Recent studies indicate that plakoglobin may have a similar function to that of β-catenin within the Wnt signaling pathway. β-catenin is known to be an oncogene in many forms of human cancer, following acquisition of stabilizing mutations in amino terminal sequences. Kolligs1 and coworkers show, however, that unlike β-catenin, plakoglobin induces neoplastic transformation of rat epithelial cells in the absence of such stabilizing mutations. Cellular transformation by plakoglobin also appears to be distinct from that of β-catenin in that it requires (...) activation of the proto-oncogene c-myc. Surprisingly, c-myc is activated more efficiently by plakoglobin than β-catenin, despite its previous identification as a target of Tcf/β-catenin.2 In contrast, a synthetic Tcf reporter gene is activated to a much greater extent by β-catenin than plakoglobin. Plakoglobin and β-catenin may therefore have different roles in Wnt signaling and cancer, which reflect their differential effects on target gene activity. BioEssays 22:961–965, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

This paper reviews Benjamin Noys’ recent attempt in Malign Velocities: Accelerationism and Capitalism to mount a critique of accelerationism. The book, persuasive in certain respects, bypasses the institutional dynamics of accelerationism’s theoretical progenitors, viz. Nick Land and the Cybernetic Culture Research Unit of Warwick University, and instead portrays it as a “defeatist strategy” of the post-’68 conjuncture of “Deleuzian Thatcherism.” Such portrayal is debatable to the extent that it exhibits a questionable appropriation of “theory” in the strict sense of (...) the term; a term the paper attempts to define with reference to Matthew Arnold, Louis Althusser and Gilles Grelet. (shrink)

The human brain has some capabilities that the brains of other animals lack. It is to these distinctive capabilities that our species owes its dominant position. Other animals have stronger muscles or sharper claws, but we have cleverer brains. If machine brains one day come to surpass human brains in general intelligence, then this new superintelligence could become very powerful. As the fate of the gorillas now depends more on us humans than on the gorillas themselves, so the fate of (...) our species then would come to depend on the actions of the machine superintelligence. But we have one advantage: we get to make the first move. Will it be possible to construct a seed AI or otherwise to engineer initial conditions so as to make an intelligence explosion survivable? How could one achieve a controlled detonation? To get closer to an answer to this question, we must make our way through a fascinating landscape of topics and considerations. Read the book and learn about oracles, genies, singletons; about boxing methods, tripwires, and mind crime; about humanity's cosmic endowment and differential technological development; indirect normativity, instrumental convergence, whole brain emulation and technology couplings; Malthusian economics and dystopian evolution; artificial intelligence, and biological cognitive enhancement, and collective intelligence. (shrink)

I argue that at least one of the following propositions is true: the human species is very likely to become extinct before reaching a ’posthuman’ stage; any posthuman civilization is extremely unlikely to run a significant number of simulations of its evolutionary history ; we are almost certainly living in a computer simulation. It follows that the belief that there is a significant chance that we shall one day become posthumans who run ancestor-simulations is false, unless we are currently living (...) in a simulation. I discuss some consequences of this result. (shrink)

This article argues that there can be epistemic dilemmas: situations in which one faces conflicting epistemic requirements with the result that whatever one does, one is doomed to do wrong from the epistemic point of view. Accepting this view, I argue, may enable us to solve several epistemological puzzles.

_Anthropic Bias_ explores how to reason when you suspect that your evidence is biased by "observation selection effects"--that is, evidence that has been filtered by the precondition that there be some suitably positioned observer to "have" the evidence. This conundrum--sometimes alluded to as "the anthropic principle," "self-locating belief," or "indexical information"--turns out to be a surprisingly perplexing and intellectually stimulating challenge, one abounding with important implications for many areas in science and philosophy. There are the philosophical thought experiments and paradoxes: (...) the Doomsday Argument; Sleeping Beauty; the Presumptuous Philosopher; Adam & Eve; the Absent-Minded Driver; the Shooting Room. And there are the applications in contemporary science: cosmology ; evolutionary theory ; the problem of time's arrow ; quantum physics ; game-theory problems with imperfect recall ; even traffic analysis. _Anthropic Bias_ argues that the same principles are at work across all these domains. And it offers a synthesis: a mathematically explicit theory of observation selection effects that attempts to meet scientific needs while steering clear of philosophical paradox. (shrink)

This is an opinionated guide to the literature on epistemic dilemmas. It discusses seven kinds of situations where epistemic dilemmas appear to arise; dilemmic, dilemmish, and non-dilemmic takes on them; and objections to dilemmic views along with dilemmist’s replies to them.

Positions on the ethics of human enhancement technologies can be (crudely) characterized as ranging from transhumanism to bioconservatism. Transhumanists believe that human enhancement technologies should be made widely available, that individuals should have broad discretion over which of these technologies to apply to themselves, and that parents should normally have the right to choose enhancements for their children-to-be. Bioconservatives (whose ranks include such diverse writers as Leon Kass, Francis Fukuyama, George Annas, Wesley Smith, Jeremy Rifkin, and Bill McKibben) are generally (...) opposed to the use of technology to modify human nature. A central idea in bioconservativism is that human enhancement technologies will undermine our human dignity. To forestall a slide down the slippery slope towards an ultimately debased ‘posthuman’ state, bioconservatives often argue for broad bans on otherwise promising human enhancements. This paper distinguishes two common fears about the posthuman and argues for the importance of a concept of dignity that is inclusive enough to also apply to many possible posthuman beings. Recognizing the possibility of posthuman dignity undercuts an important objection against human enhancement and removes a distortive double standard from our field of moral vision. (shrink)

The human desire to acquire new capacities is as ancient as our species itself. We have always sought to expand the boundaries of our existence, be it socially, geographically, or mentally. There is a tendency in at least some individuals always to search for a way around every obstacle and limitation to human life and happiness.

Epistemologists spend a great deal of time thinking about how we should respond to our evidence. They spend far less time thinking about the ways that evidence can be acquired in the first place. This is an oversight. Some ways of acquiring evidence are better than others. Many normative epistemologies struggle to accommodate this fact. In this article I develop one that can and does. I identify a phenomenon – epistemic feedback loops – in which evidence acquisition has gone awry, (...) with the result that even beliefs based on the evidence are irrational. Examples include evidence acquired under the influence of confirmation bias and evidence acquired under the influence of cognitively penetrated experiences caused by implicit bias. I then develop a theoretical framework which enables us to understand why beliefs that are the outputs of epistemic feedback loops are irrational. Finally, I argue that many popular approaches to epistemic normativity may need to be abandoned on the grounds that they cannot comfortably explain feedback loops. The scope of this last claim is broad: it includes almost all contemporary theories of justified/rational belief and of the epistemology of cognitive penetration. (shrink)

This article responds to recent debates in critical algorithm studies about the significance of the term “algorithm.” Where some have suggested that critical scholars should align their use of the term with its common definition in professional computer science, I argue that we should instead approach algorithms as “multiples”—unstable objects that are enacted through the varied practices that people use to engage with them, including the practices of “outsider” researchers. This approach builds on the work of Laura Devendorf, Elizabeth Goodman, (...) and Annemarie Mol. Different ways of enacting algorithms foreground certain issues while occluding others: computer scientists enact algorithms as conceptual objects indifferent to implementation details, while calls for accountability enact algorithms as closed boxes to be opened. I propose that critical researchers might seek to enact algorithms ethnographically, seeing them as heterogeneous and diffuse sociotechnical systems, rather than rigidly constrained and procedural formulas. To do so, I suggest thinking of algorithms not “in” culture, as the event occasioning this essay was titled, but “as” culture: part of broad patterns of meaning and practice that can be engaged with empirically. I offer a set of practical tactics for the ethnographic enactment of algorithmic systems, which do not depend on pinning down a singular “algorithm” or achieving “access,” but which rather work from the partial and mobile position of an outsider. (shrink)

Transhumanism is a loosely defined movement that has developed gradually over the past two decades. [1] It promotes an interdisciplinary approach to understanding and evaluating the opportunities for enhancing the human condition and the human organism opened up by the advancement of technology. Attention is given to both present technologies, like genetic engineering and information technology, and anticipated future ones, such as molecular nanotechnology and artificial intelligence.

Suppose that we develop a medically safe and affordable means of enhancing human intelligence. For concreteness, we shall assume that the technology is genetic engineering (either somatic or germ line), although the argument we will present does not depend on the technological implementation. For simplicity, we shall speak of enhancing “intelligence” or “cognitive capacity,” but we do not presuppose that intelligence is best conceived of as a unitary attribute. Our considerations could be applied to specific cognitive abilities such as verbal (...) fluency, memory, abstract reasoning, social intelligence, spatial cognition, numerical ability, or musical talent. It will emerge that the form of argument that we use can be applied much more generally to help assess other kinds of enhancement technologies as well as other kinds of reform. However, to give a detailed illustration of how the argument form works, we will focus on the prospect of cognitive enhancement. (shrink)

Transhumanism is a loosely defined movement that has developed gradually over the past two decades. It promotes an interdisciplinary approach to understanding and evaluating the opportunities for enhancing the human condition and the human organism opened up by the advancement of technology. Attention is given to both present technologies, like genetic engineering and information technology, and anticipated future ones, such as molecular nanotechnology and artificial intelligence.

Because of accelerating technological progress, humankind may be rapidly approaching a critical phase in its career. In addition to well-known threats such as nuclear holocaust, the propects of radically transforming technologies like nanotech systems and machine intelligence present us with unprecedented opportunities and risks. Our future, and whether we will have a future at all, may well be determined by how we deal with these challenges. In the case of radically transforming technologies, a better understanding of the transition dynamics from (...) a human to a "posthuman" society is needed. Of particular importance is to know where the pitfalls are: the ways in which things could go terminally wrong. While we have had long exposure to various personal, local, and endurable global hazards, this paper analyzes a recently emerging category: that of existential risks. These are threats that could case our extinction or destroy the potential of Earth - originating intelligent life. Some of these threats are relatively well known while others, including some of the gravest, have gone almost unrecognized. Existential risks have a cluster of features that make ordinary risk management ineffective. A final section of this paper discusses several ethical and policy implications. A clearer understanding of the threat picture will enable us to formulate better strategies. (shrink)

The ethical issues related to the possible future creation of machines with general intellectual capabilities far outstripping those of humans are quite distinct from any ethical problems arising in current automation and information systems. Such superintelligence would not be just another technological development; it would be the most important invention ever made, and would lead to explosive progress in all scientific and technological fields, as the superintelligence would conduct research with superhuman efficiency. To the extent that ethics is a cognitive (...) pursuit, a superintelligence could also easily surpass humans in the quality of its moral thinking. However, it would be up to the designers of the superintelligence to specify its original motivations. Since the superintelligence may become unstoppably powerful because of its intellectual superiority and the technologies it could develop, it is crucial that it be provided with human-friendly motivations. This paper surveys some of the unique ethical issues in creating superintelligence, and discusses what motivations we ought to give a superintelligence, and introduces some cost-benefit considerations relating to whether the development of superintelligent machines ought to be accelerated or retarded. (shrink)

The term “posthuman” has been used in very different senses by different authors.2 I am sympathetic to the view that the word often causes more confusion than clarity, and that we might be better off replacing it with some alternative vocabulary.

This paper examines two cosmological models of quantum gravity to investigate the foundational and conceptual issues arising from quantum treatments of the big bang. While the classical singularity is erased, the quantum evolution that replaces it may not correspond to classical spacetime: it may instead be a non-spatiotemporal region, which somehow transitions to a spatiotemporal state. The different kinds of transition involved are partially characterized, the concept of a physical transition without time is investigated, and the problem of empirical incoherence (...) for regions without spacetime is discussed. (shrink)

A pervasive and influential argument appeals to trivial truths to demonstrate that the aim of inquiry is not the acquisition of truth. But the argument fails, for it neglects to distinguish between the complexity of the sentence used to express a truth and the complexity of the truth expressed by a sentence.

Scientific and technological progress might change people’s capabilities or incentives in ways that would destabilize civilization. For example, advances in DIY biohacking tools might make it easy for anybody with basic training in biology to kill millions; novel military technologies could trigger arms races in which whoever strikes first has a decisive advantage; or some economically advantageous process may be invented that produces disastrous negative global externalities that are hard to regulate. This paper introduces the concept of a vulnerable world: (...) roughly, one in which there is some level of technological development at which civilization almost certainly gets devastated by default, i.e. unless it has exited the “semi-anarchic default condition”. Several counterfactual historical and speculative future vulnerabilities are analyzed and arranged into a typology. A general ability to stabilize a vulnerable world would require greatly amplified capacities for preventive policing and global governance. The vulnerable world hypothesis thus offers a new perspective from which to evaluate the risk-benefit balance of developments towards ubiquitous surveillance or a unipolar world order. (shrink)

The Sleeping Beauty problem is test stone for theories about self-locating belief, i.e. theories about how we should reasons when data or theories contain indexical information. Opinion on this problem is split between two camps, those who defend the "1/2 view" and those who advocate the "1/3 view". I argue that both these positions are mistaken. Instead, I propose a new "hybrid" model, which avoids the faults of the standard views while retaining their attractive properties. This model _appears_ to violate (...) Bayesian conditionalization, but I argue that this is not the case. By paying close attention to the details of conditionalization in contexts where indexical information is relevant, we discover that the hybrid model is in fact consistent with Bayesian kinematics. If the proposed model is correct, there are important lessons for the study of self-location, observation selection theory, and anthropic reasoning. (shrink)

Human enhancement has emerged in recent years as a blossoming topic in applied ethics. With continuing advances in science and technology, people are beginning to realize that some of the basic parameters of the human condition might be changed in the future. One important way in which the human condition could be changed is through the enhancement of basic human capacities. If this becomes feasible within the lifespan of many people alive today, then it is important now to consider the (...) normative questions raised by such prospects. The answers to these questions might not only help us be better prepared when technology catches up with imagination, but they may be relevant to many decisions we make today, such as decisions about how much funding to give to various kinds of research. Enhancement is typically contraposed to therapy. In broad terms, therapy aims to fix something that has gone wrong, by curing specific diseases or injuries, while enhancement interventions aim to improve the state of an organism beyond its normal healthy state. However, the distinction between therapy and enhancement is problematic, for several reasons. First, we may note that the therapy-enhancement dichotomy does not map onto any corresponding dichotomy between standard-contemporary-medicine and medicineas-it-could-be-practised-in-the-future. Standard contemporary medicine includes many practices that do not aim to cure diseases or injuries. It includes, for example, preventive medicine, palliative care, obstetrics, sports medicine, plastic surgery, contraceptive devices, fertility treatments, cosmetic dental procedures, and much else. At the same time, many enhancement interventions occur outside of the medical framework. Office workers enhance their performance by drinking coffee. Make-up and grooming are used to enhance appearance. Exercise, meditation, fish oil, and St John’s Wort are used to enhance mood. Second, it is unclear how to classify interventions that reduce the probability of disease and death.. (shrink)

_This paper outlines the case for believing that we will have superhuman artificial intelligence_ _within the first third of the next century. It looks at different estimates of the processing power of_ _the human brain; how long it will take until computer hardware achieve a similar performance;_ _ways of creating the software through bottom-up approaches like the one used by biological_ _brains; how difficult it will be for neuroscience figure out enough about how brains work to_ _make this approach work; (...) and how fast we can expect superintelligence to be developed once_ _there is human-level artificial intelligence._. (shrink)

I argue that an evaluational conception of love collides with the way we value love. That way allows that love has causes, but not reasons, and it recognizes and celebrates a love that refuses to justify itself. Love has unjustified selectivity, due to its arbitrary causes. That imposes a non-tradability norm. A love for reasons, rational love or evaluational love would be propositional, and it therefore allows that the people we love are tradable commodities. A moralized conception of love is (...) no less committed to treating those we love as tradable commodities; it is just that they are tradable moral commodities. An evaluative criterion of adequacy, I suggest, encourages the opposite view ? a non-rational and non-evaluational concept of love. Such a love can set up partial obligations, which may even demand that one sacrifice one's life. Only a love that has causes but not reasons can have the kind of value that we think love has, and thus it would only be rational to pursue and foster such a love. (shrink)

A Global Catastrophic Risk is one that has the potential to inflict serious damage to human well-being on a global scale. This book focuses on such risks arising from natural catastrophes, nuclear war, terrorism, biological weapons, totalitarianism, advanced nanotechnology, artificial intelligence and social collapse.

In some dark alley. . . Mugger: Hey, give me your wallet. Pascal: Why on Earth would I want to do that? Mugger: Otherwise I’ll shoot you. Pascal: But you don’t have a gun. Mugger: Oops! I knew I had forgotten something. Pascal: No wallet for you then. Have a nice evening. Mugger: Wait! Pascal: Sigh. Mugger: I’ve got a business proposition for you. . . . How about you give me your wallet now? In return, I promise to come (...) to your house tomorrow and give you double the value of what’s in the wallet. Not bad, eh? A 200% return on investment in 24 hours. (shrink)

Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind through improvement or augmentation of internal or external information processing systems. Cognition refers to the processes an organism uses to organize information. These include acquiring information (perception), selecting (attention), representing (understanding) and retaining (memory) information, and using it to guide behavior (reasoning and coordination of motor outputs). Interventions to improve cognitive function may be directed at any of these core faculties.

We present a theory of decision by sampling (DbS) in which, in contrast with traditional models, there are no underlying psychoeconomic scales. Instead, we assume that an attribute’s subjective value is constructed from a series of binary, ordinal comparisons to a sample of attribute values drawn from memory and is its rank within the sample. We assume that the sample reflects both the immediate distribution of attribute values from the current decision’s context and also the background, real-world distribution of attribute (...) values. DbS accounts for concave utility functions; losses looming larger than gains; hyperbolic temporal discounting; and the overestimation of small probabilities and the underestimation of large probabilities. Ó 2005 Elsevier Inc. All rights reserved. (shrink)

We conduct a case study analysis of a proposal for the emergence of time based upon the approximate derivation of three grades of temporal structure within an explicit quantum cosmological model which obeys a Wheeler-DeWitt type equation without an extrinsic time parameter. Our main focus will be issues regarding the consistency of the approximations and derivations in question. Our conclusion is that the model provides a self-consistent account of the emergence of chronordinal, chronometric and chronodirected structure. Residual concerns relate to (...) explanatory rather than consistency considerations. (shrink)

This article compares the concept of habitus, as formulated in the work of Mauss and Bourdieu, with the concept of habit, as formulated in the work of Merleau-Ponty and Dewey. The rationale for this, on one level, is to seek to clarify these concepts and any distinction that there may be between them – though the article notes the wide variety of uses of both concepts and suggests that these negate the possibility of any definitive definitions or contrasts. More centrally, (...) however, the purpose of the comparison is to draw out a number of important issues and debates which, it is argued, further work must address if the concepts of habit and habitus are to continue to prove useful and illuminating in social science. (shrink)

The Doomsday argument purports to show that the risk of the human species going extinct soon has been systematically underestimated. This argument has something in common with controversial forms of reasoning in other areas, including: game theoretic problems with imperfect recall, the methodology of cosmology, the epistemology of indexical belief, and the debate over so-called fine-tuning arguments for the design hypothesis. The common denominator is a certain premiss: the Self-Sampling Assumption. We present two strands of argument in favor of this (...) assumption. Through a series of thought experiments we then investigate some bizarre prima facie consequences – backward causation, psychic powers, and an apparent conflict with the Principal Principle. (shrink)

This is a draft of a chapter of a book that I was writing (in the early 2000s) on the philosophy of spacetime. It responds to Kant's argument of the lone hand, proposing a relational 'fitting' account of handedness. I plan to revise it as a stand-alone paper, but it is deposited now so that a soon to be published paper can cite a public version.

Does human enhancement threaten our dignity as some prominent commentators have asserted? Or could our dignity perhaps be technologically enhanced? After disentangling several different concepts of dignity, this essay focuses on the idea of dignity as a quality, a kind of excellence admitting of degrees and applicable to entities both within and without the human realm. I argue that dignity in this sense interacts with enhancement in complex ways which bring to light some fundamental issues in value theory, and that (...) the effects of any given enhancement must be evaluated in its appropriate empirical context. Yet it is possible that through enhancement we could become better able to appreciate and secure many forms of dignity that are overlooked or missing under current conditions. I also suggest that in a posthuman world, dignity as a quality could grow in importance as an organizing moral/aesthetic idea. (shrink)

I argue that it is epistemically permissible to believe that P when it is epistemically rational to believe that P. Unlike previous defenses of this claim, this argument is not vulnerable to the claim that permissibility is being confused with excusability.

Evolutionary development is sometimes thought of as exhibiting an inexorable trend towards higher, more complex, and normatively worthwhile forms of life. This paper explores some dystopian scenarios where freewheeling evolutionary developments, while continuing to produce complex and intelligent forms of organization, lead to the gradual elimination of all forms of being that we care about. We then consider how such catastrophic outcomes could be avoided and argue that under certain conditions the only possible remedy would be a globally coordinated policy (...) to control human evolution by modifying the fitness function of future intelligent life forms. (shrink)

Abstract: This article addresses a number of difficulties and complications in the standard formulations of motivational internalism, and considers what besires might be in the light of those difficulties and complications. Two notions of besire are then distinguished, before considering how different kinds of motivational internalism and different conceptions of besire fare against the significant argument that we may be indifferent to the demands of morality without irrationality.

I develop a theory of social virtue around the concept of a "social opening" and argue that a range of contemporary terms track various modes of success and failure with respect to social openings: ‘awesome’, ‘down’, ‘chill’, ‘sucks’, ‘wack’, ‘lame’, ‘douchebag’, and others. A basic idea is that the normative character of contemporary social life cannot be fully understood in traditional philosophical terms: ‘obligation’, ‘demand’, ‘duty’, ‘right’, ‘just’, ‘requirement’. ‘Sucks’ and ‘awesome’ (and their ilk) capture a special mode of interpersonal (...) critique. Old modes of critique fall short because contemporary social life embodies a concern for cultivating, expressing, and appreciating individuality. This is partly an aesthetic affair, which flavors the modes of response and critique that constitute the normative framework. I detail how our interest in the "ethics of awesomeness" has influenced a range of post-’60s cultural practices, including art, charity, athletics, public life, and others. (shrink)

Cognitive enhancements in the context of converging technologies. [Annals of the New York Academy of Sciences, Vol. 1093, pp. 201-207] [with Anders Sandberg] [pdf].

This paper considers the implications for the relational-substantival debate of observations of parity nonconservation in weak interactions, a much neglected topic. It is argued that 'geometric proofs' of absolute space, first proposed by Kant (1768), fail, but that parity violating laws allow 'mechanical proofs', like Newton's laws. Parity violating laws are explained and arguments analogous to those of Newton's Scholium are constructed to show that they require absolute spacetime structure--namely, an orientation--as Newtonian mechanics requires affine structure. Finally, it is considered (...) how standard relationist responses to Newton's argument might respond to the new challenge of parity nonconservation. (shrink)

A collection of essays discussing the philosophy and foundations of quantum gravity. Written by leading philosophers and physicists in the field, chapters cover the important conceptual questions in the search for a quantum theory of gravity, and the current state of understanding among philosophers and physicists.