Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

The inaugural collection in an exciting new exchange between philosophers and geographers, this volume provides interdisciplinary approaches to the environment as space, place, and idea. Never before have philosophers and geographers approached each other's subjects in such a strong spirit of mutual understanding. The result is a concrete exploration of the human-nature relationship that embraces strong normative approaches to environmental problems.

Brings together and interprets previously hard-to-find texts, new translations and passages detailing the interplay between philosophy and psychopathology.

Technical results about the time dependence of eigenvectors of reduced density operators are considered, and the relevance of these results is discussed for modal interpretations of quantum mechanics which take the corresponding eigenprojections to represent definite properties. Continuous eigenvectors can be found if degeneracies are avoided. We show that, in finite dimensions, the space of degenerate operators has co-dimension 3 in the space of all reduced operators, suggesting that continuous eigenvectors almost surely exist. In any dimension, even when degeneracies are (...) hit, we find conditions under which a theorem due to Rellich can provide continuous eigenvectors. We use this result to formulate an extended version of the modal interpretation. We also discuss eigenvector instability which we argue poses a serious problem for the modal interpretation, even in our extended version. Many examples are given to illustrate the mathematics. (shrink)

By scholarly consensus, extant fragments from, and testimony about, Aristotle’s lost dialogue Eudemus provide strong evidence for thinking that Aristotle at some point defended the human soul’s unqualified immortality (either in whole or in part). I reject this consensus and develop an alternative, deflationary, speculative, but textually supported proposal to explain why Aristotle might have written a dialogue featuring arguments for the soul’s unqualified immortality. Instead of defending unqualified immortality as a doctrine, I argue, the Eudemus was most likely offering (...) a dramatically engaging propaedeutic to the sort of philosophical inquiry about the soul and its prospects that Aristotle pursues more scientifically in the De anima and Parva naturalia. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 11.1 (2004) 35-41 [Access article in PDF] The Rationality of Psychosis and Understanding the Deluded Matthew R. Broome Campbell's important and influential paper (Campbell 2001) has framed the debate that Bayne and Pacherie (2004) most explicitly, and Klee (2004) and Georgaca (2004) more implicitly, engage in. Campbell has offered two broad ways of thinking about explanations of delusions—the empirical and the rational. He offers (...) some criticism of the former and an endorsement of the latter. Campbell uses examples from clinical psychopathology to illustrate his argument and Bayne and Pacherie in turn employ these. Campbell discusses the eponymously named delusions of Capgras and Cotard—the former a subtype of delusional misidentification and the latter a delusion whose content is colored predominantly with nihilistic and possibly hypochondriacal themes. Campbell, Bayne and Pacherie, and Klee discuss the empirical data in relation to such delusions and as an aid to discussing the empirical model more generally. It does seem a little unfortunate that these delusions, which are less than typical, become the focus of Campbell's paper, and Bayne and Pacherie's criticism of his work. Delusions are remarkably heterogeneous; this indeed may be part of the reason why there is so much difficulty in reaching a definition as Klee discusses, and occur in a wide variety of mental and neurological illnesses. The most common delusions are those of persecution and reference (World Health Organization [WHO] 1973) and typically occur in schizophrenia. By contrast, delusional misidentification occurs most commonly in patients with dementia, delirium, and focal cognitive impairment, but can occur in other functional psychoses such as an affective or schizophrenic psychosis. The most common form of delusional misidentification is not that of either the exotic Capgras or Fregoli syndromes but delusional misidentification for place; thus, although Bayne and Pacherie's arguments against Campbell may still hold, delusional misidentification tends to occur in the context of a patient believing that they are at home or on holiday rather than in hospital and may not necessarily involve close family members or other intimate relationships. Similarly, Cotard's syndrome tends to occur in the context of a severe depressive illness with mood-congruent psychotic symptoms, typically in an elderly individual. It does not have to have the content that the deluded is dead, but can include beliefs, for example, that the world no longer exists or that their internal organs are not present. Thus, a patient with either Capgras' or Cotard's syndrome is likely to differ from patients with delusions of persecution. They would [End Page 35] have different diagnoses, probably be older, and have a greater likelihood of structural abnormalities of the brain on imaging and consequent neuropsychological dysfunction. That is not to say that patients with schizophrenia have normal cerebral anatomy and neuropsychology, but rather that the Capgras' and Cotard's patients are likely to have neurological quality to their presentation that is clinically relevant, rather than what commonly the case in schizophrenia and the other functional psychoses, where the neurological abnormalities are only currently important at the level of academic research. Empirical Models of Delusion Formation Different delusions may not have that much in common, nor may the patients who believe in them. This in turn relates to the empirical paradigm that both Campbell and Bayne and Pacherie discuss. It is true that current research, and indeed the clinical practice of cognitive behavioral therapy for psychosis, is indebted to the work of Maher and it is within his legacy which we work. This, however, is not to say that we think his initial formulation was correct. Maher's (1988, 1992) work focused attempts in explaining delusions—both to support and refute his thesis that delusions are the consequence of normal cognitive mechanisms seeking to explain an anomalous sensory experience. Such a view initially led to work demonstrating delusions in the absence of anomalous perceptions, the presence of reasoning biases in the deluded population, and the possibility that abnormal sensory experience may be consequent upon biased cognitive processes (Garety and Freeman 1999). More recent work has demonstrated the prevalence of... (shrink)

Daniel Dennett is one of the most influential thinkers at the interface between philosophy and science. This book is the first comprehensive examination of Dennett ’s ideas on the nature of thought, consciousness, free will, and the significance of Darwinism. A highly original introduction to contemporary thinking about the relationship between mind and science. This is the first comprehensive examination of Dennett ’s ideas on the nature of thought, consciousness, free will, and the significance of Darwinism. Examines Dennett ’s unique (...) response to the question of when and how science should affect the conception that we have of ourselves. Casts new light on specific controversies: Could robots ever think, feel, and enjoy freedom? Does Dennett really explain consciousness? Are mental states real or merely ‘useful fictions’? Do we have free will? Is the self a ‘centre of narrative gravity’? (shrink)

This book explores how ancient philosophers, particularly Plato, Aristotle, the Stoics, and Sextus Empiricus, understood relativity and how their theories of the phenomenon affected, and were affected by, their broader philosophical outlooks.

We focus on the production of efficient descriptions of objects, actions and events. We define a type of efficiency, textual economy, that exploits the hearer’s recognition of inferential links to material elsewhere within a sentence. Textual economy leads to efficient descriptions because the material that supports such inferences has been included to satisfy independent communicative goals, and is therefore overloaded in the sense of Pollack [18]. We argue that achieving textual economy imposes strong requirements on the representation and reasoning used (...) in generating sentences. The representation must support the generator’s simultaneous consideration of syntax and semantics. Reasoning must enable the generator to assess quickly and reliably at any stage how the hearer will interpret the current sentence, with its (incomplete) syntax and semantics. We show that these representational and reasoning requirements are met in the SPUD system for sentence planning and realization. (shrink)

This paper develops a model of individual decision-making under bounded rationality in which discretionary cognitive adjustment creates a durable stock that complements choice of action. While it increases utility, adjustment also entails a cost, because focusing attention optimally is effortful and mental resources are scarce. Associated behavioral phenomena are categorized based on whether the operative motivation in adjusting is forward-looking utility maximization or justification of prior action. The theory is in line with prior conceptions of cognitive dissonance, but also offers (...) a more empirically consistent explanation of the endowment effect, persuasive advertising, and sunk-cost effects than existing accounts. (shrink)

This article considers the role of the adult epithelial stem cell, with particular reference to the intestinal epithelial stem cell. Although the potential of adult stem cells has been revealed in a number of recent publications, the organization and control of the stem cell hierarchy in epithelial tissues is still not fully understood. The intestinal epithelium is an excellent model in which to study such hierarchies, having a distinctive polarity and high rate of cell proliferation and migration. Studies on the (...) small intestinal crypt provide insight into the characteristics of the stem cells in normal and regenerating circumstances and demonstrate why a thorough understanding of these cells is an essential pre‐requisite for stem cell based therapeutic approaches. BioEssays 24:91–98, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

This thesis argues that the strongest account of moral rights entails that animals and other marginal cases hold rights. The thesis contends that mutual advantage social contract theories offer the strongest account of rights from a security perspective, and that such theories entail rights for animals and marginal cases. Both of these claims are widely contested. Chapter 1 examines the fundamental elements of a social contract theory as developed by Hobbes and Hume. Chapter 2 revises the fundamental elements of contract (...) theory to make them more persuasive, and derives from them an account of rights for animals and marginal cases. Chapter 3 examines the most plausible competing accounts of rights for animals and marginal cases: utilitarianism, neo-Kantianism, and capability theory. Chapter 4 argues that the mutual advantage account of rights is better than the leading competitors from a security perspective. (shrink)

While it is often supposed that Spinoza understood a life of virtue as one of pure activity, with as few passions as possible, this paper aims to make explicit how the passions for Spinoza contribute positively to our virtue. This requires, first, explaining how a passion can increase our power, given Spinoza’s view on the passions generally, which, in turn, requires coming to terms with the problem of passive pleasure, that is, the problem of explaining how being passive can cause (...) an increase in our power. In brief, this paper will argue that, for Spinoza, even when we are passive, we are somewhat active or, in Spinoza’s language, “adequate” to varying degrees. The passions represent activity because they exercise our understanding by providing us with intelligence about external bodies and our own bodies, in particular, the degree of our bodies’ perfection. It follows that a passion can be sufficiently adequate to bring about an increase in one’s power; in this sense, they can be virtuous. Moreover, this paper will show that the passions can also be virtuous in a moral sense. The view goes roughly as follows: according to Spinoza, the passions serve as a measure of our perfection. Consequently, they play a necessary role in moral reasoning, by indicating which activities increase or hinder our virtue. On this view, a truly virtuous person would require the passions in order to engage consistently in the sorts of activities which increase her power, in particular, following reason. Since this sort of consistency in behavior is necessary for a virtuous character, the passions can be virtuous in the sense that they are necessary aspects of the sort of character which disposes us to act according to reason. (shrink)

Volume 20, Issue 7, July 2020, Page 75-77.

This chapter is an essay in a volume that examines constitutional law in the United States through the lens of H.L.A. Hart's "rule of recognition" model of a legal system. My chapter focuses on a feature of constitutional practice that has been rarely examined: how jurists and scholars argue about interpretive methods. Although a vast body of scholarship provides arguments for or against various interpretive methods -- such as textualism, originalism, "living constitutionalism," structure-and-relationship reasoning, representation reinforcement, minimalism, and so forth (...) -- very little scholarship shifts to the meta-level and asks: What are the considerations that jurists and scholars bring to bear in arguing that one or another interpretive method is legally favored? And can we "make sense" of this body of argument? Is there a model of legal discourse that both accurately describes how U.S. jurists and scholars actually argue about interpretive methods, and that vindicates this discourse (in the sense of seeing these actors as making valid arguments)? I find that Hart's rule-of-recognition model fails to describe or vindicate how U.S. jurists and scholars argue about interpretive methods. The problem, in a nutshell, is that Hart sees legal argument as asserting or presupposing the social fact of contemporary official acceptance of a rule of recognition. By contrast, jurists and scholars typically point to social facts other than contemporary official acceptance in arguing for the legal status of an interpretive method -- for example, the fact that the method is supported by Framers' intent, or by U.S. culture and tradition, or by precedent. Further, jurists and scholars very often argue that some interpretive method is legally favored even though the method is controversial. On Hart's model, such a claim is problematic -- because, on his model, the content of the rule of recognition is not controversial, but rather a matter of consensus among officials. The upshot may just be that Hart's model is a failure. However, another possibility is to adopt an "error theory" of U.S. constitutional discourse. It may perhaps be the case that U.S. jurists and scholars often make claims for the favorable legal status of some interpretive method that are inconsistent with the best understanding of the nature of law. (shrink)

This article explores Jacques Derrida’s notion of ‘democracy to come’, showing how democracy generates what might be described as a ‘deconstructive’ relation to foundational ideas. This article opens with an overview of the political theory literature on Derrida’s political thought, arguing that scholars mistakenly present it as naïvely anti-foundationalist. The body of this article then briefly demonstrates that a Derridean approach to foundations does not aim to destroy or transcend them, but to interrupt our expectation that foundations be stable and (...) certain. Turning to Politics of Friendship and Rogues, this article shows that Derrida’s notion of the democracy to come hinges around the idea that there is precisely such a ‘deconstructive’ relation between democracy’s dual foundations of freedom and equality. Democracy is thus itself ‘deconstructive’. Far from the inconsistent and insincere defender of democracy that his critics describe, Derrida emerges as a provocative contributor to democratic theory. (shrink)

We question the generalizability of Glover's model because it fails to distinguish between different forms of planning. The highly controlled experimental situations on which this model is based, do not reflect some important factors that contribute to planning. We discuss several classes of action that seem to imply distinct planning mechanisms, questioning Glover's postulation of a single “planning system.”.

In Emotion, character, and responsibility, J. Sabini and M. Silver set out to show specifically why emotions are important in the conception of a person's character. Thus, their collection of previously published material tackles the daunting task of explaining how and why it is that it is often considered that peoples' emotions reflect upon their characters. What the present author finds particularly appealing, as well as convincing, in all of these writings is Sabini and Silver's grounding of their arguments in (...) everyday experience. This article examines whether it is appropriate to judge people on the basis of their emotions, and whether emotions and emotional responses reflect one's character. The question the present author proposes is whether the reader is prepared to make the sacrifices to the content of emotions which Sabini and Silver make in arguing for their conclusion. 2012 APA, all rights reserved). (shrink)

We show that there exist downwards properly $\Sigma _{2}^{0}$ (in fact noncuppable) e-degrees that are not high. We also show that every high e-degree bounds a noncuppable e-degree.

Robert Nisbet's influential "Many Tocquevilles" is shown to be lacking in evidence for its contentions about Tocqueville's reputation from 1870 to 1940 and about American intellectuals' interpretations of his works after 1940. The uncritical reception accorded to "Many Tocquevilles" led to distortions of Tocqueville's thought and an erasure of an important part of the historical record, resulting in significant harm to the field. Nisbet made his unsupported assertions to bolster conservative political positions. Tocqueville was widely read between 1870 and 1940. (...) No evidence exists for Nisbet's claims about interpretations of Tocqueville's works supposedly made by subsequent American commentators. (shrink)

Petti's unprecedented perspective will forever challenge the way people thinkabout God, human origins, ancient mysteries, and Revelation's foretold perilsand deceptive abuse of mistaken beliefs.

This paper provides a brief critical assessment of Ruger’s global health justice framework.

Following are two short contributions to the book, _Criminal Law Conversations_: commentaries on Paul Robinson's discussion of "Empirical Desert" and Antony Duff & Sandra Marshal's discussion of the sharing of wrongs.