Interleukin 1β‐converting enzyme (ICE)‐like proteases (caspases) play an important role in programmed cell death (apoptosis), and elucidating the consequences of their proteolytic activity is central to our understanding of the molecular mechanisms of cell death. Diverse structural and regulatory proteins and enzymes, including protein kinase Cδ, the retinoblastoma protein (a protein involved in cell survival), the DNA repair enzyme DNA‐dependent protein kinase and the nuclear lamins, undergo specific and limited endoproteolytic cleavage by various caspases during apoptosis. Since individual caspases can (...) cleave multiple substrates, the consequences of cleavage of only a single substrate are still poorly understood. Nevertheless, proteolytic activation of protein kinase Cδ may be an important early step in the cell death pathway, and cleavage of the retinoblastoma protein could suppress its cell survival function, whereas proteolytic inactivation of DNA repair enzymes might compromise the ability of the cell to reverse DNA fragmentation. On the other hand, cleavages of nuclear and cytoplasmic structural proteins (e.g. the lamins and Gas2) appear to be required for or contribute to the dramatic rearrangements in cellular architecture that are necessary for the completion of the cell death process. An emerging theme is that parallel and sequential proteolytic activation and inactivation of key protein substrates occurs during the multiple steps of apoptosis. (shrink)

We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...) for the representation of entities in the domain of disease and medical practice. Initial applications of ND will include the annotation and analysis of large data sets and patient records for Alzheimer’s disease, multiple sclerosis, and stroke. (shrink)

The paper investigates the status of gravitational energy in Newtonian Gravity, developing upon recent work by Dewar and Weatherall. The latter suggest that gravitational energy is a gauge quantity. This is potentially misleading: its gauge status crucially depends on the spacetime setting one adopts. In line with Møller-Nielsen’s plea for a motivational approach to symmetries, we supplement Dewar and Weatherall’s work by discussing gravitational energy–stress in Newtonian spacetime, Galilean spacetime, Maxwell-Huygens spacetime, and Newton–Cartan Theory. Although we ultimately concur with Dewar (...) and Weatherall that the notion of gravitational energy is problematic in NCT, our analysis goes beyond their work. The absence of an explicit definition of gravitational energy–stress in NCT somewhat detracts from the force of Dewar and Weatherall’s argument. We fill this gap by examining the supposed gauge status of prima facie plausible candidates—NCT analogues of gravitational energy–stress pseudotensors, the Komar mass, and the Bel-Robinson tensor. Our paper further strengthens Dewar and Weatherall’s results. In addition, it sheds more light upon the subtle link between sufficiently rich inertial structure and the definability of gravitational energy in NG. (shrink)

Offers a vision of wholeness for approaching human ethical responses to what science is telling us about the crises facing our environment and climate.

The epistemological literature on conspiracy theory has established that strict generalism about conspiracy theories is untenable. This chapter argues, however, that this does not license a move to naive or strict particularism. Rather, any consideration of specific conspiracy claims needs to address conspiracy theory not simply as a formal category of explanation, but as a distinctive social practice, with a history and explanatory repertoire that can give us important, if defeasible, reasons for rejecting at least some such types of claim. (...) These reasons are not merely epistemic. The moral costs of participating in such practices, and of levelling conspiracy accusations in general, generate corresponding ethical requirements for reticence about entertaining conspiracy theories. This doesn’t mean we can retreat to generalism; but it does mean particularism must be governed by a reluctance that, in practice, will rule out a great many conspiracy theory claims as candidates for serious investigation. (shrink)

For more than 20 years, research has proven the beneficial effect of natural frequencies when it comes to solving Bayesian reasoning tasks (Gigerenzer & Hoffrage, 1995). In a recent meta-analysis, McDowell & Jacobs (2017) showed that presenting a task in natural frequency format increases performance rates to 24% compared to only 4% when the same task is presented in probability format. Nevertheless, on average three quarters of participants in their meta-analysis failed to obtain the correct solution for such a task (...) in frequency format. In this paper, we present an empirical study on what participants typically do wrong when confronted with natural frequencies. We found that many of them did not actually use natural frequencies for their calculations, but translated them back into complicated probabilities instead. This switch from the intuitive presentation format to a less intuitive calculation format will be discussed within the framework of psychological theories (e.g., the Einstellung effect). (shrink)

Is childhood valuable? And is childhood as, less, or more, valuable than adulthood? In this article I first delineate several different questions that we might be asking when we think about the ‘value of childhood’, and I explore some difficulties of doing so. I then focus on the question of whether childhood is good for the person who experiences it. I argue for two key claims. First, if childhood wellbeing is measured by the same standards as adulthood, then children are (...) worse off than adults. Second, if childhood and adulthood wellbeing are measured by different standards, then we cannot compare them, and children are neither better off nor worse off than adults. This has some counter-intuitive implications, such as that we do not harm persons by depriving them of a childhood, nor by keeping them as children for elongated periods. (shrink)

There is an important disagreement in contemporary epistemology over the possibility of non-epistemic reasons for belief. Many epistemologists argue that non-epistemic reasons cannot be good or normative reasons for holding beliefs: non-epistemic reasons might be good reasons for a subject to bring herself to hold a belief, the argument goes, but they do not offer any normative support for the belief itself. Non-epistemic reasons, as they say, are just the wrong kind of reason for belief. Other epistemologists, however, argue that (...) there can be cases where non-epistemic reasons directly offer normative support for the beliefs a subject holds. -/- My aim in this paper is to remove an apparent obstacle for the view that there can be non-epistemic normative reasons for belief, by showing that the existence of non-epistemic reasons for belief does not conflict with epistemic standards for the assessment of inference. More specifically, I aim to show that the following principles are compatible: -/- Epistemic Norm of Inference (ENI): Necessarily, for all subjects, S, and inferences, I: I is a good inference for S only if S can gain a (doxastically) epistemically justified belief in I’s conclusion on the basis of I’s premises. -/- Non-Epistemic Reasons for Belief (NERB): Possibly, for some subject, S, reason, R, and belief, B: R is a good (i.e., normative) reason for S to hold B, and R is not an epistemic reason for B. -/- Guidance: For all subjects S, potential reasons R, and beliefs/actions φ: In order for R to count as a normative reason for S to φ, it must be possible for S to take R into account as relevant to the determination of whether S ought to φ. -/- One might naturally think that these principles conflict, for if there are non-epistemic reasons for belief, then they must guide deliberation, and in guiding deliberation, they would violate epistemic standards. The aim of this paper is to show that no such conflict need arise. -/- Section 2 of the paper proceeds to set out the concept of an inference, and to sketch an epistemic framework for the assessment of inferences and arguments. Section 3 sets out the distinction between normative and motivating reasons, and briefly defends the view that there can be non-epistemic reasons for beliefs. Section 4 shows that non-epistemic reasons for belief are compatible with epistemic standards for inference, because any time a reason R is a good non-epistemic reason for a subject S to hold a belief B, there is an epistemically good inference available to S which takes R as a premise and which concludes with the meta-belief that S ought to hold B. So the paper employs a level-connecting principle between normative reasons for φ-ing and epistemic reasons for believing that one ought to φ. The paper ends with clarifications of that level-connecting principle, and responses to three objections. (shrink)

In Expanding the Category "Human": Nonhumanism, Posthumanism, and Humanistic Psychology Patrick Whitehead argues that humanistic psychology must continue its sixty-year-old project of openness of inquiry and acceptance of human beings in order to stay relevant in this ever changing world.

Stokes’ earlier chapter in this volume argued that, given the role ethical considerations play in our judgments of what to believe, ethical factors will put limits on the extent to which we can embrace particularism about conspiracy theories. However, that will only be the case if there are ethical problems with conspiracy theory as a practice (rather than simply as a formal class of explanation). Utilising the Lakatosian framework for analysing conspiracy theories developed by Steve Clarke, this paper identifies a (...) morally costly feature of conspiracy theorizing: its tendency to generate and expand new accusations purely to defend the core theory from countervailing evidence. Such 'auxiliary accusations' violate important norms around justified accusation, which supplies a defeasible, but important, reason to be reluctant to take part in the practice of conspiracy theorizing. (shrink)

In this paper I reassess Floridi's solution to the Bar-Hillel-Carnap paradox (the information-yield of inconsistent propositions is maximal) by questioning the orthodox view that contradictions cannot be true. The main part of the paper is devoted to showing that the veridicality thesis (semantic information has to be true) is compatible with dialetheism (there are true contradictions), and that unless we accept the additional non-falsity thesis (information cannot be false) there is no reason to presuppose that there is no such thing (...) like contradictory information. (shrink)

This article introduces a new pragmatist-inspired perspective on the social sciences. It explores the relevance of neo-pragmatism for the philosophy of the social sciences, showing how it can lead to innovative and groundbreaking social research. The paper attempts to drive home these insights by elaborating on the affinities of neo-pragmatism with some Continental philosophers who have engaged with Husserl’s phenomenology, notably Gadamer, Levinas and Sartre. This neo-pragmatist proposal for the social sciences develops a non-representational view of knowledge and puts the (...) ongoing engagement with difference at the centre of social research. From this perspective, the process of knowledge formation is dialogical in nature whereby the researcher learns as much from those who are being researched as vice versa. The concluding section aims to show the implications of this perspective for current research in the social sciences, throwing new light on contemporary meta-discussions about social research. (shrink)

In 1990, the Federal Trade Commission (FTC) issued a consent order to the American Institute of Certified Public Accountants (AICPA). The order decreed the AICPA to lessen its longstanding ethics code which had until then banned the receipts of commissions, referral fees and contingent fees. The FTC alleged that the AICPA banned receipt of the fees as an attempt to restrain trade (FTC, 1990).In the present study, we sought to determine if CPAs'' preference for bans on commissions, referral fees and (...) contingent fees is related to their moral reasoning whereby CPAs perceive the bans to serve as a means of resolving ethical issues. While determining this matter cannot prove whether the bans did or did not actually result in restrained trade, it can offer insight into the perceived ethical importance to CPAs of the overturned rules. Based on a random sample of AICPA members and using Rest''s Defining Issues Test (DIT) to measure moral reasoning, we did not find a CPA''s moral reasoning to be related to his/her preference for ethics rules which ban commissions, referral fees or contingent fees. However, our results did indicate that most CPAs prefer banning commissions, referral fees and contingent fees, with those CPAs holding a higher financial stake in public accounting, namely partners, favoring banning referral fees and contingent fees significantly less than CPAs with a lesser stake. Further, we noted a significant negative relationship between financial stake and moral reasoning. These results seem to suggest that self-interest among CPAs may influence their moral reasoning.Further study is needed to examine the relationship between self-interest of CPAs and their moral reasoning. If self-interest clouds moral judgments made by CPAs, capital markets are in danger. Rendering an independent audit opinion must exclude self-interest. (shrink)

Modal logics have in the past been used as a unifying framework for the minimality semantics used in defeasible inference, conditional logic, and belief revision. The main aim of the present paper is to add adaptive logics, a general framework for a wide range of defeasible reasoning forms developed by Diderik Batens and his co-workers, to the growing list of formalisms that can be studied with the tools and methods of contemporary modal logic. By characterising the class of abnormality models, (...) this aim is achieved at the level of the model-theory. By proposing formulae that express the consequence relation of adaptive logic in the object-language, the same aim is also partially achieved at the syntactical level. (shrink)

The concept of media accountability is widely used but remains inadequately defined in the literature and often is restricted to a 1-dimensional interpretation. This study explores perceptions of accountability as manifestations of claims to responsibility, based on philosophical conceptions of the 2 terms, and suggests media accountability be more broadly understood as a dynamic of interaction between a given medium and the value sets of individuals or groups receiving media messages. The shape-shifting nature of the concept contributes to the volatility (...) of debate surrounding conflicting notions of press freedom and responsibility. (shrink)

Questions about dirty hands have often focused on legitimate, secure leaders deciding whether to violate important deontological principles or the rules of interpersonal morality. The purpose of this paper is to show that revolutionaries have dirty hands; revolutionaries do wrong by engaging in unilateral usurpation of the existing system with the hope that latter benefits will justify their actions. Yet, once the revolution securely generates improvements for the common good, the initial usurpation becomes increasingly irrelevant to judgments of the new (...) government’s legitimacy. The paper argues that only retroactive justification—where later success forces opponents and advocates to reinterpret the wrongness of the initial action—can fully capture the complex moral dynamics of revolutions. (shrink)

Volume 35, Issue 2, April-June 2020, Page 67-67.

A significant criticism of the anthropic principle as a scientific claim is that testable predictions cannot be derived from it. Brandon Carter has argued, however, that the principle can be used to predict on the one hand that the period of time biological evolution is intrinsically likely to require is very large, and on the other that the number of ‘critical steps’ that have occurred in the evolution of life on earth is related to the length of time life can (...) continue to evolve. I attempt to show that neither of Carter's arguments provides a convincing defence of the testability of the anthropic principle. (shrink)

Cognitive states as well as cognitive commodities play central though distinct roles in our epistemological theories. By being attentive to how a difference in their roles affects our way of referring to them, we can undoubtedly accrue our understanding of the structure and functioning of our main epistemological theories. In this paper we propose an analysis of the dichotomy between states and commodities in terms of the method of abstraction, and more specifically by means of infomorphisms between different ways to (...) classify states of information, information-bases, and evidential situations. (shrink)

This book is about what makes law possible. A stranger to contemporary legal practice might think such a book unnecessary, but the eight authors of this book share the view that what makes law possible is under siege today. The authors also share the hope that by exploring how law is a humanistic practice that involves whole persons, the siege will be reversed. The pathbreaking work of University of Michigan Law professor Joseph Vining provides the authors' focus for their varied (...) analyses of how law works not through force but, instead, through affinity.Vining's four books and other writings, spanning four decades, reveal the hidden connections by which men and women freely create and sustain a world of meaning through the phenomena we associate with law. Drawing on legal philosophy, theology, musicology, and other humanistic disciplines, the authors join Vining in discovering how law is, as Vining has written, “evidence of view and belief far stronger than academic statement or introspection can provide.” Law as Vining and the other authors reveal it is evidence of our better selves, not of the totalizing and brutalizing selves humans are capable of becoming, sometimes even under cover of law.In addition to the three editors, the book's authors are Joseph Vining, Rev. John McCausland, Hon. John T. Noonan, Jr., Steven Smith, and James Boyd White.Lawyers and all who care about law, the human future, and what human freedom can do to connect person to person as valued will find much to ponder in the chapters of this book. By avoiding jargon and the cliché, the authors follow Vining's lead in illuminating the deep springs of law's vitality and authority. (shrink)

In his most recent book Alasdair MacIntyre criticizes the dominant moral system of advanced societies, which “presents itself as morality as such.” Yet, he argues, its primary function is to channel human desires into patterns that will minimize conflict amid distinctively modern economic and political arrangements. Although he appreciates how what he calls “expressionism” has unmasked this ideological function of modern morality, he points out that expressionism is also impotent to provide adequate moral guidance amidst the “conflicts of modernity.” He (...) proposes that Neo-Aristotelianism’s account of reasoning and desire has the ability to overcome the moral failings of these modern modes of thought. Yet he relies on an excessively deductive version of reason and overlooks Aristotle’s fuller account of desire. The article shows how Bernard Lonergan’s account of both provides a superior account of both Aristotle’s own writings and the actual human phenomena of reasoning and desire. (shrink)