Extrapolation from a well-understood base population to a less-understood target population can fail if the base and target populations are not sufficiently similar. Differences between laboratory mice and humans, for example, can hinder extrapolation in medical research. Mice that carry a partial or complete human physiological system, known as humanized mice, are supposed to make extrapolation more reliable by simulating a variety of human diseases. But what justifies our belief that these mice are similar enough to their human counterparts to (...) simulate human disease? I argue that, unless three requirements are met in the process of humanizing mice, very little does. My requirements are not meant to provide necessary and sufficient conditions that guarantee a particular outcome. Instead, they serve as a heuristic for guiding scientific judgments involving extrapolation. In developing each requirement, I engage with philosophical issues concerning the nature of model-based science and the mechanistic approach (and its limits) to making generalizations in the life sciences. (shrink)

According to Haber and Benham (2012), a sufficient condition for full moral consideration is that a creature bears a genealogical relation to the Homo sapiens lineage. Since part-humans do not bear such a relation, they are not due full moral consideration on that basis. Given this argument, my aim in this commentary is twofold. First, I want to challenge its soundness by showing that it is possible for part-humans to bear a genealogical relation to the H. sapiens lineage. Second, I (...) want to argue that Haber and Benham's attempt at avoiding moral confusion by reframing ethical concerns about part-humans doesn’t work. (shrink)

In his Metaphysics of Morals (particularly in the Doctrine of Virtue), but also in other late works, Kant extends and refines the content of his earlier works on ethics (Groundwork and Critique of Practical Reason) to a considerable extent. These revisions and extensions not only show the limitations of an exclusive interpretation of Kants ethics as a deontological ethics of principles. His thoughts are also relevant for a large number of questions of theoretical morality currently under discussion. Thus, the distinction (...) drawn in the Doctrine of Virtue between perfect and imperfect obligations informs the problem of the solvability of moral conflicts and the role of supererogatory actions. Kant goes further into the question of what it means to be a good person, what moral significance is contained in close human ties such as friendship, and what role is played by happiness and the so-called obligations towards oneself. The papers each discuss Kants central ideas in the context of his earlier writings, but also within the context of our contemporary ethical debates. Thus attention is drawn to the significance and possible extent of an ethics of virtue understood in the Kantian sense. (shrink)

Comparative genomicists seem to be convinced that the unit of measurement employed in their studies is a gene that drives the function of cells and ultimately organisms. As a result, they have come to some substantive conclusions about how similar humans are to other organisms based on the percentage of genetic makeup they share. I argue that the actual unit of measurement employed in the studies corresponds to a structural rather than a functional gene concept, thus rendering many of the (...) implications drawn from comparative genomic studies largely unwarranted, if not completely mistaken. †To contact the author, please write to: Department of Philosophy, University of Utah, 215 South Central Campus Drive, Carolyn Tanner Irish Humanities Building, 4th Floor, Salt Lake City, UT 84112; e‐mail: monika[email protected]. (shrink)

Although collegial relationships are among the most prevalent types of interpersonal relationships in our lives, they have not been the subject of much philosophical study. In this paper, we take the first step in the process of developing an ethics of collegiality by establishing what qualifies two people as colleagues and then by determining what it is that gives value to collegial relationships. We argue that A and B are colleagues if both exhibit sameness regarding at least two of the (...) following three features: the same work content or domain of activity; the same institutional affiliation or common purpose; and/or the same status or level of responsibility. Moreover, we describe how the potential value of collegial relationships is grounded in the relationship goods that two colleagues have reason to generate qua colleagues, namely, collegial solidarity and collegial recognition. Two interesting conclusions that can be drawn from our analysis are that one has to be proficient at one’s work if one is to be considered a good colleague and that we are also more likely to be better colleagues if we regard the work we do as valuable. Finally, we draw special attention to the working conditions that are conducive to the generation of good collegial relationships and suggest some policies to promote them. (shrink)

This article focuses stakeholder theory on that critical juncture where stakeholder relationships and corporate policy decisions converge. A case study methodology is described that permits detailed analyses of multiple stakeholders’ objectives; it is suitable for studies of major corporate strategic decisions that are complex, controversial, involve multiple stakeholders, and require strategic trade-offs. The methodology is applied here to the dramatic decision by a Pacific Northwest forest company to phase out traditional clear-cut harvesting methods of old-growth forests. The study’s findings point (...) to new research questions and have theoretical implications for a finer grained conceptualization of stakeholder groups, stakeholder objectives, and stakeholder issues. (shrink)

The west-centrism in approaching the knowledge systems of east has been sufficiently highlighted and problematized. This paper argues that the attempts have often been restricted to a framework of colonial gaze that prevents the Indian classical philosophy from gaining a vantage of its own. The approach to the classical traditions have been largely fragmented, catering to the pressure of proving its “relevance” either as a knowledge system or as texts with useful resources and answers to contemporary problems. This “problem solving” (...) framework at the very outset de-recognizes the capacity of an entire philosophical tradition of problem identification and formulation, unsettling terrains of knowledge by asking new questions. The article presents a case for theorizing relevance as a prerequisite to resolving some of these issues. (shrink)

The development of the modern democratic society depends upon the successful integration of main democratic values in all its spheres, including education. Schools are faced with these challenges as well. The main role in the process of school change is given to the school principal, who is the leader of every innovation in school. One out of many types of school leadership is called democratic school leadership. One of the goals of such leadership is the development of school culture that (...) is based on democratic values and practices. Further on, the development of democratic school leadership opens an opportunity for students and teachers to gain knowledge an develop skills needed for them to become active citizens in their communities. The main purpose of this paper is to analyze the existing literature in the field of democratic school leadership. Special focus is on the theoretical and practical operationalization of the democratic school leadership as it is presented the literature. Further, we shall analyze the possible answers to the questions of why and how to develop the democratic school leadership, and what is its role in the development of the democratic school community. (shrink)

In an e-mail of June 2002, some women on Gender Link noticed that in Polish there is an expression, ‘husband of trust’, used to describe a person in the workplace appointed to represent workers’ interests. This role is more often than not given to women, and yet they are called ‘husbands of trust’. ‘Isn't that strange,’ they said. ‘Isn't it time to change this?’. It is. The change in gender role identities has started with questioning the language. It has started (...) with asking who has produced and is reproducing the language, and for whom. The journey has not stopped there. From looking at language it has continued through social stereotypes, work, labour, money and the division of power, and reached the law and legal system itself. In Poland, the path has been rather circuitous and uneasy for we are, more than many other countries, bound by Catholic tradition mingled with apparent freedom. We had the ethos of Solidarity, and Lech Wałęsa. Wałęsa had a badge of the Virgin Mary, Mother of Jesus on his jacket, which somehow helped label all Polish women, even those still very young, a ‘Mother Pole’. To resist that identity one needed to look beneath the image and be brave enough to call oneself just a woman. This article will try to analyse that process. (shrink)

This article generalises the refined A-translation method for extracting programs from classical proofs [U. Berger,W. Buchholz, H. Schwichtenberg, Refined program extraction from classical proofs, Annals of Pure and Applied Logic 114 3–25] to the scenario where additional assumptions such as choice principles are involved. In the case of choice principles, this is done by adding computational content to the ‘translated’ assumptions, an idea which goes back to [S. Berardi, M. Bezem, T. Coquand, On the computational content of the axiom of (...) choice, JSL 63 600–622] and has been further elaborated in [U. Berger, P. Oliva, Modified bar recursion and classical dependent choice, in: M. Baaz, S.D. Friedman, J. Kraijcek , Logic Colloquium ’01, in: Lecture Notes in Logic, vol. 20, Springer, Berlin, 2005, pp. 89–107]. We further investigate the applicability of this extension by means of a small but non-trivial example, and discuss the formalisation as well as some optimisations necessary in order to extract terminating programs. Both formalisation and term extraction have been implemented in the interactive proof assistant Minlog. (shrink)

What is the nature and what is the role of trust between teacher and student in academic education at school? Providing a philosophically informed answer to these questions is the aim of this paper. In its first part, I present a relationship account of trust based on two fundamental assumptions: first, trust between teacher and student is essentially about them being in a trust relationship, and second, the reasons for trust are relationship dependent. The second part explores the role of (...) trust by looking at two aspects of academic education at school: the student's acquisition of knowledge from the teacher's testimony and the student's development of epistemic confidence, the latter being a key constituent of competent epistemic agency. Drawing on findings from developmental psychology, I explain how trust is involved in successful academic education at school. My aim is to provide a detailed conception of trust in the teacher–student relationship, as well as a conclusive argument for the importance and the value of trust in academic education at school. (shrink)

The current study investigated age differences in the use of attentional deployment, positive reappraisal and suppression while regulating responses to sadness-eliciting content. We also tested to what extent these emotion regulation strategies were useful for each age group in managing response to age-relevant sad information. Forty-two young participants (Mage = 18.5, SE =.15) and 48 older participants (Mage = 71.42, SE = 1.15) watched four sadness-eliciting videos (about death/illness, four to five minutes long) under four conditions—no-regulation (no regulation instructions), attentional (...) deployment (divert attention away), positive reappraisal (focus on positive outcomes) and suppression (conceal emotional expressions). We assessed negative emotional experience, expression, skin conductance level (SCL) and visual fixation duration while participants watched the emotional clips and followed the instructions for each condition. Results suggest that older adults were more successful than younger adults at implementing both attentional deployment and positive reappraisal. Ability to suppress emotions appears to remain stable with age. Within age-group comparisons suggested that for the older adults, positive reappraisal was a more useful emotion regulation strategy than the others, while the pattern among younger adults was less conclusive. Age-relevant differences in motivation and successful emotion regulatory efforts based on theoretical and empirical literatures are discussed. (shrink)

The article focuses on Enoch Powell’s “Rivers of Blood” speech and its recontextualisation 50 years later in view of the rising anti-immigration sentiment and Brexit campaign. Having discussed the dynamics of the threat construction process and its role in shaping public attitudes to migration and policies related to it across time and space, we proceed to analyse Powell’s speech in terms of lexical, grammatical, and discursive fear-inciting devices and strategies. While doing so we draw on the insights from neuroscientific research (...) on the role of lexis in fear stimulation and functional-cognitive models of grammatical structure. The second part of our analysis is meant to demonstrate how the semiotic potential of cyberspace and social media, along with multimodal integration of various forms, intertextuality, and interdiscursivity they enable, endow fear-inciting discourse with new spatiotemporal and affective qualities. To this end we examine one of the most popular YouTube videos making “Rivers of Blood” speech part of its anti-immigration stance. (shrink)

Human–nonhuman chimeras have been the focus of ethical controversies for more than a decade, yet some related issues remain unaddressed. For example, little has been said about the relationship between the origin of transferred cells and the morally relevant capacities to which they may give rise. Consider, for example, a developing mouse fetus that receives a brain stem cell transplant from a human and another that receives a brain stem cell transplant from a dolphin. If both chimeras acquire morally relevant (...) capacities as a result of transplantation, and if those capacities are indistinguishable, should the difference in cell origin matter to how we classify these creatures? I argue that if morally relevant capacities are easy to detect, cell origin is irrelevant to how the chimera ought to be treated. However, if such capacities are hard to detect, cell origin should play a role in considerations about how to treat the chimera. (shrink)

Fenomén zakoušené psychedelie (doslova „vyjevení mysli“) stojí na pomezí filosofického zkoumání a antropologického bádání. V našem příspěvku se pokusíme nahlédnout jedno ze základních filosofických východisek amerického etnobotanika a antropologa Terence McKenny, které našel u Hérakleita a jeho pojetí logu. Dle Terence McKenny se při psychedelické zkušenosti děje "emanace" Logu a je to také Logos, který dle Terence McKenny promlouvá k modernímu člověku skrze technologii. V tomto článku není zkoumána úplnost oprávnění ztotožnění McKennova pojetí logu s tím Herakleitovským, ale úvodní vyložení (...) McKennových inspirativních úvah. (shrink)

This paper explores the level of corporate social responsibility contributions disclosed by central public sector enterprises in India. This paper analyses the nature and quality of CSR disclosures made by CPSEs listed in India following the issue of CSR guidelines by the Department of Public Enterprises for CPSEs in March 2010. The purpose of the study is to investigate the impact of CSR guidelines on the reporting practices of the CPSEs. A content analysis of annual reports across seven themes shows (...) that Human Resources and Community Development are the prime focus areas of CSR disclosures, whereas Carbon and Greenhouse Gas emissions are the least reported activity. The disclosures across all CSR themes are primarily narrative rather than quantitative or in monetary terms. The findings of the study may help policy makers in India to assess practices and devise detailed and specific CSRD requirements, rather than the current general mandatory requirements, to enhance the performance and quality of CSRDs by the CPSEs. (shrink)

Tinguelys gesamtes Œuvre scheint vom Vanitas-Motiv grundiert: seine sinnlosen Maschinen aus Schrott, sich selbst vernichtenden, ephemeren Artefakte, die in Form von Flügelaltären stattfindende Auseinandersetzung mit dem Tod und erst recht der eine barocke Tragikomödie referierende Cenodoxus. Dass dieser Eindruck trügt, zeigt sich sobald das scheinbar Evidente mit den frühneuzeitlichen Spielarten der Vanitas konfrontiert wird. Dennoch adaptiert und inszeniert Tinguely das Motiv mit dem melancholischen Gestus des seines Heilshorizonts verlustig gegangenen Subjekts.

_Reinventing Film Studies_ Edited by Christine Gledhill and Linda Williams London: Arnold Publishers, 2000 ISBN 0-340-67723-6 464 pp.

La intención de este trabajo consiste en perfilar algunos de los fundamentos filosóficos que envuelven la agonía existencial que se percibe a lo largo de la obra La Tía Tula de Miguel de Unamuno. Para ello hemos comparado el pensamiento de este autor con el de Kierkegaard, siendo la idea de inmortalidad la que sirve de vínculo entre ambos. Desde esta perspectiva de análisis la lucha entre fe y razón, expuesta por Unamuno, deja claro que el anhelo de inmortalidad se (...) enfrenta a categorías universales, mientras que para Kierkegaard la fe está por encima de la razón ante toda decisión por absurda que parezca. (shrink)

This interdisciplinary, social scientific analysis of the regulatory discourse on nanotechnology in the three German-speaking countries of Germany, Austria and Switzerland and in the EU between 2000 and 2013 has shown three distinct phases, characterised by shifts in the configuration of actors and in the thematic scope from nanotechnology to nano-materials. Compared to modes of governance based on traditional statutory law, modes of governance based on less binding forms of soft law and self-regulation (like codes of conduct, guidelines and certification (...) systems) and new modes of governance (like assessment studies, risk management frameworks as well as participatory and cooperative forms of communication and negotiation) have gained importance. Despite some similarities, two different cultures in governing nanotechnology can be distinguished: a product-oriented culture in statutory regulations (when speaking about products, the article is also referring to substances) and a risk-based culture in applying soft law based on new modes of governance. In addition, the different regulatory cultures have led to four strategic approaches: modes of governance mainly based on hard law and soft law at the EU level, modes of governance mainly based on cooperative and self-regulatory approaches in Germany, cooperative governance approaches in Austria and modes of governance mainly based on self-regulatory and soft law approaches in Switzerland. (shrink)

Our daily lives unfold continuously, yet our memories are organised into distinct events, situated in a specific context of space and time, and chunked when this context changes (at event boundaries). Previous research showed that this process, termed event segmentation, enhances object-context binding but impairs temporal order memory. Physiologically, peaks in pupil dilation index event segmentation, similar to emotion-induced bursts of autonomic arousal. Emotional arousal also modulates object-context binding and temporal order memory. Yet, these two critical factors have not been (...) systematically studied together. To address this gap, we ran a behavioural experiment using a paradigm validated to study event segmentation and extended it with emotion manipulation. During encoding, we sequentially presented greyscale objects embedded in coloured frames (colour changes defining events), with a neutral or aversive sound. During retrieval, we tested participants’ memory of temporal order memory and object-colour binding. We found opposite effects of emotion and event segmentation on episodic memory. While event segmentation enhanced object-context binding, emotion impaired it. On the contrary, event segmentation impaired temporal order memory, but emotion enhanced it. These findings increase our understanding of episodic memory organisation in laboratory settings, and potentially in real life with perceptual changes and emotion fluctuations constantly interacting. (shrink)

In the digital age, the use of advanced technology is becoming a new paradigm in police work, criminal justice, and the penal system. Algorithms promise to predict delinquent behaviour, identify potentially dangerous persons, and support crime investigation. Algorithm-based applications are often deployed in this context, laying the groundwork for a ‘smart criminal justice’. In this qualitative study based on 32 interviews with criminal justice and police officials, we explore the reasons why and extent to which such a smart criminal justice (...) system has already been established in Switzerland, and the benefits perceived by users. Drawing upon this research, we address the spread, application, technical background, institutional implementation, and psychological aspects of the use of algorithms in the criminal justice system. We find that the Swiss criminal justice system is already significantly shaped by algorithms, a change motivated by political expectations and demands for efficiency. Until now, algorithms have only been used at a low level of automation and technical complexity and the levels of benefit perceived vary. This study also identifies the need for critical evaluation and research-based optimization of the implementation of advanced technology. Societal implications, as well as the legal foundations of the use of algorithms, are often insufficiently taken into account. By discussing the main challenges to and issues with algorithm use in this field, this work lays the foundation for further research and debate regarding how to guarantee that ‘smart’ criminal justice is actually carried out smartly. (shrink)

Author: Korzeniowska Monika Title: “ANALYSIS OF HAPPINESS” AND JOY („O szczęściu” i radości) Source: Filo-Sofija year: 2011, vol:.13/14, number: 2011/2-3, pages: 689-698 Keywords: WŁADYSŁAW TATARKIEWICZ’S PHILOSOPHY, JOY, HAPPINESS Discipline: PHILOSOPHY Language: POLISH Document type: ARTICLE Publication order reference (Primary author’s office address): E-mail: www:The main aim of this article is to present Władysław Tatarkiewicz’s concept of joy in the context of his research on the issue of happiness. The phenomenon of joy is shown as a very important but not (...) well known problem, playing a clue role in the philosophy of Plato, Plotinus, Pseudo-Dionysius the Areopagite, Meister Eckhart, Schopenhauer, Nietzsche and Lévinas, not only in the ethical but also in the epistemological context. W. Tatarkiewicz’s Analysis of Happiness is one of a very few works in Polish humanities, which is possible to treat as the frame of reference for the philosophical euforiology. In Analysis of Happiness he compares the joy and the happiness, according to such a differences between them as intensity, permanence, transcendence or mentality. The phenomenon of joy is also interpreted as a base for the happiness in the psychological understanding. Tatarkiewicz formulates a hierarchy of good states of mind, placing the joy between the pleasure and the jollification. The work Analysis of Happiness contains also the typology of joy – from the joy of life, Elysian joy, mystical joy, the joy of love, to the joy understood as the happiness of the moment. (shrink)

This paper argues that critical realism is one of the main theoretical orientations of the social sciences in the twentieth and twenty-first centuries. Critical realism aims to study the transcende...

Humans have a fundamental need to belong. This, need, as Kimberley Brownlee argues in her book Being Sure of Each Other grounds the human right against social deprivation. But in addition to having a human right against social deprivation, we also have a right to associational freedom, which is grounded in our right to autonomy. We cannot be forced into relationships; we are free to choose our friends and loved ones.? In this paper I discuss what our right to associational (...) freedom morally permits us to do when are already in an intimate relationship and, relatedly, what our relationship-dependent duties require of us in such cases. What exactly are the constraints on our right to associational freedom? And what is the content and scope of our relationship-dependent duties, given that our right to associational freedom conflicts with the fulfillment of these duties?? After providing some clarifications as to how we should understand intimate relationships that have ended, I will first highlight what relationship-dependent duties are and how they correlate with a right to associational control. I will then discuss several break-up scenarios, the aim of which is to determine the conditions that justify constraints being imposed on the right to associational freedom and to delineate the scope of relationship-dependent duties. (shrink)

This article analyses the patterns underlying debates in sociological theory, using the debate surrounding the distinction between ‘micro’ and ‘macro’ as its case. Although – and indeed because – few authors have attempted explicit definition of the distinction, a number of different distinctions have been subsumed under these labels and research has been shaped by packages of assumptions that have gone largely unexamined in their contradictory nature. The article disaggregates the different distinctions that have been associated with the terms ‘micro’ (...) and ‘macro’ and situates theoretical strategies of the past decades in the grammar of oppositions that makes them possible and innovative. Gap-bridging has been the attempt to bring together aspects of the distinction that have been construed as direct opposites; recombination has been the attempt to release certain aspects of the distinction from their association with one side of the divide. Disaggregating the distinction can help us isolate specific theoretical problems for further work, including work that asks how aspects emphasized by different theoretical approaches vary empirically. (shrink)

The notion of empathy has been explicated in different ways in the current debate on how to understand others. Whereas defenders of simulation-based approaches claim that empathy involves some kind of isomorphism between the empathizer’s and the target’s mental state, defenders of the phenomenological account vehemently deny this and claim that empathy allows us to directly perceive someone else’s mental states. Although these views are typically presented as being opposed, I argue that at least one version of a simulation-based approach—the (...) account given by de Vignemont and Jacob—is compatible with the direct-perception view. My argument has two parts: My first step is to show that the conflict between these accounts is not—as it seems at first glance—a disagreement on the mechanism by which empathy comes about. Rather, it is due to the fact that their proponents attribute two very different roles to empathy in understanding others. My second step is to introduce Stein’s account of empathy. By not restricting empathy to either one of these two roles, her process model of empathy helps to see how the divergent intuitions that have been brought forward in the current debate could be integrated. (shrink)

Die Unverzichtbarkeit der Beratung bzw. Prüfung einer medizinischen Studie durch eine Ethikkommission ist weithin anerkannt. Dennoch sind Forschungsethikkommissionen immer wieder der Kritik, z.B. nach mehr Effizienz, Transparenz oder Konsistenz ausgesetzt. Evaluationsinstrumente für Ethikkommissionen beinhalten oft implizite Vorstellungen „guter“ Qualität. Aus ethischer Sicht sind vor allem der Schutz der Versuchsperson und eine vertretbare Schaden-Nutzen-Bewertung wichtig. Der interdisziplinäre Sammelband geht der Frage auf den Grund, wie sich eine Qualitätsverbesserung aus ethischer Sicht gewährleisten und umsetzen lässt. Der Inhalt · Ethikkommissionen im rechtlichen und (...) ethischen Diskurs · Rechtliche Rahmenbedingungen von Ethikkommissionen in der Schweiz und organisatorische und prozedurale Qualitätskriterien · Forschungs-Ethikkommissionen in der Schweiz: Qualitätsbewertung aus ethischer Sicht · Ethikkommissionen als Patientenschutzkommissionen · Die ethische Aufgabe von Ethikkommissionen angesichts normativer Divergenz von Therapie und Forschung · Ethische Theorien und die Bewertung von Forschungsvorhaben · Kriterien für die ethische Qualität des Begutachtungsprozesses · Schutz der Versuchsperson: Forderungen aus ethischer Sicht zur Struktur-, Prozess- und Ergebnisqualität Die Herausgeber Prof. Dr. Monika Bobbert lehrt und forscht zur Moraltheologie und Medizinethik an der Universität Münster. Dr. Gregor Scherzinger ist wissenschaftlicher Mitarbeiter am Institut für Sozialethik der Universität Luzern. (shrink)