This theoretical paper argues for prioritarianism as an ethical underpinning for digital health in contexts of extreme disadvantage. In support of this claim, the paper develops three prioritarian principles for making ethical decisions for digital health programme design, grounded in the normative position that the greater the need, the stronger the moral claim. The principles are positioned as an alternative view to the prevailing utilitarian approach to digital health, which the paper argues is not sufficient to address the needs of (...) the worst off. As researchers of digital health, we must ensure that the most globally marginalised are not overlooked by overtly technocentric implementation practices. Consequently, the paper concludes by advocating for use of the three principles to support stronger critical reflection on the ethics involved in the design and implementation of digital health programmes. (shrink)

The seventeenth-century French Benedictine philosopher Dom Robert Desgabets (1610–1678) has been taken by many historians as an idiosyncratic but ultimately loyal proponent of Cartesianism in the years following Descartes’ death. As a Catholic cleric aware of the importance of squaring the new philosophical conclusions of the seventeenth-century with Church theology, Desgabets wrote extensively on the ways in which this could be achieved with regard to the most contentious and complex theological Church dogma of the time: transubstantiation. Through an examination of (...) Desgabets’ writings on transubstantiation, this article argues that he was emboldened by his particular religious context and preoccupations to undertake an in-depth theological interrogation and revision of Descartes’ eucharistic thought, which motivated him to offer a more epistemologically and theologically ambitious account of transubstantiation than Descartes himself thought possible or wise. This article therefore uses Desgabets as an example of the complex interplay between theology and “new” philosophy in the early reception of Cartesianism. It shows how this interplay allowed early, theologically minded Cartesians like Desgabets to use the intellectual resources of the Catholic Church to fortify and safeguard the legacy of Cartesianism in a way Descartes himself did not do. (shrink)

Can epistemic luck be captured by modal conditions such as safety from error? This paper answers ‘no’. First, an old problem is cast in a new light: it is argued that the trivial satisfaction associated with necessary truths and accidentally robust propositions is a symptom of a more general disease. Namely, epistemic luck but not safety from error is hyperintensional. Second, it is argued that as a consequence the standard solution to deal with this worry, namely the invocation of content (...) variation, fails. Third, it is considered whether the condition can serve some restricted theoretical role; the hypothesis is rejected. Finally, it is tentatively suggested that epistemic luck’s hyperintensionality derives from its being an explanatory notion, and an analogy is drawn with failures of probabilstic conceptions of explanation in the philosophy of science. (shrink)

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically (...) analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and expression, epigenetics, complexity theory, and comparative genomics. (shrink)

This volume presents essays analysing the ambivalent history of the globally influential political and social concept of community and the paradigms it has engendered in academia and politics.

Gouvernance et libéralités de Saladin: D’après les données inédites de six documents arabes. Edited by Jean-Michel Mouyon; Dominique Sourdel; and Janine Sourdel-Thomine. Documents relatifs à l’histoire des croisades, vol. 22. Paris: AcadémIe des Inscriptions et Belles-Lettred, 2015. Pp. 148. €30.

Hans-Georg Gadamer, one of the towering figures of contemporary Continental philosophy, is best known for Truth and Method, where he elaborated the concept of "philosophical hermeneutics," a programmatic way to get to what we do when we engage in interpretation. Donatella Di Cesare highlights the central place of Greek philosophy, particularly Plato, in Gadamer's work, brings out differences between his thought and that of Heidegger, and connects him with discussions and debates in pragmatism. This is a sensitive and thoroughly readable (...) philosophical portrait of one of the 20th century’s most powerful thinkers. (shrink)

ABSTRACTThis article examines Heidegger's assessment of negativity and finitude in the late 1930s and his enlargement of these issues in the name of a leap from one type of philosophy, one type of beginning, to a wholly other beginning. The guiding concerns of this article are negativity, finitude and the leap, and how these overlapping concerns coalesce around Heidegger's attempts to move towards a wholly other type of philosophy; in fact, one which no longer understands itself to be philosophy at (...) all. The article concludes with a discussion of the role of death, sacrifice, and mourning in Heidegger's thought in the 1930s. (shrink)

What I was looking for were folk music records and the first one I saw was Odetta on the Tradition label. I went into the listening booth to hear it. Odetta was great. I had never heard of her unti...

This book presents the most complete translation to date of Erwin Schrödinger's work on colorimetry. In his work Schrödinger proposed a projective geometry of color space, rather than a Euclidean line-element. He also proposed new (at the time) colorimetric methods - in detail and at length - which represented a dramatic conceptual shift in colorimetry. Schrödinger shows how the trichromatic (or Young-Helmholtz) theory of color and the opponent-process (or Hering) theory of color are formally the same theory, or at least (...) only trivially different. These translations of Schrödinger's bold concepts for color space have a fresh resonance and importance for contemporary color theory. (shrink)

Students of geometry do not prove Euclid's first theorem by examining an accompanying diagram, or by visualizing the construction of a figure. The original proof of Euclid's first theorem is incomplete, and this gap in logic is undetected by visual imagination. While cognition involves truth values, vision does not: the notions of inference and proof are foreign to vision.

In this essay I will consider some epistemological issues raised by the following two questions:(l) Does molecular biology provide the best explanations of biological phenomena?(2) What are the best ways (i.e., fruitful strategies) to cast molecular explanations of molecular phenomena?I will argue that notwithstanding the manifest scientific successes of the molecular revolution, the assessment of the philosophical debate between reductionists and antireductionists requires an examination of the ways in which the second question is currently being answered by molecular biologists.

The dramatic increase in the number of overseas students studying in the United Kingdom and other Western countries has required academics to reevaluate many aspects of their own, and their institutions', practices. This article considers differing cultural values among overseas students toward plagiarism and the implications this may have for postgraduate education in a Western context. Based on focus-group interviews, questionnaires, and informal discussions, we report the views of plagiarism among students in 2 postgraduate management programs, both of which had (...) a high constituency of overseas students. We show that plagiarist practices are often the outcome of many complex and culturally situated influences. We suggest that educators need to appreciate these differing cultural assumptions if they are to act in an ethical manner when responding to issues of plagiarism among international students. (shrink)

What is the Bare Particular Theory? Is it committed, like the Bundle Theory, to a constituent ontology: according to which a substance’s qualities—and according to the Bare Particular Theory, its substratum also—are proper parts of the substance? I argue that Bare Particularists need not, should not, and—if a recent objection to ‘the Bare Particular Theory’ succeeds—cannot endorse a constituent ontology. There is nothing, I show, in the motivations for Bare Particularism or the principles that distinguish Bare Particularism from rival views (...) that entails a constituent ontology. I outline a version of Bare Particularism that in rejecting a constituent ontology avoids the New Objection. I argue against Theodore Sider that this really is a distinct theory to the version of Bare Particularism that endorses a constituent ontology, and not a mere terminological variant. I show that this, the best version of the Bare Particular Theory, is also defensible against the old objections. (shrink)

Knowledge excludes luck. According to the received view, this intuition reveals that knowing is essentially modal in character. This paper demurs. Either knowledge does not exclude luck, or the entailment reveals nothing about its conceptual character. It is argued that knowledge excludesaccidentality, and that this notion is not modal but causal‐explanatory. There are three central tasks. The first is to explicate the concept of accident. The second is to argue that the concepts of luck and accident are “intensionally distinct,” which (...) is to say that no member of the intension of either holds on both. The third is to argue that an anti‐accident requirement on knowledge is preferable to an anti‐luck analogue on abductive grounds. (shrink)

The English Catholic philosopher Sir Kenelm Digby (1603–1665) has enjoyed a recent spate of scholarly attention as a prodigious traveller, political figure, and man of diverse intellectual interests. This article contributes to this scholarship by assessing the commentary on salvation at the heart of Digby’s philosophy of the soul and the historical contexts in which it was produced. It argues that Digby’s thinking on the soul was a meditation on the worldly interactions a Catholic must undertake or avoid in order (...) to achieve salvation. As such, our intellectual historical understanding of Digby is much improved when he is viewed as a scholar who constructed an identity as a thinker adept at advising others on the correct path to beatitude. This article also makes the broader argument for salvation as an important conceptual tool for early modern intellectual historians wishing to accurately map the complex relationship between theology, scholarly argument, and scholarly ambition in the seventeenth century. (shrink)

'There is nothing outside the text.' Possibly no single statement has caused such a storm in critical theory as this famous observation by the French philosopher, Jacques Derrida. While it is often misunderstood as meaning that nothing is real and that political actions are therefore pointless, Debating Derrida demonstrates that Derrida's philosophy does not lack political conviction. Niall Lucy examines three key terms - text, writing and differance - as they are used in three famous debates: Derrida's disputes over (...) speech-acts with John R. Searle, over discourse with Michel Foucault and over apartheid. Lucy also takes up the issue of Derrida's relationship to postmodernism and questions the 'political imperative' of the need to justify philosophy and the humanities in general according to a notion of their 'usefulness'. Debating Derrida decisively shows that instead of disagreeing with Derrida, we should rather be defending him. (shrink)

The Health (Regulation of Termination of Pregnancy) Act 2018 was commenced on 01/01/2019 in Ireland. The Act provides for legal termination of pregnancy under defined circumstances including for any reason at < 12 weeks gestation; and where two doctors agree there is ‘a condition affecting the foetus that is likely to lead to the death of the foetus either before, or within 28 days of, birth’. As such, abortion for congenital anomaly (CA) can occur at a number of time points, (...) depending on the adjudged severity. Infants born with CAs frequently require significant medical intervention and account for a high proportion of admissions to paediatric intensive care units (PICUs). The purpose of this paper was to evaluate the number of infants with CAs admitted to an Irish PICU in the period before and after the implementation of the Act. All PICU admissions < 1 month of age to a single Irish paediatric hospital between 2012 and 2021 were analysed. CAs were recorded, and the periods before and after the commencement of the Act compared. We found a difference in admissions involving CAs, particularly those related to congenital heart disease involving single ventricle anatomy. It is plausible that this difference was as a result of improved access to abortion services following the implementation of the Act. This article explores the legal conditions related to the abortion of a foetus with a CA in Ireland, and the possible impact of the Independent Review of the Operation of the Health ( Regulation of Termination of Pregnancy) Act 2018. (shrink)

Realists about fictional characters posit a certain theoretical role and a candidate to fill this role. I will delineate the role realists take fictional characters like Emma Woodhouse to fill, and I will argue that it is better filled by what I will call ‘characterisations’. In explaining what I mean by ‘characterisations’, I will show that the existence of these entities is comparatively uncontroversial. Realists should acknowledge their existence, but doing so, I will argue, obviates the need to acknowledge the (...) existence of Emma and other fictional individuals. (shrink)

This paper maintains (following Yougrau 1987; 2000 and Hinchliff 1996) that the dead and other former existents count as examples of non-existent objects. If the dead number among the things there are, a further question arises: what is it to be dead—how should the state of being dead be characterised? It is argued that this state should be characterised negatively: the dead are not persons, philosophers etc. They lack any of the (intrinsic) qualities they had while they lived. The only (...) facts involving the dead are facts about the relations they stand in—including the relations they bear to the qualities they formerly instantiated, and the intentional relations they stand in to us. Given an appropriate conception of qualities the dead can be said to be quality-less objects: bare particulars. The ‘Bare Particular Theory’ of individuals, it is argued, is coherent if and only if it concedes that the bare particulars it allows for don’t exist. The account of the dead and other former existents as bare particulars does justice to the misfortune of death, and points the way to a general theory of nonexistent objects. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Partial Truth (Poems 2015–19) by Christopher NorrisNiall GildeaNorris, Christopher. A Partial Truth (Poems 2015–19). The Seventh Quarry Press, 2019. 133pp.“No interval but some event takes place.”(Norris, “Freeze-Frame,” A Partial Truth)A Partial Truth, a collection of thirty-seven pieces, is the seventh volume of poetry by philosopher and literary theorist Christopher Norris. Nobody familiar with Norris’s distinguished career will be surprised to learn that his recent turn to versification (...) is not a repudiation of intellectual and rhetorical seriousness, but a re-emphasis of the same using resources not typically found in academic prose. Norris, an interdisciplinarian long before that term became a slogan, has in his work clocked up considerable epistemological mileage across diverse terrain, his critical friendship with deconstruction leading him to important interventions in analytic and Continental philosophy, institutional critique, philosophy of science and mathematics, legal studies, music, politics and, after all, creative criticism.Creative criticism is a relatively embryonic genre, until recently typified generally by a prose that owes a debt to Jacques Derrida’s Cir-confession, Glas and La carte postale. This is a style that foregrounds the philosophical unsaid – the repressed autobiographical, desirous, and otherwise messy constituents of that canon. It does so in part by jettisoning the academic politesse, and let’s say timidity, which help maintain such statutes of limitation. In a more specific way, creative criticism may be understood as a Romantic development set in train by the “Yale School” of deconstruction and its fellow travelers, straining in their own ways against the subordinate role of the reader and critic instituted by the likes of Matthew Arnold and T. S. Eliot.In the foreword to his 2017 volume The Winnowing Fan, Norris at once compliments this “strong” critical rebelliousness (xii), and critiques its ecstatic, quasi-apocalyptic hubris, provisionally aligning his own creative criticism with the “poetic diction” (xxi) of eighteenth-century figures such as Dryden and Pope. It is an analogy with caveats – not least Norris’s stated allergy to the “air of arrogance” (Tempus-Fugitives ix) of [End Page 122] their heavily end-stopped tendentiousness – but one which schematizes a poetics that both carries a definite argument and could not make this argument otherwise than in a manner reliant on verse’s formal properties.Note, however, the fact that Norris takes his distance from both strong criticism and those eighteenth-century essayists on the grounds of their shared self-assurance. A steadier presiding influence is William Empson, whose enmity towards Eliotic New Criticism, which “fixes a prescriptive gulf between poetry and other kinds of discourse,” makes him a political forebear, dissenting from modern forms of literary historical doctrinalism, specifically “that whole anti-rationalist complex of ideas that made the discontinuity between poetic and non-poetic language into a shibboleth of aesthetic, ethical, and (though rarely advertised as such) socio-political principle” (Tempus-Fugitives xix–xx). Norris is no straightforward disciple of Empson – who regarded Derrida, and the other “horrible Frenchmen” Norris used to invite him to read, as “so very disgusting, in a simple moral or social way, that I cannot stomach them” (qtd. in Haffenden 52). And yet, one constant quality of both Norris’s verse and prose criticism is a welcome sobriety of explication when it comes to the more recondite or outright flamboyant enclaves of modern European thought.A Partial Truth, and Norris’s books of verse generally, are explicit in outlining the ways in which his poetry functions as a reaction to the diaristic, mumbling slackness of much contemporary poetry; but does his turn to verse also indicate some reaction to contemporary theory? A Partial Truth’s “Foreword,” with modesty, states that “[i]f these poems have any distinctive merit then it lies in the treatment of interesting ideas in a way that deploys certain formal means to draw out complexities and further implications that would lie beyond the reach of a prose rendition” (14). We will specify some of the relations between form and discursive complexity presently, but for now, it is worth suggesting that Norris’s commitment to verse forms of historically recognizable kinds forecloses from him the mealy-mouthed, argumentatively fugitive character of... (shrink)

For the relatively small number of scholars who have worked on him, the English Catholic philosopher, courtier, and pirate Sir Kenelm Digby (1603–1665) has proven a difficult figure to study compre...

Following the deaths of ten Irish republican hunger strikers in 1981, radical Basque nationalists and Irish republicans of the Basque izquierda abertzale and Irish republican movement respectively, began to develop ever closer ties of transnational “solidarity”. In addition to the relationship between Herri Batasuna and Sinn Féin, more ad hoc organisational links in areas such as youth, prisoner, and language advocacy, fostered a shared political culture at the intersection of both movements, which was periodically reflected through the prism of cultural (...) expression. Utilising a wide array of primary sources, this article explores and analyses, for the first time, the emergence and development of this transnational nexus, from the hunger strikes of 1981 to the signing of the Good Friday Agreement in 1998. (shrink)

Priming of lineage‐specific genes in pluripotent embryonic stem cells facilitates rapid and coordinated activation of transcriptional programmes during differentiation. There is growing evidence that pluripotency factors play key roles in priming tissue‐specific genes and in the earliest stages of lineage commitment. As differentiation progresses, pluripotency factors are replaced at some primed genes by related lineage‐specific factors that bind to the same sequences and maintain epigenetic priming until the gene is activated. Polycomb and trithorax group proteins bind many genes in pluripotent (...) cells generating bivalent domains that contain both active and repressive histone modifications. The properties of polycomb proteins suggest that they act as gatekeepers, helping to maintain silencing in pluripotent stem cells while establishing a chromatin environment that is permissive for priming by sequence‐specific factors. The overall effect of factor‐mediated priming is to initiate the input of information required for cell differentiation before the first lineage choices have been made. (shrink)

The relationship between cognition and culture is discussed in terms of technology and representation. The computational metaphor is discussed in relation to its providing an account of cognitive and technical development: the role of representation and self-modification through environmental manipulation and the development of open learning from stigmery. A rationalisation for the transformational effects of information and representation is sought in the physical and biological theories of Autokatakinetics and Autopoiesis. The conclusion drawn is that culture, rather than being an intrinsic (...) property of our human phenotype was learned and that cultural cognition is an information transforming system that is inadequately characterised by notions of parameterised deep-structure and that it is an open and potentially unbounded informational system. (shrink)

(2009). Structure, Sign and Play in the Discourse of Paul Auster's In the Country of Last Things. Angelaki: Vol. 14, Ecopoetics and Pedagogies, pp. 21-28.

Qualitative data typically contain multiple identifiable characteristics about people, places and events, in the unique voice of each participant. This short report considers sensitivity and security of audio-recordings, drawing attention to a lack of guidelines for researchers on the preservation or destruction of such data. The authors urge debate on this issue, with due consideration to both ethics and scientific rigour.

Lehar proposes an interesting theory of visual perception based on an explicit three-dimensional representation of the world existing in the observer's head. However, if we apply Occam's razor to this proposal, it is possible to contemplate far simpler representations of the world. Such representations have the advantage that they agree with findings in modern neuroscience.

The evidence for a kinematics of the mind is confounded by uncontrolled properties of pictures. Effects of illumination and of picture-plane geometry may underlie some evidence given for a process of mental rotation. Pictured rotation is confounded by picture similarity, gauged by gray -level correlations. An example is given involving the depicted rotation of Shepard-Metzler solids in depth. [Hecht; Kubovy & Epstein; Shepard; Todorovic].

This paper argues that the inappropriate framing and implementation of plagiarism detection systems in UK universities can unwittingly construct international students as ‘plagiarists’. It argues that these systems are often implemented with inappropriate assumptions about plagiarism and the way in which new members of a community of practice develop the skills to become full members of that community. Drawing on the literature and some primary data it shows how expectations, norms and practices become translated and negotiated in such a way (...) that legitimate attempts to conform with the expectations of the community of practice often become identified as plagiarism and illegitimate attempts at cheating often become obscured from view. It argues that this inappropriate framing and implementation of plagiarism detection systems may make academic integrity more illusive rather than less. It argues that in its current framing – as systems for ‘detection and discipline’ – plagiarism detection systems may become a new micro-politics of power with devastating consequences for those excluded. (shrink)

This paper outlines a solution to the puzzle of imaginative resistance that makes—and if successful helps to vindicate—two assumptions. The solution first assumes a relationship between moral judgements and affective states of the subject. It also assumes the correctness of accounts of imaginative engagement with fiction—like Kendall Walton’s account—that treat engagement with fiction as prop-based make-believe in which works of fiction, but also appreciators of those works, figure as props. The key to understanding imaginative resistance, it maintains, is understanding how (...) real feelings become part of fictional worlds. (shrink)

The term functional domain is often used to describe the region containing the cis acting sequences that regulate a gene locus. “Strong” domain models propose that the domain is a spatially isolated entity consisting of a region of extended accessible chromatin bordered by insulators that have evolved to act as functional boundaries. However, the observation that independently regulated loci can overlap partially or completely raises questions about functional requirements for physically isolated domain structures. An alternative model, the “weak” domain model, (...) proposes that domain structure is determined by the distribution of binding sites for positively acting factors, without a requirement for functional boundaries. The domain would effectively be the region that contains these factor-binding sites. Specificity of promoter-enhancer interactions would play a major role in maintaining the functional autonomy of adjacent genes. Sequences that interfere with these interactions (frequently characterised as insulators) would be selected against if they occurred within the domain but not at the edges, or in the interdomain regions. As a result, insulators would often be found near the borders of domains without necessarily being selected to act as boundaries. BioEssays 22:657–665, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Sir Kenelm Digby (1603–1665) was an aristocratic English Catholic philosopher who has been the subject of several recent studies, each of which has sought to demonstrate his intellectual originalit...