Understanding the mechanisms and the time and spatial evolution of penumbra following an ischemic stroke is crucially important for developing therapeutics aimed at preventing this area from evolving towards infarction. To help in integrating the available data, we decided to build a formal model. We first collected and categorised the major available evidence from animal models and human observations and summarized this knowledge in a flow-chart with the potential key components of an evolving stroke. Components were grouped in ten sub-models (...) that could be modelled and tested independently: the sub-models of tissue reactions, ionic movements, oedema development, glutamate excitotoxicity, spreading depression, NO synthesis, inflammation, necrosis, apoptosis, and reperfusion. Then, we figured out markers, identified mediators and chose the level of complexity to model these sub-models. We first applied this integrative approach to build a model based on cytotoxic oedema development following a stroke. Although this model includes only three sub-models and would need to integrate more mechanisms in each of these sub-models, the characteristics and the time and spatial evolution of penumbra obtained by simulation are qualitatively and, to some extent, quantitatively consistent with those observed using medical imaging after a permanent occlusion or after an occlusion followed by a reperfusion. (shrink)

The ethical conduct of research rests largely on researchers, and as such, an understanding of how they perceive and enact their role in research is paramount. However, the literature around ethics and research mostly focuses on researchers’ perception of Research Ethics Boards roles and functions. To fill that gap, we analyzed the perceptions of researchers, REB members, and influential parties about researchers’ role in the ethical conduct of research through discourse analysis. Three discourses emerged: researchers as reflective practitioners, protectors of (...) participants, and technicians. Understanding the commonalities and differences among the discourses may foster a shared and compelling institutional research culture. (shrink)

Le centenaire de la Grande Guerre a donné un nouvel élan à la publication d’archives de soi sur l’événement, notamment de correspondances souvent découvertes dans les greniers familiaux par la génération des petits-enfants. Spécialiste d’histoire ouvrière et de l’histoire sociale de la guerre, Rémy Cazals n’a pas de lien de parenté avec Marie-Louise et Jules Puech mais il les connait bien, pour avoir écrit sur l’un des grands amis de Jules, le Mazamétain Albert Vidal et pour avoir sauvé les (...) a... (shrink)

This dissertation aims to construct a non-dogmatic defence of common sense. It tries to show why the absence of justification for the judgements of common sense, which the sceptic reveals, does not invalidate them.

In the contemporary life sciences more and more researchers emphasize the “limits of reductionism” (e.g. Ahn et al. 2006a, 709; Mazzocchi 2008, 10) or they call for a move “beyond reductionism” (Gallagher/Appenzeller 1999, 79). However, it is far from clear what exactly they argue for and what the envisioned limits of reductionism are. In this paper I claim that the current discussions about reductionism in the life sciences, which focus on methodological and explanatory issues, leave the concepts of a reductive (...) method and a reductive explanation too unspecified. In order to fill this gap and to clarify what the limits of reductionism are I identify three reductive methods that are crucial in the current practice of the life sciences: decomposition, focusing on internal factors, and studying parts in isolation. Furthermore, I argue that reductive explanations in the life sciences exhibit three characteristics: first, they refer only to factors at a lower level than the phenomenon at issue, second, they focus on internal factors and thus ignore or simplify the environment of a system, and, third, they cite only the parts of a system in isolation. (shrink)

Agonistic Democracy explores how theoretical concepts from agonistic democracy can inform institutional design in order to mediate conflict in multicultural, pluralist societies. Drawing on the work of Foucault, Nietzsche, Schmitt, and Arendt, Marie Paxton outlines the importance of their themes of public contestation, contingency and necessary interdependency for contemporary agonistic thinkers. Paxton delineates three distinct approaches to agonistic democracy: David Owen's perfectionist agonism, Mouffe's adversarial agonism, and William Connolly and James Tully's inclusive agonism. Paxton demonstrates how each is fundamental (...) to enabling citizens to cultivate better virtues for themselves and society (Owen), motivating democratic engagement (Mouffe) and enhancing relations of respect and understanding between conflicting citizens (Connolly and Tully). Situated within the context of a deeply polarised post-Trump America and post-Brexit Britain, this book reveals the need to rethink our approach to conflict mediation through democratic institutions. Pulling together insights from experimental research with deliberative democratic innovations, Paxton explores how agonistic theory might be institutionalised further. Through discussing ways in which agonistic institutions might be developed to render democracy more virtuous, more engaging, and more inclusive, Agonistic Democracy provides a unique resource for students of contemporary political theory. (shrink)

For fifteen years, from 1662 until his death in 1677, Henry Oldenburg served the Royal Society as second Secretary and was charged with almost the entire burden of its correspondence, domestic and foreign. During this time he acted as a centre for the communication of scientific news, searching out new sources of information, encouraging men everywhere to make their work public, acting as an intermediary between scientists and, through the Philosophical Transactions, providing a medium for the publication of short scientific (...) papers. Oldenburg's contribution to scientific communication was unique in the seventeenth century, not least because he represented the Royal Society and served all its members impartially. It is not too much to say that he invented the professions of scientific administrator and scientific journalist. (shrink)

The article explores how digital images of hands are used as a symbolic representation of intimacy and intimate emotions in influencer communication on Instagram. Based on digital ethnography with female influencers in the Czech Republic, the analysis focuses on three categories of communicative practices, where hands function as a visual representation of intimacy—creating community, a sense of vulnerability, and the notion of rawness and openness. The analysis points to the gendered nature of influencer communication. It explores how intimacy is established (...) specifically by women influencers who need to navigate vulnerability with the need to protect themselves against gender-based online violence in the form of hate comments and sexualized hate speech. (shrink)

This editorial presents a special issue gathering four contributions about the patient’s lived experience in the context of deep-brain stimulation. It aims at clarifying the meaning of such an experience and its scope for medical practice, the health system and its legal frame.

Journal of Philosophy of Education, Volume 56, Issue 1, Page 22-28, February 2022.

This report characterizes the state of affairs in the field of business ethics in Central and Eastern Europe. It reveals the major problems and challenges brought about by the profound reforms to these societies and economies. It also offers some results of surveys looking at public opinion on morals and ethics, as well as on current business practices. In order to give a complex picture, it presents brief lessons from the history of particular countries. The author, devoting the most attention (...) to the Czech Republic, tries to describe not only the development of business ethics in the theoretical arena but also the first steps taken by the business world itself. (shrink)

RésuméCet article propose une réflexion théorique et méthodologique permettant de décrire et d’interpréter lestextscapesà des fins d’analyse communicationnelle. L’objectif consiste à tester le concept sémiotique detextscapelinguistique pour analyser la mise en scène des langues dans la communication des organisations sur le web. Le cadre théorique fait appel aux études du paysage linguistique (Linguistic Landscape Studies) et à la théorie des paysages textuels (textscapes). Le corpus est composé de 100 sites web d’organisations économiques (chambres de commerce,clusterséconomiques, entreprises) qui revendiquent un positionnement (...) à l’échelle transfrontalière européenne. L’étude est menée d’un point de vue statistique (analyse de métadonnées) et qualitatif (analyse sémiotique dutextscapelinguistique) en vue de préciser la place et les fonctions communicationnelles dutextscapelinguistique dans la communication multilingue. Les résultats ont permis de dégager les profils d’expression, un scénario sémiotique typique des sites web observés et surtout de localiser les (dés)équilibres communicationnels. (shrink)

In [12], P. Scowcroft and L. van den Dries proved a cell decomposition theorem for p-adically closed fields. We work here with the notion of P-minimal fields defined by D. Haskell and D. Macpherson in [6]. We prove that a P-minimal field K admits cell decomposition if and only if K has definable selection. A preprint version in French of this result appeared as a prepublication [8].

It has recently been proposed that the framework of semantic relativism be put to use to describe mental content, as deployed in some of the fundamental operations of the mind. This programme has inspired in particular a novel strategy of accounting for the essential egocentricity of first-personal or de se thoughts in relativist terms, with the advantage of dispensing with a notion of self-representation. This paper is a critical discussion of this strategy. While it is based on a plausible appeal (...) to cognitive economy, the relativist theory does not fully account for the epistemic profile that distinguishes de se thinking, as some of its proponents hope to do. A deeper worry concerns the reliance of the theory on a primitive notion of “centre” that hasn’t yet received enough critical attention, and is ambiguous between a thin and a rich reading. I argue that while the rich reading is required if the relativist analysis of the de se is to achieve its most ambitious aims, it also deprives the theory of much of its explanatory power. (shrink)

There are many kinds of negation and denial. Perhaps the most common is the Boolean negation not that applies to propositions-in-extension, i.e. truth-values. The others are, inter alia, the property of propositions of not being true which applies to propositions; the complement function which applies to sets; privation which applies to properties; negation as failure applied in logic programming; negation as argumentation ad absurdum, and many others. The goal of this paper is neither to provide a complete list, nor to (...) analyse all of them. Rather, I am going to deal with negation of propositions that come attached with a presupposition that is entailed by the positive as well as negated form of a given proposition. However, there are two kinds of negation, namely internal and external negation. I am going to prove that while the former is presupposition-preserving, the latter is presupposition-denying. This issue has much in common with the difference between topic and focus articulation within a sentence. Whereas articulating the topic of a sentence activates a presupposition, articulating the focus frequently yields merely an entailment. The main contribution of this paper is the proof that the two kinds of negation are not equivalent. While the Russellian wide-scope (external) negation gets the truthconditions of a sentence right for a subject occurring as a focus, Strawsonian narrow-scope (internal) negation is validly applicable for a subject occurring as the topic. I also deal with other kinds of presupposition triggers, in particular factive attitudes and prerequisites of a given property. My background theory is Transparent Intensional Logic (TIL). TIL is an expressive logic apt for the analysis of sentences with presuppositions, because in TIL we work with partial functions, in particular with propositions with truth-value gaps. Moreover, the procedural semantics of TIL make it possible to uncover the hidden semantic features of sentences, make them explicit and logically tractable. (shrink)

In this paper I argue that it is finally time to move beyond the Nagelian framework and to break new ground in thinking about epistemic reduction in biology. I will do so, not by simply repeating all the old objections that have been raised against Ernest Nagel’s classical model of theory reduction. Rather, I grant that a proponent of Nagel’s approach can handle several of these problems but that, nevertheless, Nagel’s general way of thinking about epistemic reduction in terms of (...) theories and their logical relations is entirely inadequate with respect to what is going on in actual biological research practice. (shrink)

This article addresses how bodily integrity has been mobilised in the context of genital cutting of male infants and the extent to which the concept is taken into account in legal decision-making in the United Kingdom. While bioethicists have debated whether interventions on children's bodies are more appropriately determined on the basis of hypothetical consent or in the child's best interest, it is clear that in law the relevant test is whether interventions are in the child's best interest. As the (...) issue of nonconsensual genital cutting of infants has become more contested, courts have been asked to adjudicate on the best interests of infants in situations where their caregivers disagree about procedures. Although this body of jurisprudence remains (surprisingly) small, in this article we argue that, while there are now discernible trends in such cases (e.g. deferring decision-making until the child has the requisite capacity to decide, engaging with certain human rights norms), too often judicial reasoning about a child's best interests remains largely empty of reasoned content, and in certain respects is regressing. Using the recent case of Re P to exemplify this logic, and drawing on our previous work advocating the value of embodied integrity, we argue that judges should adopt a more substantive framework of values in judging the child's corporeal and other interests in such cases. This would move best interests assessments beyond a mere formalistic exercise and lead to better reasoned legal judgements. (shrink)

Adventurers and discoverers are recurring figures and themes in Nietzsche’s writings. This is especially the case in Morgenröthe and Die fröhliche Wissenschaft, where this conceptual constellation belongs to the context of the “free spirits”. For Nietzsche, it seems, adventurers and discoverers represent the productive as much as destructive potential of any desire for knowledge. In this article, I will thus focus on two connected questions: (1) what are the specific epistemic characteristics of the adventurer and the discoverer, and (2) how (...) are these characteristics performed, and how do they become manifest, in a text like Morgenröthe. The analysis of the function of the “theatre eye” plays a key role here. (shrink)

How can the use of testimonies, as representations of suffering, be understood in education? What kind of potential can the use of testimonies have for pedagogical transformation? In this article, drawing on Mollenhauer and Sontag, I discuss the problem of representation as selection in education as it is easier to opt out of that which is difficult to face, to describe and to understand. As an alternative, I see what happens if representations of suffering are related to voices and remnants (...) from the past, drawing on Agamben, and as something that stands between what is possible to say and what is impossible to say, in any language. The article also draws on Spivak's theory of a representational idea based on literary reading, hacking and suturing, which urges ‘us’ to regard testimonies as relational and to listen to different voices from the past and to make room for them within our own language. (shrink)

Is Architecture Today Still an Art?Theoretical Considerations and Ethical Consequences Architecture has been proposing, for many decades now, more and more spectacular buildings. This could lead to believe that architecture has reached the top of its art. But this question requires first to define art in general, and also the authentic art of architecture. For this purpose, we will use a Bergsonian methodology in order to unveil in an unprecedented way the two different natures of art. The first nature, "ephemeral (...) art", will be analyzed as an artistic performance, which is powered by the creative gesture. The second nature, "persistent art", relies on durable productions. Using a multidisciplinary approach, we will create links between the two natures of art and German musicology: "pathogenic" and "logogenic" architectural productions will be presented to validate if architecture respects its own profound nature. We will finally analyze the modern paradigm of occidental "occulocentric" way of creating with its lack of hermeneutic substance and, thus, its important ethical consequences. (shrink)

For the past three decades, notebooks and note?taking practices have elicited growing interest in various fields of research: anthropology, media and literature studies, history of the book, history of science. In this renewal, however, scientific travelers? notes have not received all the attention they deserve. To be sure, historians of discovery and exploration are used to considering travel diaries and field notes as a principal resource, on the basis of which they can assess a traveler?s accomplishment or document his itinerary. (...) From a different perspective, field journals offer rich material to literary scholars, critics, and specialists of travel writing. Notebooks of well?known travelers like Bougainville or Humboldt are thus scrutinized in their poetic and aesthetic dimensions, from the perspective of the genesis of travel writing. Still, few studies have taken up the task, a rather mundane and down?to?earth endeavor, to look at travel notebooks for their own sake, as material objects, made of paper and cardboard, and meant to store observational data and to insure their availability through time and space. The paper sets out to do just that: to take a set of manuscript notebooks written by eighteenth? and early nineteenth?century French, German, and Swiss naturalist travelers and scientists on the move together with the techniques at work in their writing, as the focus of a historical investigation. (shrink)

The method of metaphysics of scientific practice consists in developing metaphysical claims on the basis of empirical information from and about scientific practice. This method stands in the tradition of naturalistic or scientific metaphysics on the one hand, and philosophy of science in practice on the other. In this chapter we draw on some of our own research to specify the method at work. We argue that the method is typically carried out in four steps: identifying the available empirical information (...) that might be relevant to the metaphysical topic of interest; selecting the relevant empirical information; developing a preliminary metaphysical claim that the relevant empirical information supports; mutually adjusting empirical information and metaphysics. We reveal some major methodological challenges and present ways to overcome them. We conclude that when drawing metaphysical claims from scientific practicewe need to: first, make sure that our previous metaphysical views do not influence the empirical information or its selection in problematic ways; second, explain in what sense we are doing metaphysics, countering for instance the idea that metaphysical claims must be highly general and transdisciplinary. We end the chapter by pointing to the advantages of the method of metaphysics of scientific practice. (shrink)

First Published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

There are currently two readings of Tractatus, the metaphysical and the therapeutic. I argue that neither of these is satisfactory. I develop a third reading, the elucidatory reading. This shares the therapeutic interpretation’s emphasis on the idea that Wittgenstein’s remarks are intended to work on the reader, but instead of seeing these remarks as directed (problematically) at revealing their own nonsensical status, I take the remarks to be aimed at bringing a certain order to the reader’s perception of language. The (...) point of this order, and the only test of it, is that it enables the philosophical problems to disappear. In particular, it dispels philosophical puzzlement concerning the status of logic, the relation between language and the world, and the relation between thought and language. (shrink)

L’apport de la phénoménologie allemande à l’éthique a souvent été réduit aux intentionnalités et aux vécus axiologiques et affectifs, tels qu’ils furent décrits par Husserl. Or, cet apport est limité du fait que Husserl définissait d’abord l’intentionnalité comme un rapport à un objet dont nous sommes conscients. Dans ce qui suit, nous proposons d’emprunter une autre voie pour penser l’apport de la phénoménologie à l’éthique, en étudiant la phénoménologie des actes sociaux que les phénoménologues munichois développèrent en réponse à la (...) phénoménologie husserlienne. Cette phénoménologie des actes sociaux permet de considérer, de juger et de critiquer, d’un point de vue éthique, les façons dont nous entrons en relation intentionnelle non pas avec des objets éthiques, mais avec autrui. Notre propos suivra principalement les idées développées par Reinach, Pfänder, Daubert et Scheler, et prendra pour fil directeur les actes d’adresser un impératif et une invitation à autrui. (shrink)