Recently, there has been a convergence of fields studying the processing of DNA, such as transcription, replication, and repair. This convergence has been centered around the packaging of DNA in chromatin. Chromatin structure affects all aspects of DNA processing because it modulates access of proteins to DNA. Therefore, a central theme has become the mechanism(s) for accessing DNA in chromatin. It seems likely that mechanisms involved in one of these processes may also be used in others. For example, the discovery (...) of transcriptional coactivators with histone acetyltransferase activity and chromatin remodeling complexes has provided possible mechanisms required for efficient repair of DNA in chromatin. BioEssays 21:596–603, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Phronesis is essential for good decision‐making and actions. This literature review shows how phronesis has been discussed and related to elements of the field of administration and organizations. A search in the database systems Scopus, EBSCO, Web of Science, and Scielo, based on eligibility criteria, resulted in 43 theoretical and 14 empirical works. The analysis of these studies showed the most significant empirical contributions, the most cited authors, methods, journals, and central themes addressed in studies on phronesis to understand ethics (...) in business. From a virtue ethics perspective, we discuss the major theoretical and empirical contributions, as well as the implications of a restricted understanding of phronesis when it is treated apart from other elements of the virtue ethics framework. We present a synthesis of the concepts of phronesis, based on dimensions of magnitude and amplitude of the conceptions, ranging from formal to substantive phronesis, and covering individual, organizational, or societal levels of analysis. We argue that a substantive conception of phronesis within virtue ethics may improve our understanding of ethics because it assumes the interdependence of phronesis and moral virtues, integral anthropology, and the common good. We present a future research agenda, considering the study's limitations and findings. (shrink)

Decisions where there is not enough information for a well-informed decision due to unidentified consequences, options, or undetermined demarcation of the decision problem are called decisions under great uncertainty. This paper argues that public policy decisions on _how_ and _if_ to implement decision-making processes based on machine learning and AI for public use are such decisions. Decisions on public policy on AI are uncertain due to three features specific to the current landscape of AI, namely (i) the vagueness of the (...) definition of AI, (ii) uncertain outcomes of AI implementations and (iii) pacing problems. Given that many potential applications of AI in the public sector concern functions central to the public sphere, decisions on the implementation of such applications are particularly sensitive. Therefore, it is suggested that public policy-makers and decision-makers in the public sector can adopt strategies from the argumentative approach in decision theory to mitigate the established great uncertainty. In particular, the notions of framing and temporal strategies are considered. (shrink)

The Author presents the theoretical framework of this «Governare lapaura»’ issue on the Fear of Secession. Starting from the recent cases of the Brexit and the Catalonian referendum, the main goal of this issue is reflecting on the relationship between the political crisis of unitary State and the revival of secession.

Richard Kearney’s new book, Touch: Recovering Our Most Vital Sense, has come as a way of illustrating the paradoxes of our times, most deeply felt as a result of the Covid-19 pandemic. Have a look...

El artículo presenta resultados de una investigación doctoral en género centrada en la experiencia de mujeres argentinas con las Técnicas de Reproducción Humana Asistida (TRHA). En Argentina, la ley que regula el acceso a las TRHA garantiza el acceso a una diversidad de personas usuarias que no siempre parten de un diagnóstico de infertilidad. Se propone como objetivo principal conocer las diversas relaciones de las usuarias de TRHA con la tecnología reproductiva. Desde una perspectiva feminista, se trabaja con el análisis (...) cualitativo de relatos de usuarias de TRHA, mediante su codificación. Como resultados se identifican dos grandes categorías: “relatos de reparación”, donde la decisión de usar las TRHA se vincula a la noción de infertilidad; y los “relatos de simultaneidad”, donde la tecnología reproductiva aparece posibilitando una decisión reproductiva. Estas reflexiones constituyen un aporte para pensar las tecnologías desde las propias experiencias de las usuarias, así como las tensiones en la construcción de la autonomía reproductiva. (shrink)

João Duns Escoto pode contar-se entre os continuadores de Anselmo, uma vez que acolheu favoravelmente o argumento do Proslogion, ainda que na sua singular interpretação. Mas, aquém e para além deste aspecto pontual de continuidade, há aspectos de afinidade estrutural de pensamento a estreitar os laços de razão entre os dois filósofos. Estes aspectos de mais profunda proximidade não têm que ser explicados exclusivamente por uma influência directa do legado de Anselmo no pensamento de Duns Escoto, mas acusam, a nosso (...) ver, algo como uma família de pensamento ou de espírito, ou uma orientação filosófica de fundo, capaz de atravessar os séculos e de incluir as singularidades dos diversos pensadores que nela vão tomando parte. Entre esses laços de razão, há uma afinidade fundamental ao nível da partilha de um mesmo princípio metafísico, que estrutura o pensamento quer do Doutor Magnífico quer do Doutor Subtil. Trata-se do princípio da irreflexividade das relações essenciais do ente, que Duns Escoto enuncia, como prima conclusio, no início da sua análise comparativa das ordens essenciais do ente, no Tractatus de Primo Principio. Duns Escoto assume de Agostinho a inspiração deste princípio, mas é na metafísica de Anselmo que aquele revela a força de um princípio estruturante, antes mesmo de expandir o seu alcance na metafísica escotista. O nosso propósito, neste estudo, é analisar alguns aspectos do percurso daquele princípio metafísico através do pensamento de Agostinho, do de Anselmo e do de Duns Escoto, permitindo agregar os três pensadores numa mesma família de espírito ou orientação filosófica de fundo. (shrink)

RESUMEN El artículo analiza el experimento de A. Pennycook et al., a fin de ampliar el alcance de sus hipótesis y las estrategias para contrastarlas, de modo que contemplen no solo factores cognitivos, sino también aspectos pragmáticos y contextuales implicados en la receptividad al bullshit. Se utiliza el experimento como ejemplo de las asunciones normativas implícitas en las investigaciones descriptivas de psicología y filosofía experimental, ya que, al contrastar hipótesis sobre las intuiciones filosóficas de sentido común, los investigadores parten de (...) supuestos axiológicos sobre la corrección de las respuestas y la fiabilidad de los procesos cognitivos implicados. ABSTRACT The article analyzes the experiment carried out by A. Pennycook et al., in order to expand the scope of its hypotheses and the strategies to contrast them, in such a way that, beyond cognitive contexts, they also take into account the pragmatic and contextual aspects involved in bullshit receptivity. The experiment is used as an example of the normative assumptions implicit in the descriptive research projects of experimental psychology and philosophy, given that when researchers contrast hypotheses regarding common sense philosophical intuitions, they start out from axiological assumptions with respect to the correction of answers and the reliability of the cognitive process involved. (shrink)

Razón, poesía, historia.--La cuestión del estoicismo español.--El querer.

The role of demographic terminology in the fields of medicine and public health is critical in the identification and allocation of resources to the communities that most benefit from intervention...

This article discusses pragmatic aspects of our interpretation of intensional constructions like questions and prepositional attitude reports. In the first part, it argues that our evaluation of these constructions may vary relative to the identification methods operative in the context of use. This insight is then given a precise formalization in a possible world semantics. In the second part, an account of actual evaluations of questions and attitudes is proposed in the framework of bi-directional optimality theory. Pragmatic meaning selections are (...) explained as the result of specific rankings of potentially conflicting generation and interpretation constraints. (shrink)

En este trabajo critico la interpretación moralizada de la obligación política en Hobbes que defiende Luciano Venezia. Exploro una lectura diferente que evita una dicotomía tajante entre las razones prudenciales y las razones morales y subraya en cambio la discontinuidad entre la normatividad subjetiva de la ley natural y la normatividad objetiva de la ley positiva. Sostengo que el contrato de sujeción política establece obligaciones objetivas recién cuando el soberano exige el cumplimiento de los contratos. La obligación política es entonces (...) una forma de obligación jurídica. Además, enfatizo que la comunidad moral de Hobbes solo es posible dentro del Estado. In this paper, I criticize Luciano Venezia's moralized interpretation of the Hobbesian concept of political obligation. I explore a different reading that avoids a clear-cut dichotomy between prudential and moral reasons and underscores instead the discontinuity between natural law's subjective normativity and civil law's objective normativity. I contend that the pact of political subjection establishes objective obligations only when the sovereign requires the fulfillment of contracts. Political obligation is then a form of legal obligation. In addition, I emphasize that Hobbes's moral community is only possible within the State. (shrink)

This book is a multi-faceted attempt to understand the psychological mysteries of land, space, native cultures, changing eras, and geographical dislocation. It shows us that many remote and seemingly peaceful areas of the world have their own dark and silent pasts in which their original inhabitants were often brutally wiped out. Weaving history, geography, myth, philosophy, and psychoanalysis together, this book tries to understand why such atrocities were committed, how those subjected to these 'crimes' might have perceived them, and what (...) are the long-term, trans-generational consequences of these historical events. (shrink)

Equimetrical translation of verse, which conveys the metre of the source text, should be distinguished from equiprosodic translation of verse, which conveys theversification system of the source text. Equiprosodic translation of verse can rely on the possibilities of natural language (for instance, when presumably Publius Baebius Italicus created the Ilias Latina, he made use of the quantitative structure in Latin), but it can also employ an artificial system (cf., for example, the quantitative verse in Church Slavonic or English). The Estonian (...) language makes it possible to convey the syllabic (based on the number of syllables), accentual (based on the number and configuration of accents) and quantitative (based on the configuration of durations) versification systems. In practice, combined types are most frequent, for instance, the ones in which both the syllable count and the configuration of accents is relevant; in Estonian, versification systems with theparticipation of all three principles are possible as well. Despite the contrast of quantity in Estonian, the transmission of the quantitative structure of ancient metrics still involves a number of difficulties which result from differences in the prosodic structures. The transmission of purely syllabic versification system has also been problematic: it is hard to perceive such structure as verse in Estonian and therefore it has often been conveyed with the help of different syllabic-accentual or accentual-syllabic verse metres. Although equiprosodic translation is not necessarily equimetrical, in actual translation practice it usually is so. (shrink)

Using the scope of justice perspective (Deutsch in J Soc Issues 31(3):137–149, 1975 ; Opotow in Conflict, cooperation, and justice: essays inspired by the work of Morton Deutsch, 1995 , J Soc Issues 52:19–24, 1996 ), we examined whether and how the relationship between perceived discrimination against minorities at work (i.e., racial minorities and females) and citizenship behavior toward minorities can be modified by personal value for diversity. Based on a survey of 173 employees, unexpectedly, we found a negative relationship (...) between perceived discrimination against minorities at work and citizenship behavior toward minorities. However, consistent with our expectations and the scope of justice, we found that the negative relationship was attenuated for those high in personal value for diversity. (shrink)

Free Download from Teseo Press Link Book in Spanish Este libro está dirigido a investigadores interesados en la influencia que ejerce la cultura de una empresa sobre el comportamiento ético de sus integrantes y en la conformación de la empresa como un agente moral. El fenómeno de la mentalidad compartida en una organización es estudiado bajo diversas disciplinas, partiendo de una larga experiencia de “entrenamiento ético” llevada a cabo por la autora en empresas multinacionales. Esta investigación presenta a la comunidad (...) académica un método de intervención organizacional orientado a desarrollar una conciencia ética compartida. El método heurístico propuesto busca revelar a los propios integrantes de la organización la trama de significados que ordena sus interacciones. Mediante dibujos y metáforas colectivas explora la construcción de sentido que los grupos sostienen de forma compartida a un nivel pre-racional y que influye en el carácter ético de sus decisiones personales. Este estudio aborda a la empresa como un ente causado por la convergencia de valores y reglas en el que sus integrantes pueden realizar cambios personales y aprendizajes colectivos. (shrink)

First the rationalist tradition and then the cognitive revolution put limits on the philosophy and social sciences with regard to the analysis of emotion, of irrationality in mental events and actions, to the reduction of our representations to conceptual elements, and so on. This fact caused an increasing interest in these topics. In this paper, we intend to claim the significant relations among these three issues: emotion, selfdeception and non-conceptual content, with two aims: i) to analyse the relation between non-conceptual (...) content of emotion and the phenomenon of self-deception; and ii) to explain how self-deception canbe overcome by the conceptualization of some non-conceptual elements of emotion. (shrink)

Este artigo é parte de uma pesquisa de Mestrado em Ciências Ambientais que investigou “A relação mulher-natureza na Comunidade Remanescente do Quilombo de Fojo, Itacaré – BA”, através da abordagem descritiva e análise quantitativa e qualitativa de dados, buscando aprofundamento teórico para tratar de relações de gênero, gênero e meio ambiente e a importância do papel da mulher na organização cotidiana das comunidades tradicionais, inclusive de remanescentes de quilombos. Os sujeitos da pesquisa foram mulheres e homens da Comunidade de Fojo (...) que decidiram pela participação, utilizando entrevistas semiestruturadas, observação direta e sistemática e conversas informais, em profundidade, realizadas entre 2014-2015. O recorte aqui apresentado tem por objetivo discutir o papel da mulher na comunidade do quilombo de Fojo e sua relação com a natureza. Os resultados indicam relações desiguais entre homens e mulheres na comunidade, às mulheres têm sido designado papel/posição, modos de cuidar da família, ficam responsáveis em “trazer harmonia e paz para o lar”, “cuidar e ser dona de casa”, cabendo a elas a área pertencente a do privado – a casa, alguns serviços na roça e a participação na igreja evangélica, deixando a tradição esquecida. A relação mulher-natureza, ao que parece, indica práticas agrícolas equivocadas e, ao que tudo indica, o conhecimento dos moradores sobre a agricultura ainda é tímido, demonstram fragilidades de técnicas empregadas, falta recursos à implementação de ferramentas adequadas, ausência de assistência técnica especializada e conhecimentos por parte dos produtores de técnicas básicas de produção. Palavras-chave: Relação Mulher-Natureza. Mulher Quilombola. Sustentabilidade. (shrink)

A través del presente trabajo se aborda el papel de la musicoterapia en la enfermedad de alzheimer (EA) desde el ámbito del trabajo social. Para ello, se lleva a cabo una revisión bibliográfica y se identifican conceptos claves como musicoterapia, EA e intervención del trabajo social. La información recogida lleva a considerar la musicoterapia como tratamiento coadyuvante en la enfermedad de Alzheimer a través de áreas como la integración social, la autoestima, la comunicación o la reducción del estrés. Por ello, (...) se concluye que la estimulación musical mejora la calidad de vida en pacientes con EA. (shrink)

Many philosophical counselors seem to be counselors who use or point to phil­osophical texts or use abstract indeed logical or rational methods when working with a client. I want to introduce the idea of a counseling philosopher, who uses the client’s own concrete experiences as the basis for philosophizing with the client about the nature of the client’s dilemma - using ‘the between’ (Buber) as that special creative space where one em­ploys the art of philosophizing to the unique situation. Otherwise, (...) the particularity of that client gets subsumed under theory or methods, much like what has happened in psychology and which gave rise to Achenbach’s criticisms of psychology/psychiatry. The dialogical of which Buber and Friedman speak is the give and take between client and counseling philosopher of understanding and expanding perceptions confirmed through the actual relationship. Philosophy as an art (and not a method) helps us restore the trust Buber talks about which allows us to engage the world directly and not through categories of thought grounded in psychological or philosophical texts and theories. (shrink)

We empirically test the hypothesis that a major in economics, management, business administration or accounting (for simplicity referred to as Business/economics) leads to more-conservative (right-wing) political views. We use a panel dataset of individuals (repeated observations for the same individuals over time) living in the Netherlands, drawing data from the Longitudinal Internet Studies for the Social Sciences from 2008 through 2013. Our results show that when using a simple fixed effects model, which fully controls for individuals’ time-invariant traits, any statistically (...) and quantitatively significant effect of a major in Business/economics on the Political Ideology of these individuals disappears. We posit that, at least in our sample, there is no evidence for a causal effect of a major in Business/economics on individuals’ Political Ideology. (shrink)

While dreaming amputees often experience a normal body image and the phantom limb may not be present. However, dreaming experiences in amputees have mainly been collected by questionnaires. We analysed the dream reports of amputated patients with phantom limb collected after awakening from REM sleep during overnight videopolysomnography . Six amputated patients underwent overnight VPSG study. Patients were awakened during REM sleep and asked to report their dreams. Three patients were able to deliver an account of a dream. In all (...) dreaming recalls, patients reported that the amputated limbs were intact and completely functional and they no longer experienced phantom limb sensations. Phantom limb experiences, that during wake result from a conflict between a pre-existing body scheme and the sensory information on the missing limb, were suppressed during sleep in our patients in favour of the image of an intact body accessed during dream. (shrink)

Esse trabalho tem como objetivo discutir especificamente o tempo como duração interior em Henri Bergson, tese fundamental de sua obra Ensaio sobre os dados imediatos da consciência, tendo como horizonte a noção de tempo psicológico, a qual difere totalmente do tempo externo, ou seja, do tempo espacializado. Exploraremos também a literatura de Marcel Proust, com sua obra Em busca do tempo perdido. Proust também pensa o tempo, em seu romance, a partir da realidade interior do personagem principal. No entanto, este (...) trabalho não será para mostrar uma relação entre os dois autores, mas sim para evidenciar alguns temas que perpassam suas obras, por mais que divirjam em alguns pontos. Além da realidade interior, a questão da memória é um elemento importante tanto para o filósofo quanto para o romancista. Discutiremos a maneira pela qual a concepção bergsoniana da memória foi desenvolvida na obra Matéria e memória, bem como a memória proustiana foi contemplada no mencionado romance. Deste modo, a literatura do escritor francês surge como uma maneira de expressar o verdadeiro sentido do tempo vivido. O filósofo francês já fazia referências a um suposto romancista que tiraria o véu e nos colocaria diante da realidade de nossa vida interior, dos nossos sentimentos, da duração interior. É neste sentido que Bergson se aproxima da arte para expressar o conteúdo do eu profundo. (shrink)

L’article s’interroge sur le passé de la mixité dans la Grèce des deux derniers siècles. Il présente d’abord les conceptions éducatives et souligne les deux voies parallèles proposées par l’État et la société : les garçons sont préparés à devenir des citoyens ; les filles doivent devenir des mères. Il observe ensuite les types de ségrégation puis les phénomènes qui s’opposent aux restrictions au droit des filles à l’éducation.