Highly portable and accessible MRI technology will allow researchers to conduct field-based MRI research in community settings. Previous guidance for researchers working with fixed MRI does not address the novel ethical, legal, and societal issues (ELSI) of portable MRI (pMRI). Our interdisciplinary Working Group (WG) previously identified 15 core ELSI challenges associated with pMRI research and recommended solutions. In this article, we distill those detailed recommendations into a Portable MRI Research ELSI Checklist that offers practical operational guidance for researchers contemplating (...) using this technology. (shrink)

In Situations and Individuals, Paul Elbourne argues that the natural language expressions that have been taken to refer to individuals — pronouns, proper names, and definite descriptions — have a common syntax and semantics, roughly that of definite descriptions as construed in the tradition of Frege. In the course of his argument, Elbourne shows that proper names have previously undetected donkey anaphoric readings.This is contrary to previous theorizing and, if true, would undermine what philosophers call the direct reference theory (...) (which holds that the sole contribution of a proper name to the truth conditions of a sentence is an individual) as well as the related doctrine that proper names are rigid designators. Elbourne begins by addressing donkey anaphora, relating other concerns about pronouns to the solution of this notorious problem. His subsequent argumentation provides a unified semantics for the donkey anaphoric and bound and referential uses of pronouns and discusses the prospect of unifying the syntax and semantics of pronouns with the syntax and semantics of normal definite descriptions. Elbourne's aim is not only to advance his proposal of a unified syntax and semantics but also to urge linguists and philosophers dealing with pronoun interpretation to consider a wider range of theories than they do at present, and to test the competing claims of description-based theories and dynamic semantics against the data. (shrink)

The present article illustrates a conflict between the claim that rational belief sets are closed under deductive consequences, and a very inclusive claim about the factors that are sufficient to determine whether it is rational to believe respective propositions. Inasmuch as it is implausible to hold that the factors listed here are insufficient to determine whether it is rational to believe respective propositions, we have good reason to deny that rational belief sets are closed under deductive consequences.

In attempting to form rational personal probabilities by direct inference, it is usually assumed that one should prefer frequency information concerning more specific reference classes. While the preceding assumption is intuitively plausible, little energy has been expended in explaining why it should be accepted. In the present article, I address this omission by showing that, among the principled policies that may be used in setting one’s personal probabilities, the policy of making direct inferences with a preference for frequency information for (...) more specific reference classes yields personal probabilities whose accuracy is optimal, according to all proper scoring rules, in situations where all of the relevant frequency information is point-valued. Assuming that frequency information for narrower reference classes is preferred, when the relevant frequency statements are point-valued, a dilemma arises when choosing whether to make a direct inference based upon relatively precise-valued frequency information for a broad reference class, R, or upon relatively imprecise-valued frequency information for a more specific reference class, R*. I address such cases, by showing that it is often possible to make a precise-valued frequency judgment regarding R* based on precise-valued frequency information for R, using standard principles of direct inference. Having made such a frequency judgment, the dilemma of choosing between and is removed, and one may proceed by using the precise-valued frequency estimate for the more specific reference class as a premise for direct inference. (shrink)

Abstract.In evolving to its great size the human brain has retained the distinctive features and chemistry of three kinds of brains that reflect an ancestral relationship to reptiles, early mammals, and late mammals. It constitutes, so to speak, a psychencephalon comprised of three‐brains‐in‐one, a triune brain. In the evolution from reptiles to mammals two key changes were the development of nursing and maternal care. Through the agency of “newer” parts of the brain a parental concern for family eventually generalizes not (...) only to other members of the species but to the entire biosphere, a psychological development that amounts to the evolution of responsibility and what we call conscience. Given our freedom to decide “yes” or “no” on various issues, we need not look beyond the evolving family to find a reason for being, an ethic to live by. (shrink)

This article explores Karl Barth's early and later understanding of the incarnation with a view toward answering two very important theological questions: did Barth so historicize his Christology in his doctrine of Reconciliation that he could no longer accept his own earlier view that “His Word would still be His Word apart from this becoming [incarnate], just as Father, Son and Holy Spirit would be none the less eternal God, if no world had been created”? Or did his earlier view (...) enable him to present a more powerful understanding of how God himself was at work in the history of Jesus of Nazareth and in human history effecting the reconciliation of the world both from the side of God and from the human side? This article argues that Barth never historicized his Christology to such an extent that he ever would have espoused the idea that Jesus' human history “constituted” his being as the second person of the Trinity, since any such thinking undermines Barth's belief that Jesus' divinity must be recognized as “definitive, authentic and essential” if it is to be truly recognized at all. It is further argued that those who do espouse this view have confused epistemology and ontology by mistakenly assuming that since we cannot know the eternal Trinity except through the human history of Jesus as the incarnate Word, that must mean that the eternal Word never existed without that human history so that, strictly speaking, we can no longer distinguish between the immanent and the economic Trinity and the logos asarkos and logos incarnandus . This article suggests that those who hold that God realizes his own eternal being by suffering and dying for us have missed a crucial point of Barth's trinitarian doctrine which is that God realizes his purposes for us in the suffering, death and resurrection of Jesus, but that he did not thereby realize his own being as the triune God, since God's eternal being and act does not need any realization by virtue of the fact that God is perfect and acts toward us in the overflow of that perfect love in perfect freedom. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:SOME DOGMATIC CONSEQUENCES OF PAUL F. KNITTER'S UNITARIAN THEOCENTRISM PAUL D. MOLNAR St. John's University Jamaica, New York EACTIONS TO Paul Knitter's No Other Nanie? vary from criticizing his "unitarian theocentrism" 1 and his sliding away from "creedal Chrisitology" 2 to unequivocail endorsement of his" less Christocentric approach to a theo1ogy of religions;" 3 this shows the challenge Knitter poses to current dogmatics. This 1arHcile w1ll (...) explore three critical dogmatic issues related to Knitter's non-normative ChristoJogy. First, can the idea that Jesus is one savior among others be defonded froni within the Christian-Catholic 1tradition without yie1ding the truth of Christology? Second, if "Jesus remains universailly normativ ;e " for Christians while " other revelations or rev;ea:lers might also be universaUy normative," then does this not p:vomote some form of docetic Christology and lead to a unitarianism, exduded by the naiture of the God revealed in Christ? Third, on the basis of " l'eligious experience " Knitter olaims to perceive an" evolution from ecolesiocentrism to chrfatocentrism to theocentrism" and finally to "soteriooentrism." 4 Is there 1!1ea1ly such an evolution? And if there is noit, oan those who de- ~end the tradition succeed by arguing from experience and praxis rather than from revelation and faith? 5 Moreover, if 1"Review Symposium: Paul Knitter's No Other Name?: A Critical Survey of OMistian Attitudes toward the World Religions," in Horizons 13 (1986): 116-135. This is the view of Daniel Sheridan, p. llS. 2 This is the view of Denise Carmody. Ibid., p. 122. s This is the view of William Cenkner. Ibid., p. 127. 4 Ibid., pp. 133-34. 5 Denise Carmody, e.g., believes that we should stress praxis more than 449 450 PAUL D. MOLNAR we think the tradition should not be defended, have we not ceased to think about theological truth? Rather, have we not made divinity itself indis:tingiuishab1e from our human experiences and praxis at the outset? And does this not open the door to both polytheism allJd pantheism? By making God hut noit Christ normative, Knitter's " nonnormati ¥e" Christology re-1transiates the truth of Jesus' oonsubstantiality with the Father into the content of a myth, an experienice or a vailue judgment having no re1ality in itseH.6 It then defines :reveiLation and salvation.aocording to a unitarian view of God. While Knitter denies this,7 his reasoning aictuaUy is unitarian: In my proposed model, Jesus remains universally normative, but I am asking whether Christians can recognize that other revelations or revealers might also be universally normative. Could there be a complementary uniqueness among the religious traditions of the world? To try to answer that question, 'intellectual conversion;... is a requisite. But it will have to be an intellectual conversion that walks more than' the way to Nicea and Chalcedon'... only on the basis of the praxis of authentic dialogue-grounded in intellectual, moral, and religious conversion-can we know the unique~ ness of Christ.8 doctrine without relativizing Christ. Thus, for her, Rahner's Christology does not mean " that Christians cannot be open to the Buddha or Lord Krishna," Ibid., p. 126. The problem is that this very thinking already relativizes Christ. 6 Even theologians who do not intend the radical views of John Hick run a similar risk by beginning Christology from below in the manner of Paul Knitter. Cf., e.g., Edward L. Krasevac, O.P., "' Christology From Above' And 'Christology From Below '," The Thomist, 51 (1987) : 299-306, arguing that "Christological faith is an apostolic faith that has its origins in a historical process which began with the public ministry of our Lord...." (p. 300) causes us to ask what makes Christology true? Is it "the actual apostolic process " (306) or is it Jesus as the Lord who is and remains the sole foundation and validation for faith in any age? Does this approach not leave the door open to the kind of evolution which Knitter claims to have discovered in Christianity, which then enables him to move beyond Jesus as the only Lord and Savior? 1 Review Symposium, Horizons, p. 131. s Ibid., p. 133. KNITTER'S UNITARIAN THEOCENTRISM 451 Here the ha:.sis... (shrink)

In previous work, we studied four well known systems of qualitative probabilistic inference, and presented data from computer simulations in an attempt to illustrate the performance of the systems. These simulations evaluated the four systems in terms of their tendency to license inference to accurate and informative conclusions, given incomplete information about a randomly selected probability distribution. In our earlier work, the procedure used in generating the unknown probability distribution (representing the true stochastic state of the world) tended to yield (...) probability distributions with moderately high entropy levels. In the present article, we present data charting the performance of the four systems when reasoning in environments of various entropy levels. The results illustrate variations in the performance of the respective reasoning systems that derive from the entropy of the environment, and allow for a more inclusive assessment of the reliability and robustness of the four systems. (shrink)

Of the six basic categories which a normative ethical theory may recognize and exemplify, The first five are fairly clearly employed by kant in the "tugendlehre", But the sixth is not given adequate recognition by him. In order to establish those conclusions, One has to investigate the leading notion of the "tugendlehre", That of obligatory ends. Closely connected with that notion is kant's division of duties into perfect and imperfect ones. Consideration of a number of ways of elucidating that division (...) leads one to conclude that it is not really so sharp as kant suggests. The sphere of duty comprises a continuum of duties of wider and of narrower obligation; beyond that sphere belong many things which one morally "ought" to prize and to pursue, But which do not constitute obligatory ends for men. (shrink)

The point, for the 946,326th time is that people get elected to office by currying the favor of powerful interest groups. They don’t get elected for their excellence as political philosophers.Congress has consistently failed to solve some serious problems with the cost, effectiveness, and safety of pharmaceuticals. In part, this failure results from the pharmaceutical industry convincing legislators to define policy problems in ways that protect industry profits. By targeting campaign contributions to influential legislators and by providing them with selective (...) information, the industry manages to displace the public’s voice in developing pharmaceutical policy. (shrink)

The molecular mechanism of temperature‐dependent sex determination (TSD) is a long‐standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. Here we propose a novel hypothesis we call 3D‐TSD (the three dimensions of thermolabile sex determination). We postulate that the genome has capacity to remodel (...) in response to temperature by changing 3D chromatin conformation, perhaps via temperature‐sensitive transcriptional condensates. This could rewire enhancer–promoter interactions to alter the expression of key sex‐determining genes. This hypothesis can accommodate monogenic or multigenic thermolabile sex‐determining systems, and could be combined with upstream thermal sensing and transduction to the epigenome to commit gonadal fate. (shrink)

This article is the attempt at a dialogue with Bruce McCormack about the position he espoused in The Cambridge Companion to Karl Barth concerning the relation between God's Election of grace and God's Triunity. I had criticized McCormack's position in my book, Divine Freedom and the Doctrine of the Immanent Trinity (2002), but I did not elaborate on it in great detail. To develop the dialogue I will: 1) consider McCormack's claim that in CD II/2 Barth made Jesus Christ “rather (...) than” the Eternal Logos the subject of election; 2) consider what Barth means when he speaks of Jesus Christ “in the beginning”; 3) compare McCormack's thesis that the Father never had regard for the Son, apart from the humanity to be assumed, with Barth's belief that we must not dispute the eternal will of God which “precedes even predestination”; 4) analyze in detail McCormack's rejection of Barth's belief that the logos asarkos in distinction from the logos incarnandus is a necessary concept in trinitarian theology; 5) discuss Barth's concept of the divine will in relation to the concept advanced by McCormack and suggest that McCormack has fallen into the error of Hermann Schell by thinking that God in some sense takes his origin from himself, so that God would only be triune if he elected us; 6) explain why it is a problem to hold, as McCormack does, that God's self-determination to be triune and his election of us should be considered one and the same act; and finally 7) explain McCormack's confusion of time and eternity in his latest article on the subject in the February, 2007 issue of the Scottish Journal of Theology, and his own espousal of a kind of indeterminacy on God's part (which he theoretically rejects). (shrink)

It is hypothesized that repeated, non‐invasive stimulation of the vestibular (balance) system, via a small electrical current to the skin behind the ears, will cause the brain centers that control energy homeostasis to shift the body toward a leaner physique. This is because these centers integrate multiple inputs to, in effect, fix a set‐point for body fat, which though difficult to alter is not immutable. They will interpret repeated stimulation of the parts of the vestibular system that detect acceleration as (...) a state of chronic activity. During such a physiologically challenging time it is preferable, from an energy homeostasis viewpoint, to both utilize fat reserves, and reduce the volume of these reserves and thus the energy cost of carrying them around. Hence, this type of vestibular stimulation could potentially be a therapeutic option for metabolic syndrome disorders such as obesity. This hypothesis is eminently testable via a clinical trial. (shrink)

In summary, then, I have presented a program for analysis of physical causal statements in terms of the following metaphysical primitives: space (made up of ordered points), time (also ordered and punctiliar), causal density, haecceity and causal necessity. These can be ‘read off’ the theories in question. I claim that theevent-singular cases are crucial, and that other cases can be reduced to this via set theory and (causal) modal logic. I have given several examples of this sort of translation and (...) a rough indication of how more complicated cases could be dealt with. (shrink)

Drawing on past work, we introduce a new approach to the New Riddle of Induction, showing that the inductive projection of gruesome properties is unreliable under particular ideal conditions that are sufficient for the reliable inductive projection of non-gruesome properties. As an auxiliary to our account, we introduce rules for resolving conflicts between background information and the conclusions of otherwise reliable inductive inferences. Our approach to the New Riddle of Induction is quite permissive in the range of properties it recognizes (...) as suitable for inductive projection, allowing for the inductive projection of highly gerrymandered non-natural properties. However, as an addendum to our discussion of the New Riddle, we show that natural properties do form a more reliable basis for inductive projection in cases where one’s sample is small. (shrink)

On July 2, 2001, a medical milestone was reached when Robert Tools received a total artificial heart implant at Jewish Hospital in Louisville, Kentucky. Tools was implanted with an AbioCor artificial heart, one of several brands of new-generation artificial hearts that has been approved by the U.S. Food and Drug Administration for clinical trial. The AbioCor heart was developed by Abiomed of Danvers, Massachusetts.Following the surgery, physicians were guardedly enthusiastic about the device and optimistic about the patient’s future. Tools, 59, (...) has had a history of numerous heart attacks and by-pass surgery, as well as diabetes and kidney problems. He met the requirements of the AbioCor protocol because he was not a candidate for transplant, death was otherwise probable within thirty days, and other interventions were deemed ineffective. Researchers hope that strengthening his heart function will result in increased function of his other vital organs, thus prolonging the patient's life and increasing his energy. But because the device is experimental, nothing can be promised. (shrink)

This article presents results from a simulation‐based study of inheritance inference, that is, inference from the typicality of a property among a “base” class to its typicality among a subclass of the class. The study aims to ascertain which kinds of inheritance inferences are reliable, with attention to the dependence of their reliability upon the type of environment in which inferences are made. For example, the study addresses whether inheritance inference is reliable in the case of “exceptional subclasses” (i.e., subclasses (...) that are known to be atypical in some respect) and attends to variations in reliability that result from variations in the entropy level of the environment. A further goal of the study is to show that the reliability of inheritance inference depends crucially on which sorts of base classes are used in making inferences. One approach to inheritance inference treats the extension of any atomic predicate as a suitable base class. A second approach identifies suitable base classes with the cells of a partition (of a preselected size k) of the domain of objects that satisfies the condition of maximizing the similarity of objects that are assigned to the same class. In addition to permitting more inferences, our study shows that the second approach results in inheritance inferences that are far more reliable, particularly in the case of exceptional subclasses. (shrink)

There are two central distinctions upon which the present argument is predicated. First is the distinction between two correlative aspects of what is involved in a value-judgment or in an “experiencing” of value: actualized-value and value-ideal. This we find to be a distinction without which all attempt at clear talk about “value” is so hopelessly ambiguous as to be unintelligible. Second is the distinction between property-platonism and platonism-proper. After these two sets of distinctions have been explicated, our thesis will be (...) pursued: Moore is not a value-platonist-proper at all, because his famous “non-natural” property, goodness, is not a value-ideal. Moore is merely a value-property-platonist. (shrink)

The advent of digital cameras has provided photographers, with varying levels of expertise, the opportunity to accumulate large repositories of digital images. However, this expansion has also brought the attendant difficulty of image retrieval. This paper reviews the considerable work already carried out on image retrieval and identifies critical constraints in attempting to handle the underlying semantics of photographic images. The authors address the issue of how an amateur photographer, storing several thousand images a year, can effectively and efficiently manage (...) a personal collection. A number of surprisingly simple techniques are proposed utilising a sparse lexical ontology alongside iconic visual clues to identify key representative events in the collection. The photographer’s associated knowledge and experience, often shared by others who are attuned to the context of the collection, are critical to the effective management of the images. The authors recommend the use of existing browsers and a simple keyword table to facilitate concise and effective image storage and retrieval. Photographers can further enrich the representation of their collection by clustering images in accordance with their perceived relevance and aesthetic qualities. The authors argue that these properties can also be exploited to enhance retrieval. (shrink)

This 2004 book reconfigures the basic problem of Christian thinking - 'How can human discourse refer meaningfully to a transcendent God?' - as a twofold demand for integrity: integrity of reason and integrity of transcendence. Centring around a provocative yet penetratingly faithful re-reading of Kant's empirical realism, and drawing on an impelling confluence of contemporary thinkers Paul D. Janz argues that theology's 'referent' must be located within present empirical reality. Rigorously reasoned yet refreshingly accessible throughout, this book provides an (...) important, attentively informed alternative to the growing trends toward obscurantism, radicalization and anti-reason in many recent assessments of theological cognition, while remaining equally alert to the hazards of traditional metaphysics. In the book's culmination, epistemology and Christology converge around problems of noetic authority and orthodoxy with a kind of innovation, depth and straightforwardness that readers of theology at all levels of philosophical acquaintance will find illuminating. (shrink)

Circadian rhythms are responsible for 24‐hour oscillations in diverse biological processes. While the central genes governing circadian pacemaker rhythmicity have largely been identified, clock‐controlled output molecules responsible for regulating rhythmic behaviors remain largely unknown. Two recent reports from McDonald and Rosbash1 and Claridge‐Chang et al.2 address this issue. By identifying a large number of genes whose mRNA levels show circadian oscillations, the reports provide important new information on the biology of circadian rhythm. In addition, the reports illustrate both the power (...) and limitations of microarray‐based methods for profiling mRNA expression on a genomic scale. BioEssays 24:494–498, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Many commentators on Kant’s views on idealism, such as Kemp-Smith [1918], Strawson [1966] and, more recently, Guyer [1983 and 1987], begin by offering two choices. Either objects in space are nothing in themselves, or they exist independently of all knowers and all thought. After a fleeting, adolescent romance with idealism in the first edition of the Critique of Pure Reason Kant is often said to emerge a mature realist in the second edition. It is said that for the later Kant (...) there is a noumenal realm of things-in-themselves which metaphysically grounds the phenomena we experience. We cannot have knowledge of things-in-themselves for reality must be taken as it comes, transformed by human cognitive capacities. Kant’s empirical realism is thus a genuine realism since it involves an ontologically separate mind-independent reality; yet it is an empirical realism because reality is accessible only by means of its causal impact on the senses. Moreover Kant is still an idealist since he holds that the nature of reality as experienced by humans is dependent on their cognitive structure. (shrink)