Graphical models are a powerful tool for causal model specification. Besides allowing for a hierarchical representation of variable interactions, they do not require any a priori specification of the functional dependence between variables. The construction of such graphs hence often relies on the mere testing of whether or not model variables are marginally or conditionally independent. The identification of causal relationships then solely requires some general assumptions on the relation between stochastic and causal independence, such as the Causal Markov Condition (...) and the Faithfulness Condition (Spirtes et al. 2000; Pearl 2000). However, a procedure would require further assumptions to hold. Namely those the independence tests themselves are based on. In continuous settings, Spirtes et al. (2000) suggest causal inference based on a very restrictive formulation of independence, that is, vanishing partial correlations. Such a measure does, however, limit the applicability of causal inference to linear systems. This constitutes a serious drawback especially for the social sciences where an a priori specification of the functional form proves difficult or at odds with linearity. In short: graphical models theoretically reduce specification uncertainty regarding functional dependence, but their implementation in practice deprives them of this virtue. In this paper we investigate how causal structures in continuous settings can be identified when both functional forms and probability distributions of the variables remain unspecified. We focus on tests exploiting the fact that if X and Y are conditionally independent given a set of variables Z, the two conditional densities f (X|Y, Z) and f (X|Z) must coincide. We start by estimating the conditional densities f(X|Y, Z) and f(X|Z) via nonparametric techniques (kernel methods). We proceed by testing if some metric expressing the distance between these very conditional densities is sufficiently close to zero. Out of several metrics available in the literature to express such distance we choose two, the Euclidean, and the Hellinger distance. We investigate in a Monte Carlo study how different tests involving either measure are able to detect statistical independence, conditioned on a small set of variables. One limitation may result from nonparametric density estimation being subject to the curse of dimensionality. As the number of variables increases, the estimated empirical density converges at a slower rate to its population value. To compensate this drawback we use a local bootstrap procedure which consists of resampling the data for each test. While local bootstrap strongly increases the computational time of the test, it succeeds in counterbalancing the curse of dimensionality. (shrink)

It may be possible, one day, to use gene therapy to treat diseases whose genetic defects have been discerned. Because many genes responsible for inherited eye disorders within the retina have been identified, diseases of the eye are prime candidates for this form of therapy. The eye also has the advantage of being highly accessible with altered immunological properties, important considerations for easy delivery of virus and avoidance of systemic immune responses. Currently, adenovirus, adeno‐associated virus and lentivirus have been used (...) to successfully transfer genetic material to retinal pigment epithelium and photoreceptor cells. By harnessing therapeutic genes to these viruses, researchers have been able to demonstrate rescue in rodent models of retinitis pigmentosa, providing evidence that this form of therapy can be effective in delaying photoreceptor cell death. Future challenges include confirming therapeutic effects in animal models with eyes more anatomically similar to those of humans and demonstrating long‐term rescue with minimal toxicity. BioEssays 23:662–668, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This paper examines cancer through the lens of abjection. While cancer can be understood as an abject lifeform, we explore what we name the abject ontologies created through both cancer detection technologies/practices and cancer treatment, specifically the drug combination Adriamycin and Cytoxan. We ask: what are the abject ontologies produced through living with and living on from cancer diagnosis and treatment? Our concern is to map how cancer undoes our supposedly stable categories inherited from modernist logic, challenges our very ideas (...) of what it means to be human, and demands an ethical reorientation of public cancer discourse. (shrink)

This brief introduction explains the historical background of the Hoffman Report, the 2015 independent counsel's investigation into the American Psychological Association's role in aiding ‘enhanced interrogations’ of detainees in the Bush Administration's Global War on Terror. It also outlines the articles in this special section of History of the Human Sciences on the Hoffman Report in Historical Context.

Aus einer philosophisch-phanomenologischen und literaturwissenschaftlichen Perspektive heraus gewinnt Nadine Benz nahere Erkenntnisse uber das temporale Phanomen des Wartens. Zunachst wird die historische Entwicklung der Zeitvorstellung aus philosophisch-phanomenologischer Sicht thematisiert, spezifisch im Hinblick auf die Fragen nach Messbarkeit, Vermitteltheit und nach objektiven und subjektiven Komponenten von Zeiterfahrung in ihrer Aporetik. Im Anschluss wird vom Konzept der Lebenswelt zur Literatur ubergeleitet: Die vorliegende Studie bindet die Aporien der Zeit zunachst theoretisch in eine Narratologie von Zeiterfahrung ein, die vor allem den Faktor (...) des Fiktiven produktiv berucksichtigt. Schliesslich werden die gewonnenen Erkenntnisse und Instrumente fur eine Analyse von Erzahltexten des 20. und 21. Jahrhunderts fruchtbar gemacht. Hier erlangen die literarischen Konfigurationen von Wartezeit als Semantiken des Wartens fur die Subjekte der fiktiven Zeiterfahrung einen konstitutiven Status. (shrink)

How do the practices of philosophy and film converge in ethical and political theory? Untimely Affects is an ethical and aesthetic interweaving of Deleuzian philosophy and close film analysis to discern how thought persists productively after the horrors of World War II. In the first extensive analysis of Chris Marker and Alain Resnais' films, Nadine Boljkovac draws on concepts and images that interrogate 'what we are now living through', in the words of Klossowski's Nietzsche. Mindful of the seen and (...) unseen 'that quicken the heart', this book of film-philosophy discerns new and deeply ethical life-affirming possibilities through its weave of cine-philosophy. As such, this book speaks directly to essences of cinema, thought and life through creative untimeliness and the idea of the 'ever new'. (shrink)

In his article “Issues of Pragmaticism” published in 1905, in The Monist, Charles S. Peirce complains that “Logicians have been at fault in giving Vagueness the go-by, so far as not even to analyze it.” That same year, occupying himself with the consequences of “Critical commonsensism,” he affirmed, “I have worked out the logic of vagueness with something like completeness,” a statement that causes the majority of the commentators on his work, including the editors of the Collected Papers to ask (...) where this logic is to be found. The fever for finding Peirce's manuscripts is fed by the hope of some researchers of discovering the logic of vagueness, a hope that has grown since Carolyn Eisele's publication of his mathematical works. Others - and I count myself among them - believe that in reality this is a matter of something already known. That is, they interpret the affirmation ending the paragraph of reproach addressed to logicians, “The present writer has done his best to work out the Stechiology, Critic, and Methodeutik of the subject,” as a tripartite semiotic of the vague, still limited, according to Peirce's older works, to symbols, that is, to the signs of natural language examined from the perspective of logic. (shrink)

The Druze movement originated at the beginning of the eleventh century and developed out of the Ismā'īlī faction of Shī'ī Islām. Founded by the Ismā'īlī Ḥamza ibn 'Alī, the Tawḥīd is a philosophical and spiritual path that incorporates the fundamentals of Islam, Christianity, and Judaism referred to in the Qur'ān, together with the ancient philosophies of Pythagoras, Plato, Aristotle, Plotinus, and others. It is a synthesis and a unification of the most contradictory thoughts, a synthesis that leads to the real (...) Tawḥīd or "third course".The specificity of the Tawḥīd consists in establishing a bridge between monotheism and non-dualism. To say that God is One does not merely mean... (shrink)

The artistic work of photographer Gudio Baselgia focuses on landscapes formed by nature s forces and, more recently, on the sky with the stellar and solar movements and phenomena as we see them from earth. Celestial mechanics have fascinated mankind in all known cultures, the Babylonians and ancient Egyptians as well as the Greek and Celts, the Maya, or the ancient Indians and Chinese. Until the present day we look at the sky and keep being amazed, and try to read (...) what it tells us. Many artists throughout history have been captivated by the spectacle we observe above us day and night. The modern term astrodynamics describes all movements of celestial bodies, in particular the solar system including the moon and other satellites, asteroids and comets, but also movements of stars within a stellar system or galaxy, or of galaxies towards each other. They are well understood today and depicted in coordinate systems and elaborate visualizations. Guido Baselgia s artistic project on astrodynamics and celestial phenomena has no scientific or didactic ambition. His analogue camera is used as a recorder inscribing the movement of stars on the light-sensitive surface of photographic paper. Thus Baselgia s images make traceable the trajectory of celestial bodies invisible to the human eye and show us astounding occurrences of light and shadow. Baselgia has been captivated in particular also by the phenomenon of the umbra, planet earth s shadow thrown into space. It becomes visible occasionally on a clear evening at sunset when a slight mist lies at the horizon: looking in opposite direction to the sun, a dark and sharply marked band of shadow can be seen rising while sun sets behind the observer. But also by recording sunrise and sunset at the polar circle or the tropic, Baselgia visualizes the geometry of celestial mechanics and the concurrence of forces, as well as the miracle of light as such that leaves us awestruck today as much as it did our ancestors. The new book "Guido Baselgia Light Fall" presents 80 outstanding black-and-white images from the artist s Light Fall project taken in Norway, the Tierra del Fuego archipelago in Argentina, in Ecuador, and the Swiss Alps. The brilliant tritone plates are complemented with essays by the German scholar Andrea Gnam and Swiss photography critic Nadine Olonetzky. ". (shrink)

For more than twenty years, Swiss photographer Tobias Madörin has been working on his photo series Topos. Creating staged tableaux in the manner of nineteenth-century painters, Madörin investigates the interaction between the inhabitants and their surrounding environments in countries as diverse as Spain, Uganda, Indonesia, and Japan. His large-scale images examine communal spaces, the outskirts of metropolises, waste disposals sites, and landscapes marked by agriculture and mining. Madörin's work reveals that these locations are the products of human visions and ideals, (...) yet they are also places of environmental exploitation. This tension, as well as Madörin's intelligent and empathetic approach to his subjects, makes his photographs evocative and complex. This book includes lavish, full-page photographs, many of which have never been published, and an introductory essay by Nadine Olonetzky that explains and contextualizes the photographer's oeuvre. (shrink)

The visual arts have managed to make the zombie an essential figure in popular culture. The cinematographic medium has contributed to building with him an imaginary of disaster against the backdrop of a pandemic. We will show the adequacy of the zombie with a collective imagination for which the world to come is inscribed under the sign of zombie collapse.

This book project intends to serve as a course adoption book unpacking theories of biopolitical life-making and death-making, with chapters dedicated to specific objects that ostensibly affirm life (and argue for life's inextricable links to capital), but that ultimately reify a politics of death and erasure. Specific objects, such as the pink Kommen Foundation-branded handgun, the 'super user' of health care resources, and fat cells allow the authors to discuss the political junctures at which determinations of healthy and unhealthy, life (...) and death, are made. (shrink)

Trois lois ont, entre 1993 et 2002, codifié le dispositif français dit de « l’accouchement sous X », qui autorise une femme à accoucher gratuitement dans une maternité sans révéler son identité. La première a durci ce dispositif en l’insérant dans le code civil, la seconde a tenté de l’assouplir et la dernière a créé un organisme chargé de faciliter, pour les personnes nées « sous X », l’accès à la connaissance de leurs origines. Dans les débats parlementaires qui ont (...) précédé l’adoption de ces lois, l’histoire a largement été utilisée comme argument, mais on est passé de l’histoire nationale à l’histoire personnelle, et de la « tradition française » justifiant le maintien du secret de l’accouchement, au droit à la vérité de la biographie légitimant la possibilité de la réversibilité du secret. (shrink)

The paper aims to show how the Tv series True Detective (season 1, 2014 – created and written by Nic Pizzolatto) aids us understanding the status of power whether in its political, judicial or religious form. The conjunction of sex and death is depicted through acts of paedophilia, rape, and murder of women and children. The study aims to elucidate the logic which is inherent to those acts of violence and which founds the reproduction of social domination mechanisms.

This article argues that Simone de Beauvoir's The Second Sex continues to teach academic feminism why difference feminism holds productive and generative potential for feminists and why equality feminism has been consistently subject to criticism since the second wave of feminism. Using Hegel's master—slave dialectic as a lens to interpret subjectivity in The Second Sex, this text reveals an aspect of equality feminism that relies upon masculine subjectivity, a subjectivity that inherently constitutes otherness. This reliance on masculine subjectivity is anathema (...) to difference feminism because the otherness inherently constituted by such subjectivity simultaneously and paradoxically constitutes women's ongoing subordination. In assuming equality with men by adopting masculine subjectivity, women are not immune to constituting women as other. Difference feminisms, on the other hand, start from where women are as they choose to see themselves socially, economically, racially, sexually. The Second Sex reveals that difference feminisms imagine freedom in order to identify the difference that would empower women, not strictly towards sex equality with a stable referent, but towards emancipatory projects that make a difference for women themselves. The Second Sex portends that such imagined freedom has not been actualized, thus the present remains circumscribed by power that subordinates the difference in question. When read alongside The Second Sex, the tension between equality and difference feminisms can still be read as feminisms that coexist with one another, each with their limitations, each with productive potential and cautionary rejoinders. (shrink)

A so-called revision of the history of World War 11, which began shortly after the war, was popularized in France in the 1980s through the progressively combined action of extreme-right and former ultra-left militants. This "revision," actually a negation of the genocide perpetrated by the Nazis against the Jews, has focused on what were precisely the means of this mass murder, that is, the gas chambers. Using traditional patterns of antiSemitism, this peculiar rewriting of history claims that the genocide never (...) took place and was in fact a hoax, built up by an international Jewish plot, to extort gigantic amounts of money from the Germans as reparations. In today's France, where racism and exclusion are strongly encouraged by a growing extreme right, and where anti-Semitism progressively comes out of the silence it has been forced to keep since 1945, such a "revisionist" view could gain a certain popularity. (shrink)

Name der Zeitschrift: Neue Zeitschrift für Systematische Theologie und Religionsphilosophie Jahrgang: 58 Heft: 3 Seiten: 285-308.

A partir de l’étude de corpus de textes, manuelle et informatique, nous présentons une réflexion sur l’analyse de texte ou de discours à travers l’exemple de l’exposition didactique. Celle-ci peut s’envisager à différents grains. Nous posons la question de la taille du texte, de son style collectif à travers sa disposition et ses marques. Nous interrogeons la pertinence du modèle choisi en relation avec la notion d’échelle. Enfin, nous posons la question de la résolution adéquate pour des logiciels d’analyse, à (...) l’aide d’une dizaine d’exemples. (shrink)

"2009 realisierte [Jules Spinatsch] im Rahmen seiner "Surveillance Panorama Projects" während des Wiener Opernballs ein riesiges Panorama, das aus 10 008 Einzelbildern besteht. Zwei computergesteuerte Kameras nahmen diese vom Einlass der rund 7000 Gäste um 20:32 Uhr bis zum Ende des Balls um 05:17 Uhr auf. Das Sittengemälde aus chronologisch zusammengesetzten Fragmenten des umtriebigen Gesamtgeschehens zeigt eine ganze Reihe fotografischer Genres: Porträts, Stillleben, filmische Szenen und Paparazzi-Schnappschüsse.... Das Opernball-Panorama führt die Fotografie als Medium der Dokumentation, aber auch Überwachung vor Augen."--P.5 (...) of v.3. (shrink)

Zusammenfassung Der Beitrag stellt eine differenzierungstheoretische Perspektive auf Sportbeteiligung und Sportinteresse der Erwachsenenbevölkerung vor. Zugrunde liegen empirische Daten aus einer eigenen repräsentativen Bevölkerungsumfrage in Deutschland vom Herbst 2003, in der die Inklusion der Erwachsenen in sämtliche gesellschaftlichen Teilsysteme ermittelt wurde. Die Inklusion in den Sport wird mit Bezug auf die sekundäre Leistungsrolle des Breitensportlers und die Publikumsrolle des Sportzuschauers betrachtet; sodann wird möglichen Zusammenhängen zwischen der Ausprägung der Inklusion in den Sport mit ungleichheitstheoretisch geläufigen Merkmalen sozialer Lage, darüber hinaus dann (...) auch mit der Ausprägung anderer Inklusionsverhältnisse nachgegangen. (shrink)

Zusammenfassung Der Beitrag stellt eine differenzierungstheoretische Perspektive auf Sportbeteiligung und Sportinteresse der Erwachsenenbevölkerung vor. Zugrunde liegen empirische Daten aus einer eigenen repräsentativen Bevölkerungsumfrage in Deutschland vom Herbst 2003, in der die Inklusion der Erwachsenen in sämtliche gesellschaftlichen Teilsysteme ermittelt wurde. Die Inklusion in den Sport wird mit Bezug auf die sekundäre Leistungsrolle des Breitensportlers und die Publikumsrolle des Sportzuschauers betrachtet; sodann wird möglichen Zusammenhängen zwischen der Ausprägung der Inklusion in den Sport mit ungleichheitstheoretisch geläufigen Merkmalen sozialer Lage, darüber hinaus dann (...) auch mit der Ausprägung anderer Inklusionsverhältnisse nachgegangen. (shrink)

The informed consent process presents challenges for psychological trauma research (e.g. Institutional Review Board [IRB] apprehension). While previous research documents researcher and IRB-member perspectives on these challenges, participant views remain absent. Thus, using a mixed-methods approach, we investigated participant views on consent guidelines in two convenience samples: crowdsourced (N = 268) and undergraduate (N = 265) participants. We also examined whether trauma-exposure influenced participant views. Overall, participants were satisfied with current guidelines, providing minor feedback and ethical reminders for researchers. Moreover, (...) participant views for consent were similar irrespective of trauma-exposure. Our study has implications for IRBs and psychological researchers. (shrink)