Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

1 L’oggettivazione psicologistico-riduzonistico-introiettivistica Nella seconda metà del V secolo a. C. si ha in Grecia una radicale conversione del modo in cui l’uomo intende se stesso e il mondo nel quadro della cultura intellettuale europea che da quel momento sarà poi dominante: si tratta dell’oggettivazione psicologistico-riduzionistico-introiettivistica. Il mondo empirico viene smembrato in seguito alla separazione di un mondo interiore psichico ritenuto diverso per ogni possessore di c...

This book investigates the role of inference in argumentation, considering how arguments support standpoints on the basis of different loci. The authors propose and illustrate a model for the analysis of the standpoint-argument connection, called Argumentum Model of Topics. A prominent feature of the AMT is that it distinguishes, within each and every single argumentation, between an inferential-procedural component, on which the reasoning process is based; and a material-contextual component, which anchors the argument in the interlocutors’ cultural and factual common (...) ground. The AMT explains how these components differ and how they are intertwined within each single argument. This model is introduced in Part II of the book, following a careful reconstruction of the enormously rich tradition of studies on inference in argumentation, from the antiquity to contemporary authors, without neglecting medieval and post-medieval contributions. The AMT is a contemporary model grounded in a dialogue with such tradition, whose crucial aspects are illuminated in this book. (shrink)

Hermann Weyls "Philosophie der Mathematik und Naturwissenschaft" erschien erstmals 1928 als Beitrag zu dem von A. Bäumler und M. Schröter herausgegebenen "Handbuch der Philosophie". Die amerikanische Ausgabe, auf der die deutsche Übersetzung von Gottlob Kirschmer beruht, erschien 1949 bei Princeton University Press. Das nunmehr bereits in der 8. Auflage vorliegende Werk ist längst auch in Deutschland zum Standardwerk geworden.

The paper attempts to show that Kant's criticism of eudaemonism does not affect Plato's moral theory, because the kind of eudaemonism which Plato embraces is different from that rejected by Kant. Whereas the target of Kant's criticism is the view that virtuous actions are an instrumental means to becoming happy, Plato regards virtue as a constitutive part of happiness and is, thus, committed to what Gregory Vlastos has called a "noninstrumentalist form of eudaemonism".

Radically reoriented presentation of Einstein's Special Theory and one of most valuable popular accounts available derives relativity from Newtonian ideas, ...

More and more cities develop urban food strategies to guide their efforts and practices towards more sustainable food systems. An emerging theme shaping these food policy endeavours, especially prominent in North and South America, concerns the enhancement of social justice within food systems. To operationalise this theme in a European urban food governance context we adopt Nancy Fraser’s three-dimensional theory of justice: economic redistribution, cultural recognition and political representation. In this paper, we discuss the findings of an exploratory document analysis (...) of the social justice-oriented ambitions, motivations, current practices and policy trajectories articulated in sixteen European UFSs. We reflect on the food-related resource allocations, value patterns and decision rules these cities propose to alter and the target groups they propose to support, empower or include. Overall, we find that UFSs make little explicit reference to social justice and justice-oriented food concepts, such as food security, food justice, food democracy and food sovereignty. Nevertheless, the identified resources, services and target groups indicate that the three dimensions of Fraser are at the heart of many of the measures described. We argue that implicit, fragmentary and unspecified adoption of social justice in European UFSs is problematic, as it may hold back public consciousness, debate and collective action regarding food system inequalities and may be easily disregarded in policy budgeting, implementation and evaluation trajectories. As a path forward, we present our plans for the RE-ADJUSTool that would enable UFS stakeholders to reflect on how their UFS can incorporate social justice and who to involve in this pursuit. (shrink)

As a standard, health has proven to be as fecund a source of philosophic interest as it is enigmatic. The metaphor of health peppers the history of Western philosophy from its inception, and brings with it a network of questions related to the highly problematic constructions of the relationships between body and mind with which this history is littered. In particular, the connection between medical and political discourses in archaic and classical Greece is well documented, and reveals the extent to (...) which the metaphor of health has proven operative in multiple realms of classical Greek thought. This intertwining of medical and political discourses is powerfully present in the dialogues of Plato as well, and in the Republic in particular. This dissertation addresses itself to the role of medicine within Plato's Republic, and takes as its overarching project the investigation of the role of doctors and medicine in this dialogue in order to indicate the manner in which medicine is used to make clearer the position of the philosopher within the city. The following pages attempt to show that, when faced in the Republic with the need to give an account of the philosopher within the city, Plato found the medical art indispensable to this enterprise. Thus medicine emerges as intimately connected to the paradoxical coincidence of philosophy and political power for which the Republic calls. (shrink)

This is an exploratory study of corporate social performance in firms with family members in executive, governance, or strong ownership positions. Family firmsdominate the economy in most countries, including the United States, and families are thought to be more concerned with personal wealth creation and risk avoidance than social performance. Although such firms have been shown to have superior financial performance, I found no evidence of superior (or inferior) social performance among family firms in the S&P 500. In a departure (...) from the methodological norm in business and society, I used KLD data as dependent variables instead of independent variables. I was able to predict KLD scores from firm size, industry, and strategy variables, but family firm status rarely played a role. (shrink)

By presenting a case study based on the argumentative analysis of news in the press, this article introduces and discusses strategic manoeuvring with contextual frames. Drawing on the linguistic notion of frame, I introduce the concept of contextual frame to refer to the news context, that is, the background against which a certain event is presented as a piece of news. I argue that newspapers and journalists make use of contextual frames in the apparently neutral genre of news reporting to (...) propose specific interpretations of the facts at issue, which become the basis for explicit comments and editorials. To show how this works, I investigate in detail a case of newspaper coverage of a complex episode using the pragma-dialectical notion of strategic manoeuvring and the Argumentum Model of Topics to analyse argument schemes. I show that, in the use of contextual frames, there is a prominent relation between presentational devices and topical potential; contextual frames provide the implicit material premises which are at the basis of argumentations through which newspapers interpret and comment on the news. (shrink)

Many biologists appeal to the so-called Krogh principle when justifying their choice of experimental organisms. The principle states that “for a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied”. Despite its popularity, the principle is often critiqued for implying unwarranted generalizations from optimal models. We argue that the Krogh principle should be interpreted in relation to the historical and scientific contexts in which it has (...) been developed and used. We interpret the Krogh Principle as a heuristic, i.e., as a recommendation to approach biological problems through organisms where a specific trait or physiological mechanism is expected to be most distinctively displayed or most experimentally accessible. We designate these organisms “Krogh organisms.” We clarify the differences between uses of model organisms and non-standard Krogh organisms. Among these is the use of Krogh organisms as “negative models” in biomedical research, where organisms are chosen for their dissimilarity to human physiology. Importantly, the representational scope of Krogh organisms and the generalizability of their characteristics are not fixed or assumed but explored through experimental studies. Research on Krogh organisms is steeped in the comparative method characteristic of zoology and comparative physiology, in which studies of biological variation produce insights into general physiological constraints. Accordingly, we conclude that the Krogh principle exemplifies the advantages of studying biological variation as a strategy to produce generalizable insights. (shrink)

The founding of the Carnegie Institute’s Department of Embryology in 1913, alongside its systematization of embryo staging, contributed to the mechanization of developmental stages of embryo growth in the early 20th century. For a brief period in the middle of the century, attention to the detailed interrelation between embryo development and time made pre-existing ideas about pregnancy ends less determinative of ideas about that developmental course. However, the turn to the genetic scale led to the disappearance of this attention, replaced (...) by a sense of biological life as seamlessly scripted. This study examines the history of what I refer to as temporal attention: attention to the live, unfolding potentialities within vital matter. The reintroduction of temporal attention to discussions of development allows us to more fully consider non-human vitality and the experiences of beings that house or otherwise intimately intersect with that vital tissue, regardless of outcomes. (shrink)

In considering what it means to lead organizations effectively and ethically, the literature comprising spirituality at work and spiritual leadership theory has become highly influential, especially in the USA. It has also attracted significant criticism. While in this paper, we endorse this critique, we argue that the strand of literature which purportedly takes a Christian standpoint within the wider SAW school of thought, largely misconstrues and misapplies the teaching of its founder, Jesus. As a result, in dismissing the claims and (...) application of SAW and SLT, there is a real risk that we lose the vital contribution of Christian thought, not least some of the timeless counter-cultural wisdom of Jesus which, we contend, offers a vital foundation to the practice of ethical leadership and business ethics in organizations. In proposing a way forward, two thorny issues which face all leaders are addressed: dealing with ego and closing the gap between what we say and what we do. The more we understand about the dynamics of human nature, the more we learn about the profundity of Jesus’ teachings. We then propose a number of ways in which Jesus-centred ethical leadership can be practised. Each is radical and each implies risk: both the personal risk of inner renewal arising from repentance as a doorway to personal integrity, as well as the risk of opposing unethical practices and promoting the excellence of core practices in the workplace. (shrink)

The present article is devoted to the second part of chapter 10 of Aristotle’s De interpretatione (20 a 16-40), which mainly deals with the logical relations between statements whose predicate is finite (i. e., of the affirmative form “is P”) and statements whose predicate is infinite (i. e., of the negative form “is not-P”). I attempt to show that this part of the chapter contains both a section the text of which is corrupt (20 a 20-23) and a section which (...) is misplaced (20 a 37-40). In the former section the likely false reading of the manuscripts τῇ δὲ … ἡ ἀντι- κειμένη ὅτι … (“while from ‘…’ the opposite [statement follows] that …”) should be corrected into ἡ δὲ … τῇ ἀντικειμένῃ ὅτι … (“while ‘…’ [follows] from the opposite [statement] that …”), and the latter section should be placed immediately after the former, with which it is intimately connected. (shrink)

Dieses Buch versucht, am Beispiel der Logik der Forschung K. R. Poppers, den Ansatz der modernen Wissenschaftstheorie mit transzendentalphilosophischen Fragestellungen Kants zu vermitteln.

L'écologie cherche à connaître les conditions d'existence des organismes par rapport à leur milieu physique et biotique.D'une part elle étudie les exigences des organismes envers le milieu et leurs adaptations à celui-ci; d'autre part, elle recherche comment le milieu influe sur les organismes. Or, puisque chaque être vivant fait partie du milieu des autres et que sa présence et son activité modifient le milieu physique et biotique pour lui-même comme pour les autres, l'écologie est amenée à considérer en général les (...) interactions entre les facteurs constitués par les organismes ainsi que par les agents inorganiques.Toutefois, la complexité de ces interactions est telle qu'à leur analyse physico-chimique s'opposent des difficultés partiellement insurmontables. La raison en est que les multiples facteurs écologiques n'agissent pas isolément, mais en combinaison dans l'espace et dans le temps. Il en résulte des états d'équilibre relatif dont seule l'expérience multiséculaire de la nature nous révèle l'aboutissement avec certitude. Aussi bien l'écologiste qui veut en tenir compte commence-t-il ses recherches par le relevé qualitatif et quantitatif des groupements biologiques spontanés. Le chercheur les reconnaît à la constance relative de leur composition, dans les divers endroits où ils sont réalisés, constance résultant de l'équilibre relatif entre les facteurs. C'est exactement pour de tels groupements queMöbius à créé le terme de biocénose. Ainsi la biocénotique peut être considérée comme la propédeutique d'une écologie justement conçue; elle ne serait que préparatoire et provisoire si la Science pouvait un jour entièrement éclaircir le jeu des forces écologiques.Enfin en essayant de bien situer l'écologie dans le cadre des disciplines biologiques voisines, il est utile d'avoir présent à l'esprit l'ébauche suivante d'un nouveau système de la biologie:Dans mes „Analyses et synthèses biocénotiques” , j'ai discuté la conception d'Agrell, qui se base sur des stations-types préétablies. Depuis,Agrell a consacrédeux articles polémiques à soutenir que ses „Bestandestypen” s'identifient aux groupements écologiques tels que je le conçois.Il n'en est rien.Dans l'idée d'Agrell, tous les relevés provenant d'un même type de stations font a priori partie d'un même „Bestandestyp”. La conséquence en est que certaines espèces en réalité vicariantes, c'est-à-dire ne cohabitant jamais -Tetracanthella wahlgreni etFolsomia brevicauda, par exemple — se trouvent réunies, sur le papier, dans une même „communauté”. Au contraire, dans mon système, les relevés faits dans un certain type de stations sont classés tantôt dans un groupement , tantôt dans un autre , d'après leur composition faunistique servant d'indicateur. Cette différence explique amplement les discordances qu'Arell relève entre mes indices d'abondance-fréquence et les siens, discordance prouvant une fois de plus que les „Bestandestypen” et les groupements ne sont pas la même chose.Agrell qualifie de résidu l'un de mes groupements. Or, rien n'est plus résiduel queson Bestandestyp 2, qui représente l'ensemble de 7 stations sur 10, celles qui restent après avoir retranché les 3 stations de milieux extrêmes.Agrell reproche à ma méthode de laisser inclassables certains relevés dépourvusd'espèces vicariantes. Cela n'est-il pas préférable au classement de force de relevés, fragmentaires et aux calculs hasardeux basés sur des unités hétérogènes?Enfin,Agrell estime que le choix des espèces caractéristiques est subjectif. J'ai: montré qu'il ne l'est ni plus ni moins que celui des caractères spécifiques en taxonomie.Oekologie, Ethologie, Biogeographie und Biocoenotik werden noch häufig miteinander verwechselt. Diese Disziplinen lassen sich an Hand des Schemas unterscheiden, das in vorstehenden Schlussfolgerungen wiedergegeben ist. Dieses Schema ist zugleich ein Beitrag zu einem neuen, dreidimensionalen System der Biologie.Speziell wird auf den methodischen Unterschied zwischen Oekologie und Biocoenotik eingegangen. Die Biocoenotik kann als eine unentbehrliche Vorstufe der Oekologie angesehen werden, insofern sie die natürliche Vergemeinschaftung der Organismen als ein grossartiges, von der Natur selbst eingesetztes Experiment betrachtet. Ihre Aufgabe ist es, dass Ergebnis dieses Experiments zu beschreiben. Die Lebensgemeinschaften, die sie dabei unterscheidet, sind gekennzeichnet durch ihre häufig wiederkehrende, einigermassen konstante Zusammensetzung, entsprechend den relativen Faktoren-Gleichgewichten, welche sich im Laufe der Jahrhunderte einstellen. Die Lebensgemeinschaften sind aber viel leichter zu erfassen als die Faktoren-Gleichgewichte und deren biologische Bedeutung. Ihre Abgrenzung erfolgt, — wie in der Taxonomie diejenige der Arten — auf Grund objektiver Diskontinuitäten. Letztere gründen sich in der Biocoenotik auf die sich ökologisch ersetzenden Arten. Sie sind die Prüfsteine für die Grundeinheiten der Biocoenotik: die Biocoenosen.] Soweit die Organismen einer Biocoenose aufeinander einwirken, stellen sie gleichzeitig einen Konnex dar; und soweit sie in ihren Ansprüchen oder Anpassungen übereinstimmen, gehören sie auch zum gleichen Lebensformen-Typ. Es ist praktisch, drei Grössenordnungen von Biocoenosen zu unterscheiden: Synusien, Assoziationen und Biome. (shrink)

The politics of populism is the politics of belonging. It reflects a deep challenge to the liberal democratic state, which attempts to maintain social boundaries (as an imperative of state capacity) but also allow immigration. Boundaries—established through citizenship and norms of belonging—must be both coherent and malleable. Changes to boundaries become sites of contestation for exclusionary populists in the putative interest of “legitimate” citizens. Populism is an inevitable response to liberal democratic adjustment; any liberal democracy that redefines citizenship opens itself (...) to populist challenge. (shrink)

The origin of moral agency is a much-debated issue. While rationalists or Kantians have argued that moral agency is rooted in reason, sentimentalists or Humeans have ascribed its origin to empathic feelings. This debate between rationalists and sentimentalists still stands with respect to persons with mental disorders, such as individuals diagnosed with mild forms of Autism Spectrum Disorder, without intellectual impairment. Individuals with ASD are typically regarded as moral agents, however their ability for empathy remains debated. The goal of this (...) paper is to investigate the mechanisms of moral actions in people with ASD, by finding arguments for the origin of their moral actions, supporting either the sentimentalist or the rationalist view of the dispute. We propose to revisit the debate using Interpretative Phenomenological Analysis to study the autobiographies of individuals with High-Functioning Autism and Asperger Syndrome. While conducting the systematic analysis of 10 autobiographies, we re-examined both the rationalist and the sentimentalist positions, considering the links between empathic feelings and moral agency. The investigation of the temporal dimensions of emotional experiences, an aspect overlooked by previous research, indicated that individuals with ASD empathize with others, but in different ways as compared to neurotypicals. A relationship between emotional experience and the type of moral agency exhibited by individuals with forms of ASD was established. As a consequence, our analyses support the sentimentalist stance on moral action. (shrink)

Decolonial/anti-colonial Black, Indigenous and Mestiza feminist movements and scholar-activists foreground how the oft-touted apocalypse that the Covid-19 pandemic heralds is not new, nor does it signify the great rupture into chaos that those from within modernity-coloniality often claim it to be. Rather Covid-19 is preceded by and will be out-lived by the apocalyptic anti-life onto-epistemological logics that are foundational to the (re)production of hetero-patriarchal capitalist-(settler) coloniality. However, one would commit the violence of reproduction of the epistemological logics and (ir)rationalities constitutive (...) of the current system if the story ended there. We have survived (despite our losses) and our survival points to the urgent necessity and responsibility of (critical) social theory to listen to the story of the pandemic from a Black/Indigenous genealogy and to begin the sense-making of the Covid-19 pandemic, from prior to this particular virus, outside, against and beyond the politics of knowledge of critical social theory itself. Thus, I invite you to journey to an affirmative re-enfleshment of reason and theory-making in relation to and dialogue with Black, Indigenous, and subaltern Mestiza feminist movements in southwest Colombia and in southeast so-called Australia in the unceded lands of the Awabakal and the Worimi. I explore this through the metaphor, the materiality, the cosmology and the herstory of the mangrove swamps a knowing-being otherwise (in)visible to the dehumanising gave of Whiteness and bring to thought three stories of a politics of knowledge of/as the Black/racialised and feminised body/flesh. To do this is to suggest that the co-creation of pathways which are life affirming and life making beyond and out of the post-Covid 19 conjuncture involves an epistemological-political project which decolonises and feminises the containments of reason and knowing (non)being of coloniality/modernity. (shrink)

This article highlights Gareth Matthews's contributions to the field of philosophy for young children, noting especially the inventiveness of his style of engagement with children and his confidence in children's ability to analyze perplexing issues, from cosmology to death and dying. I relate here my experiences in introducing philosophical topics to adolescents, to show how Matthews's work can be successfully extended to older students, and I recommend taking philosophy outside the university as a way to foster critical thinking in young (...) students and to improve the public status of the profession. (shrink)

Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Alzheimer’s Disease is characterized by a constellation of limitations derived from progressive cognitive impairment, which is usually viewed as a global uniform phenomenon. In this paper it is argued that looking independently at the loss and recovery of pragmatic function related to illocutionary and perlocutionary abilities can be a productive way of understanding the progressive deterioration of communicative capacities (...) by patients or their improvement under targeted treatment. (shrink)

The Making of Modern Law: Foreign, Comparative and International Law, 1600-1926, brings together foreign, comparative, and international titles in a single resource. Its International Law component features works of some of the great legal theorists, including Gentili, Grotius, Selden, Zouche, Pufendorf, Bijnkershoek, Wolff, Vattel, Martens, Mackintosh, Wheaton, among others. The materials in this archive are drawn from three world-class American law libraries: the Yale Law Library, the George Washington University Law Library, and the Columbia Law Library.Now for the first time, (...) these high-quality digital scans of original works are available via print-on-demand, making them readily accessible to libraries, students, independent scholars, and readers of all ages.+++++++++++++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: +++++++++++++++Columbia University Law LibraryLP3C001240019060101The Making of Modern Law: Foreign, Comparative, and International Law, 1600-1926Heidelberg: Carl Winter's, 190649, [1] p. 23 cmGermany. (shrink)