Results for 'Nick Barker'

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  1. Catenins, Wnt signaling and cancer.Nick Barker & Hans Clevers - 2000 - Bioessays 22 (11):961-965.
    Recent studies indicate that plakoglobin may have a similar function to that of β-catenin within the Wnt signaling pathway. β-catenin is known to be an oncogene in many forms of human cancer, following acquisition of stabilizing mutations in amino terminal sequences. Kolligs1 and coworkers show, however, that unlike β-catenin, plakoglobin induces neoplastic transformation of rat epithelial cells in the absence of such stabilizing mutations. Cellular transformation by plakoglobin also appears to be distinct from that of β-catenin in that it requires (...)
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  2. John Barker.Nick Zangwill - 2009 - Sztuka I Filozofia (Art and Philosophy) 35.
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  3.  67
    Slow Down: on benjamin noys’ critique of accelerationism.Jason Barker - 2016 - Angelaki 21 (2):227-235.
    This paper reviews Benjamin Noys’ recent attempt in Malign Velocities: Accelerationism and Capitalism to mount a critique of accelerationism. The book, persuasive in certain respects, bypasses the institutional dynamics of accelerationism’s theoretical progenitors, viz. Nick Land and the Cybernetic Culture Research Unit of Warwick University, and instead portrays it as a “defeatist strategy” of the post-’68 conjuncture of “Deleuzian Thatcherism.” Such portrayal is debatable to the extent that it exhibits a questionable appropriation of “theory” in the strict sense of (...)
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  4. Superintelligence: paths, dangers, strategies.Nick Bostrom (ed.) - 2003 - Oxford University Press.
    The human brain has some capabilities that the brains of other animals lack. It is to these distinctive capabilities that our species owes its dominant position. Other animals have stronger muscles or sharper claws, but we have cleverer brains. If machine brains one day come to surpass human brains in general intelligence, then this new superintelligence could become very powerful. As the fate of the gorillas now depends more on us humans than on the gorillas themselves, so the fate of (...)
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  5. Are We Living in a Computer Simulation?Nick Bostrom - 2003 - Philosophical Quarterly 53 (211):243-255.
    I argue that at least one of the following propositions is true: the human species is very likely to become extinct before reaching a ’posthuman’ stage; any posthuman civilization is extremely unlikely to run a significant number of simulations of its evolutionary history ; we are almost certainly living in a computer simulation. It follows that the belief that there is a significant chance that we shall one day become posthumans who run ancestor-simulations is false, unless we are currently living (...)
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  6. Dilemmic Epistemology.Nick Hughes - 2019 - Synthese 196 (10):4059-4090.
    This article argues that there can be epistemic dilemmas: situations in which one faces conflicting epistemic requirements with the result that whatever one does, one is doomed to do wrong from the epistemic point of view. Accepting this view, I argue, may enable us to solve several epistemological puzzles.
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  7. Anthropic Bias: Observation Selection Effects in Science and Philosophy.Nick Bostrom - 2002 - New York: Routledge.
    _Anthropic Bias_ explores how to reason when you suspect that your evidence is biased by "observation selection effects"--that is, evidence that has been filtered by the precondition that there be some suitably positioned observer to "have" the evidence. This conundrum--sometimes alluded to as "the anthropic principle," "self-locating belief," or "indexical information"--turns out to be a surprisingly perplexing and intellectually stimulating challenge, one abounding with important implications for many areas in science and philosophy. There are the philosophical thought experiments and paradoxes: (...)
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  8. (1 other version)Epistemic Dilemmas: A Guide.Nick Hughes - forthcoming - In Essays on Epistemic Dilemmas. Oxford University Press.
    This is an opinionated guide to the literature on epistemic dilemmas. It discusses seven kinds of situations where epistemic dilemmas appear to arise; dilemmic, dilemmish, and non-dilemmic takes on them; and objections to dilemmic views along with dilemmist’s replies to them.
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  9. In defense of posthuman dignity.Nick Bostrom - 2005 - Bioethics 19 (3):202–214.
    Positions on the ethics of human enhancement technologies can be (crudely) characterized as ranging from transhumanism to bioconservatism. Transhumanists believe that human enhancement technologies should be made widely available, that individuals should have broad discretion over which of these technologies to apply to themselves, and that parents should normally have the right to choose enhancements for their children-to-be. Bioconservatives (whose ranks include such diverse writers as Leon Kass, Francis Fukuyama, George Annas, Wesley Smith, Jeremy Rifkin, and Bill McKibben) are generally (...)
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  10. A history of transhumanist thought.Nick Bostrom - 2005 - Journal of Evolution and Technology 14 (1):1-25.
    The human desire to acquire new capacities is as ancient as our species itself. We have always sought to expand the boundaries of our existence, be it socially, geographically, or mentally. There is a tendency in at least some individuals always to search for a way around every obstacle and limitation to human life and happiness.
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  11. Epistemic feedback loops (or: how not to get evidence).Nick Hughes - 2021 - Philosophy and Phenomenological Research 106 (2):368-393.
    Epistemologists spend a great deal of time thinking about how we should respond to our evidence. They spend far less time thinking about the ways that evidence can be acquired in the first place. This is an oversight. Some ways of acquiring evidence are better than others. Many normative epistemologies struggle to accommodate this fact. In this article I develop one that can and does. I identify a phenomenon – epistemic feedback loops – in which evidence acquisition has gone awry, (...)
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  12. Algorithms as culture: Some tactics for the ethnography of algorithmic systems.Nick Seaver - 2017 - Big Data and Society 4 (2).
    This article responds to recent debates in critical algorithm studies about the significance of the term “algorithm.” Where some have suggested that critical scholars should align their use of the term with its common definition in professional computer science, I argue that we should instead approach algorithms as “multiples”—unstable objects that are enacted through the varied practices that people use to engage with them, including the practices of “outsider” researchers. This approach builds on the work of Laura Devendorf, Elizabeth Goodman, (...)
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  13. Transhumanist Values.Nick Bostrom - 2005 - Journal of Philosophical Research 30 (Supplement):3-14.
    Transhumanism is a loosely defined movement that has developed gradually over the past two decades. [1] It promotes an interdisciplinary approach to understanding and evaluating the opportunities for enhancing the human condition and the human organism opened up by the advancement of technology. Attention is given to both present technologies, like genetic engineering and information technology, and anticipated future ones, such as molecular nanotechnology and artificial intelligence.
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  14. The reversal test: Eliminating status quo bias in applied ethics.Nick Bostrom & Toby Ord - 2006 - Ethics 116 (4):656-679.
    Suppose that we develop a medically safe and affordable means of enhancing human intelligence. For concreteness, we shall assume that the technology is genetic engineering (either somatic or germ line), although the argument we will present does not depend on the technological implementation. For simplicity, we shall speak of enhancing “intelligence” or “cognitive capacity,” but we do not presuppose that intelligence is best conceived of as a unitary attribute. Our considerations could be applied to specific cognitive abilities such as verbal (...)
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  15. Human genetic enhancements: A transhumanist perspective.Nick Bostrom - 2003 - Journal of Value Inquiry 37 (4):493-506.
    Transhumanism is a loosely defined movement that has developed gradually over the past two decades. It promotes an interdisciplinary approach to understanding and evaluating the opportunities for enhancing the human condition and the human organism opened up by the advancement of technology. Attention is given to both present technologies, like genetic engineering and information technology, and anticipated future ones, such as molecular nanotechnology and artificial intelligence.
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  16. (1 other version)Existential risks: analyzing human extinction scenarios and related hazards.Nick Bostrom - 2002 - J Evol Technol 9 (1).
    Because of accelerating technological progress, humankind may be rapidly approaching a critical phase in its career. In addition to well-known threats such as nuclear holocaust, the propects of radically transforming technologies like nanotech systems and machine intelligence present us with unprecedented opportunities and risks. Our future, and whether we will have a future at all, may well be determined by how we deal with these challenges. In the case of radically transforming technologies, a better understanding of the transition dynamics from (...)
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  17. Infinite Ethics.Nick Bostrom - 2011 - Analysis and Metaphysics 10:9–59.
  18. Ethical issues in advanced artificial intelligence.Nick Bostrom - manuscript
    The ethical issues related to the possible future creation of machines with general intellectual capabilities far outstripping those of humans are quite distinct from any ethical problems arising in current automation and information systems. Such superintelligence would not be just another technological development; it would be the most important invention ever made, and would lead to explosive progress in all scientific and technological fields, as the superintelligence would conduct research with superhuman efficiency. To the extent that ethics is a cognitive (...)
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  19.  29
    (1 other version)Why I Want to be a Posthuman When I Grow Up.Nick Bostrom - 2013 - In Max More & Natasha Vita-More, The Transhumanist Reader: Classical and Contemporary Essays on the Science, Technology, and Philosophy of the Human Future. Chichester, West Sussex, UK: Wiley-Blackwell. pp. 28-53.
    The term “posthuman” has been used in very different senses by different authors.2 I am sympathetic to the view that the word often causes more confusion than clarity, and that we might be better off replacing it with some alternative vocabulary.
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  20. Existential Risk Prevention as Global Priority.Nick Bostrom - 2013 - Global Policy 4 (1):15–31.
     
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  21. The (A)temporal Emergence of Spacetime.Nick Huggett & Christian Wüthrich - 2018 - Philosophy of Science 85 (December):1190-1203.
    This paper examines two cosmological models of quantum gravity to investigate the foundational and conceptual issues arising from quantum treatments of the big bang. While the classical singularity is erased, the quantum evolution that replaces it may not correspond to classical spacetime: it may instead be a non-spatiotemporal region, which somehow transitions to a spatiotemporal state. The different kinds of transition involved are partially characterized, the concept of a physical transition without time is investigated, and the problem of empirical incoherence (...)
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  22. Trivial Truths and the Aim of Inquiry.NicK Treanor - 2012 - Philosophy and Phenomenological Research 89 (3):552-559.
    A pervasive and influential argument appeals to trivial truths to demonstrate that the aim of inquiry is not the acquisition of truth. But the argument fails, for it neglects to distinguish between the complexity of the sentence used to express a truth and the complexity of the truth expressed by a sentence.
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  23. The Vulnerable World Hypothesis.Nick Bostrom - 2018
    Scientific and technological progress might change people’s capabilities or incentives in ways that would destabilize civilization. For example, advances in DIY biohacking tools might make it easy for anybody with basic training in biology to kill millions; novel military technologies could trigger arms races in which whoever strikes first has a decisive advantage; or some economically advantageous process may be invented that produces disastrous negative global externalities that are hard to regulate. This paper introduces the concept of a vulnerable world: (...)
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  24. Sleeping Beauty and Self-location: A Hybrid Model.Nick Bostrom - 2007 - Synthese 157 (1):59-78.
    The Sleeping Beauty problem is test stone for theories about self-locating belief, i.e. theories about how we should reasons when data or theories contain indexical information. Opinion on this problem is split between two camps, those who defend the "1/2 view" and those who advocate the "1/3 view". I argue that both these positions are mistaken. Instead, I propose a new "hybrid" model, which avoids the faults of the standard views while retaining their attractive properties. This model _appears_ to violate (...)
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  25. Ethical issues in human enhancement.Nick Bostrom & Rebecca Roache - 2007 - In Jesper Ryberg, Thomas S. Petersen & Clark Wolf, New waves in applied ethics. New York: Palgrave-Macmillan. pp. 120--152.
    Human enhancement has emerged in recent years as a blossoming topic in applied ethics. With continuing advances in science and technology, people are beginning to realize that some of the basic parameters of the human condition might be changed in the future. One important way in which the human condition could be changed is through the enhancement of basic human capacities. If this becomes feasible within the lifespan of many people alive today, then it is important now to consider the (...)
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  26. How long before superintelligence?Nick Bostrom - 1998 - International Journal of Futures Studies 2.
    _This paper outlines the case for believing that we will have superhuman artificial intelligence_ _within the first third of the next century. It looks at different estimates of the processing power of_ _the human brain; how long it will take until computer hardware achieve a similar performance;_ _ways of creating the software through bottom-up approaches like the one used by biological_ _brains; how difficult it will be for neuroscience figure out enough about how brains work to_ _make this approach work; (...)
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  27. Love: gloriously amoral and arational.Nick Zangwill - 2013 - Philosophical Explorations 16 (3):298 - 314.
    I argue that an evaluational conception of love collides with the way we value love. That way allows that love has causes, but not reasons, and it recognizes and celebrates a love that refuses to justify itself. Love has unjustified selectivity, due to its arbitrary causes. That imposes a non-tradability norm. A love for reasons, rational love or evaluational love would be propositional, and it therefore allows that the people we love are tradable commodities. A moralized conception of love is (...)
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  28.  38
    Global Catastrophic Risks.Nick Bostrom & Milan M. Cirkovic (eds.) - 2008 - Oxford University Press.
    A Global Catastrophic Risk is one that has the potential to inflict serious damage to human well-being on a global scale. This book focuses on such risks arising from natural catastrophes, nuclear war, terrorism, biological weapons, totalitarianism, advanced nanotechnology, artificial intelligence and social collapse.
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  29. (1 other version)The wisdom of nature: an evolutionary heuristic for human enhancement.Nick Bostrom & Anders Sandberg - 2009 - In Nick Bostrom & Julian Savulescu, Human Enhancement. Oxford University Press. pp. 375--416.
  30. (1 other version)Pascal's mugging.Nick Bostrom - 2009 - Analysis 69 (3):443-445.
    In some dark alley. . . Mugger: Hey, give me your wallet. Pascal: Why on Earth would I want to do that? Mugger: Otherwise I’ll shoot you. Pascal: But you don’t have a gun. Mugger: Oops! I knew I had forgotten something. Pascal: No wallet for you then. Have a nice evening. Mugger: Wait! Pascal: Sigh. Mugger: I’ve got a business proposition for you. . . . How about you give me your wallet now? In return, I promise to come (...)
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  31. Teleological Dispositions.Nick Kroll - 2017 - Oxford Studies in Metaphysics 10.
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  32. Smart Policy: Cognitive Enhancement and the Public Interest.Nick Bostrom - 2011 - In Julian Savulescu, Ruud ter Meulen & Guy Kahane, Enhancing Human Capacities. Blackwell.
    Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind through improvement or augmentation of internal or external information processing systems. Cognition refers to the processes an organism uses to organize information. These include acquiring information (perception), selecting (attention), representing (understanding) and retaining (memory) information, and using it to guide behavior (reasoning and coordination of motor outputs). Interventions to improve cognitive function may be directed at any of these core faculties.
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  33. Decision by sampling.Nick Chater & Gordon D. A. Brown - unknown
    We present a theory of decision by sampling (DbS) in which, in contrast with traditional models, there are no underlying psychoeconomic scales. Instead, we assume that an attribute’s subjective value is constructed from a series of binary, ordinal comparisons to a sample of attribute values drawn from memory and is its rank within the sample. We assume that the sample reflects both the immediate distribution of attribute values from the current decision’s context and also the background, real-world distribution of attribute (...)
     
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  34. Finding Time for Wheeler-DeWitt Cosmology.Nick Huggett & Karim Thebault - manuscript
    We conduct a case study analysis of a proposal for the emergence of time based upon the approximate derivation of three grades of temporal structure within an explicit quantum cosmological model which obeys a Wheeler-DeWitt type equation without an extrinsic time parameter. Our main focus will be issues regarding the consistency of the approximations and derivations in question. Our conclusion is that the model provides a self-consistent account of the emergence of chronordinal, chronometric and chronodirected structure. Residual concerns relate to (...)
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  35.  52
    Habit and Habitus.Nick Crossley - 2013 - Body and Society 19 (2-3):136-161.
    This article compares the concept of habitus, as formulated in the work of Mauss and Bourdieu, with the concept of habit, as formulated in the work of Merleau-Ponty and Dewey. The rationale for this, on one level, is to seek to clarify these concepts and any distinction that there may be between them – though the article notes the wide variety of uses of both concepts and suggests that these negate the possibility of any definitive definitions or contrasts. More centrally, (...)
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  36. The Doomsday Argument Adam & Eve, UN++, and Quantum Joe.Nick Bostrom - 2001 - Synthese 127 (3):359-387.
    The Doomsday argument purports to show that the risk of the human species going extinct soon has been systematically underestimated. This argument has something in common with controversial forms of reasoning in other areas, including: game theoretic problems with imperfect recall, the methodology of cosmology, the epistemology of indexical belief, and the debate over so-called fine-tuning arguments for the design hypothesis. The common denominator is a certain premiss: the Self-Sampling Assumption. We present two strands of argument in favor of this (...)
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  37.  16
    Through the Looking Glass and What Immanuel Found There.Nick Huggett - manuscript
    This is a draft of a chapter of a book that I was writing (in the early 2000s) on the philosophy of spacetime. It responds to Kant's argument of the lone hand, proposing a relational 'fitting' account of handedness. I plan to revise it as a stand-alone paper, but it is deposited now so that a soon to be published paper can cite a public version.
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  38. (1 other version)Dignity and enhancement.Nick Bostrom - 2008 - In Adam Schulman, Human dignity and bioethics: essays commissioned by the President's Council on Bioethics. Washington, D.C.: [President's Council on Bioethics.
    Does human enhancement threaten our dignity as some prominent commentators have asserted? Or could our dignity perhaps be technologically enhanced? After disentangling several different concepts of dignity, this essay focuses on the idea of dignity as a quality, a kind of excellence admitting of degrees and applicable to entities both within and without the human realm. I argue that dignity in this sense interacts with enhancement in complex ways which bring to light some fundamental issues in value theory, and that (...)
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  39.  90
    Uniqueness, Rationality, and the Norm of Belief.Nick Hughes - 2019 - Erkenntnis 84 (1):57-75.
    I argue that it is epistemically permissible to believe that P when it is epistemically rational to believe that P. Unlike previous defenses of this claim, this argument is not vulnerable to the claim that permissibility is being confused with excusability.
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  40. Negative Properties.Nick Zangwill - 2011 - Noûs 45 (3):528-556.
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  41. Human Enhancement Ethics: The State of the Debate.Nick Bostrom & Julian Savulescu - 2007 - In Nick Bostrom & Julian Savulescu, [no title]. Oxford University Press. pp. 1--22.
  42. Moral epistemology and the Because Constraint.Nick Zangwill - 2006 - In James Lawrence Dreier, Contemporary Debates in Moral Theory. Malden, MA: Wiley-Blackwell. pp. 263--281.
  43. The Future of Human Evolution.Nick Bostrom - unknown
    Evolutionary development is sometimes thought of as exhibiting an inexorable trend towards higher, more complex, and normatively worthwhile forms of life. This paper explores some dystopian scenarios where freewheeling evolutionary developments, while continuing to produce complex and intelligent forms of organization, lead to the gradual elimination of all forms of being that we care about. We then consider how such catastrophic outcomes could be avoided and argue that under certain conditions the only possible remedy would be a globally coordinated policy (...)
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  44. Essays on Epistemic Dilemmas.Nick Hughes (ed.) - forthcoming - Oxford University Press.
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  45. Besires and the Motivation Debate.Nick Zangwill - 2008 - Theoria 74 (1):50-59.
    Abstract: This article addresses a number of difficulties and complications in the standard formulations of motivational internalism, and considers what besires might be in the light of those difficulties and complications. Two notions of besire are then distinguished, before considering how different kinds of motivational internalism and different conceptions of besire fare against the significant argument that we may be indifferent to the demands of morality without irrationality.
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  46. On Being Awesome: A Unified Theory of How Not to Suck.Nick Riggle - 2017 - New York: Penguin Books.
    I develop a theory of social virtue around the concept of a "social opening" and argue that a range of contemporary terms track various modes of success and failure with respect to social openings: ‘awesome’, ‘down’, ‘chill’, ‘sucks’, ‘wack’, ‘lame’, ‘douchebag’, and others. A basic idea is that the normative character of contemporary social life cannot be fully understood in traditional philosophical terms: ‘obligation’, ‘demand’, ‘duty’, ‘right’, ‘just’, ‘requirement’. ‘Sucks’ and ‘awesome’ (and their ilk) capture a special mode of interpersonal (...)
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  47. Converging cognitive enhancements.Nick Bostrom & Anders Sandberg - manuscript
    Cognitive enhancements in the context of converging technologies. [Annals of the New York Academy of Sciences, Vol. 1093, pp. 201-207] [with Anders Sandberg] [pdf].
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  48. Reflections on parity nonconservation.Nick Huggett - 2000 - Philosophy of Science 67 (2):219-241.
    This paper considers the implications for the relational-substantival debate of observations of parity nonconservation in weak interactions, a much neglected topic. It is argued that 'geometric proofs' of absolute space, first proposed by Kant (1768), fail, but that parity violating laws allow 'mechanical proofs', like Newton's laws. Parity violating laws are explained and arguments analogous to those of Newton's Scholium are constructed to show that they require absolute spacetime structure--namely, an orientation--as Newtonian mechanics requires affine structure. Finally, it is considered (...)
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  49.  36
    Beyond Spacetime: The Foundations of Quantum Gravity.Nick Huggett, Keizo Matsubara & Christian Wüthrich (eds.) - 2020 - Cambridge: Cambridge University Press..
    A collection of essays discussing the philosophy and foundations of quantum gravity. Written by leading philosophers and physicists in the field, chapters cover the important conceptual questions in the search for a quantum theory of gravity, and the current state of understanding among philosophers and physicists.
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  50. First-person intentionality.Nick Georgalis - 2006 - In Nicholas Georgalis, The Primacy of the Subjective: Foundations for a Unified Theory of Mind and Language. Cambridge MA: Bradford Book/MIT Press.
     
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