In what constitutes the only English-language collection of essays ever dedicated to the analysis of Montesquieu's contributions to political science, the contributors review some of the most vexing controversies that have arisen in the interpretation of Montesquieu's thought. By paying careful attention to the historical, political, and philosophical contexts of Montesquieu's ideas, the contributors provide fresh readings of The Spirit of Laws, clarify the goals and ambitions of its author, and point out the pertinence of his thinking to the problems (...) of our world today. (shrink)

Taking a broad historical perspective, Public Passion traces the role of emotion in political thought from its prominence in classical sources, through its resuscitation by Montesquieu, to the present moment. Combining intellectual history, philosophy, and political theory, Rebecca Kingston develops a sophisticated account of collective emotion that demonstrates how popular sentiment is compatible with debate, pluralism, and individual agency and shows how emotion shapes the tone of interactions among citizens. She also analyzes the ways in which emotions are (...) shared and transmitted among citizens of a particular regime, paying particular attention to the connection between political institutions and the psychological dispositions that they foster. Public Passion presents illuminating new ways to appreciate the forms of popular will and reveals that emotional understanding by citizens may in fact be the very basis through which a commitment to principles of justice can be sustained. (shrink)

This article examines the formation of consciousness among women at the beginning stages of the women's movement. The author analyzes the complexity of pathways to feminism across the political spectrum, comparing women who were active on the Left in Students for a Democratic Society with women active in the leading conservative organization of the 1960s, Young Americans for Freedom. She finds an unexpected division among women in both groups between those who identify discrimination by their male peers and those who (...) do not. The author argues there are three stages in the formation of feminist consciousness: identification of inequality or mistreatment, discovering a language or framing by which to interpret these experiences, and the social construction of a collective identity. Factors for each of these three stages that help or hinder the formation of feminist consciousness are discussed. (shrink)

ExcerptI have apologized privately to Prof. Perry—and do so again publicly—for my incorrect notation about her speech and my lack of precise citation. I was unaware of the published article, but had heard the speech at a regional AAS conference. I made assumptions about its nature (not its content) that I should not have done. I do not wish to elaborate here on our different ways of framing historical arguments and questions. Over many years, I have been an admiring reader (...) of Prof. Perry's impressive corpus of work, even as I have disagreed with elements of it (as is normal…. (shrink)

What role does audience uptake play in determining whether a speaker refuses or consents to sex? Proponents of constitution theories of uptake argue that which speech act someone performs is largely determined by their addressee’s uptake. However, this appears to entail a troubling result: a speaker might be made to perform a speech act of sexual consent against her will. In response, we develop a social constitution theory of uptake. We argue that addressee uptake can constitute a speaker’s utterance of (...) ‘no’ as a speech act of consent under some conditions, but that this does not prevent us from judging that an addressee committed rape. Second, we claim that addressee uptake is not the only form of uptake that matters—the uptake of other members of the discursive community matters too, and can override the addressee’s uptake, constituting the speaker’s utterance as the speech act it was intended to be. (shrink)

Members of the serine/arginine (SR)‐rich protein family of splicing factors play versatile roles in RNA processing steps and are often essential for normal development. Dynamic changes in RNA processing and turnover allow fast cellular adaptions to a changing microenvironment and thereby closely cooperate with transcription factor networks that establish cell identity within tissues. SR proteins play fundamental roles in the processing of pre‐mRNAs by regulating constitutive and alternative splicing. More recently, SR proteins have also been implicated in other aspects of (...) RNA metabolism such as mRNA stability, transport and translation. The‐ emerging noncanonical functions highlight the multifaceted functions of these SR proteins and identify them as important coordinators of gene expression programmes. Accordingly, most SR proteins are essential for normal cell function and their misregulation contributes to human diseases such as cancer. (shrink)

A recent spate of exposés about Mao Zedong's China, in English and Chinese, announces a finality to the tendency toward the temporal-spatial conflation of twentieth-century Chinese and global history. This sense was confirmed when the New York Times reported in late January 2006 that George W. Bush's recent bedtime reading had been Jung Chang and Jon Halliday's Mao: The Unknown Story,1 or when, later in 2006, according to a column in the British paper The Guardian, “the Council of Europe's parliamentary (...) assembly voted to condemn the ‘crimes of totalitarian communist regimes’, linking them with Nazism.”2 The temporal-spatial conflation hence is,…. (shrink)

Children’s fine motor skills link to cognitive development, however, research on their involvement in language processing, also with adults, is scarce. Lexical items are processed differently depending on the degree of sensorimotor information inherent in the words’ meanings, such as whether these imply a body-object interaction or a body-part association. Accordingly, three studies examined whether lexical processing was affected by FMS, BOIness, and body-part associations in children and adults. Analyses showed a differential link between FMS and lexical processing as a (...) function of age. Whereas response latencies indicated that children’s FMS were associated with “hand” words, adults’ FMS linked to the broader concept of BOI. Findings have implications for shared activation theories positing that FMS support lexical processing. (shrink)

In qualitative research into emotions, researchers and participants share emotion-laden interactions. Few demonstrate how the analytic value of emotions may be harnessed. In this article we provide an account of our emotional experiences conducting research with two groups: adults living with cystic fibrosis and spouse caregivers of cancer patients. We describe our emotion work during research interviews, and discuss its methodological and theoretical implications. Reflections depict competing emotion norms in qualitative research. Experiences of vulnerability and involuntary “emotional callusing” illustrate the (...) insight into participants’ experiences afforded to us through emotion work. This prompted us to extend Hochschild’s theory to incorporate unconscious activity mediated through habitus, allowing us to demonstrate how the “emotional” nature of emotions research can galvanize analytic insight. (shrink)

In this review, we discuss the application of mouse models to the identification and pre‐clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large‐scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross‐species comparative ‘omics‐based approaches to this problem. We highlight recent progress in modelling late‐stage disease using mice, (...) and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection. (shrink)

Given the undeniable hype around artificial intelligence (AI), it is imperative to investigate both how researchers of AI negotiate this hype as well as wrestle with it in their research. To do so, we study the perspectives of these scientists actively transforming contemporary life via machine learning (ML). Using qualitative interviews with 108 researchers, we explore communication challenges: addressing the hype surrounding AI and ML, communicating technical knowledge, and publication pressures. We report how these unique conditions shape this population’s writing (...) practices: document cycling, writing-to-learn, and video production/social media activity. Ultimately, we aim to provide insight into the breadth of practices in this rapidly-evolving discipline, without advocating for any. (shrink)

ABSTRACTIn two experiments, we explored whether anecdotal stories influenced how individuals reasoned when evaluating scientific news articles. We additionally considered the role of education level and thinking dispositions on reasoning. Participants evaluated eight scientific news articles that drew questionable interpretations from the evidence. Overall, anecdotal stories decreased the ability to reason scientifically even when controlling for education level and thinking dispositions. Additionally, we found that article length was related to participants' ratings of the news articles. Our study demonstrates that anecdotes (...) can discourage scientific reasoning while also pointing to the potential influence of article length on judgements of quality. (shrink)

In his metaphysical summa of 1986, The Plurality of Worlds, David Lewis famously defends a doctrine he calls ‘modal realism’, the idea that to account for the fact that some things are possible and some things are necessary we must postulate an infinity possible worlds, concrete entities like our own universe, but cut off from us in space and time. Possible worlds are required to account for the facts of modality without assuming that modality is primitive – that there are (...) irreducibly modal facts. We argue that on one reading, Lewis’s theory licenses us to assume maverick possible worlds which spread through logical space gobbling up all the rest. Because they exclude alternatives, these worlds result in contradictions, since different spread worlds are incompatible with one another. Plainly Lewis’s theory must be amended to exclude these excluders. But, we maintain, this cannot be done without bringing in modal primitives. And once we admit modal primitives, bang goes the rationale for Lewis’s modal realism. (shrink)

Science and Community: Ending Obesity Improving Health (S&C) aimed to reduce obesity in Houston by developing community partnerships to identify research priorities and develop a sustainable obesity reduction program. Partnership members were recruited from S&C events and invited to participate in in‐depth interviews to gain insight into obesity prevalence, causes, and solutions. Members (n = 22) completed a 60–90‐min in‐depth interview. The interview guide consisted of 30 questions about pressing health problems in the community, potential solutions to health problems and (...) obesity and how the environment has impacted obesity and health behaviors in the community. Interviewees (n = 12 women and 10 men) were mostly Hispanic/Latino (n = 9) and African American (n = 7). Common problems identified were childhood obesity, balancing a healthy diet and physical inactivity. Interviewees identified obesity as a major problem in their communities and cited access to quality food and physical activity resources as both a problem and a solution. Additional emergent themes focused on solutions, including increasing awareness and education, coordinated efforts among organizations and using an ecologic approach to combat obesity. Community insight gleaned from this study may be used to enhance relevance and sustainability of programs developed to reduce obesity and suggests possible avenues for participatory research and intervention. (shrink)

Cette étude examine les pratiques du Parlement de Bordeaux dans les années 1714-1726. Nouvelle interprétation de la théorie politique de Montesquieu.

" "Montesquieu and His Legacy supplements the conventional focus on the institutional teachings of Montesquieu with attention to the theme of morals and manners ...

Volume 24, Issue 6, September 2019, Page 676-679.

This article provides an assessment of Jeremy Waldron's arguments (in God, Locke and Equality and his subsequent 'Response to Critics') that Locke provides us with a compelling version of liberal equality. A close examination of the case of the criminally convicted in The Second Treatise shows how Locke's commitment to the principle of equality is compromised. This is revealed in part through recourse to contextualist considerations. This leads to the suggestion that Waldron's principled rejection of contextualist approaches to the history (...) of political ideas can lead to a distorted understanding. It also suggests a need for a more thorough consideration of how a substantive principle of moral equality should apply in the field of criminal justice and in liberal democracy more generally. (shrink)

Language plays a role in the genocide of the Rohingya people in Myanmar and continues to shape their experiences in displacement, yet their linguistic rights are rarely discussed in relation to their human rights and humanitarian concerns. International human rights standards offer important foundations for conceptualizing the “right to language” and identifying how linguistic rights can be violated both in situ and in displacement. The Rohingya case highlights how language policies are weaponized to oppress unwanted minorities; their outsider status is (...) reinforced by the country’s language education policy and they face additional rights challenges in displacement—including obstacles to effectively accessing humanitarian aid. Moving forward, norms associated with self-determination and language rights offer a conceptual foundation for shifting attitudes and altering negative perceptions of Rohingya identity. (shrink)

This essay aims to elucidate how multiple voices and traditions should interact with one another in the practice of ethics. First, it explores some of the major ways in which questions of bodily autonomy function in secular feminist and Jewish bioethical discourses. It then uses case studies to illuminate ways each discourse's concepts of bodily autonomy can be deeply problematic, and argues that the strengths in each discourse can serve as important correctives for the weaknesses in the other. It suggests (...) that some formal features of rabbinic texts can serve as a model for a discourse of constant and animated mutual correction. Finally, it examines two case studies in light of this model. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

A novel Protocol Ethics Tool Kit (‘Ethics Tool Kit’) has been developed by a multi-stakeholder group of the Multi-Regional Clinical Trials Center of Brigham and Women9s Hospital and Harvard. The purpose of the Ethics Tool Kit is to facilitate effective recognition, consideration and deliberation of critical ethical issues in clinical trial protocols. The Ethics Tool Kit may be used by investigators and sponsors to develop a dedicated Ethics Section within a protocol to improve the consistency and transparency between clinical trial (...) protocols and research ethics committee reviews. It may also streamline ethics review and may facilitate and expedite the review process by anticipating the concerns of ethics committee reviewers. Specific attention was given to issues arising in multinational settings. With the use of this Tool Kit, researchers have the opportunity to address critical research ethics issues proactively, potentially speeding the time and easing the process to final protocol approval. (shrink)

Bluffing, a common and consequential form of competitive behavior, has been comparably ignored in the management literature, even though misleading one's rivals is suggested to be an advantageous skill in a multifaceted and highly competitive environment. To address this deficiency and advance scholarship on competitive dynamics, our study investigates the moral reasoning behind competitive bluffing and, using a simulated market-entry game, examines the performance effects of bluffing. Findings suggest that decision makers' views on the ethicality of bluffing competitors differ from (...) their beliefs on the ethicality of misleading other organizational stakeholders. Analysis also indicates that decision makers who view competitor bluffing as more ethical (less unethical) are more willing to engage in competitive bluffing. Finally, while bluffing is often thought to be an effective business practice, results show that in the context of repeated interaction, bluffing is not conducive to high levels of performance and, in fact, can have undesirable consequences. (shrink)

The child was 2 years, 8 months old and weighed 25 pounds, one-fifth the weight of her mother, for whom she was to be the bone marrow donor. The mother had suffered a relapse of acute myelogenous leukemia; her physicians recommended a bone marrow transplant. The child was the closest human leukocyte antigen match and thus the best donor candidate for her mother's transplant.

Interprofessional education – students of different professions learning together, from and about each other – is increasingly common in health professional degrees. Despite its explicit aims of transforming identities, practices and relationships within/across health professions, IPE remains under-theorised sociologically, with most IPE scholarship focussed on evaluating specific interventions. In particular, the significance of a shared knowledge base for shaping professional power and subjectivity in IPE has been overlooked. In this paper we begin to develop a framework for theorising IPE in (...) allied health, by drawing parallels with a cognate area in which there has already been fruitful conceptual development: interdisciplinarity. Specifically, we offer a worked example of how the two areas may be brought into dialogue, by deploying Barry, Born and Weszkalnys’ conceptualisation of interdisciplinarity as a lens for understanding IPE. Following Barry et al. we delineate a number of ‘modes’ and ‘logics’ of knowledge-production that emerge both in IPE literature and in our own empirical study of IPE. Our empirical data are drawn from 32 semi-structured interviews with 19 allied health students participating in an IPE curriculum at one Australian university. Findings point to the emergence of interprofessional practitioner identities among students that have the potential to undermine traditional epistemological boundaries and transcend role-based distinctions in future health professions. We argue that Barry et al.’s ‘logic of ontology’ sheds light on previously unidentified processes of transformation within IPE, and offers a theoretical framework that can explain the importance of a shared pan-professional knowledge base for the reflexive individual construction of new interprofessional ontological subjects. (shrink)

The American Journal of Bioethics, Volume 12, Issue 1, Page 16-18, January 2012.

Previous research has suggested that corporate social performance is positively related to firms’ attractiveness as employers. The authors propose and test an alternative model whereby job applicants’ familiarity with employers mediates the relationship between corporate social performance and organizational attractiveness. Applicants’familiarity with firms may serve as a signal of firms’suitability as employers, with more familiar firms considered more attractive. Furthermore, a firm’s overall level of corporate social activity (whether “good deeds” or “ misdeeds”) may contribute directly to firm familiarity and (...) indirectly to attractiveness through familiarity. The authors’ results support this model; firm familiarity completely mediates the relationship between corporate social performance and organizational attractiveness. (shrink)