Psychonarratology is an approach to the empirical study of literary response and the processing of narrative. It draws on the empirical methodology of cognitive psychology and discourse processing as well as the theoretical insights and conceptual analysis of literary studies, particularly narratology. The present work provides a conceptual and empirical basis for this interdisciplinary approach that is accessible to researchers from either disciplinary background. An integrative review is presented of the classic problems in narratology: the status of the narrator, events (...) and plot, characters and characterization, speech and thought, and focalization. For each area, Bortolussi and Dixon critique the state of the art in narratology and literary studies, discuss relevant work in cognitive psychology, and provide a new analytical framework based on the insight that readers treat the narrator as a conversational participant. Empirical evidence is presented on each problem, much of it previously unpublished. (shrink)

Although alterations in Ras signalling are found in about 30% of human cancers, the transforming activity of oncogenic Ras is not fully understood. In a recent paper, a putative Ras1 effector in S. pombe, named Scd1, was reported to localize to mitotic apindies. Scd1 physically associates with Moe1, a factor that may contribute to the inherent inatability of microtubules (MTs) and appears to be needed for proper apindle function. Altered MT dynamics within the spindle are likely to affect spindle assembly (...) and chromosome capture, processes that need to be delicately controlled if cells are to guard against genome instability adn transformation. BloEssays 23: 307‐310,2001.©2001 John Willey & Sons, Inc. (shrink)

En ese artículo de naturaleza bibliográfica explicamos porque el diálogo intercientífico permite que se transcienda la homogeneidad de una epistemología involucrada en sí misma, expandiéndose para la transdisciplinariedad cultural y epistemológica. Analizamos dos nuevos modelos de paradigma alternativo, a saber: el vivir bien y el desarrollo endógeno sustentable. Consideramos que esas concepciones filosóficas tienen el desafío de desarrollar nuevas posibilidades epistemológicas y metodológicas que permitan el cambio de la realidad social e histórica. Palabras clave: Diálogo Intercientífico. Epistemología Transdisciplinar. Desarrollo Endógeno (...) Sustentable. Vivir Bien. (shrink)

This paper critically investigates the implementation of the UN guiding principles on business and human rights (UNGPs) into the corporate setting through the concept of ‘translation’. In the decade since the creation of the UNGPs, little academic research has focussed specifically on the corporate implementation of human rights. Drawing on qualitative case studies of two multinational corporations—an oil and gas company and a bank—this paper unpacks how human rights are translated into the corporate context. In doing so, the paper focuses (...) on the “resonance dilemma” translators encounter, the strategies used to make human rights understandable and palatable, and the difficulties that emerge from this process. We contend that the process of making human rights understandable and manageable can change their form and content, which may act as an obstacle to human rights realisation and corporate accountability for human rights. (shrink)

The question I address in this paper is whether and under what conditions it is morally right to bring a person into existence. I defend the commonsensical thesis that, other things being equal, it is morally wrong to create a person who will be below some threshold of quality of life, even if the life of this potential person, once created, will nevertheless be worth living. However commonsensical this view might seem, it has shown to be problematic because of the (...) so-called 'Non-Identity Problem'. Both utilitarian and rights-based approaches have been unable to provide a solution to this problem. I rest my thesis on two premises: that causing a disability or impairment in a future person is prima facie wrong, so long as we can avoid causing such a disability to that very person; and that reproduction, under normal conditions, is prima facie morally indifferent. From these two premises, I conclude that it is prima facie wrong to bring into existence a person with a non-trivial disability or impairment (which might be, nonetheless, compatible with a worthwhile life), even if the only available alternative is to remain childless. (shrink)

Edited by Ivette Fred-Rivera and Jessica Leech. What is the relationship between ontology and modality: between what there is, and what there could be, must be, or might have been? Throughout a distinguished career, Bob Hale’s work has addressed this question on a number of fronts, through the development of a Fregean approach to ontology, an essentialist theory of modality, and in his work on neo-logicism in the philosophy of mathematics. This collection of new essays engages with these themes (...) in Hale’s work in order to make further progress in our understanding of ontology, modality, and the relations between them. Some essays directly address questions in modal metaphysics, drawing on ontological concerns. Others raise questions in modal epistemology and its links to matters of ontology, such as the challenge to give an epistemology of essence. There are also several essays engaging with questions of what might be called ‘modal ontology’: the study of whether and what things exist necessarily or contingently. Such issues can be raised and addressed directly, but they also have an important bearing on the kinds of semantic commitments engendered in logic and mathematics, e.g., to the existence of sets, or numbers, or properties, and so on. It is thus explored in some chapters to what extent one’s ontology—and indeed, one’s ontology of necessary beings—interacts with other plausible assumptions and commitments. (shrink)

The paper explores the contact between the literary notion of the end of the world as depicted in H.G. Wells’s science fiction novel _The Time Machine_ and the concept of extinction, in the sense developed by the French naturalist Georges Cuvier, who at the turn of the 19 th century formulated a thesis about the structure of the world with a built-in end. The time traveller in Wells’s novel is driven into the distant future by an obsessive desire to know (...) the fate of the world. He encounters it on the shores of an already dead sea, where he is greeted by the image of a dying world, unmoving in the dull red light of a never-setting sun. Cuvier, on the other hand, encounters the end of the world as a reader of traces of history as told by nature through its layering and piling up. Within these layers, Cuvier recognises moments of repetitive interruptions that have left behind not only whole species and genera, but also entire worlds in the great natural history. The key question, then, is the status of the end within the proposed mechanism of return and repetition. (shrink)

Starting for the good results reached in physics researchers in economics and finance have been interested in testing nonlinear dependence and chaos in economic models and data. A wide variety of reasons for this interest have been suggested, including an attempt to improve the forecasting accuracy of linear time series models and to better explain the dynamics of the underlying variables of interest using a richer class of models than that permitted by limiting the set to the linear case. But (...) chaos theory has not had the same impact in the economics as it has in the hard sciences like physics. The literature did not provide a solid support for chaos as a consequence of the high noise level that exists in most economic time series, the relatively small sample sizes of data, and the weak robustness of chaos tests for these data. (shrink)

El artículo intenta realizar una síntesis de la cuestión de la libertad y los valores, su sentido ético y su anclaje onto-antropológico con el fin de señalar el contexto amplio en que éstos se sitúan en el pensamiento de Francisco Leocata. Uno de los objetivos principales de la obra de Leocata ha sido fortalecer el concepto de persona, su racionalidad y sus raíces metafísicas en respuesta a corrientes filosóficas contemporáneas que ponen en peligro la consistencia y el destino de la (...) existencia humana. (shrink)

Industrial shrimp farming has been promoted by international development and financial institutions in coastal indebted poor countries as a way to obtain foreign exchange earnings, reimburse external debt, and promote development. The promotion of the shrimp industry is a clear example of a more general trend of support of export-oriented primary products, consisting in monocultures of commodities, as opposed to the promotion of more diverse, traditional production directed to feed the local population. In general, it is assumed that export-oriented aquaculture (...) and agriculture, in a framework of liberalization policies, facilitates economic growth and this is associated with poverty reduction and the improvement of food security. However, it has been shown that the promotion of export-oriented production, mostly in the hands of big corporations, can have detrimental consequences for the livelihoods of local populations and the environment. As a result, international institutions, NGOs, and the industry aim to minimize these impacts by promoting sustainable export-oriented production. But some impacts may remain, since the main issue is the primary focus on international deregulated markets and the search for cheap primary products. To illustrate the relationships between the mainstream concept of development, the environmental and social impact of industrial farming systems, and the promotion of export-oriented production in developing countries, this article analyzes the case of the shrimp aquaculture industry. (shrink)

Computational simulations are now useful tools in experimental life. Their novelty and continuous development make it very difficult to understand their epistemic relevance. In this paper a first evaluation of them is presented through a parallel between thought experiments and computational simulations. Both simulations that play the role of actual experiment and also simulations that are part of experiments will be under scrutiny, since both of them are important in the understanding of contemporary experiments. But simulations as parts of actual (...) experiments can especially show a new face in the complex relation theory-experiment. (shrink)

O estudo aqui apresentado propõe uma interpretação do amor de si como o pathos primordial, da forma como Rousseau o pressentiu.

What is considered normal determines clinical practice in medicine and has implications at an individual level, doctor-patient relationship and health care policies. With the increase in medical information and technical abilities it is urgent to have a clear concept of normality in medicine so that crucial discussions can be held with unequivocal terms.The different meanings for normality were analyzed throughout the literature and grouped according to their relevance in the academic community in models, namely the Biostatistical Theory (BST), Health, Ideal, (...) Process and Biological advantage. The BST is the most established naturalistic approach, however normal variability can arguably constitute a problem. Health is similar and raises the question of setting the boundaries of pathology. Normality as an Ideal is an useful tool but is naturally unrealistic. As a Process it is comprehensible but is hard to frame for practical purposes. If considered as a Biological Advantage, seems intuitive but abnormality should tend to disappear.After, three examples were presented to discuss these models. They were Anemia, Psychiatric diseases and Psychopathy. In the case of Anemia the BST was applied and the arbitrary boundaries but with social impact were exposed. Psychiatric diseases was discussed under the process of self-organization and non-suffering ideal. With Psychopathy the boundaries of biological advantage are questioned.This review appeals to the importance of redesigning of the concept of normality in medicine according to current times and stresses the importance of integrating concepts such as variability and autonomy. (shrink)

The purpose of this paper is threefold: To show the basic contours of transcendental subjectivity in the later work of Edmund Husserl, especially the Cartesian Meditations and the Crisis, and in the strictly phenomenological work of Michel Henry, especially Material Phenomenology; to highlight Henry’s radical critique of Husserlian intersubjectivity and show that such critique, while valuable in its intention, is ultimately misguided because it neglects the important contribution Husserl’s complicated vocabulary of lifeworld makes to the study of intersubjectivity; and to (...) point toward a phenomenological conception of intersubjective practice we may call the realm of we-synthesis that prioritizes the first-person perspective rooted in empathy, which enables meaningful engagement with the second-person perspective. Working in conjunction with Husserl and Henry on the phenomenological conception of shared life enables the recuperation of the fragile line between subjectivity and intersubjectivity. (shrink)

The concept of a communal type of privacy shared by interconnected social groups has wide applications in the healthcare field, specifically in genetic testing and genetic data privacy (Pyrrho, Cam...

This is the first study to focus on the idea of virtue and its place in political thought in eighteenth-century France. Virtue could be used to impart moral authority to arguments about political power. The development of this strategic idea is traced through the works of key Enlightenment thinkers. There is also consideration of the ways in which numerous popular writers of the day, including clerics, eulogists, journalists, novelists and lawyers, employed the idea of virtue in polemical discussions in their (...) writings. (shrink)

The article intends to show that MacIntyre’s notion of friendship (which, according to him, would be a reappropriation of Aristotle’s notion of philia), while ignoring the political aspect explicitly emphasized by Aristotle, reduces the notion of friendship to its social or civic aspect, thereby weakening the political nature of man.

In lieu of an abstract, here is a brief excerpt of the content:One Interpreter's Journey of Interpreting for Pregnancy LossMarisa Rueda WillInterpreters have to know everything." This is what I thought as I watched and shadowed a seasoned interpreter at a world-renowned medical center, during my J-term internship. The fact that I had gotten this opportunity was still hard to believe. There I was, shadowing medical interpreters at one of the best hospitals in the world during my senior year of (...) college after abruptly dropping my secondary education minor to pursue a career in medical interpreting. I felt fortunate for the opportunity and seized the chance to learn from the best of the best.When that same institution hired me after I graduated college in 2006, my training consisted of shadowing other interpreters and having them shadow me. There was no strict process, just one-on-one on-the-job training. The training I received was the best it could be at the time, but not even close to what it takes for an interpreter to become confident and prepared to interpret for most appointments.Growing up I hadn't been interested in the medical profession. When I started working as an interpreter, I soon learned that in addition to my A and B languages, I also needed to learn a C language—the language of medicine. Just as I learned Spanish, I had to learn that a CAT scan was a type of imaging study, and a creatinine level was a measure of kidney function. I was fascinated by the language of medicine. The acronyms, medications, diseases, body parts, hormones, markers, genes, everything.As fascinating as medicine was, it wasn't the reason I considered medical interpreting my calling. As soon as I started working as a volunteer healthcare interpreter at a local free clinic, I knew it was the way I wanted to make a difference in the world. The Spanish speakers I was helping were low-income, underprivileged people with serious medical conditions and a host of other socioeconomic problems. These were people who needed help. These were people who needed to be heard. These were people who needed to be seen. As an interpreter, I would be able to give them a voice. Fast forward 18 years and I am still making a difference in the lives of patients with Limited English Proficient (LEP) by giving them the gift of communicative autonomy, or the right to be in control of and responsible for their own communication.Communicative autonomy is one of the founding principles of the medical interpreting profession. It differentiates the professionals from ad-hoc interpreters and bilingual family and friends. This is because upholding communicative autonomy means that regardless of my personal beliefs, I must remain impartial in all situations. I must interpret what is said and allow all parties involved [End Page 156] to guide the conversation as they see fit. Ideally, I only intervene to mediate for cultural or linguistic reasons when needed.Some of the most ethically conflicting cases I have had to interpret have centered around pregnancy loss and abortion. When I started interpreting, I was a young single woman with a relatively liberal view on reproductive rights. However, one stillbirth and three healthy pregnancies later, my personal beliefs on the subject have become more complicated. Each time I interpret for a loss or induced abortion, I must dig deep and ask myself if I can remain impartial. I can still remember the first time I faced this dilemma.One evening, I was called to interpret for a labor and delivery case. When I arrived, I was informed that it was an induction of an 18-week-gestation fetus that had tested positive for Down syndrome on genetic testing. At the time, I didn't have strong beliefs about abortion. I had never been pregnant and really wasn't sure where I stood on the spectrum of a woman's body, a woman's choice, and abortion is murder. However, there I was, smack dab in the middle of an elective abortion on a weeknight.The bereavement nurse was seasoned and experienced. If it hadn't been for her guidance and poise, the ordeal would have been... (shrink)

Microcredit has emerged as an effective instrument for achieving financial inclusion, stimulating productive activities, and with this support, reinforcing economic growth. This study aims to examine the characteristics of microcredit financing in Ecuador and to quantify its impact on economic growth. The study employs quarterly data from 2013 to 2023. An Error Correction (VEC) model was utilized to ascertain the short- and long-term effects of microcredit and investment on GDP. The findings indicate that microcredit and investment do not exert a (...) significant short-term influence on GDP. However, in the long term, a 1% change in investment is associated with a 0.11% positive impact on GDP. Similarly, a 1% shift in microcredit is linked to a 1.17% favorable effect on GDP. Ultimately, there is a unidirectional causal relationship between GDP and microcredit. (shrink)

Genetic research in human beings poses deep ethical problems, one being the problem of distributive justice. If we suppose that genetic technologies are able to produce visible benefits for the well being of people, and that these benefits are affordable to only a favored portion of society, then the consequence is obvious. We are introducing a new source of inequality. In the first section of this paper, I attempt to justify some concern for the distributive consequences of applying genetics to (...) human beings. This concern transcends a mere preoccupation for material equality. I argue that genetic inequality can undermine the very basis of social cooperation, at least regarding health care. The second section is more practical. My aim is to defend how, at least in some legal and cultural frameworks , the undesired distributive consequences of genetics are more likely to arise and more difficult to avoid. (shrink)