Long non‐coding RNAs (lncRNAs) have recently gained increasing attention because of their crucial roles in gene regulatory processes. Functional studies using mammalian skin as a model system have revealed their role in controlling normal tissue homeostasis as well as the transition to a diseased state. Here, we describe how lncRNAs regulate differentiation to preserve an undifferentiated epidermal progenitor compartment, and to maintain a functional skin permeability barrier. Furthermore, we will reflect on recent work analyzing the impact of lncRNAs on the (...) progression from normal epithelium to the development of skin disorders and cancer. (shrink)

RNAs have emerged as a major target for diagnostics and therapeutics approaches. Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility. They can fold into complex structures and interact with proteins, DNA, and other RNAs, thus modulating activity, localization, or interactome of multi‐protein complexes. Thus, ncRNAs confer regulatory plasticity and represent a new layer of regulatory control. Interestingly, long noncoding RNAs (lncRNAs) tend to acquire complex secondary and tertiary structures and their function—in many cases—is dependent on structural conservation rather than (...) primary sequence conservation.Whereas for many proteins, structure and its associated function are closely connected, for lncRNAs, the structural domains that determine functionality and its interactome are still not well understood. Numerous approaches for analyzing the structural configuration of lncRNAs have been developed recently. Here, will provide an overview of major experimental approaches used in the field, and discuss the potential benefit of using combinatorial strategies to analyze lncRNA modes of action based on structural information. (shrink)

Here, we provide an ethical analysis of discrimination in private insurance to guide the application of non-discriminatory algorithms for risk prediction in the insurance context. This addresses the need for ethical guidance of data-science experts, business managers, and regulators, proposing a framework of moral reasoning behind the choice of fairness goals for prediction-based decisions in the insurance domain. The reference to private insurance as a business practice is essential in our approach, because the consequences of discrimination and predictive inaccuracy in (...) underwriting are different from those of using predictive algorithms in other sectors. Here we focus on the trade-off in the extent to which one can pursue indirect non-discrimination versus predictive accuracy. The moral assessment of this trade-off is related to the context of application—to the consequences of inaccurate risk predictions in the insurance domain. (shrink)

The relationship between psychological states and the brain remains an unresolved issue in philosophy of psychology. One appealing solution that has been influential both in science and in philosophy is Dennett’s concept of the intentional stance, according to which beliefs and desires are real and objective phenomena, but not necessarily states of the brain. A fundamental shortcoming of this approach is that it does not seem to leave any causal role for beliefs and desires in influencing behavior. In this paper, (...) I show that intentional states ascribed from the intentional stance should be seen as real causes, develop this to an independently plausible ontological position, and present a response to the latest interventionist causal exclusion worries. (shrink)

BackgroundValue sensitivity – the ability to recognize value-related issues when they arise in practice – is an indispensable competence for medical practitioners to enter decision-making processes related to ethical questions. However, the psychological competence of value sensitivity is seldom an explicit subject in the training of medical professionals. In this contribution, we outline the traditional concept of moral sensitivity in medicine and its revised form conceptualized as value sensitivity and we propose an instrument that measures value sensitivity.MethodsWe developed an instrument (...) for assessing the sensitivity for three value groups in a four step procedure: 1) value identification ; 2) value representation ; 3) vignette construction and quality evaluation ; and 4) instrument validation by comparing nursing professionals with hospital managers.ResultsWe find that nursing professionals recognize and ascribe importance to principle-related issues more than professionals from hospital management. The latter are more likely to recognize and ascribe importance to strategy-related issues.ConclusionsThese hypothesis-driven results demonstrate the discriminatory power of our newly developed instrument, which makes it useful not only for health care professionals in practice but for students and people working in the clinical context as well. (shrink)

Although scientific realism is the default position in the life sciences, philosophical accounts of realism are geared towards physics and run into trouble when applied to fields such as biology or neuroscience. In this paper, I formulate a new robustness-based version of entity realism, and show that it provides a plausible account of realism for the life sciences that is also continuous with scientific practice. It is based on the idea that if there are several independent ways of measuring, detecting (...) or deriving something, then we are justified in believing that it is real. I also consider several possible objections to robustness-based entity realism, discuss its relationship to ontic structural realism, and show how it has the potential to provide a novel response to the pessimistic induction argument. (shrink)

Levels of organization are structures in nature, usually defined by part-whole relationships, with things at higher levels being composed of things at the next lower level. Typical levels of organization that one finds in the literature include the atomic, molecular, cellular, tissue, organ, organismal, group, population, community, ecosystem, landscape, and biosphere levels. References to levels of organization and related hierarchical depictions of nature are prominent in the life sciences and their philosophical study, and appear not only in introductory textbooks and (...) lectures, but also in cutting-edge research articles and reviews. In philosophy, perennial debates such as reduction, emergence, mechanistic explanation, interdisciplinary relations, natural selection, and many other topics, also rely substantially on the notion. -/- Yet, in spite of the ubiquity of the notion, levels of organization have received little explicit attention in biology or its philosophy. Usually they appear in the background as an implicit conceptual framework that is associated with vague intuitions. Attempts at providing general and broadly applicable definitions of levels of organization have not met wide acceptance. In recent years, several authors have put forward localized and minimalistic accounts of levels, and others have raised doubts about the usefulness of the notion as a whole. -/- There are many kinds of ‘levels’ that one may find in philosophy, science, and everyday life—the term is notoriously ambiguous. Besides levels of organization, there are levels of abstraction, realization, being, analysis, processing, theory, science, complexity, and many others. In this article, the focus will be on levels of organization and debates associated with them, and other kinds of levels will only be discussed when they are relevant to this main topic. (shrink)

Benjamin Libet’s work paved the way for the neuroscientific study of free will. Other scientists have praised this research as groundbreaking. In philosophy, the reception has been more negative, often even dismissive. First, I will propose a diagnosis of this striking discrepancy. I will suggest that the experiments seem irrelevant, from the perspective of philosophy, due to the way in which they operationalize free will. In particular, I will argue that this operational definition does not capture free will properly and (...) that it is based on a false dichotomy between internal and external causes. However, I will also suggest that this problem could be overcome, as there are no obvious obstacles to an operationalization of free will that is in accord with the philosophical conception of free will. (shrink)

We discuss the concept of women’s empowerment in FemTech, considering cultural and legal differences, ethical concerns, and legal consequences. We claim that it is crucial to prioritize privacy, a fundamental right, especially in the case of changes in laws related to women’s health, such as Roe v. Wade in the US.

Recently Kenneth Kendler and Peter Zachar have raised doubts about the correspondence theory of truth and scientific realism in psychopathology. They argue that coherentist or pragmatist approaches to truth are better suited for understanding the reality of psychiatric disorders. In this article, I show that rejecting realism based on the correspondence theory is deeply problematic: It makes psychopathology categorically different from other sciences, and results in an implausible view of scientific discovery and progress. As an alternative, I suggest a robustness-based (...) approach that can accommodate the significance of coherence and pragmatic factors without rejecting scientific realism and the correspondence theory of truth. (shrink)

J.L. Schellenberg’s Argument from Divine Hiddenness maintains that if a perfectly loving God exists, then there is no non-resistant non-belief. Given that such nonbelief exists, however, it follows that there is no perfectly loving God. To support the conditional claim, Schellenberg presents conceptual and analogical considerations, which we subject to critical scrutiny. We also evaluate Schellenberg’s claim that the belief that God exists is logically necessary for entering into a relationship with the Divine. Finally, we turn to possible variants of (...) Schellenberg’s case, and argue that the modifications necessary to accommodate our criticismas leave those variants with much less of a sting than originally suggested by his provocative formulation. (shrink)

The levels of selection debate is generally taken to be a debate about how natural selection can occur at the various levels of biological organization. In this paper, we argue that questions about levels of selection should be analyzed separately from questions about levels of organization. In the deflationary proposal we defend, all that is necessary for multilevel selection is that there are cases in which particles are nested in collectives, and that both the collectives and the particles that compose (...) them each separately undergo natural selection. We argue that adopting this deflationary account helps to disentangle the levels of selection and the levels of organization, and thereby contributes to advancing the levels of selection debate. (shrink)

Cognitive science began as a multidisciplinary endeavor to understand how the mind works. Since the beginning, cognitive scientists have been asking questions about the right methodologies and levels of explanation to pursue this goal, and make cognitive science a coherent science of the mind. Key questions include: Is there a privileged level of explanation in cognitive science? How do different levels of explanation fit together, or relate to one another? How should explanations at one level inform or constrain explanations at (...) some other level? Can the different approaches to the mind, brain, and culture be unified? The aim of this issue of topiCS is to provide a platform for discussing different answers to such questions and to facilitate a better understanding between the different strands of thinking about the right levels of explanation in cognitive science. (shrink)

ABSTRACT:The notion of “democracy” has become a much-debated concept in scholarship on business ethics, management, and organization studies. The strategy of this paper is to distinguish between a principle of organization that fosters participation (type I democracy) and a principle of legitimation that draws on consent (type II democracy). Based on this distinction, we highlight conceptual shortcomings of the literature on stakeholder democracy. We demonstrate that parts of the literature tend to confound ends with means. Many approaches employ type I (...) democracy notions of participation and often take for granted that this also improves type II democratic legitimation. We hold this to be a mistake. We provide examples of the ambiguity of organizational procedures and show that under some circumstances a decrease in the degree of participation may actually increase legitimation because a governance structure that results in higher productivity can provide higher benefits for all parties involved, serve their interests and therefore meet their agreement. Less type I democracy may mean more type II democracy. We believe this to be an important insight for judging (and further improving) the legitimacy of both capitalistic firms and competitive markets. (shrink)

In this highly original book, Markus Gabriel presents 'Neo-Existentialism', an anti-naturalist view that holds that human mindedness consists in an open-ended proliferation of mentalistic vocabularies. Challenged by Charles Taylor, Andrea Kern and Jocelyn Benoist, Gabriel deftly refutes naturalism's metaphysical claim to epistemic exclusiveness.

This reference work offers a representative and reliable survey of classical, medieval, and modern history in regards to the philosophical term, truth .

Psychological measurement has received strong criticism throughout the history of psychological science. Nevertheless, measurements of attributes such as emotions or intelligence continue to be widely used in research and society. I address this puzzle by presenting a new causal perspective to psychological measurement. I start with assumptions that both critics and proponents of psychological measurement are likely to accept: a minimal causal condition and the observation that most psychological concepts are ill-defined or ambiguous. Based on this, I argue that psychological (...) measurement is fundamentally different from measurement in the physical sciences but can nevertheless be useful. (shrink)

Dass wir durch Wahrnehmung einen Zugang zur materiellen Welt haben, scheint selbstverständlich zu sein. Und dass die visuelle Wahrnehmung dabei einen prominenten Platz einnimmt, scheint ebenfalls selbstverständlich zu sein. Doch was genau sehen wir: die Gegenstände selbst oder bloß ihre wahrnehmbaren Eigenschaften? Wie gelingt es uns überhaupt, etwas zu sehen? Können wir allein aufgrund von optischen und physiologischen Vorgängen etwas sehen, oder setzt das Sehen bereits Begriffe voraus, mithilfe derer wir etwas als etwas sehen können? -/- Diese Fragen, die in (...) der gegenwärtigen Wahrnehmungs- und Erkenntnistheorie ausgiebig erörtert werden, waren bereits in der Frühen Neuzeit Gegenstand intensiver Debatten. In vielfacher Hinsicht legten die Diskussionen im 17. und 18. Jahrhundert sogar die Grundlage für heutige Theorien, da sie zum einen die Probleme in aller Schärfe benannten, zum anderen aber auch Lösungsstrategien vorlegten, die auch heute noch von Bedeutung sind. -/- Der Band soll diese Debatten (von Descartes bis Reid) neu erschließen und einem breiten philosophisch interessierten Publikum zugänglich machen. Es soll gezeigt werden, dass die Frühe Neuzeit kein ehrwürdiges Museum der Philosophiegeschichte ist, sondern eine äußerst produktive und anregende philosophische Epoche, die zu einem Dialog einlädt. (shrink)

The conditional analysis of dispositions is widely rejected, mainly due to counterexamples in which dispositions are either “finkish” or “masked.” David Lewis proposed a reformed conditional analysis. This view avoids the problem of finkish dispositions, but it fails to solve the problem of masking. I will propose a reformulation of Lewis’ analysis, and I will argue that this reformulation can easily be modified so that it avoids the problem of masking. In the final section, I will address the challenge that (...) some dispositions appear to lack any stimulus condition, and I will briefly turn to the issue of reductionism. (shrink)

Humans face many game problems that are too large for the whole game tree to be used in their deliberations about action, and very little is understood about how they cope in such scenarios. However, when a human player’s chosen strategy is conditioned on her limited perspective of how the game might progress, then it should be possible to manipulate her into changing her planned move by mentioning a possible outcome of an alternative move. This paper demonstrates that human players (...) can be manipulated this way: in the game The Settlers of Catan, where negotiation is only a small part of what one must do to win the game thereby generating uncertainty about which outcomes to the negotiation are good and which are bad, the likelihood that a player accepts a trade offer that deviates from their declared preferred strategy is higher if it is accompanied by a description of what that trade offer can lead to. (shrink)

It is the nature of powerful ideas that they can summarize a ground-breaking concept in a plain and simple message. In this sense, the concept of sustainability is a very powerful idea. However, although the sustainability debate has already brought about considerable conceptual progress, a pivotal dimension to sustainable development has so far been widely neglected. This article argues that in addition to the ecological, economic, and social dimension, sustainability critically depends on the moral dimension of institutional legitimacy. Against the (...) backdrop of globalization, conventional models of creating and legitimizing institutions are increasingly challenged. Therefore, it is also business that is to play an ever more important role in contributing to fair and functioning institutions. The article discusses “corporate citizenship” as an economic concept as a useful starting point for this new understanding of the business of business. In effect, the underlying objective of this paper is to present a theoretical link between the concepts of sustainability and corporate citizenship. The central thesis is that private enterprises who cooperatively take responsibility for their institutional environment strengthen the moral dimension of institutional legitimacy: They actively contribute to empowering sustainability by corporate citizenship. (shrink)

Interpreters of Machiavelli easily agree that his political writings have profoundly influenced our fundamental ideas of state and society, yet these interpreters rarely agree on what Machiavelli really thought. Did Machiavelli seek to recover classical republicanism in the Aristotelian tradition, or did he aspire to usher in modernity? Was he a cynic who assumed human beings to be inescapably wicked and offered technical advice to tyrants, or did he aim at some version of "the good life"? Did he create a (...) general theory of politics, or did he teach us that political issues should be approached in a particular contextual, dialectical, or rhetorical manner? Through systematic analysis, Markus Fischer's cogent and articulate study succeeds in resolving these questions. Well-Ordered License will appeal both to new students of Machiavelli and to scholars who have long sought to reconcile the seeming incoherence of his work. (shrink)

Many consider the nature of human consciousness to be one of the last great unsolved mysteries. Why should the light turn on, so to speak, in human beings at all? And how is the electrical storm of neurons under our skull connected with our consciousness? Is the self only our brain's user interface, a kind of stage on which a show is performed that we cannot freely direct? In this book, philosopher Markus Gabriel challenges an increasing trend in the (...) sciences towards neurocentrism, a notion which rests on the assumption that the self is identical to the brain. Gabriel raises serious doubts as to whether we can know ourselves in this way. In a sharp critique of this approach, he presents a new defense of the free will and provides a timely introduction to philosophical thought about the self – all with verve, humor, and surprising insights. Gabriel criticizes the scientific image of the world and takes us on an eclectic journey of self-reflection by way of such concepts as self, consciousness, and freedom, with the aid of Kant, Schopenhauer, and Nagel but also Dr. Who, The Walking Dead, and Fargo. (shrink)

Although we agree that a constructivist approach to emotional experience makes sense, we propose that implicit (visceromotor and somatomotor) emotional processes are dissociable from explicit (attention and reflection) emotional processes, and that the conscious experience of emotion requires an integration of the two. Assessments of implicit emotion and emotional awareness can be helpful in the neuroscientific investigation of emotion.

Diese Einleitung skizziert neben einigen begrifflichen Vorbemerkungen zwei Themenfelder, nämlich den Müll und eine Gruppe von Menschen, die in der Soziologie „die Überflüssigen“ genannt werden. Einerseits wird deutlich, dass der Müll die Rückseite der materiellen Kultur in ihrer Vielfältigkeit darstellt und dass die Geschichte der materiellen Kultur immer auch eine Geschichte dessen ist, was Menschen hinter sich lassen, wessen sie sich entledigen und was sie entsorgen. Andererseits macht die soziologische Ungleichheitsforschung deutlich, dass die „Überflüssigkeit“ von Menschen in einen Zusammenhang mit (...) dem Problem der sozialen Exklusion und damit mit gezielter Ausgrenzung und funktionaler Ausschließung gebracht werden kann. (shrink)

Der Aufsatz beschäftigt sich am Beispiel des deutschen "Kopftuchstreits" mit der rechtlich-politischen Auseinandersetzung um subjektive Rechte innerhalb des liberalen Rechtsstaats. Wie Christoph Menke in seiner Deutung der für den politischen Liberalismus wesentlichen politischen Konflikte gezeigt hat, bezieht sich diese Auseinandersetzung vorrangig auf zwei Fragen: Wer sollte Anspruch darauf genießen, ein politisches Subjekt zu sein, das heißt, als Gleiche oder Gleicher berücksichtigt zu werden? Welche Ansprüche politischer Subjekte könneen als schützenswerte Verwirklichung subjektiver Rechte gelten? Der vorliegende Beitrag beschäftigt sich vorwiegend mit (...) der Frage, wie die politischen Konflikte des letztgenannten Typs auf die rechtliche Auseinandersetzung um Grundrechte abfärben. Damit wende ich mich gegen ein Verständnis der Grundrechte, das diese als Garant der ethischen Neutralität eines liberalen Gemeinwesens ansieht. Ich möchte zeigen, dass der Sinn subjektiver Rechte in der liberalen Demokratie zwar unter anderem genau darin besteht, dass sie partikulare ethische Wertvorstellungen neutralisieren und die Bürgerinnen und Bürger innerhalb eines vernünftigen Rahmens vor Unterdrückung schützen. Wie eine Analyse der Entscheidungen des Bundesverfassungsgerichts (BVerfG) zum "Kopftuchstreit" zeigt, wird diese Funktion aber stets zugleich durch die partikulare Interpretation gleicher Rechte unterminiert. Dies bezeichne ich als die Dekonstruktion der Neutralität, die sich im Recht vollzieht. (shrink)

In this paper, we will discuss Peter van Inwagen’s contribution to the epistemological debate about revealed peer disagreement. Roughly, this debate focuses on situations in which at least two participants disagree on a certain proposition based on the same evidence. This leads to the problem of how one should react rationally when peer disagreement is revealed. Van Inwagen, as we will show, discusses four possible reactions, all of which he rejects as unsatisfying. Our proposal will be to point to hidden (...) assumptions in van Inwagen’s reasoning and ask whether he is willing to reject at least one of these to get rid of the problem. In short, our thesis amounts to the following: Of the two epistemological claims, which we call “Weak” and “Full-blown Fallibilism”, van Inwagen cannot simultaneously accept the first and reject the latter, while this is what he seems to suggest. Revealing this potential dilemma for van Inwagen’s position will lead to a more detailed discussion of how “rationality”, “truth”, “evidence” and “justification” interrelate and how a closer look at their relation might help solving the puzzle of revealed peer disagreement. (shrink)

The article explores the relationship between visual culture and the fight for visibility and attention in contemporary society. It draws on a concept of visual culture which not only sees the rising significance of the visual and the proliferation of images as its defining traits, but also the fact that, today, people are—to a much higher degree—both consumers as well as producers of images. Based on this definition, it is argued that in visually oriented communication and media societies, the anthropologically (...) fundamental need for attention manifests itself as a fight for visibility which takes on the form of ever more extreme forms of public self-display. Furthermore, a portrait of two social figures—the star and the voyeur—will serve as further analysis and description of the social trends which can be tied to the emergence of today's visual culture. The article will close by discussing attention and visibility in terms of inclusion and exclusion and by proposing an analytical model for differentiating four modes of existence in a visual culture. (shrink)

This interview deals with the major themes in the work of Ruth Millikan. Her most fundamental idea is that the intentionality of inner and outer representations can be understood in analogy to biological functions. Another innovative feature is the view that thought and language stand parallel to each other. Thirdly, the basic ideas concerning the ontology and the epistemology of concepts are explained. Millikan aims at clarifying her position by contrasting it with Dretske, Fodor, Sellars, and Brandom. Finally, the interview (...) addresses topics that pose problems for her account as well as questions she does not treat in her work. (shrink)

1. Bd. Die Grundlagen. Die spezielle Relativitätstheorie.- 2. Bd. Die allgemeine Relativitätstheorie.

Advanced old age has been characterized as a biologically highly vulnerable life phase. Biological, morbidity-, and cognitive impairment-related factors play an important role as mortality predictors among very old adults. However, it is largely unknown whether previous findings confirming the role of different wellbeing domains for mortality translate to survival among the oldest-old individuals. Moreover, the distinction established in the wellbeing literature between hedonic and eudaimonic wellbeing as well as the consideration of within-person variability of potentially relevant mortality predictors has (...) not sufficiently been addressed in prior mortality research. In this study, we examined a broad set of hedonic and eudaimonic wellbeing indicators, including their levels, their changes, as well as their within-person variability, as predictors of all-cause mortality in a sample of very old individuals. We used data from the LateLine study, a 7-year longitudinal study based on a sample of n = 124 individuals who were living alone and who were aged 87–97 years at baseline. Study participants provided up to 16 measurement occasions between 2009 and 2016. Dates of death were available for 118 individuals who had deceased between 2009 and 2021. We ran longitudinal multilevel structural equation models and specified between-person level differences, within-person long-term linear change trends, as well as the “detrended” within-person variability in three indicators of hedonic and four indicators of eudaimonic wellbeing as all-cause mortality predictors. Controlling for age, gender, education, and physical condition and testing our sets of hedonic and eudaimonic indictors separately in terms of their mortality impact, solely one eudaimonic wellbeing indicator, namely, autonomy, showed significant effects on survival. Surprisingly, autonomy appeared “paradoxically” related with mortality, with high individual levels and intraindividual highly stable perceptions of autonomy being associated with a shorter residual lifetime. Thus, it seems plausible that accepting dependency and changing perceptions of autonomy over time in accordance with objectively remaining capabilities might become adaptive for survival in very old age. (shrink)

Dans ce livre très original, Markus Gabriel avance une théorie du soi humain qui surmonte les blocages inhérents aux positions standards en philosophie de l'esprit contemporaine. Son point de vue, le néo-existentialisme, est intégralement antinaturaliste, en ce sens qu'il rejette toute théorie selon laquelle l'ensemble de nos meilleures connaissances scientifiques naturelles serait pleinement capable de rendre compte de l'esprit humain. L'auteur montre plutôt que l'esprit humain consiste en une prolifération ouverte de vocabulaires mentalistes. Leur rôle dans la forme de (...) vie humaine consiste à rendre compte du fait que l'être humain ne se fond pas simplement dans la nature inanimée et le reste du règne animal. Les humains s'appuient sur un autoportrait qui les situe dans un contexte aussi large que possible au sein de l'univers. Ce qui distingue cet autoportrait de notre connaissance de la réalité naturelle, c'est que nous changeons en vertu de nos croyances, vraies ou fausses, au sujet de nous-mêmes. (shrink)

In Western thinking, the tradition of the argument for the existence of God beganwith Plato and Aristotle. It was carried forward in medieval scholasticism,eminently in Aquinas‟s so-called quinque viae, and reached its peak in modernphilosophy. To date approximately 1850 different proofs for the existence of Godare known. The most frequently represented and well-known types of proofs arethe ontological, cosmological, teleological and the moral or deontological type,referring respectively to the arguments of Anselm, Aquinas , and Kant. In this paper I will (...) discuss the development of modernphilosophical proofs, from Descartes‟s and Spinoza‟s ontological arguments,through, Leibniz‟s cosmological argument to Swinburne‟s revision of Leibniz. (shrink)

Philosophers have spent millennia accumulating knowledge about knowledge. But negative epistemological phenomena, such as ignorance, falsity, and delusion, are persistently overlooked. Markus Gabriel argues that being wrong is part and parcel of subjectivity itself, adding a novel perspective on epistemic failures to debates around New Realism.

At the centre of modern epistemology lurks the problem of scepticism: how can we know that the forms of our cognition are compatible with the world? How can we state success conditions for knowledge claims without somehow transcending our discursive and fallible nature as knowers? By distinguishing different forms of scepticism, Markus Gabriel shows how all objective knowledge relies on shared discourses and how the essential corrigibility of knowledge claims is a crucial condition of their objectivity. We should understand (...) scepticism not so much as posing a threat, but as offering a vital lesson about the fallibility of discursive thinking. By heeding this lesson, we can begin to reintegrate the solipsistic subject of modern epistemology back into the community of actual knowers. Taking his cue from Hegel, Wittgenstein and Brandom, Gabriel shows how intentionality as such is a public rather than a private phenomenon. He concedes that the sceptic can prove the necessary finitude of objective knowledge, but denies that this has to lead us into an aporia. Instead, it shows us the limits of the modern project of epistemology. Through an examination of different kinds of sceptical paradoxes, Gabriel not only demonstrates their indispensable role within epistemological theorising, but also argues for the necessary failure of all totalizing knowledge claims. In this way, epistemology, as the discipline that claims knowledge about knowledge, begins to grasp its own fallibility and, as a result, the true nature of its objectivity. The Limits of Epistemology will be of great value to students and scholars of philosophy. (shrink)

Self-consciousness, first-person reference, and personal identity are linked fields of research. The book contains contributions from international researchers about topics like pre-reflective and reflexive consciousness, embodiment, temporality, self-location, and the practical implications of personal identity. Among the contributors are Amit Anurag, Irene Breuer, Tony Cheng, Heidi Haanila, Markus Herrmann, Muriel Leuenberger, Maik Niemeck and Jorg Noller.