Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Tosaka Jun (1900-1945) was one of modern Japan's most unique and important critics of capitalism, the emperor system, imperialism, and everyday life in wartime Japan. This collection of translations contains some of Tosaka's most important essays and original articles on Tosaka.

Zusammenfassung: In Abschnitt (1) dieses Aufsatzes diskutiere ich Rawls’ theologische Kritik des Verdienstes in seiner frühen Schrift Über Sünde, Glaube und Religion. Im Gegensatz zur Theorie der Gerechtigkeit kritisiert der frühe Rawls eine Berufung auf das eigene Verdienst nicht als kognitiven Irrtum oder moralische Willkür, sondern sieht darin den sündhaften Ausdruck menschlichen Stolzes. Diese Kritik des Stolzes beruht auf einem schöpfungstheologischen Argument und mündet in ein Plädoyer für religiöse Demut. Abschnitt (2) zeigt, dass Rawls’ Diskussion von Verteilungsgrundsätzen in den übergreifenden (...) Versuch einer gerechtigkeitstheoretischen Zähmung des Zufalls eingebettet ist. Rawls entwickelt in der Theorie der Gerechtigkeit eine bestimmte Typologie des Zufalls und diskutiert, wie die vier von ihm diskutierten Lesarten des zweiten Grundsatzes der Gerechtigkeit auf den Zufall reagieren. Die gerechtigkeitstheoretische Zähmung des Zufalls distanziert sich sowohl von der Dystopie einer völligen Eliminierung des Zufalls als auch von einer fatalistischen Affirmation des Zufalls. In Abschnitt (3) erläutere ich zunächst die unterschiedlichen Begriffe des Verdienstes, welche Rawls in der Theorie der Gerechtigkeit vorstellt. Ich versuche Rawls’ Kritik des Verdienstes zu klären, indem ich diese gegen ein Missverständnis in Schutz nehme, welches Samuel Schefflers und Thomas Scanlons Interpretationen kennzeichnet. Schließlich beschäftige ich mich mit Robert Nozicks Suche nach dem „positive argument“ von Rawls’ Kritik des Verdienstes, komme dabei jedoch zu einem ganz anderen Ergebnis als Nozick. Meiner Meinung findet sich das „positive argument“, nach dem Nozick vergeblich sucht, nicht in der Theorie der Gerechtigkeit, sondern verdankt sich dem kreatürlichen Egalitarismus von Rawls’ theologischer Frühschrift. (shrink)

In recent years there has been a notable increase in the use of phenomenology as a research method, particularly in educational research. With the rise of phenomenology as a research method, confusion has also arisen concerning what counts as phenomenology, and how best to practice phenomenological research in non-philosophical contexts. Consequently, this article will be concerned with three issues: firstly, to contextualise the debate, I provide a brief overview of three popular and influential approaches to phenomenology as a research method: (...) (1) Giorgi’s descriptive phenomenological method; (2) van Manen’s hermeneutic phenomenology; and, (3) Smith’s interpretative phenomenological analysis; secondly, for the sake of conceptual clarity, I then turn my attention to a critical discussion of these approaches and argue that these approaches tend to converge phenomenology into either a descriptive or interpretative focus that essentially transforms phenomenology into a kind of solipsist subjectivism; and, lastly, to progress the debate forward, I argue that it makes sense to look beyond the qualitative or educational research literature to successful applications of phenomenology in non-philosophical contexts because there are plenty of relevant resources that can offer significant theoretical and methodological support to researchers. (shrink)

In this essay I intentionally employ Nietzsche's genealogical method as a means to critique the complex concept of ‘good’ teaching, and at the same time reconstitute ‘good’ teaching in a form that is radically different from contemporary accounts. In order to do this, I start out by undertaking a genealogical analysis to both reveal the complicated historical development of ‘good’ teaching and also disentangle the intertwining threads that remain hidden from us so we are aware of the core threads that (...) hold it together. Two major threads are identified in my analysis, which I refer to as: Genealogy I: Teaching as applied science or practice; and, Genealogy II: Teaching as a vocational calling or neutral profession. With this in mind, I take the two value systems presented in my critique of ‘good’ teaching, and rather than return to old, or create new values, I argue that the true task of any educational endeavour is to make human beings human. Therefore, in the spirit of Nietzsche, I revive and extend Nietzsche's account of Bildung as a dynamic way of living timeless educational aims, such as learning to see, think, speak, write and feel in becoming true human beings. (shrink)

This article argues that psychological discourse fails miserably to provide an account of learning that can explain how humans come to understand, particularly understanding that has been grasped meaningfully. Part of the problem with psychological approaches to learning is that they are disconnected from the integral role embodiment plays in how I perceive myself, other persons and other things in the world. In this sense, it is argued that a central tenet of any educational learning involves being taught to perceive, (...) come to know ourselves and the world around us. This may seem like stating the obvious, but there is a general tendency to take the experience of perception for granted. Since phenomenology according to Merleau-Ponty recognises that perceptual experience is the basis of ‘all rationality’ makes it particularly apt for explaining the significant role embodiment plays in understanding what has been learned, and understanding that has been grasped meaningfully. What makes this account of embodied learning educationally significant is that the whole person is treated as a whole being, permitting the person to experience him or herself as a holistic and synthesised acting, feeling, thinking being-in-the-world, rather than as separate physical and mental qualities which bear no relation to each other. (shrink)

The use of phenomenology and phenomenography as a method in the educational research literature has risen in popularity, particularly by researchers who are interested in understanding and generati...

The discipline area of physical education has historically struggled for legitimacy, sometimes being seen as a non-serious pursuit in educational terms compared to other subjects within the school curriculum. This book represents the first attempt in nearly 30 years to offer a coherent philosophical defence and conceptualisation of physical education and sport as subjects of educational value, and to provide a philosophically sound justification for their inclusion in the curriculum. The book argues that rather than relegating the body to ‘un-thinking’ (...) learning, a person’s essential being is not confined to their rationality but involves an embodied dimension. It traces the changing conceptions of the body, in philosophy and theology, that have influenced our understanding of physical education and sport, and investigates the important role that embodiment and movement play in learning about, through and in physical education. Physical education is defended as a vital and necessary part of education because the whole person goes to school, not just the mind, but the thinking, feeling and acting facets of a person. It is argued that physical education has the potential to provide a multitude of experiences and opportunities for students’ to become aware of their embodiment, explore alternative modes of awareness and to develop insights into and new modes of being not available elsewhere in the curriculum, and to influence moral character through the support of a moral community that is committed to that practice. Representing a sophisticated and spirited defence of the educational significance and philosophical value of physical education and sport, this book will be fascinating reading for any advanced student or researcher with an interest in physical education, the philosophy of sport, or the philosophy of education. (shrink)

Journal of Philosophy of Education, Volume 55, Issue 1, Page 186-203, February 2021.

This essay argues that much can be gained from a close examination of Nietzsche’s work with respect to education. In order to contextualise my argument, I provide a brief critique of Nietzsche’s thinking on aesthetics, educators and education. I then turn my attention to the work of Thus Spoke Zarathustra, the figures Zarathustra and the Übermensch, and other Nietzschean works with a view to outline what I mean by a Nietzschean education. My central thesis being that a Nietzschean education is (...) primarily concerned with the cultivation of the self. This is certainly not an easy undertaking as it requires both an educator and education that can reveal to students “what one is” now, and who they could become. In order to bring this about, Nietzsche employs the use of an aesthetic model in the form of an exemplar for students to aspire to become. Here, the exemplar plays an important educative function in Nietzsche’s thinking because the role of the ideal type is to unsettle the student so that they are inspired to attain their unattained self that they recognise in the other. Consequently, what makes my account of a Nietzschean education significant is due to its concern with fostering timeless educational aims, such as learning to see, think, speak, write, and feel, by unsettling students with an ideal educator and true education so that students can get a sense of who they are now and who they could become. (shrink)

Physical education is often justified within the curriculum as academic study, as a worthwhile activity on a par with other academic subjects on offer and easy to assess. Part of the problem has been that movement studies in physical education are looked upon as disembodied and disconnected from its central concerns which are associated with employing physical means to develop the whole person. But this, Merleau-Ponty would say, is to ignore the nature of experience and to consider the cognitive aspects (...) of our perceptual experience in isolation from the personal meaning gained when looked at from the ?inside? or participatory perspective of the moving agent. In this sense, physical education has lost meaning for some students because our embodied relationship with the world is not an external or contemplative one. Phenomenology, according to Merleau-Ponty, is significant for physical education because it highlights what it is like to be embodied and recognises the role corporeal movement and embodiment plays in learning, in, by and through physical education. What makes this account educationally significant for physical education is that the whole person should benefit by the experience, as it includes an emphasis on all three educational domains (the psychomotor, the cognitive and the affective), rather than as separate physical and mental qualities that bear no relation to each other. (shrink)

BackgroundEnd-of-life decisions remain a hotly debated issue in many European countries and the acceptance in the general population can act as an important anchor point in these discussions. Previous studies on determinants of the acceptance of end-of-life interventions in the general population have not systematically assessed whether determinants differ between withdrawal of life-prolonging treatment and euthanasia.MethodsA large, representative survey of the Austrian adult population conducted in 2014 included items on WLPT and EUT. We constructed the following categorical outcome: rejection of (...) both WLPT and EUT, approval of WLPT but rejection of EUT, and approval of both WLPT and EUT. The influence of socio-demographics, personal experiences, and religious and socio-cultural orientations on the three levels of approval were assessed via multinomial logistic regression analysis.ResultsHigher education and stronger socio-cultural liberal orientations increased the likelihood of approving both WLPT and EUT; personal experience with end-of-life care increased only the likelihood of approval of WLPT; and religiosity decreased approval of EUT only.ConclusionThis study found evidence for both shared and different determinants for the acceptance of WLPT and EUT. (shrink)

Drawing from Nietzsche, I explore the topic of aesthetic education. Even though Nietzsche never formally uses the term “aesthetic education” in his works, this is a novel initiative of my own doing based on what I think he would have to say on the topic. Just as Nietzsche adopted his own experimental approach or style, in a sense, my intention is to experiment with a narrative, which takes the form of a fictional dialogue between Nietzsche and a student. To make (...) sense of what Nietzsche has to say on the topic, I examine certain aspects of his thought as they relate to art, aesthetics, creative activity, creativity, the important role of Bildung (self-cultivation), and other associated areas of interest. This essay critically discusses and analyzes the narrative in relation to Nietzsche's appropriation of the mythical figure of Dionysus, as well as the tragic wisdom it is supposed to incarnate. As such, I argue that Dionysian wisdom is an exposition of the paradoxical characteristics of the creative life that has significant ramifications for aesthetic education. (shrink)

In 1792, with the aim of defending Kant's doctrine of freedom, Reinhold redefined freedom of will as the ability to decide for or against the moral law. Thus freedom of will represents a foundation of moral philosophy, if not of philosophy as a whole. The present volume seeks to reinterpret and to discuss this chapter of the post-Kantian discourse on freedom from various perspectives.

From a prima facie point of view, Nietzsche’s use of virtue may appear to be a form of virtue ethics. Certainly, this is one position that has been established within the secondary literature; however, I argue that a more fruitful philosophical reading is to view his use of virtue as a part of his drive psychology. Indeed, what makes Nietzsche’s philosophical psychology relevant to this topic, is the way in which he characterises the “sovereign individual” as an agent that is (...) in control of good or appropriate actions because they are strong enough in character to sublimate their “drives” in the act of willing. Nietzsche’s philosophical psychology has important educational implications because an obvious place to cultivate the sovereign individual is through education, but to Nietzsche, education and educational institutions seem only interested in promoting certain Christian virtues (e.g., faith, hope, and charity), and herd forming virtues (e.g., obedience, guilt, and equality) that breed sick young people who are decadent and weak willed. In response to this dilemma, I turn my attention to how Nietzsche overcomes this problem by proposing new virtues that should figure in a new type of education which is concerned with educating the will of the sovereign individual. Central to Nietzsche’s new type of education is the painful labour of self-cultivation (Bildung), the revaluation of one’s values, and a ceaseless striving to overcome obstacles (will to power), so we are able to educate ourselves against life-negating virtues or vices that make us decadent and weak willed. (shrink)

Background Care-dependency constitutes an important issue with regard to the approval of end-of-life decisions, yet attitudes towards assisted suicide and euthanasia are understudied among care-dependent older adults. We assessed attitudes towards assisted suicide and euthanasia and tested empirical correlates, including socio-demographics, religiosity, physical illness, psychological distress and social isolation. Methods A nationwide cross-sectional survey among older care allowance recipients in private households in Austria was conducted in 2016. In computer-assisted personal interviews, 493 respondents were asked whether or not they approved (...) of the availability of assisted suicide and euthanasia in case of long-term care dependency and whether or not they would consider using assisted suicide or euthanasia for themselves. Multiple logistic regression analysis was used to assess the impact of potential determinants of attitudes towards assisted suicide and euthanasia. Results About a quarter of the sampled care-dependent older adults approved of the availability of assisted suicide and euthanasia respectively indicated the will to make use of assisted suicide or euthanasia. Attitudes towards assisted suicide were most favourable among care-dependent older adults living in urban areas, those who did not trust physicians, those who reported active suicide ideation, and individuals with a strong fear of dying. With regard to euthanasia, living alone, religiosity and fear of dying were the central determinants of acceptance. Conclusions Positive attitudes towards and will to use assisted suicide and euthanasia were expressed by a substantial minority of care-dependent older adults in Austria and are driven by current psychological suffering and fear of the process of dying in the future. Community-based psychosocial care should be expanded to address psychological distress and fears about end-of-life issues among care-dependent older adults. (shrink)

The use of narrative – in this case a fictional dialogue – has been a time-honoured way of exploring ideas and most importantly indispensable for learning, at least since the time of the Sophists. Indeed, the dialogues of Plato exemplify this thesis because the qualities and characteristics of philosophy and philosophising are revealed through their lives. Extending on this premise, we would argue that we learn to understand both the unity and complexity of philosophy – particularly in education and educational (...) research – not by formal philosophical arguments, necessary as they are in some contexts, but by narratives that are relevant, narratives that make the actions of one or more characters intelligible and justifiable. As a result, this article uses a narrative approach for the dual purpose of exhibiting the relevance of philosophy intelligibly exhibited through the examples of the characters put forward, but at the same time characters we our... (shrink)

Becoming Marxist offers a series of studies that take up the importance of philosophy for the development of an open and critical Marxism.

Changes in the conscious and unconscious influences of memory over time were assessed in two experiments by using a variant of the process-dissociation procedure. In both experiments, performance on a stem-completion task was measured under both inclusion and exclusion instructions. Across the two experiments, there were four different retention intervals: 2 minutes, 2 days, 2 weeks, and 2 months. The results indicated that conscious influences decreased systematically across retention interval. In contrast, unconscious influences of memory in the absence of conscious (...) influences increased between 2 minutes and 2 days, and then remained relatively stable from 2 days to 2 weeks to 2 months. These results stand in apparent contrast to those of McBride and Dosher (1999), which showed equal rates of forgetting for conscious and unconscious influences of memory on performance. The implications for models of the relation between conscious and unconscious influences of memory on performance are discussed. (shrink)

This article argues that assessment is a central feature of teaching, particularly as a means to determine whether what has been taught has been learnt. However, I take issue with the current trend in education which places a significant amount of emphasis upon large-scale public testing, which in turn has exacerbated the ‘teaching-to-the-test’ syndrome, not to mention distorting teaching decisions that are detrimental to the overall development of student knowledge and understanding. Part of the problem with assessment in education seems (...) to revolve around the nature of knowledge and how best to assess human knowledge and understanding. Although much philosophical uncertainty and disagreement exists surrounding the nature of knowledge, I argue that coming to know something is a sine qua non of any education. In saying this, I highlight the limits of assessment by demonstrating how certain activities are resistant to large-scale public testing because they are not easily reducible to facts which can be tested for, or at least in the same way as propositional forms of knowledge. Consequently, my argument is a philosophical one to the effect that assessment, particularly large-scale public testing is incapable of assessing all forms of learning, or even the quality of student understanding because the instruments available are both too blunt and tend to capture a certain kind of knowledge that privileges theory over practice, and mental skills over physical skills. (shrink)

When the Ottoman Empire defaulted on its public debt in 1875, British bondholders launched a campaign to win government intervention on their behalf. This article interprets the unprecedented success of this campaign as a matter of knowledge production. Mobilizing the newly established Corporation of Foreign Bondholders as a kind of ‘centre of calculation’, bondholders argued that they deserved assistance because of the unique size of the Ottoman default and the proportion of it that was held by British subjects. Yet neither (...) of these numbers was easily calculated. In fact, influential bondholders worked closely with accountants and members of the Statistical Society to devise an accurate method for quantifying the Ottoman debt – and concluded that such a method did not exist. Historians of quantification and accounting have argued that the scientific status of nineteenth-century accounting depended on its disinterestedness. In the case of the Ottoman default, however, calculation was understood to be inseparable from material interest and political debate. (shrink)

Colonial and Postcolonial Linguistics. The scholarly articles assembled in this volume discuss various topics related to languages such as Chamorro, Chuuk, Ewe, Ewondo, Kanuri, Khoekowap, Nauruan, Weskos.

This article argues that assessment is a central feature of teaching, particularly as a means to determine whether what has been taught has been learnt. However, I take issue with the current trend in education which places a significant amount of emphasis upon large-scale public testing, which in turn has exacerbated the ‘teaching-to-the-test’ syndrome, not to mention distorting teaching decisions that are detrimental to the overall development of student knowledge and understanding. Part of the problem with assessment in education seems (...) to revolve around the nature of knowledge and how best to assess human knowledge and understanding. Although much philosophical uncertainty and disagreement exists surrounding the nature of knowledge, I argue that coming to know something is a sine qua non of any education. In saying this, I highlight the limits of assessment by demonstrating how certain activities are resistant to large-scale public testing because they are not easily reducible to facts which can be tested for, or at least in the same way as propositional forms of knowledge. Consequently, my argument is a philosophical one to the effect that assessment, particularly large-scale public testing is incapable of assessing all forms of learning, or even the quality of student understanding because the instruments available are both too blunt and tend to capture a certain kind of knowledge that privileges theory over practice, and mental skills over physical skills. (shrink)

This article argues that analytical sociology an approach that attempts to study social mechanisms ‘without, black boxes’ can benefit from the use of explanatory mixed methods. Analytical sociologists mainly relate their theoretical and agent-based models to representative surveys and experiments. While their central claim is to find and test the actual mechanisms that have produced the explanandum. the mechanisms they postulate often remain speculative. Neither agent-based models, nor experiments or mainstream quantitative methods, give access to some of the central elements (...) of the causal mechanisms and the relevant subjective and objective contextual parameters. One of the most important reasons for this lies in the fact that social reality is changing fast., characterized by strong diversity and complexified by the phenomenon of cultural meanings. I argue that by creating and testing the models of analytical sociology with explanatory mixed methods, researchers have the possibility of getting closer to their object of research and therefore of having the chance to create more valid explanations. (shrink)

This article explores phenomena of marginality in different areas of medieval culture. The introduction explains medieval concepts of the “margin”. In the first part, the author analyzes the tension between the “centre” and the “margin” as found in medieval conceptions of the world such as labyrinths and the mappae mundi. Secondly, he examines the interdependency of social and textual marginalization as it occurs in the 14th century Hausbuch of Michael de Leone. The third part of the article is dedicated to (...) the Munich manuscript of Wolframs von Eschenbach Titurel, a text situated on the margins of the famous Parzival-novel both in terms of its physical location and also its poetic thought. The survey of these examples shows that margins often refer to the centre of cultural constellations despite their allegedly subsidiary role. (shrink)