Gravitational interactions allowed astronomers to conclude that dark matter rings all luminous galaxies in gigantic halos, but this only accounts for a fraction of the total mass of dark matter believed to exist. Where is the rest? We hypothesize that some of it resides in dark galaxies, pure dark matter halos that either never possessed or have totally lost their baryonic matter. This article explores methodological challenges that arise because of the nature of observation in astrophysics and examines how the (...) blend of observation, simulation, and theory we call the Observing the Invisible approach might make detecting such dark objects possible. (shrink)

In Finite and Infinite Goods, Adams develops a sophisticated and richly detailed Platonic-theistic framework for ethics. The view is Platonic in virtue of being Good-centered; it is theistic both in identifying God with the Good and, more distinctively, in including a divine command theory of moral obligation. Readers familiar with Adams’s earlier divine command theory will recall that in response to the worry that God might command something evil, Adams introduced an independent value constraint, claiming that only the commands of (...) a loving God were fit to constitute moral obligations. In Finite and Infinite Goods he develops this notion of a loving and good God in what is now a fundamentally Good-centered ethical framework with a subordinate divine command theory of moral obligation. There is much of worth here, especially for theists wishing to think through the merits of a good-based theistic ethics, but also for those nontheists like myself who have a general interest in the nature of value and obligation. (shrink)

Realists about practical reasons agree that judgments regarding reasons are beliefs. They disagree, however, over the question of how such beliefs motivate rational action. Some adopt a Humean conception of motivation, according to which beliefs about reasons must combine with independently existing desires in order to motivate rational action; others adopt an anti-Humean view, according to which beliefs can motivate rational action in their own right, either directly or by giving rise to a new desire that in turn motivates the (...) action. I argue that the realist who adopts a Humean model for explaining rational action will have a difficult time giving a plausible account of the role that desire plays in this explanation. I explore four interpretations of this role and argue that none allows a Humean theory to explain rational action as convincingly as an anti-Humean theory does. The first two models, in different ways, make acting on a reason impossible. The third allows this possibility, but only by positing a reason-sensitive desire that itself demands an explanation. The fourth avoids this explanatory challenge only by retreating to an empty form of the Humean view. In contrast, an anti-Humean theory can provide an intuitively plausible explanation of rational action. I conclude that the realist about reasons should adopt an anti-Humean theory to explain rational action. (shrink)

The Common Anatomy Reference Ontology (CARO) is being developed to facilitate interoperability between existing anatomy ontologies for different species, and will provide a template for building new anatomy ontologies. CARO has a structural axis of classification based on the top-level nodes of the Foundational Model of Anatomy. CARO will complement the developmental process sub-ontology of the GO Biological Process ontology, using it to ensure the coherent treatment of developmental stages, and to provide a common framework for the model organism communities (...) to classify developmental structures. Definitions for the types and relationships are being generated by a consortium of investigators from diverse backgrounds to ensure applicability to all organisms. CARO will support the coordination of cross-species ontologies at all levels of anatomical granularity by cross-referencing types within the cell type ontology (CL) and the Gene Ontology (GO) Cellular Component ontology. A complete cross-species CARO could be utilized in other ontologies for cross-product generation. (shrink)

In Slaves of the Passions, Mark Schroeder provides a systematic, rigorously argued defense of a Humean theory of reasons for action, taking pains to respond to influential objections to the view. While inspired by Hume, Schroeder makes it clear that he aims to develop a Humean theory, not necessarily one that Hume himself embraced, and for this reason little is said about Hume in the book. One respect in which Schroeder takes himself to be departing from Hume is in developing (...) a normative account. On his reading, Hume held that only beliefs could stand in the reason relation (187, n11), whereas Schroeder, like many contemporary Humeans, holds that actions can as well. He sets out to develop a theory of this .. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

The book is both a call to action and a how-to guide to effective teaching.

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Research and engineering in the quantum domain involve long chains of activity involving theory development, hypothesis formation, experimentation, device prototyping, device testing, and many more. At each stage multiple paths become possible, and of the paths pursued, the majority will lead nowhere. Our quantum metascience approach provides a strategy which enables all stakeholders to gain an overview of those developments along these tracks, that are relevant to their specific concerns. It provides a controlled vocabulary, built out of terms that are (...) designed to be maximally comprehensible to all groups of stakeholders and across all the sub-fields of the quantum domain. (shrink)

This chapter argues that Kant’s aesthetic theory of the sublime has particular relevance for his ethics of virtue. Kant contends that our readiness to revel in natural sublimity depends upon a background commitment to moral ends. Further lessons about the emotional register of the sublime allow us to understand how Kant can plausibly contend that the temperament of virtue is both sublime and joyous at the same time.

In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J. Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)

By addressing specific global problems and placing them within an ethical context, "The Environment in Question" provides the reader with both a theoretical and practical understanding of environmental issues. The contributors are internationally known figures drawn from the various disciplines which bear upon these issues, such as geography, psychology, social policy, and philosophy. The contributions range from those tackling individual concrete issues (such as nuclear waste and the threat to the rain forest) to those addressing matters of policy, principle and (...) attitude (such as our obligations to future generations and the nature of technological risk). "The Environment in Question" is designed as a text for students of philosophy, environmental science, environmental education, ecology, and teacher education. It can be used as an inter-disciplinary, self-contained course book or in conjunction with relevant material. In addition, as the essays directly and controversially address current environmental debates in a non-technical manner, it is of great interest both to professionals in those areas and to readers who care about the planet's future. The substantial cross-section of concerns and approaches will enable all readers to develop the necessary level of understanding required to initiate and sustain debate on environmental issues. Contributors: Robert Allsion, David E. Cooper, Barry S. Gower, F. G. T. Holliday, C. A. Hooker, Mary Midgley, Philip Neal, Joy A. Palmer, Robert Prosser, Holmes Rolston III, Mark Sagoff, Vandana Shiva, Stephen Sterling, Rosemary J. Stevenson, Jennifer Trusted. (shrink)

This article examines the theoretical status of the three CSR models of William C. Frederick. Using the method of systematics, it disaggregates the elements of the three models and suggests one integrative means of re-sorting them. The article argues the need to develop a theoretical logic to understand behavior in this area and supplies one in the form of the beginnings of an explicit theory of normative referencing. The processes of normative referencing, including normative selection, normative commitment, normative instruction, normative (...) implementation, normative administration, normative outcomes production, normative accounting, and normative adjustment are described. (shrink)

The concept of scientific field lacks a definition in a form allowing the distinction of whether a particular academic area of study is or is not a true scientific field. Starting with the classic definition by Whitley of a field as a “reputational work organization,” this essay extracts eleven explicit and implied features of a field from Whitley’s definition and discussion, extending his analysis. The article reviews Hambrick and Chen’s model of field formation as an “admittance-seeking social movement.” Hambrick and (...) Chen argue that strategic management followed that model with success, offering the SIM Division of the Academy of Management as an unsuccessful example. The article notes errors in their assessment of SIM, argues that Hambrick and Chen are really offering a model of what I term condensation and promulgation of a field and that their model cannot be used to determine whether a field exists. The article applies the extended Whitley model of a field to examine three candidate fields within SIM: corporate social responsibility (CSR)/corporate social performance (CSP), stakeholder theory, and corporate political activity (CPA). I conclude that none is technically a field, and considering as well the comments of three senior scholars who contributed to the symposium, the article discusses the potential trajectory of fields in SIM. (shrink)

Interdisciplinary perspectives on the feature of conscious life that scaffolds every act of cognition: subjective time. Our awareness of time and temporal properties is a constant feature of conscious life. Subjective temporality structures and guides every aspect of behavior and cognition, distinguishing memory, perception, and anticipation. This milestone volume brings together research on temporality from leading scholars in philosophy, psychology, and neuroscience, defining a new field of interdisciplinary research. The book's thirty chapters include selections from classic texts by William James (...) and Edmund Husserl and new essays setting them in historical context; contemporary philosophical accounts of lived time; and current empirical studies of psychological time. These last chapters, the larger part of the book, cover such topics as the basic psychophysics of psychological time, its neural foundations, its interaction with the body, and its distortion in illness and altered states of consciousness. Contributors Melissa J. Allman, Holly Andersen, Valtteri Arstila, Yan Bao, Dean V. Buonomano, Niko A. Busch, Barry Dainton, Sylvie Droit-Volet, Christine M. Falter, Thomas Fraps, Shaun Gallagher, Alex O. Holcombe, Edmund Husserl, William James, Piotr Jaśkowski, Jeremie Jozefowiez, Ryota Kanai, Allison N. Kurti, Dan Lloyd, Armando Machado, Matthew S. Matell, Warren H. Meck, James Mensch, Bruno Mölder, Catharine Montgomery, Konstantinos Moutoussis, Peter Naish, Valdas Noreika, Sukhvinder S. Obhi, Ruth Ogden, Alan o'Donoghue, Georgios Papadelis, Ian B. Phillips, Ernst Pöppel, John E. R. Staddon, Dale N. Swanton, Rufin VanRullen, Argiro Vatakis, Till M. Wagner, John Wearden, Marc Wittmann, Agnieszka Wykowska, Kielan Yarrow, Bin Yin, Dan Zahavi. (shrink)

An experiment is proposed to test Bell’s theorem in a purely macroscopic domain. If realized, it would determine whether Bell inequalities are satisfied for a manifestly local, classical system. It is stressed why the inequalities should not be presumed to hold for such a macroscopic system without actual experimental evidence. In particular, by providing a purely classical, topological explanation for the EPR-Bohm type spin correlations, it is demonstrated why Bell inequalities must be violated in the manifestly local, macroscopic domain, just (...) as strongly as they are in the microscopic domain. (shrink)

This study re-examined the impact of personal and organizational values congruency on positive work outcomes and investigated the extent to which this relationship is affected by demographic variables. Data collection paralleled an earlier study (Posner and Schmidt, Journal of Business Ethics 12,1993, 341) and validated those findings, lending additional credibility to the continuing importance of this phenomenon. Both personal values congruence and organizational values clarity were significantly related to commitment, satisfaction, motivation, anxiety, work stress, and ethics using a cross-sectional sample (...) of 711 managen from across the United States. Gender, educational level, and functional area did not impact these relationships, although years of experience (expressed by age, managerial experience, and hierarchical level) did make a difference. (shrink)

This volume explores a central paradox in the evolution of psychoanalytic thought and practice and the ways in which they were used.

While agreeing with me on many issues, Revonsuo rejects my claim that phenomenal states could be co-conscious without being spatially related (in experience). In defence of my claim I described a thought-experiment in which.

First Published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.

Knowledge and Civilization advances detailed criticism of philosophy's usual approach to knowledge and describes a redirection, away from textbook problems of epistemology, toward an ecological philosophy of technology and civilization. Rejecting theories that confine knowledge to language or discourse, Allen situates knowledge in the greater field of artifacts, technical performance, and human evolution. His wide ranging considerations draw on ideas from evolutionary biology, archaeology, anthropology, and the history of cities, art, and technology.

The reality of current clinical practice in the UK is that where a patient’s family refuses to agree to testing for brain stem death (BD), such cases will ultimately end up in court. This situation is true of both adults and children and reinforced by recent legal cases. While recourse to the courts might be regrettable in such tragic cases, if public trust in the medical diagnosis of BD is to be maintained all aspects of the process must be conducted (...) in a way that is transparent and open to scrutiny. This is not an ‘ineffective expenditure’ of resources, but an essential element of a human rights-compliant legal system. (shrink)