Genotoxic stress leads to DNA damage which can be detrimental to the cell. A well‐orchestrated cellular response is mounted to manage and repair the genotoxic stress‐induced DNA damage. Our understanding of genotoxic stress response is derived mainly from studies focused on transcription, mRNA splicing, and protein turnover. Surprisingly not as much is understood about the role of mRNA translation and decay in genotoxic stress response. This is despite the fact that regulation of gene expression at the level of mRNA translation (...) and decay plays a critical role in a myriad of cellular processes. This review aims to summarize some of the known findings of the role of mRNA translation and decay by focusing on two categories of examples. We discuss examples of mRNA whose fates are regulated in the cytoplasm and RNA‐binding proteins that regulate mRNA fates in response to genotoxic stress. (shrink)

Opening the round table, I. T. Frolov, editor-in-chief of Voprosy filosofii, stated that discussing problems of this type today, the task lies not so much in emphasizing their general and traditional aspects but in finding a scientific and practical solution to new problems of interaction of man and nature that can now be solved only on a global scale. Furthermore, he observed that discussion of these problems as questions of morality, in terms of pessimistic or optimistic evaluation, is very important (...) but certainly entirely inadequate. Not only social and philosophical but many political conclusions follow from a discussion of problems of interaction between man and nature. Investigation and solution of these problems, which require concrete scientific and practical approaches, may facilitate the development of such policies as peaceful coexistence, strengthening of neighborly treaty relations, and so forth. Solving these problems will help peoples come closer together and contribute to the firmer establishment of peace throughout the world. (shrink)

-- v. 4. Tshad ma rig pa -- v. 5. Dbu ma -- v. 6. Mdzod ʼdul.

Many different writers have employed what might be termed the ‘existence criterion’ when offering realist analyses of perception. In all these realist accounts, a basic argument may be detected. If any experience—e.g. the having of either a sensory or a mental image—is to be a form of perceiving, then the statement reporting that experience must satisfy a condition which applies to all perceiving-statements. Any putative perceptual statement of the form ‘S perceives x’ must entail a statement to the effect that (...) x, or some y, does exist as a public perceptual object in S’s perceptual range. For example, my statement ‘I see Peter’ will be a proper perceptual statement only if Peter is a public perceptual object now in my line of vision, or only if I take some other public perceptual object now in my line of vision to be Peter. Statements about our having images of things, this basic argument continues, cannot satisfy this condition. The object imaged —e.g. Peter—is not always present in the subject’s perceptual range at the time of the imaging, and the subject does not necessarily take a public perceptual object in his perceptual range to be that object. Hence, any statement reporting our imaging something must be false if it is construed as a report of a perceiving. (shrink)

t. 1. Igry rynka -- t. 2. Torgovet︠s︡ v Khrame.

Sanskrit treatise on Jaina ethics and doctrines.

-- ch. 2. Tekhnosfera i osnovy sovremennykh tekhnologiĭ.

Après avoir situé la signification politique de la Convention et du projet de Constitution, l’article analyse la place reconnue aux valeurs dans le projet européen, d’abord dans l’histoire de l’institution européenne depuis 1950, ensuite dans son développement. Il met ensuite en avant la nécessité d’un débat politique interconvictionnel sur les questions fondamentales du sens dans la société européenne. Il situe dans ce cadre les débats difficiles qui ont eu lieu autour des préambules de la Charte des droits fondamentaux et de (...) la Constitution , et autour de l’article 51 . Enfin, il explicite quelques conditions d’une participation féconde des Églises au débat européen. (shrink)

The systems approach and systems research as a whole are currently experiencing a period of intensive development, which is due both to widening of their areas of application and incorporation into this area of various kinds of practical activity connected with science and technology and to a more intensive treatment of certain aspects of this approach. All of this inevitably demands further development of the philosophical range of inquiry into the systems approach.