AMP‐activated protein kinase (AMPK) is an evolutionarily conserved cellular switch that activates catabolic pathways and turns off anabolic processes. In this way, AMPK activation can restore the perturbation of cellular energy levels. In physiological situations, AMPK senses energy deficiency (in the form of an increased AMP/ATP ratio), but it is also activated by metabolic insults, such as glucose or oxygen deprivation. Metformin, one of the most widely prescribed anti‐diabetic drugs, exerts its actions by AMPK activation. However, while the functions of (...) AMPK as a metabolic regulator are fairly well understood, its actions in neuronal cells only recently gained attention. This review will discuss newly emerged functions of AMPK in neuroprotection and neurodegeneration. Additionally, recent views on the role of AMPK in autophagy, an important catabolic process that is also involved in neurodegeneration and cancer, will be highlighted. (shrink)

Social media is full of dead people. Untold millions of dead users haunt the online world where we increasingly live our lives. What do we do with all these digital souls? Can we simply delete them, or do they have a right to persist? Philosophers have been almost entirely silent on the topic, despite their perennial focus on death as a unique dimension of human existence. Until now. -/- Drawing on ongoing philosophical debates, Digital Souls claims that the digital dead (...) are objects that should be treated with loving regard and that we have a moral duty towards. Modern technology helps them to persist in various ways, while also making them vulnerable to new forms of exploitation and abuse. This provocative book explores a range of questions about the nature of death, identity, grief, the moral status of digital remains and the threat posed by AI-driven avatars of dead people. In the digital era, it seems we must all re-learn how to live with the dead. (shrink)

One important task of metaphysics is to answer the question of what it is for an object to exist. The first part of this book offers a systematic reconstruction and critique of contemporary views on existence. The upshot of this part is that the contemporary debate has reached an impasse because none of the considered views is able to formulate a satisfactory answer to this fundamental metaphysical question. The second part reconstructs Thomas Aquinas’s view on existence (esse) and argues that (...) it contributes a new perspective which allows us to see why the contemporary debate has reached this impasse. It has come to this point because it has taken a premise for granted which Aquinas’s view rejects, namely, that the existence of an object consists in something’s having a property. A decisive contribution of Aquinas’s theory of esse is that it makes use of the ideas of metaphysical participation and composition. In this way, it can be explained how an object can have esse without being the case that esse is a property of it. This book brings together a reconstruction from the history of philosophy with a systematic study on existence and is therefore relevant for scholars interested in contemporary or medieval theories of existence. (shrink)

L’article commence par dresser un résumé de la controverse sur la traduction d’ Aufhebung qui, depuis la fin des années 1990, a opposé l’auteur à Lucien Sève, qui prit soin de récuser l’« idée fausse, non marxienne d’abolition » pour lui substituer celle de « dépassement ». Après avoir analysé les rétractations successives de Sève, l’article élargit les données du problème traductologique en examinant les usages chez Marx et Engels d’un autre terme signifiant sans conteste « abolition » ou « (...) suppression », Abschaffung, et conclut que le concept d’abolition est bel et bien un concept clef du marxisme, comme du mouvement social et révolutionnaire porté par son époque. (shrink)

This paper develops and refines the suggestion that logical systems are conceptual artefacts that are the outcome of a design-process by exploring how a constructionist epistemology and meta-philosophy can be integrated within the philosophy of logic.

The Polymath Project is an online collaborative enterprise that was initiated in 2009, when Timothy Gowers asked whether and how groups could work together to solve mathematical problems that “do not naturally split up into a vast number of subtasks.” Gowers proposed to answer this question himself by actually trying to set up such a collaboration, based on interactions taking place in the comment-threads of a series of posts on a WordPress blog. Hence, the first project officially started in early (...) 2009, to be proclaimed successful only 6 weeks later (Gowers and Nielsen 2009). From its inception until April 2018, 15 more Polymath problems (and a handful of smaller or related ones) have been launched. These projects have attracted attention from different scholarly communities, including the philosophy of mathematical practices, from the perspective of which the Polymath Project can be seen as a vast repository of mathematics in action. This chapter continues previous work by its authors on the topic in question and topics related. More specifically, for the purposes of this volume, it is our aim to both summarize and expand upon these earlier contributions. The starting point is the above observation that in the past decade, the issue of “massively collaborative mathematics” (to be qualified below) has drawn quite some attention. However, does it also warrant intensive philosophical attention in particular? For, as exciting as these developments might be from mathematical and other points of view, the enhanced possibilities that have come with it do not per se give rise to any philosophical import. In Van Bendegem (2011), one of us has indeed tentatively argued for the philosophical relevance of these new dynamics of proof construction flowing from the wide availability and efficiency of Internet technology. We shall below briefly rehearse and update the argument given there. (shrink)

The well-known classification of legal procedure into “four feet” presents certain conceptual problems for the Indian legal tradition that various Smṛtikāras and commentators have attempted to resolve in different and sometimes contradictory ways. These difficulties arise because the four feet originally referred in Indian legal theory to four distinct, hierarchical legal domains rather than procedural means for reaching a verdict. The earliest attested discussion of the four feet, found in Kauṭilya’s Arthaśāstra, indicates that early legal theorists understood the greater legal (...) order as being comprised of four hierarchical domains and that these domains were ordered by the state as expressed in the original formulation of the four feet. Among the four legal domains, that of vyavahāra was developed by the state itself as a realm of public, transactional law meant to address disputes that could not be resolved in other legal forums. From this we can conclude that the origin of Indian jurisprudence lies with state efforts to formalize and enforce the laws of public transactions. The reinterpretation of the four feet by later jurists was motivated perhaps by resistance to one of the fundamental relationships expressed in the four feet, namely that royal authority possessed the greatest legal authority, independent of Brāhmaṇical law. (shrink)

This is an open access book which explores phenomenology as both an exceptionally diverse movement in philosophy as well as an active research method that crosses disciplinary boundaries. The volume brings together lively overviews of major areas and schools of phenomenology, as well as the most recent applications across a range of fields. The first part reviews the state-of-the-art in various areas of contemporary phenomenology, including several distinct schools of Husserl and Heidegger scholarship, as well as approaches derived from Merleau-Ponty, (...) de Beauvoir, Fanon, and others. An innovative quantitative analysis of citation networks provides rich visualizations of the field as a whole. The second part showcases phenomenology as a living discipline that can advance research in other areas. While some areas of interaction between phenomenology and other disciplines are by now well established (e.g. cognitive science), this volume sheds light on newer areas of application. The goal is to move beyond discussions of philosophical method and highlight scholars who are actually doing phenomenology in a variety of areas, including: Embodiment and questions of gender, race, and identity, The arts (visual art, literature, architecture), and Archaeology and anthropology. This volume offers a concise introduction to cutting edge phenomenological research and is suitable for both students and specialists. (shrink)

Thomas & Karmiloff- Smith raise the excellent and, in retrospect, obvious point that in a dynamic learning environment where feedback is possible, we should expect networks to adapt to damage by altering details of their behavior. We should therefore not expect that developmental disorders should result in “normal” modules. The implications of this point go much further, since interprocess dependency in the brain does not rely only on learned neural connections. This argues strongly against behavioral and process-related definitions, as opposed (...) to structural and architecture-related definitions, of mental modularity. (shrink)

The distinction between “passive” and “active” euthanasia, though problematic and highly criticized, retains a certain intuitive appeal. When a patient is allowed to die, nature appears simply to be taking its course. Yet when a patient is killed by, say, a lethal injection, humans appear to be causing his or her death. Guilt seems to follow naturally from the latter act while not from the former. Yet this view only holds up if age‐old and vague ideasabout “nature” and “artifice” go (...) unscrutinized. Once examined more closely the functional relevance of particular machines to particular bodies becomes evident. And the innocence and guilt less clear. (shrink)

ABSTRACT This article addresses two related questions about belief, inquiry, and persuasion. The first is a question about the nature of epistemic paternalism, which is, roughly, the activity of interfering in other people’s inquiry, for their own epistemic benefit. The second question is about rational persuasion, and whether it can ever be paternalistic, or (better) whether it can be disrespectful and prima facie wrong in the same way that at least some cases of paternalism are disrespectful and prima facie wrong. (...) The article argues that if rational persuasion is paternalistic, it is epistemically paternalistic. It then considers how best to characterize epistemic paternalism and answers a challenge to its justifiability. Finally, the article responds to George Tsai’s view that rational persuasion can be problematically paternalistic, arguing that Tsai’s central case falls short of the ideal of rational persuasion. (shrink)

The various academic works about the analysis of the actual functionning of alternation in professionnal training reveal a great descrepancy with the prescriptive model, qualified institutionnal or organisationnal model. In order to take some distance from this technical coordinative model of alternation in training, the hypothesis is made that the alternant is the one creating bonds.The results of an active resarch, based on the experimentation of a pro-training arrangement made to support this bonding work, are presented and put in perspective (...) with the initial hypothesis. This bonding work is considered a reliance activity of the alternants. Also, the pro-training arrangement built from the richness of the class-group, born from the commitment of the alternants, creates a typical dynamic which we chose to call actor-network. (shrink)

This paper argues that it is permissible for computer scientists and engineers—working with advanced militaries that are making good faith efforts to follow the laws of war—to engage in the research and development of lethal autonomous weapons systems. Research and development into a new weapons system is permissible if and only if the new weapons system can plausibly generate a superior risk profile for all morally relevant classes and it is not intrinsically wrong. The paper then suggests that these conditions (...) are satisfied by at least some potential LAWS development programs. More specifically, since LAWS will lead to greater force protection, warfighters are free to become more risk-acceptant in protecting civilian lives and property. Further, various malicious motivations that lead to war crimes will not apply to LAWS or will apply to no greater extent than with human warfighters. Finally, intrinsic objections—such as the claims that LAWS violate human dignity or that it creates ‘responsibility gaps’—are rejected on the basis that they rely upon implausibly idealized and atomized understandings of human decision-making in combat. (shrink)

Experimental research by social and cognitive psychologists has established that cooperative groups solve a wide range of problems better than individuals. Cooperative problem solving groups of scientific researchers, auditors, financial analysts, air crash investigators, and forensic art experts are increasingly important in our complex and interdependent society. This comprehensive textbook--the first of its kind in decades--presents important theories and experimental research about group problem solving. The book focuses on tasks that have demonstrably correct solutions within mathematical, logical, scientific, or verbal (...) systems, including algebra problems, analogies, vocabulary, and logical reasoning problems.The book explores basic concepts in group problem solving, social combination models, group memory, group ability and world knowledge tasks, rule induction problems, letters-to-numbers problems, evidence for positive group-to-individual transfer, and social choice theory. The conclusion proposes ten generalizations that are supported by the theory and research on group problem solving. Group Problem Solving is an essential resource for decision-making research in social and cognitive psychology, but also extremely relevant to multidisciplinary and multicultural problem-solving teams in organizational behavior, business administration, management, and behavioral economics. (shrink)

According to Keith DeRose, the invariantist's attempt to account for the data which inspire contextualism fares no better, in the end, than the "desperate and lame" maneuvers of "the crazed theory of 'bachelor'", whereby S's being unmarried is not among the truth conditions of 'S is a bachelor', but merely an implicature generated by an assertion thereof. Here, I outline the invariantist account I have previously proposed. I then argue that the prospects for sophisticated invariantism — either as a general (...) approach, or in the specific form I have recommended — are not nearly as dim as DeRose suggests. (shrink)

This article discusses some orthographical questions which relate to the text of Sophocles. It pays special attention to the editor’s duty to present the evidence for ancient orthography accurately, consistently, and efficiently.

This paper provides a response to Hanna Pickard and Stephen Pearce’s paper ‘Balancing costs and benefits: a clinical perspective does not support a harm minimisation approach for self-injury outside of community settings.’ This paper responded to my article ‘Should healthcare professionals sometimes allow harm? The case of self-injury.’ There is much in the paper that I would agree with, but I feel it is important to respond to a number of the criticisms of my paper in order to clarify my (...) position and to facilitate ongoing debate in relation to this important issue. (shrink)

I argue that some perceptual experiences are vague. To do so, I identify a characteristic feature of vagueness and show that some perceptual experiences have this feature. These include blurry experiences, experiences of color under low lighting, and experiences of number, as in the case of the speckled hen. The conclusion that these experiences are vague has two noteworthy consequences. First, it presses us to see whether and how existing theories of vagueness can be extended to perceptual experience. Second, it (...) sheds light on several puzzles in the philosophy of perception. (shrink)

In this paper we devise some technical tools for dealing with problems connected with the philosophical view usually called mathematical instrumentalism. These tools are interesting in their own right, independently of their philosophical consequences. For example, we show that even though the fragment of Peano's Arithmetic known as IΣ₁ is a conservative extension of the equational theory of Primitive Recursive Arithmetic (PRA). IΣ₁ has a super-exponential speed-up over PRA. On the other hand, theories studied in the Program of Reverse Mathematics (...) that formalize powerful mathematical principles have only polynomial speed-up over IΣ₁. (shrink)

We present an argument in support of the legal prohibition of infant male circumcision (IMC) in developed Western countries. We submit that all IMC, irrespective of whether the motivation behind it be secular or religious, violates children’s rights to self-determination (autonomy) and bodily integrity and is therefore morally illegitimate. And while IMC’s being morally wrong does not entail that it ought to be criminalised, we contend that it should be legally proscribed so as to protect children against harm and to (...) uphold their rights. We consider and reject an argument that an exemption from the legal ban should be granted to religious parents who perceive themselves to be under a moral obligation to subject their male infants to IMC. We argue that since IMC sets back children’s basic interests and violates their rights, there is no room, and no case, for the conferring of a religious exemption. (shrink)

Informational conceptions of logic are barely novel. We find them in the work of John Corcoran, in several papers on substructural and constructive logics by Heinrich Wansing, and in the interpretation of the Routley-Meyer semantics for relevant logics in terms of Barwises and Perrys theory of situations. Allo & Mares [2] present an informational account of logical consequence that is based on the content-nonexpantion platitude, but that also relies on a double inversion of the standard direction of explanation (in- formation (...) doesnt depend on a prior notion of meaning, but is used to naturalize meaning, and informational content is not defined relative to a pre-existing logical space, but that space is constructed relative to the level of abstraction at which information is assessed). In this paper I focus directly on one of the main ideas introduced in that paper, namely the contrast between logical discrimination and deductive strength, and use this contrast to (1) illustrate a number of open problems for an informational conception of logical consequence, (2) review its connection with the dynamic turn in logic, and (3) situate it relative to the research agenda of the philosophy of information. (shrink)

Care has become an overdetermined word in the medical humanities and beyond, a focus not only of debate around the nature and purpose of the field, but also of the wider issue of the status of medicine in relation to society and the individual. As a symptom of this problematic, this article proposes care as an ‘untranslatable’, in the sense defined by Barbara Cassin. This is pursued via an engagement with the history of the ethics of care and with its (...) translation into francophone contexts as une éthique du care, in tension with the philosophie du soin elaborated in the work of Frédéric Worms, and then with the several translations into French and English of Sorge and its derivations Besorgen and Fürsorge in Martin Heidegger's Sein und Zeit (Being and Time). A genealogy of care is thus established, and what emerges as the principal motif of its untranslatability is the relation between a primary form of relationality and the socio-technical dimension in which we may recognise healthcare. (shrink)

Many philosophers assume that philosophical theories about the psychological nature of moral judgment can be confirmed or disconfirmed by the kind of evidence gathered by natural and social scientists (especially experimental psychologists and neuroscientists). I argue that this assumption is mistaken. For the most part, empirical evidence can do no work in these philosophical debates, as the metaphorical heavy-lifting is done by the pre-experimental assumptions that make it possible to apply empirical data to these philosophical debates. For the purpose of (...) this paper, I emphasize two putatively empirically-supported theories about the psychological nature of moral judgment. The first is the Sentimental Rules Account, which is defended by Shaun Nichols. The second is defended by Jesse Prinz, and is a form of sentimentalist moral relativism. I show that both of the arguments in favour of these theories rely on assumptions which would be rejected by their philosophical opponents. Further, these assumptions carry substantive moral commitments and thus cannot be confirmed by further empirical investigation. Because of this shared methodological assumption, I argue that a certain form of empirical moral psychology rests on a mistake. (shrink)

The March 2002 symposium Human Dignity and Reproductive Technology brought together philosophers, theologians, scientists, lawyers, and scholars from across the United States. The essays of this book are the contributions of the symposium's participants.

An American conservative movement developed rapidly after World War II. It brought together intellectuals and politicians opposed to the New Deal in domestic policy and Soviet communism in foreign policy. The movement's first presidential candidate, Barry Goldwater, lost the election of 1964 but its second, Ronald Reagan, won the election of 1980. It has remained an influential force in American life up to the present, despite strong internal contradictions, which include disagreements about centralized power, about religion, about tradition, about elites, (...) and about the free market. To some of the movement's early luminaries, such as Russell Kirk, free-market capitalism was the antithesis of conservatism since it required perpetual innovation and the sweeping away of traditional forms. To others, such as Ayn Rand, capitalism was the heart and soul of conservatism because it alone preserved the dignity and freedom of the individual. (shrink)

I defend the position argued previously by Germain Grisez and me that total brain death is a valid criterion of death on the grounds that a human being is essentially a rational animal, and a brain-dead body lacks the radical capacity for rational actions. I reply to Josef Seifert’s objection that our positions rest on a reductionist view of the human person, and to other objections concerning the inter-relation between the human soul, its powers, and functions of the brain. I (...) argue that a brain-dead body lacks the material dispositions needed for having the form or soul of a human being. (shrink)

This introduction provides background information on the emerging field of nanotechnology and its ethical dimensions. After defining nanotechnology and briefly discussing its status as a discipline, about which there exists a meta-controversy, this introduction turns to a discussion of the status of nanoethics and lays out particular issues of concern in the field, both current and emerging.