerning the contemporary relevance of psychoanalysis, it will be suggested that psychoanalysis and the Oedipus complex are to be understood as symptomatic of a wider ‘malaise’ that can be discerned within psychiatry, psychotherapy, and contemporary capitalist society itself, and that it is this that forms the broader target of the book’s critique. Accordingly, by providing an accessible and critical introduction to Anti‐Oedipus, the paper also hopes to stimulate further discussion and research regarding both the critique and the contribution that the work can make to contemporary psychiatry, psychotherapy, and mental health nursing generally. (shrink)

In order for the valuable research published in the Anthropology of Consciousness (AoC) journal to have the impact it ought to have upon the anthropological mainstream, contributors must demonstrate that they appreciate the historical tradition of anthropology as an intellectual forebear. Although “ethnometaphysics” has been cited sporadically by anthropologists over the past half-century, it never really caught on as an interdisciplinary speciality like ethnobotany, ethnomusicology, and ethnomathematics. Pointing to the example of discord in the West between viewing psychoactive substances as (...) either “hallucinogens” or “entheogens,” I reassert ethnometaphysics in an aim to revamp the overlooked coining of this sub-field by anthropologist A. Irving Hallowell. Such a position rebrands SAC's alternative outlook in a way that could be seen by mainstream colleagues as less radical, thus giving the Society a more realistic opportunity to provoke progressive changes in the mainstream of our discipline. (shrink)

Liberalism is the dominant ideology of our time, yet its character remains the subject of intense scholarly and political controversy. Inspired by the work of Michael Freeden, this book brings together an internationally-respected cast of scholars to debate liberalism and to redefine the very essence of what it is to be a liberal.

Dispositional accounts of various phenomena have claimed that dispositions can be intrinsically masked. In cases of intrinsic masking, something has a disposition while also having an intrinsic property that would prevent that disposition from manifesting in the face of its stimulus. This paper develops a theory of disposition ascriptions capable of recognizing such dispositions. The theory is modeled on the view that dispositions are powers. I propose that having a disposition is a matter of exerting a corresponding kind of influence. (...) Unlike powers theories, however, the account largely falls silent on questions of fundamental metaphysics. It does not build dispositions into fundamental ontology, posit necessary connections between properties, or otherwise appeal to sui generis modality. (shrink)

This paper outlines the often striking parallels of various approaches to ontic vagueness, as well as their even more striking differences. Though circling around the same idea, some of these approaches were developed to solve quite diverse theoretical problems and encounter different challenges. In addition to these difficulties, the frequently disregarded epistemological problems of all theories of ontic vagueness turn out to be even more serious under critical scrutiny. The same holds for the difficulties of deciding, for every case of (...) vagueness, whether the vagueness involved is semantic or ontic. (shrink)

In a recent article in this journal, Remsen attacked moral objections to killing birds for museum collections, objections that are frequently raised by the general public and scientific community alike. The only grounds for moral objections against killing birds that Remsen considers and rejects are reverence for all life or personal, that is sentimental reasons. What Remsen ignores is avian sentience and the moral imperative of respecting it.

The passion of inequality exists in the discourse that binds people by their adhesion to the beliefs about the hierarchic distribution of positions in society. In this manner the differences that structure the (apparently) natural titles to be governed or to govern are put in a state of aggregation. The apparent naturalness of these titles masks a principle of equality, a necessary artifact that breaches the nature of the social bond. This article argues that despite the hegemonic pressure of inequality, (...) the situation of apprenticeship can contain events of emancipation. For this, the 'master' must articulate two complementary artifacts in his relation with his apprentice. First, he must occupy a posture of ignorance. Second, he must ascribe priority to the object to be known or listened to (the text, the words ...) in such a way that a connection is made between the intelligences that he is interrogating and, thus, that their equality is verified. (shrink)

Technological changes affect Western culture in three ways: the ratio between the lifetimes of technologies and the human lifetime is inverted; the three principal realms of human life (the home, the workplace, and leisure activity), as well as political systems, are affected; and the cohesion of the social body is threatened. The impact on Eastern culture is softened by a clearer role assigned to school, the resulting level of education, and the influence of Confucian ethics. However, acculturation will vary among (...) countries, depending on the communication ability in the respective societies and the degree of development of social cellular structures, which are the most able to manage complexity. (shrink)

��Is moral judgment accomplished by intuition or conscious reasoning? An answer demands a detailed account of the moral principles in question. We investigated three principles that guide moral judgments: (a) Harm caused by action is worse than harm caused by omission, (b) harm intended as the means to a goal is worse than harm foreseen as the side effect of a goal, and (c) harm involving physical contact with the victim is worse than harm involving no physical contact. Asking whether (...) these principles are invoked to explain moral judgments, we found that subjects generally appealed to the first and third principles in their justifications, but not to the second. This finding has significance for methods and theories of moral psychology: The moral principles used in judgment must be directly compared with those articulated in justification, and doing so shows that some moral principles are available to conscious reasoning whereas others are not. (shrink)