ABSTRACT16p11.2 deletion syndrome is a severe genetic disorder associated with the deletion of 27 genes from a Copy Number Variant region on human chromosome 16. Symptoms associated include cognitive impairment, language and motor delay, epilepsy or seizures, psychiatric disorders, autism spectrum disorder (ASD), changes in head size and body weight, and dysmorphic features, with a crucial need to define genes and mechanisms responsible for symptomatology. In this review, we analyze the clinical associations and biological pathways of 16p11.2 locus genes and (...) identify that a majority of 16p11.2 genes relate to metabolic processes. We present a hypothesis in which changes in the dosage of 16p11.2 metabolic genes contribute to pathology through direct or indirect alterations in pathways that include amino acids or proteins, DNA, RNA, catabolism, lipid, energy (carbohydrate). This hypothesis suggests that research into the specific roles of each metabolic gene will help identify useful therapeutic targets. (shrink)

Sarah Richmond’s translation makes an important contribution to Sartrean scholarship. L’Etre et le néant was first translated by Hazel Barnes in 1956 but it contained various errors. Richmond also had access to the internet and to Sartre’s French and German sources. Her edition also contains an Introduction and a ‘Notes on the translation’ section.Sartre published his work in 1943 and, unable to access all the works he cited, he often did so from memory. He also adopted certain translators’ neologisms: (...) for example, Corbin’s translation of Heidegger’s Qu’est-ce que la métaphysique?, and when he quoted Nietzsche, he used two different translations, and he quotes Spinoza using a text by Hegel. He quotes a line from the playwright Beaumarchais without clarifying the context.Sarah Richmond deals with many of these problems and also notes that the French gender system can be problematic. Also, Sartre’s neologisms rendered finding English equivalents difficult. This is an excellent translation. (shrink)

This article surveys most of the recent reviews of Sarah Richmond’s excellent new translation of L’Être et le néant. It offers some close textual comparisons between Richmond’s translation, Hazel Barnes’ translation, and the Checklist of Errors of Hazel Barnes’ Translation of L’Être et le néant. This article concludes that Richmond delivers a higher semantic resolution translation that overcomes nearly all the liabilities found in Barnes and does so without sacrificing much by way of readability.

These texts, the property of the Egypt Exploration Society, were purchased, together with other literary and documentary material, from a Greek lady at Medînet-el-Faiyûm by Dr. J. de M. Johnson in 1914. I am grateful to the Secretary of the Society for permission to publish them.

The Promise of Friendship investigates what makes friendship possible and good for human beings. In dialogue with authors ranging from Aristotle and Montaigne to Proust, Levinas, and Derrida, Sarah Horton argues that friendship is suited to our finitude—that is, to the limits within which human beings live—and proposes a novel understanding of friendship as translation: friends translate the world for each other so that each one experiences the world not as the other does but in light of the friend's (...) always-unknowable experience. The very distance between friends that makes it impossible for them to know each other wholly also makes it possible for them to be transformed by friendship. Friendship, then, is possible and good for those who love precisely that they can never wholly know the friend. Friendship is a profound, mutual self-giving that highlights the irreplaceability of each person, fundamentally shapes the self, and is one of the greatest joys of human existence. (shrink)

The Archival and Constructive views of memory offer contrasting characterizations of remembering and its relation to memory errors. I evaluate the descriptive adequacy of each by offering a close analysis of one of the most prominent experimental techniques by which memory errors are elicited—the Deese-Roediger-McDermott paradigm. Explaining the DRM effect requires appreciating it as a distinct form of memory error, which I refer to as misremembering. Misremembering is a memory error that relies on successful retention of the targeted event. It (...) differs from both successful remembering and from confabulation errors, where the representation produced is wholly inaccurate. As I show, neither the Archival nor the Constructive View can account for the DRM effect because they are insensitive to misremembering’s unique explanatory demands. Fortunately, the explanatory limitations of the Archival and Constructive Views are complementary. This suggests a way.. (shrink)

This papyrus was acquired, with some others, for the Egypt Exploration Society in 1914 at Medînet-el-Faiyûm by Dr. John Johnson. It consists of five large pieces; of these four join and together measure 37 × 24·5 cm.; they contain remains of three adjacent columns. Another piece measures 5 × 13·5 cm., and a small unplaced scrap 4·5 × 3·7 cm. The writing of the recto, which runs along the fibres, is large, regular, rounded, and clear, but not elegant; I would (...) assign it to the second century B.C. The verso was written across the fibres; the hand may be the same, but seems more cursive; the surface is very damaged and no whole word is legible. A certain irregularity in the spacing of letters and lines suggests that the papyrus was used again for a document. (shrink)

This papyrus was acquired, with some others, for the Egypt Exploration Society in 1914 at Medînet-el-Faiyûm by Dr. John Johnson. It consists of five large pieces; of these four join and together measure 37 × 24·5 cm.; they contain remains of three adjacent columns. Another piece measures 5 × 13·5 cm., and a small unplaced scrap 4·5 × 3·7 cm. The writing of the recto, which runs along the fibres, is large, regular, rounded, and clear, but not elegant; I would (...) assign it to the second century B.C. The verso was written across the fibres; the hand may be the same, but seems more cursive; the surface is very damaged and no whole word is legible. A certain irregularity in the spacing of letters and lines suggests that the papyrus was used again for a document. (shrink)

À première vue, la précaution n’a plus de rôle majeur à jouer face aux risques liés aux changements climatiques dont l’origine anthropique est désormais avérée. Elle aurait ainsi laissé la place en partie à la prévention, ce qui n’a rien de surprenant puisque ces deux approches s’inscrivent dans un continuum. Les risques générés par les changements climatiques ont cependant la particularité d’être des risques globaux à la fois en raison de la multiplicité des acteurs qui en sont à l’origine et (...) de la portée des préjudices qui découlent de leur réalisation. Or il reste au moins deux éléments d’incertitude scientifique qui concernent, d’une part, les liens entre les effets globaux des changements climatiques et les effets au niveau local et, d’autre part, les interactions possibles entre risques multiples. Face à ces éléments d’incertitude variables, la précaution est le curseur permettant de déterminer à un instant précis l’acceptabilité sociale des risques. L’approche de précaution constitue l’origine et le principe directeur d’un processus de recherche et de décision caractérisé par la pluralité : des situations de précaution ouvrent la voie à des degrés de précaution et à différents niveaux de mesures de précaution. Cette dynamique se manifeste du point de vue juridique au niveau du processus d’identification des risques, de la détermination des obligations des Etats et enfin de l’engagement de leur responsabilité. (shrink)

In this article, we discuss expertise by considering the activity of reading. Cognitive scientists have traditionally conceptualised reading as a single, well-defined task, namely the decoding of letter sequences into meaningful sequences of speech sounds. This definition captures a core feature of the reading activity at the computational level, but it is an overly narrow model of how reading behaviour occurs in the real world. We propose a more expansive model of expertise. In our view, expertise in general is best (...) conceptualised as a distributed process that takes place within a cultural-cognitive ecosystem. Our model allows for a more inclusive view of expertise in reading. We argue that reading is better understood as a manifold task domain that admits multiple reasonable criteria for evaluating performance. We draw on ethnographic data to show how our model allows for a wider appreciation of what expertise in reading amounts to in educational contexts. (shrink)

In this reflection, I respond to Anthony Reddie's reflections and assertions about the sacramentality of black flesh in a world shaped by white supremacy. I locate myself as Korean American and refer to my experience of ministering to university students during the rise of Black Lives Matter in the US. Instead of offering cognate claims for the sacramentality of Asian flesh, I ask what theological repentance should look like in light of the historical profaning of the black body. Using the (...) work of two black American artists, jazz musician Robert Glasper and painter Titus Kaphar, I offer beginning reflections on how our liturgies and practices need to change as part of theological repentance—including lament. (shrink)

Whereas traditional abolitionist arguments call for putting an end to capital punishment, French-Algerian philosopher Jacques Derrida emphasizes its survival, writing that “even when it will have been abolished, the death penalty will survive.” My dissertation interprets this perplexing claim by attending to the specificity of Derrida’s discourse on survival or survivance, contending that the death penalty serves an irreducible role in the constitution of the (individual or collective) subject, such that, even in the event of its abolition, some form of (...) the death penalty must continue. Through close readings of Heidegger, Kant, Nietzsche, Freud, Michel de Montagne, and Victor Hugo, as well as Shakespeare, linguist Émile Benveniste, Hungarian psychoanalysts Abraham and Torok, and the nineteenth-century political theorist Juan Donoso Cortés, the dissertation provides an account of the function of the death penalty as a specific institution within the modern penal system of a collective political body and as the legacy of ancient political economies based on sacrificial rites. This analysis interprets the death penalty both structurally and specifically, accounting for the indissociable relationship between the institution and its conceptual structure more broadly. Survivance, I argue, only ever occurs through an other, leaving open the question of the survival of the death penalty to the dissemination of indefinite and unpredictable forms that could consist in its abolition. (shrink)

What role can intellectual virtues play in an account of knowledge when we interpret those virtues internalistically, i.e., as depending only on internal states of the cognizer? Though it has been argued that internalist virtues are ill suited to play any role in an account of knowledge, I will show that, on the contrary, internalist virtues can play an important role in recent accounts of knowledge developed to utilize externalist virtues. The virtue account of knowledge developed by Linda Zagzebski is (...) intended to be supplemented by her version of the intellectual virtues which require an external success component. John Greco and Wayne Riggs both develop credit accounts of knowledge on which the abilities we use when we get credit for a true belief must be reliable. I examine the similarities between these three accounts of knowledge and demonstrate that internalist virtues fit into these accounts just as well as externalist virtues. Thus, although internalist virtues do not require a reliable connection to truth, they can still play an important role in defining the truth-requiring concept of knowledge. (shrink)

ABSTRACTGaze-cuing refers to the spontaneous orienting of attention towards a gazed-at location, characterised by shorter response times to gazed-at than non-gazed at targets. Previous research suggests that processing of these gaze cues interacts with the processing of facial expression cues to enhance gaze-cuing. However, whether only negative emotions can enhance gaze-cuing is still debated, and whether this emotional modulation varies as a function of individual differences still remains largely unclear. Combining data from seven experiments, we investigated the emotional modulation of (...) gaze-cuing in the general population as a function of participant sex, and self-reported subclinical trait anxiety, depression, and autistic traits. We found that emotional enhancement of gaze-cuing can occur for both positive and negative expressions, the higher the score on the Attention to Detail subscale of the Autism Spectrum Quotient, the smaller the emotiona... (shrink)

What is the best model of epistemic agency for virtue epistemology? Insofar as the intellectual and moral virtues are similar, it is desirable to develop models of agency that are similar across the two realms. Unlike Aristotle, the Stoics present a model of the virtues on which the moral and intellectual virtues are unified. The Stoics’ materialism and determinism also help to explain how we can be responsible for our beliefs even when we cannot believe otherwise. In this paper I (...) show how a neo-Stoic model of epistemic agency can address common objections to treating epistemic and moral agency similarly and allow a robust explanatory role for character in determining our actions and beliefs. The picture of epistemic responsibility that flows from this model also explains why we often deserve credit for our knowledge, while demonstrating that the truth of our beliefs is not something for which we are epistemically responsible. (shrink)

Named one of the Ten Best Books of 2016 by the New York Times, a spirited account of a major intellectual movement of the twentieth century and the revolutionary thinkers who came to shape it, by the best-selling author of How to Live Sarah Bakewell. Paris, 1933: three contemporaries meet over apricot cocktails at the Bec-de-Gaz bar on the rue Montparnasse. They are the young Jean-Paul Sartre, Simone de Beauvoir, and longtime friend Raymond Aron, a fellow philosopher who raves (...) to them about a new conceptual framework from Berlin called Phenomenology. "You see," he says, "if you are a phenomenologist you can talk about this cocktail and make philosophy out of it!" It was this simple phrase that would ignite a movement, inspiring Sartre to integrate Phenomenology into his own French, humanistic sensibility, thereby creating an entirely new philosophical approach inspired by themes of radical freedom, authentic being, and political activism. This movement would sweep through the jazz clubs and cafés of the Left Bank before making its way across the world as Existentialism. Featuring not only philosophers, but also playwrights, anthropologists, convicts, and revolutionaries, At the Existentialist Café follows the existentialists' story, from the first rebellious spark through the Second World War, to its role in postwar liberation movements such as anti-colonialism, feminism, and gay rights. Interweaving biography and philosophy, it is the epic account of passionate encounters--fights, love affairs, mentorships, rebellions, and long partnerships--and a vital investigation into what the existentialists have to offer us today, at a moment when we are once again confronting the major questions of freedom, global responsibility, and human authenticity in a fractious and technology-driven world. (shrink)

Collections of living organisms are reservoirs of biological knowledge that operate across times and places. From the mid-20th century, scientific institutions dedicated to the cultivation of such collections have routinized and professionalized their care. But “care,” for these collections, is focused not just on individual organisms—instead, a principal aim of a curator is to maintain the integrity of a reproducing “strain,” “variety,” “line,” or “stock,” and the composition of a collection as a whole. This paper explores the forms, the material (...) dimensions, the temporalities, and the values of that care, to recover the conditions under which scientist-custodians maintain continuity of research over many decades. This paper does so by focusing on two rather different kinds of scientific collection: that of Drosophila fruit flies on the one hand, and plant seeds on the other. Their comparison is valuable because their vastly different needs and life cycles engender very different practices of care. Comparing the materialities, life cycles, needs, and values of these divergent collections helps to draw attention to the routine and the apparently mundane. First, the paper asks: what kinds of work go into managing such collections—that is, the day-to-day management and cultivation, surveillance, and administration of information? Second, it asks: how do these practices maintain the integrity of the strains and stocks, and the collections themselves? What kinds of value does this work create? Third, what are the future imaginaries that are rhetorically drawn into the funding strategies of these collections, and how do they envision future use, ownership, and control? (shrink)

Introduction to a special issue of The Acorn guest edited by Sanjay Lal: In this issue of The Acorn, Lal defends the thesis of his book-length argument that a democratic state should exercise a more engaged interest in religious education and practice, the better to ensure a more perfect union between religion and democracy. Acorn reviewer Gail Presbey looks at Sarah Azaransky’s book about This Worldwide Struggle that revisits connections between Black struggle in the US and nonviolent resistance in (...) India. Azaransky’s work pays special attention to Bayard Rustin. In his book, Gandhi After 9/11, Douglas Allen labors to free Gandhian philosophy from dogmas and absolutes, sometimes in keeping with Gandhi’s own flexibility, other times challenging the inflexibility or myopia of the Mahatma. In an author-meets-critics session, Karsten Struhl and Sanjay Lal take up Allen’s project in a robust dialogue. -/- In an article on “Revolutionary Nondualism,” Sanjay Lal apprehends a vital philosophical kinship between Stoic philosophy and Gandhi that allows Lal to apply Nussbaum’s critique of the Stoics to Gandhi for the purpose of showing how Gandhi might respond. In “Techno-Satyagraha,” Michael Allen presents a Gandhi-inspired, anti-dogmatic approach to political economy that is responsive to technological innovations. In “Why Pacifist Leadership Overcomes the Over-Demandingness Objection,” Federico Germán Abal defends a special case: whereas many people may lapse from pacifism without failing to be good, it is not over-demanding to expect more rigorous moral behavior from pacifist leadership. In a review of Judith Butler's book The Force of Nonviolence, Will Barnes discusses Butler's view that nonviolence is a demand for an equality of grieveability. And considering the book War and Health: The Medical Consequences of the Wars in Iraq and Afghanistan, edited by Catherine Lutz and Andrea Mazzarino, Acorn reviewer Tom Hastings presents the case that a syndemics approach to the past two decades would explore how disease has been aggravated by social, environmental, or economic factors such as the post-9/11 wars. (shrink)

The issue which I wish to address in this paper is the widespread tendency in Anglophone philosophy to insist on a separation between the history of philosophy and the history of ideas or intellectual history. This separation reflects an anxiety on the part of philosophers lest the special character of philosophy will be dissolved into something else in the hands of historians. And it is borne of a fundamental tension between those who think of philosophy's past as a source of (...) ideas and arguments of interest to the present, and those who hold that the philosophy of the past should be studied on its own terms, in relation to its immediate context, without reference to the present. The challenge, then, is to re-historicise the history of philosophy, and to keep the philosophers onside. (shrink)

As befits an emerging field of enquiry, there is on-going discussion about the scope, role and future of the medical humanities. One relatively recent contribution to this debate proposes a differentiation of the field into two distinct terrains, ‘medical humanities’ and ‘health humanities,’ and calls for a supersession of the former by the latter. In this paper, we revisit the conceptual underpinnings for a distinction between ‘the medical’ and ‘health’ by looking at the history of an analogous debate between ‘medical (...) geography’ and ‘the geographies of health’ that has, over the last few years, witnessed a re-blurring of the distinction. Highlighting the value of this debate within the social sciences for the future development of the medical humanities, we call for scholars to take seriously the challenges of critical and cultural theory, community-based arts and health, and the counter-cultural creative practices and strategies of activist movements in order to meet the new research challenges and fulfill the radical potential of a critical medical humanities. (shrink)

In this study, we conducted two experiments to examine the effect of relationship commitment on the reaction of shoppers to receiving too much change, controlling for the amount of excess change. Hypotheses based on equity theory, opportunism and guilt were set up and tested. The first study showed that, when the less committed consumer is confronted with a large excess of change, he/she is less likely to report this mistake, compared with a small excess. Conversely, consumers with a high commitment (...) towards the retailer are more likely to tell when they receive too much change, especially when the amount is large. The second experiment provided an explanation for these findings: the less committed consumer is driven by opportunism, whereas guilt-related feelings play an important role in a high commitment relationship. These results have several implications for both retail management and future research. (shrink)

Rather than focusing on the legal and political questions that surround genocidal rape, in this paper I treat a vital area of inquiry that has received much less attention: the moral significance of genocidal rape. My aim is to augment existing moral accounts of rape in order to address the specific contexts of genocidal rape. I move beyond understanding rape primarily as a violation of an individual's interests or agential abilities. The account I offer builds on these approaches (as well (...) as on a pluralist approach), by arguing that rape, as a moral injury, negatively affects the very human dignity of victims. My account also emphasizes the relational harm that marks genocidal rape. (shrink)

The study of reciprocal altruism, or the exchange of goods and services between individuals, requires attention to both evolutionary explanations and proximate mechanisms. Evolutionary explanations have been debated at length, but far less is known about the proximate mechanisms of reciprocity. Our own research has focused on the immediate causes and contingencies underlying services such as food sharing, grooming, and cooperation in brown capuchin monkeys and chimpanzees. Employing both observational and experimental techniques, we have come to distinguish three types of (...) reciprocity. Symmetry-based reciprocity is cognitively the least complex form, based on symmetries inherent in dyadic relationships (e.g., mutual association, kinship). Attitudinal reciprocity, which is more cognitively complex, is based on the mirroring of social attitudes between partners and is exhibited by both capuchin monkeys and chimpanzees. Finally, calculated reciprocity, the most cognitively advanced form, is based on mental scorekeeping and is found only in humans and possibly chimpanzees. (shrink)

This article responds to two ethical conundrums associated with the practice of disability passing. One of these problems is the question of whether or not passing as abled is morally wrong in that it constitutes deception. The other, related difficulty arises from the tendency of the able-bodied in contemporary society to reinforce the activity of passing despite its frequent condemnation as a form of pretense or fraud. We draw upon recent scholarship on transgender and disability passing to criticize and explore (...) some alternatives to the problematic theory of personal identity that is presupposed by the claim that passing as abled always amounts to deceit. We additionally demonstrate the moral indefensibility of society’s reinforcement of disability passing by showing that it may derive, at least in part, from ablest assumptions concerning distributive justice as it relates to disabled individuals. (shrink)

In this paper, I argue that the supposition of divine omnipotence entails a contradiction: omnipotence both must and must not be intrinsic to God. Hence, traditional theism must be rejected. To begin, I separate out some theoretical distinctions needed to inform the discussion. I then advance two different arguments for the conclusion that omnipotence must be intrinsic to God; these utilise the notions of essence and aseity. Next, I argue that some necessary conditions on being omnipotent are extrinsic, and that (...) this means omnipotence cannot be intrinsic to God. I consider three different ways of resolving this conflict, but contend that each is unsuccessful. Before concluding, I explain why the type of strategy used to resolve the traditional paradoxes of omnipotence cannot be successfully employed against the paradox presented here. (shrink)

In Minds, Brains, and Norms , Pardo and Patterson deny that the activities of persons (knowledge, rule-following, interpretation) can be understood exclusively in terms of the brain, and thus conclude that neuroscience is irrelevant to the law, and to the conceptual and philosophical questions that arise in legal contexts. On their view, such appeals to neuroscience are an exercise in nonsense. We agree that understanding persons requires more than understanding brains, but we deny their pessimistic conclusion. Whether neuroscience can be (...) used to address legal issues is an empirical question. Recent work on locked-in syndrome, memory, and lying suggests that neuroscience has potential relevance to the law, and is far from nonsensical. Through discussion of neuroscientific methods and these recent results we show how an understanding of the subpersonal mechanisms that underlie person-level abilities could serve as a valuable and illuminating source of evidence in legal and social contexts. In so doing, we sketch the way forward for a no-nonsense approach to the intersection of law and neuroscience. (shrink)

Artificial intelligence is increasingly inputting into various human resource management functions, such as sourcing job applicants and selecting staff, allocating work, and offering personalized career coaching. While the use of AI for such tasks can offer many benefits, evidence suggests that without careful and deliberate implementation its use also has the potential to generate significant harms. This raises several ethical concerns regarding the appropriateness of AI deployment to domains such as HRM, which directly deal with managing sometimes sensitive aspects of (...) individuals’ employment lifecycles. However, research at the intersection of HRM and technology continues to largely center on examining what AI can be used for, rather than focusing on the salient factors relevant to its ethical use and examining how to effectively engage human workers in its use. Conversely, the ethical AI literature offers excellent guiding principles for AI implementation broadly, but there remains much scope to explore how these principles can be enacted in specific contexts-of-use. By drawing on ethical AI and task-technology fit literature, this paper constructs a decision-making framework to support the ethical deployment of AI for HRM and guide determinations of the optimal mix of human and machine involvement for different HRM tasks. Doing so supports the deployment of AI for the betterment of work and workers and generates both scholarly and practical outcomes. (shrink)

In this paper, I propose that the distinction between what is at-issue and what is not can be modeled as a distinction between two components of assertion. These two components affect the common ground in different ways. The at-issue component of an assertion, which is negotiable, is treated as a proposal to update the common ground. The not-at-issue component of an assertion, which is not negotiable, is added directly to the common ground. Evidence for this proposal comes from evidentials, which (...) I argue grammaticize this distinction. It has been observed that sentences with evidentials make both an ‘evidential’ and a ‘propositional’ contribution (Faller 2002, 2006, Matthewson et al. 2008). The evidential contribution is not directly challengeable or up for negotiation. In contrast, the propositional contribution, the ‘main point’ of the sentence, is directly challengeable and up for negotiation. I analyze these two contributions of evidentials as the not-at-issue component of assertion and the at-issue component of assertion, respectively. Supporting data comes from Cheyenne, a language with evidentials that are part of the illocutionary mood paradigm. (shrink)

This paper defends a version of epistemic contextualism that accounts for the ordinary judgements and theoretical principles that motivate pragmatic encroachment. Adopting this contextualist view, we can avoid the counterintuitive consequences of pragmatic encroachment, while still preserving its attractive applications.

This project tested a two-way model of communication between lay groups and experts about genetic medicine in Perth, Western Australia. Focus group discussion with community group participants was followed by a communication workshop between community group participants and experts. Four groups of concerns or themes emerged from discussion: clinical considerations; legislative concerns; research priorities, and ethical and wider considerations. Community group concerns are not always met by the actions of "experts". This is, in part, because of the differing life-worlds of (...) each group. However, the communication workshop showed the potential of two-way communication for both lay and expert members in understanding the others' viewpoint. Further, the approach developed here offers one possible way for community groups to participate in a substantial way in policy formulation processes. (shrink)

This article critically examines the ways in which the trope of prosthesis has been used in recent theory to understand human-technology relationships. Analyzing the trope from a number of angles, including disability, factory labor practices, mass production, and marketing, the author scrutinizes ways in which technologies are simultaneously wounding and enabling in ways for which the prosthesis trope cannot account.

Risk communicators often need to communicate probabilistic predictions. On occasion, an event with 10% likelihood will occur, or one with 90% likelihood will not – a probabilistically unexpected ou...