The decision to initiate invasive, first-in-human trials involving Parkinson’s disease presents a vexing ethical challenge. Such studies present significant surgical risks, and high degrees of uncertainty about intervention risks and biological effects. We argue that maintaining a favorable riskbenefit balance in such circumstances requires a higher than usual degree of confidence that protocols will lead to significant direct and/or social benefits. One critical way of promoting such confidence is through the application of stringent evidentiary standards for preclinical studies. We close (...) with a series of recommendations for strengthening the internal and external validity of preclinical studies, reducing their tendency toward optimism and publication biases, and improving the knowledge base used to design and evaluate preclinical studies. (shrink)

Was the emperor as sovereign allowed to seize the property of his subjects? Was this handled differently in late medieval Roman law and in the practice and theory of zabt in Mughal India? How is political sovereignty relating to the church's powers and to trade? How about maritime sovereignty after Grotius? How was the East India Company as a 'corporation' interacting with an Indian Nawab? How was the Shogunate and the emperor negotiating 'sovereignty' in early modern Japan? The volume addresses (...) such questions through thoroughly researched historical case studies, covering the disciplines of History, Political Sciences, and Law. Contributors include: Kenneth Pennington, Fabrice Micallef, Philippe Denis, Sylvio Hermann De Franceschi, Joshua Freed, David Dyzenhaus, Michael P. Breen, Daniel Lee, Andrew Fitzmaurice and Kajo Kubala, Nicholas Abbott, Tiraana Bains, Cornel Zwierlein, Mark Ravina. (shrink)

This second edition of the book contains a new chapter on the notions of natural-kind words and natural kinds.

In a series of incisive readings of signature historical works, Mark Poster charts the move from social history to new practices of cultural history that are drawing strength from poststructuralist interpretive strategies and raising issues found in feminist and postcolonialist discourse. In the process, he sets forth an outline for a postmodern historiography that can negotiate the contested terrain between the ambiguities of discourse and the pull of the "real." As Poster provides close readings of leading historians and theorists (...) such as Lawrence Stone, Francois Furet, Michel de Certeau, and Michel Foucault, key themes animate his work: the often irreducible difference between past and present; the relationship of writing and representation to power and domination; the dissolving distinctions between high and low culture, production and consumption, and reality and fiction; and, most important, a new perspective on human agency and the construction of political subjects. (shrink)

To surmount the notorious difficulties of defining life, we should evaluate theories of life not by whether they provide necessary and sufficient conditions for our current preconceptions about life but by how well they explain living phenomena and how satisfactorily they resolve puzzles about life. On these grounds, the theory of life as supple adaptation (Bedau 1996) gets support from its natural and compelling resolutions of the following four puzzles: (1) How are different forms of life at different levels of (...) the vital hierarchy related? (2) Is there a continuum between life and non-life? (3) Does life essentially concern a living entity’s material composition or its form? (4) Are life and mind intrinsically connected? (shrink)

Philosophers from Plato and Augustine to Heidegger, Nozick, and Baudrillard have warned us of the dangers of living on too heavy a diet of illusion and make-believe. But contemporary cultural life provides broader, more attractive opportunities to do so than have existed at any other point in history. The gentle forms of self-deceit that such experiences require of us, and that so many have regarded as ethically unwholesome or psychologically self-destructive, can in fact serve as vital means to political reconciliation, (...) cultural enrichment, and even (a kind of) utopia. -/- The first half of the book provides a highly schematic definition of simulated experience and compares it with some claims about the nature of simulation made by other philosophers about what it is for one thing to be a simulation of another. The author then provides a critical survey of the views of some major authors about the value of certain specific types of simulated experience, mainly in order to point out the many puzzling inconsistencies and ambiguities that their thoughts upon the topic often exhibit. In the second half of the book, the author defends an account of the positive social value of simulated experience and compares his own position to the ideas of a number of utopian political thinkers, as well as to Plato's famous doctrine of the "noble lie." He then makes some tentative practical suggestions about how a proper appreciation of the value of simulated experience might influence public policy decisions about such matters as the justification of taxation, paternalistic "choice management," and governmental transparency. (shrink)

It has been argued in the conservation literature that giving conservation absolute priority over competing interests would best protect the environment. Attributing infinite value to the environment or claiming it is ‘priceless’ are two ways of ensuring this priority (e.g. Hargrove 1989; Bulte and van Kooten 2000; Ackerman and Heinzerling 2002; McCauley 2006; Halsing and Moore 2008). But such proposals would paralyse conservation efforts. We describe the serious problems with these proposals and what they mean for practical applications, and we (...) diagnose and resolve some conceptual confusions permeating the literature on this topic. (shrink)

In this volume, Mark Douglas offers a new vision of the history of Christian pacifism within the context of a warming world. He narrates this story in a way that recognizes the complexities of the tradition and aligns it with a coherent theological vision, one that shapes the tradition to encompass the new causes and types of wars fought during the Anthropocene. Along the way, Douglas draws from research in historical climatology to recover the overlooked role that climate changes (...) have always played in shaping not only the Christian pacifist tradition but also the movement of traditions through western history. Scholars across a range of disciplines - peace studies, Christian theology and history, environmentalism, and environmental conflict studies - will benefit from this model of critical and charitable engagement with the complex history of Christian pacifism, the resources of which will be important for addressing wars in a warming world. (shrink)

The contemporary canon of what constitutes ancient political thought was fixed in the course of the nineteenth century by the then newly reigning discipline of the philosophy of history. It made little difference whether this discipline was positivistically or dialectically inclined. Whatever the methodological commitment there was general agreement that the sources of ancient wisdom on the nature and ends of social and political life were to be found in the political and ethical writings of Plato and Aristotle and, to (...) a lesser extent, Cicero. Here Cicero was read, in part, as a repository of a Stoic political wisdom that had not survived in the original texts. According to this tradition, genuine, if not final, political wisdom is to be found in the reflections of these ancient thinkers -- not a totally unexpected conclusion to come from philosophers. For these nineteenth-century practitioners of Geistesgeschichte the essence of ancient experience is distilled in its inner life, its art, literature, religion, and above all in its philosophical speculation, but not, for instance, in its political experience as recorded in its history. (shrink)

Lottery puzzles involve an ordinary piece of knowledge which seems to imply knowledge of a so-called “lottery proposition,” which itself seems unknown: I might be said to know that I won’t be going on safari next year. But if I were to win the lottery, I would go, and I don’t know that I won’t win the lottery. Examples can be multiplied. Thus we seem left either with the paradoxical position of knowing certain ordinary propositions, but failing to know the (...) lottery propositions they imply, or else conceding to the skeptic. I present a version of reliabilism according to which empirical knowledge is true belief produced by a reliable process causally connecting belief and fact. According to this theory, if my ordinary belief and my belief in the lottery proposition are suitably connected to the facts that render them true, both count as knowledge. In cases where my ordinary belief and my belief in the lottery proposition are not suitably connected to the relevant facts, neither count as knowledge. Thus the paradoxical air of lottery puzzles is removed, and skepticism is avoided. (shrink)

This is one of those cases to which Dr. 8 oodhouse's remark applies with all its force, that a method which leads to true results must have its logic — H.S Smith (" On Some of the Methods at Present in Use in Pure Geometry," p. 6) A goodly amount of modern metaphysics has concerned itself, in one form or another, with the question: what attitude should we take in regard to a language whose semantic underpinnings seem less than certain? (...) Since much of standard English is surely of this type, many philosophers have felt driven to extreme and unpalatable resolutions — wholesale rejection of attractive logical rules, radical "antirealism", "minimalism" about truth, and so forth, Scientists, however, have long dealt with analogous foundational insecurities and, under the duress of practicality, have framed a set of shifting attitudes towards language and reasoning that seem far more commonsensical than the extreme positions to which pure philosophy has often been led. Following this lead, this essay will recommend a more nuanced approach to linguistic insecurity that is neither naively optimistic nor mired in the gloomy sloughs of antirealism. (shrink)

Virtue is among the most venerable concepts in philosophy, and has recently seen a major revival. However, new challenges to conceptions of virtue have also arisen. In _Current Controversies in Virtue Theory_, five pairs of cutting-edge philosophers square off over central topics in virtue theory: the nature of virtue, the connection between virtue and flourishing, the connection between moral and epistemic virtues, the way in which virtues are acquired, and the possibility of attaining virtue. Mark Alfano guides his readers (...) through these essays, with a synthetic introduction, succinct abstracts of each debate, suggested further readings and study questions for each controversy, and a list of further controversies to be explored. (shrink)

Rebellions and Peripheries in the Cuneiform World. Edited by Seth Richardson. American Oriental Series, vol. 91. New Haven: American Oriental Society, 2010. Pp. xxxii + 109. $35.

If temporal parts are bona fide parts, then it is fitting to clarify and extend that notion (and related ones) using the resources of a theory of parts. But it often seems that those engaged in the 3D/4D debate appear to take for granted that, aside from introducing a welcome measure of rigor to the discussion, issues regarding theories of parthood can be allowed to recede into the background. What follows challenges that assumption — I demonstrate that the nature of (...) the fundamental mereological relation1 can decisively influence the outcome of the debate over persistence. In short, I show that if the fundamental mereological relation is proper parthood-at-atime then four-dimensionalism is false.2 Recognizing this does at least two things for us. First, it supplies a framework in which three-dimensionalists can clarify two things they have tended to say all along, namely that persisting things are ‘wholly present’ throughout their careers and that they do not have temporal parts. Second, it re-focuses the debate on a narrower and perhaps more tractable question: “What is the nature of the fundamental mereological relation?”. (shrink)

_A leading thinker asks why “faster” is synonymous with “better” in our hurried world and suggests how to take control of our runaway lives_ We live in an ever-accelerating world: faster computers, markets, food, fashion, product cycles, minds, bodies, kids, lives. When did everything start moving so fast? Why does speed seem so inevitable? Is faster always better? Drawing together developments in religion, philosophy, art, technology, fashion, and finance, Mark C. Taylor presents an original and rich account of a (...) great paradox of our times: how the very forces and technologies that were supposed to free us by saving time and labor now trap us in a race we can never win. The faster we go, the less time we have, and the more we try to catch up, the farther behind we fall. Connecting our speed-obsession with today’s global capitalism, he composes a grand narrative showing how commitments to economic growth and extreme competition, combined with accelerating technological innovation, have brought us close to disaster. Psychologically, environmentally, economically, and culturally, speed is taking a profound toll on our lives. By showing how the phenomenon of speed has emerged, Taylor offers us a chance to see our pace of life as the product of specific ideas, practices, and policies. It’s not inevitable or irreversible. He courageously and movingly invites us to imagine how we might patiently work towards a more deliberative life and sustainable world. (shrink)

New scholarship paves the way for Earth-loving spirituality grounded in the ancientChristian image of God as an avian life form.

Animal Century records some of the most important events and influences behind this often overlooked element of our social history, paying tribute to the courage and endurance that has helped to create a groundswell of public sympathy for our fellow creatures in many countries of the world. Mark Gold's moving and thought-provoking account includes in-depth previously unpublished interviews with many key players - including Maneka Gandhi, Jane Goodall, Celia Hammond, Virginia McKenna and Peter Singer - and celebrates the compassion (...) of countless others who have worked bravely and tirelessly to protect animals. (shrink)

BondsMark Evan, Absolute Music: The History of an Idea, Oxford: OUP, 2014. pp. 375. £23.99.