ABSTRACT16p11.2 deletion syndrome is a severe genetic disorder associated with the deletion of 27 genes from a Copy Number Variant region on human chromosome 16. Symptoms associated include cognitive impairment, language and motor delay, epilepsy or seizures, psychiatric disorders, autism spectrum disorder (ASD), changes in head size and body weight, and dysmorphic features, with a crucial need to define genes and mechanisms responsible for symptomatology. In this review, we analyze the clinical associations and biological pathways of 16p11.2 locus genes and (...) identify that a majority of 16p11.2 genes relate to metabolic processes. We present a hypothesis in which changes in the dosage of 16p11.2 metabolic genes contribute to pathology through direct or indirect alterations in pathways that include amino acids or proteins, DNA, RNA, catabolism, lipid, energy (carbohydrate). This hypothesis suggests that research into the specific roles of each metabolic gene will help identify useful therapeutic targets. (shrink)

Sarah Richmond’s translation makes an important contribution to Sartrean scholarship. L’Etre et le néant was first translated by Hazel Barnes in 1956 but it contained various errors. Richmond also had access to the internet and to Sartre’s French and German sources. Her edition also contains an Introduction and a ‘Notes on the translation’ section.Sartre published his work in 1943 and, unable to access all the works he cited, he often did so from memory. He also adopted certain translators’ (...) neologisms: for example, Corbin’s translation of Heidegger’s Qu’est-ce que la métaphysique?, and when he quoted Nietzsche, he used two different translations, and he quotes Spinoza using a text by Hegel. He quotes a line from the playwright Beaumarchais without clarifying the context.Sarah Richmond deals with many of these problems and also notes that the French gender system can be problematic. Also, Sartre’s neologisms rendered finding English equivalents difficult. This is an excellent translation. (shrink)

This article surveys most of the recent reviews of Sarah Richmond’s excellent new translation of L’Être et le néant. It offers some close textual comparisons between Richmond’s translation, Hazel Barnes’ translation, and the Checklist of Errors of Hazel Barnes’ Translation of L’Être et le néant. This article concludes that Richmond delivers a higher semantic resolution translation that overcomes nearly all the liabilities found in Barnes and does so without sacrificing much by way of readability.

If the world itself is metaphysically indeterminate in a specified respect, what follows? In this paper, we develop a theory of metaphysical indeterminacy answering this question.

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

The Promise of Friendship investigates what makes friendship possible and good for human beings. In dialogue with authors ranging from Aristotle and Montaigne to Proust, Levinas, and Derrida, Sarah Horton argues that friendship is suited to our finitude—that is, to the limits within which human beings live—and proposes a novel understanding of friendship as translation: friends translate the world for each other so that each one experiences the world not as the other does but in light of the friend's (...) always-unknowable experience. The very distance between friends that makes it impossible for them to know each other wholly also makes it possible for them to be transformed by friendship. Friendship, then, is possible and good for those who love precisely that they can never wholly know the friend. Friendship is a profound, mutual self-giving that highlights the irreplaceability of each person, fundamentally shapes the self, and is one of the greatest joys of human existence. (shrink)

The Archival and Constructive views of memory offer contrasting characterizations of remembering and its relation to memory errors. I evaluate the descriptive adequacy of each by offering a close analysis of one of the most prominent experimental techniques by which memory errors are elicited—the Deese-Roediger-McDermott paradigm. Explaining the DRM effect requires appreciating it as a distinct form of memory error, which I refer to as misremembering. Misremembering is a memory error that relies on successful retention of the targeted event. It (...) differs from both successful remembering and from confabulation errors, where the representation produced is wholly inaccurate. As I show, neither the Archival nor the Constructive View can account for the DRM effect because they are insensitive to misremembering’s unique explanatory demands. Fortunately, the explanatory limitations of the Archival and Constructive Views are complementary. This suggests a way.. (shrink)

À première vue, la précaution n’a plus de rôle majeur à jouer face aux risques liés aux changements climatiques dont l’origine anthropique est désormais avérée. Elle aurait ainsi laissé la place en partie à la prévention, ce qui n’a rien de surprenant puisque ces deux approches s’inscrivent dans un continuum. Les risques générés par les changements climatiques ont cependant la particularité d’être des risques globaux à la fois en raison de la multiplicité des acteurs qui en sont à l’origine et (...) de la portée des préjudices qui découlent de leur réalisation. Or il reste au moins deux éléments d’incertitude scientifique qui concernent, d’une part, les liens entre les effets globaux des changements climatiques et les effets au niveau local et, d’autre part, les interactions possibles entre risques multiples. Face à ces éléments d’incertitude variables, la précaution est le curseur permettant de déterminer à un instant précis l’acceptabilité sociale des risques. L’approche de précaution constitue l’origine et le principe directeur d’un processus de recherche et de décision caractérisé par la pluralité : des situations de précaution ouvrent la voie à des degrés de précaution et à différents niveaux de mesures de précaution. Cette dynamique se manifeste du point de vue juridique au niveau du processus d’identification des risques, de la détermination des obligations des Etats et enfin de l’engagement de leur responsabilité. (shrink)

In this article, we discuss expertise by considering the activity of reading. Cognitive scientists have traditionally conceptualised reading as a single, well-defined task, namely the decoding of letter sequences into meaningful sequences of speech sounds. This definition captures a core feature of the reading activity at the computational level, but it is an overly narrow model of how reading behaviour occurs in the real world. We propose a more expansive model of expertise. In our view, expertise in general is best (...) conceptualised as a distributed process that takes place within a cultural-cognitive ecosystem. Our model allows for a more inclusive view of expertise in reading. We argue that reading is better understood as a manifold task domain that admits multiple reasonable criteria for evaluating performance. We draw on ethnographic data to show how our model allows for a wider appreciation of what expertise in reading amounts to in educational contexts. (shrink)

In this reflection, I respond to Anthony Reddie's reflections and assertions about the sacramentality of black flesh in a world shaped by white supremacy. I locate myself as Korean American and refer to my experience of ministering to university students during the rise of Black Lives Matter in the US. Instead of offering cognate claims for the sacramentality of Asian flesh, I ask what theological repentance should look like in light of the historical profaning of the black body. Using the (...) work of two black American artists, jazz musician Robert Glasper and painter Titus Kaphar, I offer beginning reflections on how our liturgies and practices need to change as part of theological repentance—including lament. (shrink)

Whereas traditional abolitionist arguments call for putting an end to capital punishment, French-Algerian philosopher Jacques Derrida emphasizes its survival, writing that “even when it will have been abolished, the death penalty will survive.” My dissertation interprets this perplexing claim by attending to the specificity of Derrida’s discourse on survival or survivance, contending that the death penalty serves an irreducible role in the constitution of the (individual or collective) subject, such that, even in the event of its abolition, some form of (...) the death penalty must continue. Through close readings of Heidegger, Kant, Nietzsche, Freud, Michel de Montagne, and Victor Hugo, as well as Shakespeare, linguist Émile Benveniste, Hungarian psychoanalysts Abraham and Torok, and the nineteenth-century political theorist Juan Donoso Cortés, the dissertation provides an account of the function of the death penalty as a specific institution within the modern penal system of a collective political body and as the legacy of ancient political economies based on sacrificial rites. This analysis interprets the death penalty both structurally and specifically, accounting for the indissociable relationship between the institution and its conceptual structure more broadly. Survivance, I argue, only ever occurs through an other, leaving open the question of the survival of the death penalty to the dissemination of indefinite and unpredictable forms that could consist in its abolition. (shrink)

The three dialogues in this contribution concern 21st century application of life‐like robots in the care of older adults. They depict conversations set in the near future, involving a philosopher (Dr Phonius) and a nurse (Dr Myloss) who manages care at a large facility for assisted living. In their first dialogue, the speakers discover that their quite different attitudes towards human‐robot interaction parallel fundamental differences separating their respective concepts of consciousness. The second dialogue similarly uncovers deeply contrasting notions of personhood (...) that appear to be associated with respective communities of nursing and robotics. The additional key awareness that arises in their final dialogue links applications of life‐like robots in the care of older adults with potential transformations in our understandings of ourselves – indeed, in our understandings of the nature of our own humanity. This series of dialogues, therefore, appears to address a topic in nursing philosophy that merits our careful attention. (shrink)

In this paper I respond to Trenton Merricks's (2005) paper ‘Composition and Vagueness’. I argue that Merricks's paper faces the following difficulty: he claims to provide independent motivation for denying one of the premisses of the Lewis-Sider vagueness argument for unrestricted composition, but the alleged motivation he provides begs the question.

What role can intellectual virtues play in an account of knowledge when we interpret those virtues internalistically, i.e., as depending only on internal states of the cognizer? Though it has been argued that internalist virtues are ill suited to play any role in an account of knowledge, I will show that, on the contrary, internalist virtues can play an important role in recent accounts of knowledge developed to utilize externalist virtues. The virtue account of knowledge developed by Linda Zagzebski is (...) intended to be supplemented by her version of the intellectual virtues which require an external success component. John Greco and Wayne Riggs both develop credit accounts of knowledge on which the abilities we use when we get credit for a true belief must be reliable. I examine the similarities between these three accounts of knowledge and demonstrate that internalist virtues fit into these accounts just as well as externalist virtues. Thus, although internalist virtues do not require a reliable connection to truth, they can still play an important role in defining the truth-requiring concept of knowledge. (shrink)

ABSTRACTGaze-cuing refers to the spontaneous orienting of attention towards a gazed-at location, characterised by shorter response times to gazed-at than non-gazed at targets. Previous research suggests that processing of these gaze cues interacts with the processing of facial expression cues to enhance gaze-cuing. However, whether only negative emotions can enhance gaze-cuing is still debated, and whether this emotional modulation varies as a function of individual differences still remains largely unclear. Combining data from seven experiments, we investigated the emotional modulation of (...) gaze-cuing in the general population as a function of participant sex, and self-reported subclinical trait anxiety, depression, and autistic traits. We found that emotional enhancement of gaze-cuing can occur for both positive and negative expressions, the higher the score on the Attention to Detail subscale of the Autism Spectrum Quotient, the smaller the emotiona... (shrink)

What is the best model of epistemic agency for virtue epistemology? Insofar as the intellectual and moral virtues are similar, it is desirable to develop models of agency that are similar across the two realms. Unlike Aristotle, the Stoics present a model of the virtues on which the moral and intellectual virtues are unified. The Stoics’ materialism and determinism also help to explain how we can be responsible for our beliefs even when we cannot believe otherwise. In this paper I (...) show how a neo-Stoic model of epistemic agency can address common objections to treating epistemic and moral agency similarly and allow a robust explanatory role for character in determining our actions and beliefs. The picture of epistemic responsibility that flows from this model also explains why we often deserve credit for our knowledge, while demonstrating that the truth of our beliefs is not something for which we are epistemically responsible. (shrink)

Named one of the Ten Best Books of 2016 by the New York Times, a spirited account of a major intellectual movement of the twentieth century and the revolutionary thinkers who came to shape it, by the best-selling author of How to Live Sarah Bakewell. Paris, 1933: three contemporaries meet over apricot cocktails at the Bec-de-Gaz bar on the rue Montparnasse. They are the young Jean-Paul Sartre, Simone de Beauvoir, and longtime friend Raymond Aron, a fellow philosopher who raves (...) to them about a new conceptual framework from Berlin called Phenomenology. "You see," he says, "if you are a phenomenologist you can talk about this cocktail and make philosophy out of it!" It was this simple phrase that would ignite a movement, inspiring Sartre to integrate Phenomenology into his own French, humanistic sensibility, thereby creating an entirely new philosophical approach inspired by themes of radical freedom, authentic being, and political activism. This movement would sweep through the jazz clubs and cafés of the Left Bank before making its way across the world as Existentialism. Featuring not only philosophers, but also playwrights, anthropologists, convicts, and revolutionaries, At the Existentialist Café follows the existentialists' story, from the first rebellious spark through the Second World War, to its role in postwar liberation movements such as anti-colonialism, feminism, and gay rights. Interweaving biography and philosophy, it is the epic account of passionate encounters--fights, love affairs, mentorships, rebellions, and long partnerships--and a vital investigation into what the existentialists have to offer us today, at a moment when we are once again confronting the major questions of freedom, global responsibility, and human authenticity in a fractious and technology-driven world. (shrink)

Introduction to a special issue of The Acorn guest edited by Sanjay Lal: In this issue of The Acorn, Lal defends the thesis of his book-length argument that a democratic state should exercise a more engaged interest in religious education and practice, the better to ensure a more perfect union between religion and democracy. Acorn reviewer Gail Presbey looks at Sarah Azaransky’s book about This Worldwide Struggle that revisits connections between Black struggle in the US and nonviolent resistance in (...) India. Azaransky’s work pays special attention to Bayard Rustin. In his book, Gandhi After 9/11, Douglas Allen labors to free Gandhian philosophy from dogmas and absolutes, sometimes in keeping with Gandhi’s own flexibility, other times challenging the inflexibility or myopia of the Mahatma. In an author-meets-critics session, Karsten Struhl and Sanjay Lal take up Allen’s project in a robust dialogue. -/- In an article on “Revolutionary Nondualism,” Sanjay Lal apprehends a vital philosophical kinship between Stoic philosophy and Gandhi that allows Lal to apply Nussbaum’s critique of the Stoics to Gandhi for the purpose of showing how Gandhi might respond. In “Techno-Satyagraha,” Michael Allen presents a Gandhi-inspired, anti-dogmatic approach to political economy that is responsive to technological innovations. In “Why Pacifist Leadership Overcomes the Over-Demandingness Objection,” Federico Germán Abal defends a special case: whereas many people may lapse from pacifism without failing to be good, it is not over-demanding to expect more rigorous moral behavior from pacifist leadership. In a review of Judith Butler's book The Force of Nonviolence, Will Barnes discusses Butler's view that nonviolence is a demand for an equality of grieveability. And considering the book War and Health: The Medical Consequences of the Wars in Iraq and Afghanistan, edited by Catherine Lutz and Andrea Mazzarino, Acorn reviewer Tom Hastings presents the case that a syndemics approach to the past two decades would explore how disease has been aggravated by social, environmental, or economic factors such as the post-9/11 wars. (shrink)

This article responds to two ethical conundrums associated with the practice of disability passing. One of these problems is the question of whether or not passing as abled is morally wrong in that it constitutes deception. The other, related difficulty arises from the tendency of the able-bodied in contemporary society to reinforce the activity of passing despite its frequent condemnation as a form of pretense or fraud. We draw upon recent scholarship on transgender and disability passing to criticize and explore (...) some alternatives to the problematic theory of personal identity that is presupposed by the claim that passing as abled always amounts to deceit. We additionally demonstrate the moral indefensibility of society’s reinforcement of disability passing by showing that it may derive, at least in part, from ablest assumptions concerning distributive justice as it relates to disabled individuals. (shrink)

In Minds, Brains, and Norms , Pardo and Patterson deny that the activities of persons (knowledge, rule-following, interpretation) can be understood exclusively in terms of the brain, and thus conclude that neuroscience is irrelevant to the law, and to the conceptual and philosophical questions that arise in legal contexts. On their view, such appeals to neuroscience are an exercise in nonsense. We agree that understanding persons requires more than understanding brains, but we deny their pessimistic conclusion. Whether neuroscience can be (...) used to address legal issues is an empirical question. Recent work on locked-in syndrome, memory, and lying suggests that neuroscience has potential relevance to the law, and is far from nonsensical. Through discussion of neuroscientific methods and these recent results we show how an understanding of the subpersonal mechanisms that underlie person-level abilities could serve as a valuable and illuminating source of evidence in legal and social contexts. In so doing, we sketch the way forward for a no-nonsense approach to the intersection of law and neuroscience. (shrink)

E. A. Burtt, dans Metaphysical foundations of modern physic remarque que, «dans toutes les études génétiques qui sont entreprises aujourd’hui avec une telle confiance, la nature précise et les assomptions de la pensée scientifique moderne elle-même n’ont jamais fait l’objet d’une recherche critique réellement désintéressée ». Si cela est vrai dans la science moderne, c’est surtout vrai dans la philosophie moderne. Demander quels sont les postulats d’un système quelconque est devenu une question habituelle, depuis que les mathématiques modernes ont mis (...) en question la vérité des postulats d’Euclide et que la logique moderne en a fait ensuite autant de ceux d’Aristote. On recherche ici quels sont les postulats fondamentaux des systèmes cartésiens. (shrink)

This essay addresses the relation between ghosts and the fires of writing. It allows itself to dream of purely burning, of consuming and leaving behind all objects, topics and occasions in an absolutely concrete, singular, sensational experience of reading. It is written to and for ghosts – the only ones who can survive in the blazing building that writing can become. The ghosts live in burning house scenes, in poems about dream rooms and erotic hauntings, and in the intellectual tension (...) of literary and non-literary texts. They have something to do with the fires of sexuality, and the intensities of sublimation. It is all about love and death. (shrink)

Many adolescents use their electronic devices to send each other sexually explicit texts, photos, and videos of themselves—commonly known as sexting. This can be fun and is not usually problematic. However, if the intended recipient decides to share these sexts with a broader audience, the consequences for the depicted can be detrimental. The purpose of this study was to investigate the prevalence of sext-sharing among Dutch adolescents and explore the characteristics of those who do, to gain a better understanding of (...) factors involved in dissemination. We used data from “Sex under the age of 25,” a representative national survey on sexual health among a sample of 20,834 Dutch 12–24-year-olds. The prevalence of sext-sharing was estimated using Complex Samples. Logistic regressions were used to assess associations between demographics, school-based sexting education, sexual- and online behavior, and mental health and sext-sharing. About 4% of the adolescents reported having shared someone else's sext in the last six months. Being male, aged 12–14 years, frequent social media usage, watching online porn, sexual experience, and being subjected to sext-sharing themselves associated most strongly with sext-sharing. Our findings show that the likelihood of sext-sharing is lower in older adolescents and that it associates with the extent of adolescents' sexual curiosity and online activity. The overlap between sharing sexts of others and having one's own sext shared suggests that dissemination of personal sexual content might be normalized or used as an act of retribution. Further research could be helpful to explain the mechanisms underlying this overlap. The results of this study illustrate the importance of exposing adolescents to evidence based preventive educational interventions on sexting from 12 years onwards and not just within the context of traditional school-based sex education, but also as a part of the media-literacy curriculum. (shrink)

This extended editorial takes stock of the first volume of the journal Ethics and Social Welfare, offering an overview of the types of contributions in the first four issues and suggesting future themes. A critical summary is given of the contributions so far, which have included: moral philosophical theorizing; analysis of key ethical concepts; exploration of contested areas of policy and practice; empirical studies of living conditions, perceptions, attitudes and professional interventions; accounts of ethical issues in practice; ethical issues in (...) research; and models of professional ethical decision making. Themes identified for future consideration include: service user perspectives on aspects of social welfare practice; development of practice-based ethical theories for the social welfare professions; ideas about teaching professional and practical ethics; ethical issues in managing and distributing resources; critical analysis of the ethical implications of public policies; further contributions offering moral, political and social philosophical perspectives on issues of social justice, cultural diversity, global and local policies for tackling environmental and humanitarian crises. (shrink)

The Art of Contact: Comparative Approaches to Greek and Phoenician Art. By S. Rebecca Martin. Philadelphia: University of Pennsylvania Press, 2017. Pp. 282, illus. $59.95.

Early modern natural philosophers such as Francis Bacon are frequently seen as providing a legitimating ideology for British imperial expansion. Although this has been challenged by one recent study, much of Bacon's work on English colonisation remains unexplored. This article argues that far from being an ideological apologist for English colonisation, Bacon had two sets of colonial anxieties. The first derived from a tradition of civic humanism which concerned the moral corruption, dispossession of indigenous people and the greed involved in (...) the British colonization of Ireland and America. Bacon's second anxiety was not moral but epistemological, and stemmed from his natural philosophy. For Bacon, colonies were not simply new commonwealths, they were places which potentially produced the natural knowledge vital for the recreation of man's original, epistemic empire over the world. Consequently, Bacon was not only interested in the morality of colonising, but also whether the knowledge produced in colonies was reliable. An exploration of Bacon's views on colonisation also offers us a point of entry into the scholarly debate about the relationship between Bacon's natural philosophy and his political thought. (shrink)