Advances in biochemistry, chemistry and engineering have enabled the development of a new gene expression assay. This ‘chip‐based’ approach utilizes microscopic arrays of cDNAs printed on glass as high‐density hybridization targets. Fluorescent probe mixtures derived from total cellular messenger RNA (mRNA) hybridize to cognate elements on the array, allowing accurate measurement of the expression of the corresponding genes. Array densities of >1,000 cDNAs per cm2 enable quantitative expression monitoring of a large number of genes in a single hybridization. A two‐color (...) fluorescence detection scheme allows rapid and simultaneous differential expression analysis of independent biological samples. Mass‐produced microarrays provide a new tool for genome expression analysis that may revolutionize genetic dissection, drug discovery and human disease diagnostics. (shrink)

Mark Richard presents an original theory of meaning, as the collection of assumptions speakers make in using it and expect their hearers to recognize as being made. Meaning is spread across a population, inherited by each new generation of speakers from the last, and evolving through the interactions of speakers with their environment.

Geach's problem, the problem of accounting for the fact that judgements expressed using moral terms function logically like other judgements, stands in the way of most noncognitive analyses of moral judgements. The non-cognitivist must offer a plausible interpretation of such terms when they appear in conditionals that also explains their logical interaction with straightforward moral assertions. Blackburn and Gibbard have offered a series of accounts each of which interprets such conditionals as expressing higher order commitments. Each then invokes norms for (...) the coherent acceptance of attitudes to explain why we hold certain combinations inconsistent. Against these accounts the paper presses two related objections: (1) The norms needed to do the explanatory work cannot be strong enough to do that work without also ruling clearly consistent attitudes inconsistent. And (2), the norms of rational attitude acceptance do not neatly track the distinction between consistent and inconsistent attitudes. (shrink)

NATURAL LAW ARGUMENTS CONCERNING the political order characteristically appeal, at some point or other, to the common good of the political community. To take the clearest example: Aquinas, perhaps the paradigmatic natural law theorist, appeals to the common good in his accounts of the definition of law, of the need for political authority, of the moral requirement to adhere to the dictates issued by political authority, and of the form political authority should take. But while united on the point that (...) arguments for normative political conclusions must take the common good as a principle, natural law theorists have not been united in their understanding of the nature of the common good. The differences among natural law views on the character of the common good are not trivial: they concern such deep issues as whether the common good should be understood as an intrinsic or an instrumental good, and whether the common good should be understood in relation to the good of individuals of that community or solely in relation to the good of the community as a whole. If one aims to develop a natural law account of the political order, then, one cannot remain neutral with respect to the various natural law understandings of the common good, for these various understandings are almost certain to yield differing conclusions on the source, functions, and limits of political authority. (shrink)

At various times, mathematicians have been forced to work with inconsistent mathematical theories. Sometimes the inconsistency of the theory in question was apparent (e.g. the early calculus), while at other times it was not (e.g. pre-paradox na¨ıve set theory). The way mathematicians confronted such difficulties is the subject of a great deal of interesting work in the history of mathematics but, apart from the crisis in set theory, there has been very little philosophical work on the topic of inconsistent mathematics. (...) In this paper I will address a couple of philosophical issues arising from the applications of inconsistent mathematics. The first is the issue of whether finding applications for inconsistent mathematics commits us to the existence of inconsistent objects. I then consider what we can learn about a general philosophical account of the applicability of mathematics from successful applications of inconsistent mathematics. (shrink)

In this chapter, we address the roles that exemplars might play in a comprehensive response to epistemic injustice. Fricker defines epistemic injustices as harms people suffer specifically in their capacity as (potential) knowers. We focus on testimonial epistemic injustice, which occurs when someone’s assertoric speech acts are systematically met with either too little or too much credence by a biased audience. Fricker recommends a virtue­theoretic response: people who do not suffer from biases should try to maintain their disposition towards naive (...) testimonial justice, and those who find themselves already biased should cultivate corrective testimonial justice by systematically adjusting their credence in testimony up or down depending on whether they are hearing from someone whom they may be biased against or in favor of. We doubt that the prominent admiration-­emulation model of exemplarism will be much use in this connection, so we propose two ways of learning from negative exemplars to better conduct one’s epistemic affairs. In the admiration-­emulation model, both the identification of what a virtue is and the cultivation of virtues identified thusly proceed through the admiration of virtuous exemplars. We show that this model has serious flaws and argue for two alternatives: the envy-­agonism model and the ambivalence-avoidance model. (shrink)

For fifty years Hubert Dreyfus has done pioneering work which brings phenomenology and existentialism to bear on the philosophical and scientific study of the mind. This is a selection of his most influential essays, developing his critique of the representational model of the mind in analytical philosophy of mind and mainstream cognitive science.

While the Catholic Church has taken a number of steps to create a safe environment for children, its largely procedural approach to the sexual abuse crisis leaves a lot to be desired. If the Catholic Church wants to identify and counteract the elements that precipitated this crisis, it needs to enlist Catholic universities and parents, as universities possess the intellectual resources to understand the crisis in its full depth and breadth and parents are the most capable protectors of children in (...) the Catholic Church. Empowering these two constituencies and relying on them to lead child protection efforts represent the best chance to overcome a legacy of pain and distrust and to create a Church that is nurturing and safe for its children. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:166 BOOK REVIEWS Those who read this handsome book and study the paintings and sculptures of Zarlenga in excellent color will be able to follow the phases of his artistic development and find many subjects for medita· tion and enjoyment. Aquinas Institute of Theology St. Louis, Missouri BENEDICT M. ASHLEY, O.P. The Thought of Thomas Aquinas. By BRIAN DAVIES, O.P. Oxford: Oxford University Press, 1992 (cloth); Oxford: Clarendon Press, (...) 1993 (paper). Pp. xv + 391. An establishing circumstance of the ' restoration ' of Christian philosophy at the end of the last century, and the turn of this century, was that the medieval authors whom Christian philosophers turned to were, by profession, theologians whose appropriation of philosophy was for explicitly theological ends. By and large, however, the modern authors who set about retrieving medieval thought had an agenda quite different from that of their medieval luminaries. Still reeling from the philosophical fall-out of the Enlightenment, and encountering rationalism, idealism, and empiricism on all sides, committed Christian thinkers sought a source of philosophical reflection and, perhaps more importantly, justification, that could buttress the claims made by Christianity for those who were within the believing community, and defend the faith from the intellectual attacks of those who were not. The enduring philosophical inheritance of the Middle Ages, and particularly the philosophia perennis of St. Thomas Aquinas, was that source, wrote Leo XIII in his Aeterni patris, and Catholic philosophers soon collected. But the inheritance was not fully collected. With distinctive philosophical goals in mind, Christian philosophers focused upon the putative philosophy of medieval writers, particularly Aquinas, and largely left theological reflection alone. And, when theological contentions on the part of medieval authors did make their way into the discussion, they were almost inevitably appropriated as a legitimate incorporation of revealed teaching into what somehow remained the philosophical project. The result was 'Christian Philosophy.' Although this resulted in the flurry of Catholic philosophical study during the first half of this century, the picture that emerged of the medieval authors, and of Thomas in particular, was inevitably one-sided, and incomplete. An overly pessimistic assessment of the situation would be to say that, for all the hard work of the Gilsons and Maritains, Van Steenberghens and DeKonincks, we are no nearer to Thomas today than we were in the 1870s. BOOK REVIEWS 167 Brian Davies's endeavor seeks to change that, because it attempts to provide the modern reader with a comprehensive introduction to the great expanse of Thomas's thought according to the manner in which Thomas himself presented it in his mature theological masterpiece, the Summa theologiae. Fr. Davies has succeeded magnificently, and his book will become, as it should, a mainstay on the bookshelves of university libraries, students, and teachers alike. Professional philosophers whose work never leads them to Thomas's discussion on Christ, say, can readily get a good working knowledge of how Thomas approaches this center of Christian faith and practice. And the student who is altogether new to Aquinas can grasp something of the ' movement ' of Thomas's thought by reading, and re-reading, Davies judicious renderings of Thomas's doctrine on human acts. This is a book of many uses, all of them instructive and helpful. Considering this book to be an introduction, as Fr. Davies does (p. viii), does not do justice to the quantity of his achievement in writing it, or of the student's investment in reading it. The work occupies some 391 pages, reading made difficult by the tightly-knit character of Thomas's thought, though Davies' easy writing helps to allay the burden. The physical constitution of the book, in slightly off-white octavo paper and an 11-point base font, makes for comfortable reading. Davies has avoided excessive footnoting, giving references to Thomas's text judiciously, and he also provides a well-tailored and impressively diverse bibliography at the end.of the volume which can be effectively consulted by his reader. The author himself is a foundational theologian at Blackfriars in Oxford, so one might expect him instinctively to address the particular audience he encounters in his work. But, save on a very few occasions, Fr. Davies is mindful that in... (shrink)

L'auteur expose la tentative faite par Bolzano de définir le concept de proposition en soi analytique à l'aide du concept de variation de représentation. Puis, il discute les difficultés qui résultent de ce modèle quant à la définition bolzanienne du concept étroit de vérité logiquement analytique ou de vérité logique. En conclusion, il compare la définition bolzanienne du concept de proposition en soi analytique et la définition husserlienne: celle-ci se découvre être une application de l'idée fondamentale de Bolzano — employer (...) la variation de représentation pour définir les concepts logiques fondamentaux. The author tries to outline Bolzano's proposal to define the concept of an analytic proposition by using the concept of idea variation. He discusses the problems that arise for Bolzano's attempt to define the concept of a logical truth on the same lines. He ends by comparing Bolzano's and Husserl's definition of the concept of an analytical proposition: Husserl's definition can be seen as an original application of Bolzano's basic idea to define basic logical notions with recourse to the concept of idea variation. (shrink)

One of the most distinctive cultural phenomena of recent years has been the rise and rise of fame. In this book, Mark Rowlands argues that our obsession with fame has transformed it. Fame was once associated with excellence or achievement in some or other field of endeavour. But today we are obsessed with something that is, in effect, quite different: fame unconnected with any discernible distinction, fame that allows a person to be famous simply for being famous. This book (...) shows why this new fame is simultaneously fascinating and worthless. To understand this new form of fame, Rowlands maintains, we have to engage in an extensive philosophical excavation that takes us back to a dispute that began in ancient Greece between Plato and Protagoras, and was carried on in a remarkable philosophical experiment that began in eighteenth-century France. Somewhat like contestants on a reality TV show, today we find ourselves, unwittingly, playing out the consequences of this experiment. (shrink)

This dissertation examines the two most popular contemporary revivals of Aristotelian ethics, communitarianism and casuistry. I consider how these two schools of thought which take Aristotle's ethics as their starting point, can seem to be so diametrically opposed. The communitarian approach to ethics, personified by Alasdair MacIntyre, Michael Sandel, and Ezekiel J. Emanuel argues that a shared notion of the self or the good life must be sought prior to resolving ethical problems. Conversely, the new casuistic movement, exemplified by the (...) recent work of Albert Jonsen, Stephen Toulmin, and Carson Strong eschews such theoretical baggage in favor of a case-based ethics. By examining each school of thought in the light of their Aristotelian aspirations, namely, their desire to re-establish an ethics based upon prudence that overcomes the fact/value distinction, spurious elements of their rhetoric are rejected. This allows us to see the compatible strains in communitarianism and casuistry and to demonstrate the elements they must borrow from each other in order to be viable approaches to ethical and political philosophy. (shrink)

Since Aristotle, it has been common to understand wonder as a psychological state characterized by an absence of rational understanding. Drawing on this idea, a number of historians have suggested that the wonder which had long characterized the experience of automata, declined in the early modern period alongside the increased availability of theoretical treatises on mechanics. This article seeks to challenge this view by examining the relationship between rational and practical modes of technical understanding in John Wilkins’ Mathematicall Magick (1648). (...) My aim is to show that a close reading of the second book of the Mathematicall Magick reveals an alternative conception of wonder as an experience of skilled workmanship that both tolerates theoretical understanding and is increased through practical experience. It will be my claim that the conception of technical wonder which emerges from Wilkin’s descriptions of automata, reveals how the concept of Aristotelian wonder is too reductive to capture the variety of ways in which mechanical technology was experienced in early modern England. (shrink)

Stephen Stich has criticized the possibility of providing a legitimate set of norms for reasoning, since such norms are justified via reference to pretheoretical intuitions. I argue that through a process of perspicuously mapping the belief sphere one can generate a list of intellectual virtues that instrumentally lead to true beliefs. Hence, one does not have to rely on intuitions since the norms of reason are derived from factual claims about the intellectually virtuous agent.

In protreptic passages in three Aristotelian texts (Nicomachean Ethics I.7, Parts of Animals I.5 and Metaphysics A.1–2), there is a close relationship betweenthe use of the language of thaumaston (marvelous or admirable) and that of timion (honorable). These texts exhibit a progressive opening of Aristotle’s students to further horizons of philosophical awareness, within which is embedded a global transformation of the meanings of thaumaston. They mark the itinerary of a spiritual formation in which a new relationship through language to (...) phenomena and to others liberates the student from a psychology of emulation into a discipline of radically free inquiry. (shrink)

This volume of new essays provides a comprehensive and structured examination of Kant's justification of norms, a crucial but neglected theme in Kantian practical philosophy.

He notes that the order of the book is random and arbitrary, and that there is no unity, thematic or otherwise--an innovative approach to making sense of the universe. Several of the dozen essays have been previously published. No index.

If we want to be autonomous, what do we want? The author shows that contemporary value-neutral and metaphysically economical conceptions of autonomy, such as that of Harry Frankfurt, face a serious problem. Drawing on Plato, Augustine, and Kant, this book provides a sketch of how "ancient" and "modern" can be reconciled to solve it. But at what expense? It turns out that the dominant modern ideal of autonomy cannot do without a costly metaphysics if it is to be coherent.

This book is an introductory narrative of the foundational educational history and philosophy of the American system. The author presents the history of education as a part of the larger picture of the development of civilization. Therefore, the historic and philosophical antecedents of our current education system are explained.

One of the cardinal assumptions about the nature of grammar is that it is a formal system, meaning that the operations and symbols in the grammar should have a precise meaning, so that one can tell precisely how it functions, and whether a given structure is in fact created by the grammar. The issue of how much information is available to the grammar, viewed as a computational device that computes structures, is called the issue of computational complexity. The computational powers (...) of various grammars, and the capacity of recognition devices to characterize as licit or not the structures that they generate, has been the province of mathematical linguistics, but has also occasionally been felt to have implications for empirical syntactic theory. One central question that has raised its head over the years is the question of whether or not grammar ( which is now referred to as CHL, for Computation of Human Language (Chomsky (1995)) is Markovian, an issue first raised in Chomsky (1957). For a computational device to be Markovian, it can only make reference to the current state that the device is in, when deciding what the next state of the device can be; it cannot, for example, make reference to alternative states, earlier states, future states, or , as a consequence of its being a formal system, factors outside of the computational device. (shrink)

This paper discusses the theology of Alexander Penrose Forbes, Bishop of Brechin in the Scottish Episcopal Church and the first Anglican bishop in the British Isles to be deeply influenced by Tractarianism. A close confidant of Edward Bouverie Pusey, he extended Pusey's patristic proof-texting method into discussion of the Church of England formularies, especially the Thirty-nine Articles of Religion. His main work was an explanation of this key reformation text, which offers a good illustration of a historicist understanding of Catholicism. (...) Like Pusey, Forbes was involved in ecumenical discussion with Roman Catholics, and was motivated principally by the attempt to find a common conservative front against the perceived liberalism that seemed to be affecting European religion and politics in the mid-nineteenth century. (shrink)

This paper addresses the second and third volumes of Edward Bouverie Pusey's Eirenicon, which were published as open letters to John Henry Newman. Written in the run up to the First Vatican Council in 1870, these books discuss respectively the Marian dogmas and infallibility. Like the first volume they reveal the profound difference between Pusey's Anglo-Catholicism, which was a ‘catholicism of the word’ defined by the explicit doctrinal formulations of the undivided church, and Newman's Roman Catholicism with its emphasis on (...) the doctrine of development. Compared to the first volume, which provoked significant discussion, the impact of the second and third volumes was modest primarily because the declaration of infallibility meant that ecumenical discussion no longer seemed possible. Pusey's hopes for reunion were completely dashed and he removed himself from ecumenical discussion permanently. (shrink)

Hume's Reception in Early America: Expanded Edition brings together the original American responses to one of Britain's greatest men of letters, David Hume. Now available as a single volume paperback, this new edition includes updated further readings suggestions and dozens of additional primary sources gathered together in a completely new concluding section. From complete pamphlets and booklets, to poems, reviews, and letters, to extracts from newspapers, religious magazines and literary and political journals, this book's contents come from a wide variety (...) of sources published in colonial America and the early United States between 1758 and 1850. As well as classics by Thomas Jefferson, John Adams and Alexander Hamilton, it contains scores of unknown and hard-to-locate items, many of which have not been reprinted since their original publication. These responses are divided into four parts covering Hume's Essays; his Philosophical Writings; his History of England; and his Character and Death. Each of those parts has a separate introductory essay, and every selection is introduced by a short headnote that sets the piece in its historical context and provides bibliographical references. Packed with new insights into Hume and American thought and culture, Hume's Reception in Early America reveals the relevance and impact of Hume on American political, philosophical, historical, religious, and aesthetic debates. (shrink)

The paper rehearses arguments for and against the prediction of massive technological unemployment. The main argument in favor is that robots are entering a large number of industries; making more expensive human labor redundant. The main argument against the prediction is that for two hundred years we have seen a massive increase in productivity with no long term structural unemployment caused by automation. The paper attempts to move past this argumentative impasse by asking what humans contribute to the supply side (...) of the economy. Historically; humans have contributed muscle and brains to production but we are now being outcompeted by machinery; in both areas; in many jobs. It is argued that this supports the conjecture that massive unemployment is a likely result. It is also argued that a basic income guarantee is a minimal remedial measure to mitigate the worst effects of technological unemployment. (shrink)