In this paper, we apply the perspective of intra-organismal ecology by investigating a family of ecological models suitable to describe a gene therapy to a particular metabolic disorder, the adenosine deaminase deficiency (ADA-SCID). The gene therapy is modeled as the prospective ecological invasion of an organ (here, bone marrow) by genetically modified stem cells, which then operate niche construction in the cellular environment by releasing an enzyme they synthesize. We show that depending on the chosen order (a choice that cannot (...) be made on \textit{a priori} assumptions), different kinds of dynamics are expected, possibly leading to different therapeutic strategies. This drives us to discuss several features of the extension of ecology to intra-organismal ecology. (shrink)

v. 1. Institutes of metaphysic.--v. 2. Lectures on Greek philosophy.--v. 3. Philosophical remains.

According to the iterative conception of set, each set is a collection of sets formed prior to it. The notion of priority here plays an essential role in explanations of why contradiction-inducing sets, such as the Russell set, do not exist. Consequently, these explanations are successful only to the extent that a satisfactory priority relation is made out. I argue that attempts to do this have fallen short: understanding priority in a straightforwardly constructivist sense threatens the coherence of the empty (...) set and raises serious epistemological concerns; but the leading realist interpretations---ontological and modal interpretations of priority---are deeply problematic as well. I conclude that the purported explanatory virtues of the iterative conception are, at present, unfounded. (shrink)

Starting from three theatrical rewritings of the parable of the prodigal son played on the stages of the Jesuits, the Fair and the Comédie-Française, the article focuses on analysing dramatic, dramaturgical and scenic choices that correspond to the narrative processes of the parable to renew its approach at the beginning of the eighteenth century, which is the turning point of a movement of secularization of biblical subjects. The open guidance of the word of Christ as reported by Luke is followed (...) by another form of guidance towards various interpretations corresponding to the expectations of the spectator, and plural readings that give a perception of the literacy of the New Testament narrative. (shrink)

Cinq mille ans d'Histoire consignée nous montrent à la fois une humanité créatrice d'indéniables progrès et, simultanément, prisonnière de schémas qui la paralysent ou l'affolent. C'est comme si l'humanité cherchait son bonheur en suivant obstinément des stratégies qui lui assurent rarement une satisfaction durable. Assurément, il doit exister de sérieuses raisons à ces choix de comportements inefficaces, alors même que personne ne dispose d'une seconde vie pour rattraper les échecs de la première. Dans Le paradoxe humain, l'auteur resitue le psychisme (...) de l'Homme dans le contexte de l'évolution et en analyse les caractéristiques fondamentales. Il souligne l'importance des limitations de ce psychisme à l'origine du malaise de l'homme, inextricablement enchevêtré dans le désir d'ouverture aux autres et la nécessité, toujours en vigueur, de se battre irréductiblement pour exister à quelque prix que ce soit. Cette étude nous confronte aux potentialités et aux limitations inhérentes du psychisme de notre espèce et nous amène à une vision à la fois réaliste et optimiste de l'humanité. A la croisée de la psychologie et de l'anthropologie, cet ouvrage offre, avec un regard neuf, une réflexion sur le psychisme humain fondée sur la psychologie des profondeurs et constitue une contribution de la psychologie à une organisation de la vie sociale et politique centrée sur l'homme et son épanouissement. (shrink)

On peut lire " L'Emprise " de deux manières : comme un texte de rupture ou bien de continuité. Dans le premier cas, assez subalterne, on y verra le " persiste et signe " de l'hérétique après les foudres qui l'ont frappé lors de la guerre du Kosovo. Dans le second, plus intéressant, une mise à jour du " Pouvoir intellectuel " (1979), pour décrire comment l'ordre moral est aujourd'hui passé aux mains d'un nouveau magistère, la presse. Assumant avec les (...) moyens du bord la fonction immémoriale de pouvoir spirituel, le journalisme serait alors la figure moderne du cléricalisme. Dans cette situation, il n'est pas inutile de rappeler que le règne du clergé n'est pas celui du bon Dieu. (shrink)

Pour le collectif Erato STENE créé par les auteurs, il existe non pas une géographie mais des géographies et les différences entre elles peuvent révéler des enjeux importants. Chaque auteur fait le point sur le vocabulaire de la géographie qu'il pratique. Sont ainsi proposées des fiches épistémologiques qui peuvent être comparées. Parmi les termes traités : centralité, dynamique, habitat, paysage.

Masochism brings Freud up against the accursed share of analysis, which was always the female. Masoch undermines the epistemological apparatus of the Freudian unconscious, which could reinvent sex, but not the world : it gives way to the old demons of metaphysics, where the death drive triumphs. The return of the repressed.

Cases or examples can be often explained by the interplay of arguments in favour or against their outcomes. This paper addresses the problem of finding explanations for a collection of cases where an explanation is a labelled argumentation graph consistent with the cases, and a case is represented as a statement labelling. The focus is on semi-abstract argumentation graphs specifying attack and subargument relations between arguments, along with particular complete argument labellings taken from probabilistic argumentation where arguments can be excluded. (...) The framework and computational considerations lead to an iterated local iterative deepening depth-first search to collect ‘interesting’ semi-abstract argumentation graphs consistent with a collection of statement labellings. Finally, the framework is illustrated and evaluated with a proof-of-concept implementation. (shrink)

Our aim is to show that translating the modal graphs of Moretti’s “n-opposition theory” (2004) into set theory by a suited device, through identifying logical modal formulas with appropriate subsets of a characteristic set, one can, in a constructive and exhaustive way, by means of a simple recurring combinatory, exhibit all so-called “logical bi-simplexes of dimension n” (or n-oppositional figures, that is the logical squares, logical hexagons, logical cubes, etc.) contained in the logic produced by any given modal graph (an (...) exhaustiveness which was not possible before). In this paper we shall handle explicitly the classical case of the so-called 3(3)-modal graph (which is, among others, the one of S5), getting to a very elegant tetraicosahedronal geometrisation of this logic. (shrink)

This paper proposes an approach to investigate norm-governed learning agents which combines a logic-based formalism with an equation-based counterpart. This dual formalism enables us to describe the reasoning of such agents and their interactions using argumentation, and, at the same time, to capture systemic features using equations. The approach is applied to norm emergence and internalisation in systems of learning agents. The logical formalism is rooted into a probabilistic defeasible logic instantiating Dung’s argumentation framework. Rules of this logic are attached (...) with probabilities to describe the agents’ minds and behaviours as well as uncertain environments. Then, the equation-based model for reinforcement learning, defined over this probability distribution, allows agents to adapt to their environment and self-organise. (shrink)

We provide characterizations of the equal division values and their convex mixtures, using a new axiom on a fixed player set based on player nullification which requires that if a player becomes null, then any two other players are equally affected. Two economic applications are also introduced concerning bargaining under risk and common-pool resource appropriation.

Alan Gewirth's Reason and Morality directed philosophical attention to the possibility of presenting a rational and rigorous demonstration of fundamental moral principles. Now, these previously unpublished essays from some of the most distinguished philosophers of our generation subject Gewirth's program to thorough evaluation and assessment. In a tour de force of philosophical analysis, Professor Gewirth provides detailed replies to all of his critics--a major, genuinely clarifying essay of intrinsic philosophical interest.

The concept of continuing professional development (CPD) for teachers combines issues of training, recognition, and professional effectiveness. In this article, we examine the conditions and effects of the implementation of CPD policies at the international and national levels, before looking comparatively at concrete CPD training provision in two “academies” in France. We seek to identify certain conditions for the renewal of in-service teacher training engineering devices and, more broadly, to document major contemporary issues for the teaching profession: attractiveness, recognition, renewal, (...) mobility, and professional development. (shrink)

It is often thought that the literature dealing with religion is nothing more than the expression of a thought elaborated by the theologian, which he struggles to express: the Bible, the primary text, is initially interpreted by theologians, and then writers gather their interpretations. But it is not always so, as the reception of Judas Iscariote testifies: from Klosptock to Kazantzakis through Victor Hugo and Gérard de Nerval, it is the people of letters who preceded the exegetes in the interpretation (...) of the figure of the one who betrayed Jesus. (shrink)

I argue that absolutism, the view that absolutely unrestricted quantification is possible, is to blame for both the paradoxes that arise in naive set theory and variants of these paradoxes that arise in plural logic and in semantics. The solution is restrictivism, the view that absolutely unrestricted quantification is not possible. -/- It is generally thought that absolutism is true and that restrictivism is not only false, but inexpressible. As a result, the paradoxes are blamed, not on illicit quantification, but (...) on the logical conception of set which motivates naive set theory. The accepted solution is to replace this with the iterative conception of set. -/- I show that this picture is doubly mistaken. After a close examination of the paradoxes in chapters 2--3, I argue in chapters 4 and 5 that it is possible to rescue naive set theory by restricting quantification over sets and that the resulting restrictivist set theory is expressible. In chapters 6 and 7, I argue that it is the iterative conception of set and the thesis of absolutism that should be rejected. (shrink)

Na[sdotu]īr al-Dīn al-[Tdotu]ūsī, Memoir on Astronomy . [Sdotu]adr al-Sharī‘a. An Islamic Response to Greek Astronomy: Kitāb Ta‘dīl Hay’at al-Aflāk of [sdotu]adr al-Sharīa , Edited with Translation and Commentary by Ahmad S. Dallal, X + 461 pp., figs., index. Leiden - New York - Köln, E.J. Brill, 1995.

Review of *How Literature Changes the Way We Think*, by Michael Mack (Continuum, 2012).

The Itinerarium provides a concise introduction to Bonaventure's theological understanding. This new translation presents Latin and English on facing pages, followed by an extensive and detailed commentary on the historical, scriptural, and linguistic contexts of the text and its translation.

À partir de l'observation du nord de la région Midi-Pyrénées, cet article défend l'hypothèse que les logiques économiques, les réseaux sociaux et les jeux d'acteurs locaux sont à l'origine de la construction d'une identité territoriale. Fruit d'une histoire collective celle-ci n'empêche pas l'expression d'enjeux et de stratégies aux intérêts divergents mais entraîne deux changements majeurs. Elle permet de penser de façon positive le futur de ce territoire et conduit à l'envisager à partir des relations qu'il entretient avec d'autres espaces parfois (...) fort éloignés.From the observation of the northern region of Midi-Pyrénées, this article defends the hypothesis that economic logic, social networks and local games are at the origin of the construction of a regional identity. Result of a collective history it does not prevent the expression of issues and strategies with different interests but has two major changes. It helps to think positively the future of this country and led to the consideration from its relations with other areas sometimes far apart. (shrink)