The vertebrate nervous system performs the most complex functions of any organ system. This feat is mediated by dedicated assemblies of neurons that must be precisely connected to one another and to peripheral tissues during embryonic development. Motor neurons, which innervate muscle and regulate autonomic functions, form an integral part of this neural circuitry. The first part of this review describes the remarkable progress in our understanding of motor neuron differentiation, which is arguably the best understood model of neuronal differentiation (...) to date. During development, the coordinate actions of inductive signals from adjacent non‐neural tissues initiate the differentiation of distinct motor neuron subclasses, with specific projection patterns, at stereotypical locations within the neural tube. Underlying this specialisation is the expression of specific homeodomain proteins, which act combinatorially to confer motor neurons with both their generic and subtype‐specific properties. Ensuring that specific motor neuron subtypes innervate the correct target structure, however, requires precise motor axon guidance mechanisms. The second half of this review focuses on how distinct motor neuron subtypes pursue highly specific projection patterns by responding differentially to spatially discrete attractive and repulsive molecular cues. The tight link between motor neuron specification and axon pathfinding appears to be established by the dominant role of homeodomain proteins in dictating the ways that navigating motor axons interpret the plethora of guidance cues impinging on growth cones. BioEssays 23:582–595, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Directional deep brain stimulation contacts provide greater spatial flexibility for therapy than traditional ring-shaped electrodes, but little is known about longitudinal changes of impedance and orientation. We measured monopolar and bipolar impedance of DBS contacts in 31 patients who underwent unilateral subthalamic nucleus deep brain stimulation as part of a randomized study. At different follow-up visits, patients were assigned new stimulation configurations and impedance was measured. Additionally, we measured the orientation of the directional lead during surgery, immediately after surgery, and (...) 1 year later. Here we contrast impedances in directional versus ring contacts with respect to local anatomy, active stimulation contact, and over time. Directional contacts display larger impedances than ring contacts. Impedances generally increase slightly over the first year of therapy, save for a transient decrease immediately post-surgery under general anesthesia during pulse generator placement. Local impedances decrease at active stimulation sites, and contacts in closest proximity to internal capsule display higher impedances than other anatomic sites. DBS leads rotate slightly in the immediate postoperative period but otherwise remain stable over the following year. These data provide useful information for setting clinical stimulation parameters over time. (shrink)

Over the past decade, investments in agricultural and food technology startups have grown to previously unknown dimensions. Mushrooming agri-food tech startups that promise to solve critical issues in the agri-food system through technological innovation are increasingly perceived as an attractive new investment opportunity for venture capitalists and investors. This paper investigates how digital agri-food technologies are narrated, constructed, and promoted for financial investment. Through qualitative content analysis of agri-food tech industry reports, articles, and commentaries we trace the logic, rationales, and (...) narratives of this most recent investment rush, and reveal its immanent techno-finance fixes. We conceptualize the agri-food imaginaries produced within the agri-food tech discourse as financialized imaginaries, and argue that they are specifically tailored to construct, incentivize, and legitimize this new agri-food tech space for financial investment. In their attempt to raise money from investors, venture capital firms further fuel this development by discursively creating an ‘agri-food tech investment rush’—similar to the land and gold rushes of the past. Investments in agri-food tech startups, however, are presented to investors as both a profitable investment opportunity as well as a moral obligation, allowing for food production to cope with neo-malthusian and environmental threats. This paper contributes to our understanding of digitization as a socio-technical project, which includes the active envisioning and promotion of desirable agri-food futures. (shrink)

All of us have personal ideals. We are committed to being good (enough) friends, parents, neighbors, teachers, citizens, human beings, and more. In this paper, I examine the thick and thin aspects of these ideals: (i) their substance (to internalize an ideal is to endorse a particular way of being) and (ii) their accountability to reason (to internalize an ideal is to assume that this is really a good way to be). In considering how these two aspects interact in the (...) ideal of rational agency, I address two philosophical debates that are generally conducted in isolation of each other: (i) debates over the anti-ideal of normative “fetishism” and (ii) debates over whether acting for a reason is acting “under the guise of the good.” In the final two sections of the paper, I further explore the relations among the thick and the thin. I note the role that coherence constraints play in the process whereby our ideals gain determinacy. At the same time, I argue, our ideals constrain the possibility and desirability of coherence. This has implications for a third debate: the debate over the possibility of moral dilemmas. (shrink)

Earth system science (ESS) has identified worrying trends in the human impact on fundamental planetary systems. In this conceptual article, we discuss the implications of this research for business schools and management education (ME). We argue that ESS findings raise significant concerns about the relationship between business and nature and, consequently, a radical reframing is required to embed economic and social activity within the global sustainability of natural systems. This has transformative implications for ME. To illustrate this reframing, we apply (...) the ESS lenses of social-ecological interdependence, multiscalar relations, environmental governance, and environmental values to the ME functional domains of institutional purpose, social context and engagement, pedagogical practice, curricular design, and research focus. Our work contributes to the literature on business education for sustainability and the business-society-nature nexus. We explore and apply key ESS findings and concepts, discuss normative implications of these ideas, and offer guidance on transformational pathways for business schools and ME. (shrink)

Toxoplasma gondii is a highly successful parasite capable of infecting virtually all warm-blooded animals by actively invading nucleated host cells and forming a modified compartment where it replicates within the cytosol. The parasite-containing vacuole provides a safe haven, even in professional phagocytes such as macrophages, which normally destroy foreign microbes. In an effort to eliminate the parasite, the host up-regulates a family of immunity-related p47 GTPases (IRGs), which are recruited to the parasite-containing vacuole, resulting in membrane rupture and digestion of (...) the parasite. To avoid this fate, highly virulent strains of Toxoplasma coat the external surface of their vacuole with a secretory serine/threonine kinase, known as ROP18. At this host-pathogen interface, ROP18 phosphorylates and inactivates IRGs, thereby protecting the parasite from killing. These findings reveal a novel molecular mechanism by which the parasite disarms host innate immunity. (shrink)

This is an attack on the very notion of narrow content. In particular, I argue against two-factor theories of mental content, Chalmers's epistemic two-dimensional account of narrow content and Segal's truth-conditional account of narrow content.

Launched in 1999, at a time of radical change for the publishing industry, Persephone Books has become a successful independent publisher of neglected female authors mainly from the 20th-century inter-war period. Publishing being an industry primarily shaped by the differential distribution of symbolic and economic capital, competing principles of cultural legitimacy within an increasingly commercial climate clarify the position of modern publishing at the intersection of culture and commerce. This article explores how Persephone Books’ understated assertion of publishing’s ‘middle ground’ (...) and commitment to the historically reviled ‘middlebrow’ genre have reconciled the perennial tension between culture and commerce to create a thriving yet unintentional publishing brand. (shrink)

Advances in the study of Paul’s anthropology during the past century have been limited, particularly because of dominant theological approaches that leave many unresolved issues regarding the apostle’s understanding of humans. This article introduces a new approach, which grounds Paul’s anthropological discourse in eschatology, and underscores the importance of transformation. Through the application of this new approach, the esō anthrōpos, instantiated in believers through the Holy Spirit, is shown to be the locus of renewal, and to encompass the entire human. (...) A clear understanding of this concept provides support for the postulation of an intermediate state in Paul’s symbolic universe, a claim that is contested by many scholars. (shrink)

The story of Anna is a brief description of a faithful prophetess which is consciously paired with the previous and more developed narrative of Simeon. Hannah’s story is significant to the Lukan Gospel and yet her voice, which men and women visiting the temple heard repeatedly, is not articulated by Luke. She has been the topic of much research, in as much as three verses in their context can provide, while no one has sought to let Hannah speak for herself. (...) This article aims to do this by exploring her story within the Lukan narrative, considering prophetesses in the Old Testament, and echoing the dynamics of the Jewish story of Judith with which she is intertextually paired. (shrink)

Although I quickly review Philip Rossi’s larger argument in The Ethical Commonwealth in History, my focus in this article is on the implications of Rossi’s work for our characterizations of justice and citizenship on a Kantian account. For in arguing that a wise reading of Kant’s political theory allows us better to grasp his overarching aims, Rossi provides convincing evidence for a pair of challenges to the currently popular interpretation of that theory. These address the relationship between Kant’s moral and (...) political theories and the nature of the political task or project that Kantian citizens undertake. In challenging popular readings of these elements of Kant’s view, I suggest, Rossi supports an interpretation of Kantian political thought with particular resonance for our time. (shrink)

Recent discussions about violence against women have shifted their attention to specific forms of violence in relation to migration and Islam. In this article, I consider different modes of representing women's experiences in French immigrant communities. These representations relate to the French feminist movement Ni Putes Ni Soumises (neither whore nor submissive), a movement that in the early 2000s deplored both the sustained degradation of certain banlieue neighborhoods and also the charges and restrictions that this entails, particularly for young women. (...) Drawing on different narratives and images of women's painful experience, I consider, in a first step, how the question of representing violence against (post)migrant women is framed in terms of the tension between universality and particularity within French republicanism. In the next part of my argument, I bring into focus the question of how to access women's suffering. For a perspective on pain not as an interiorized, private experience but as an accessible complex of practices, articulations, memories, visions and social reconfigurations, I consider Smaïn Laacher's sociological study (2008) about written testimonies of violent experience that had been addressed by (post)migrant women to French women organizations such as Ni Putes Ni Soumises. I finally suggest reading women's accounts on violence not in relation to a universal discourse of rights, but as a political contestation of the naturalized order of representing violence, suffering and agency inside French banlieue communities. Drawing on Jacques Rancière's notion of dissensus, such a contestation can be staged through words by those who have no visibility in the representational order, words not to criticize the unaccomplished ideals of universal equality, but to create a universal community and a common language of experience in the mode of ‘as-if’. (shrink)

This encyclopedia consists of short pieces on specific topics. My contribution concerns the nature of thought and its implications for the status of social sciences.

This article considers an apparent tension between, on the one hand, a widespread belief among literature teachers that the appreciation of a poem involves an experience of form-content inseparability and, on the other hand, these same teachers’ use of paraphrase to encourage appreciation. Using Terrence Deacon’s model of art experience, I argue that the tensions of this ‘paraphrase paradox’ mirror tensions inherent in poetic experience. Section II draws upon work by Rafe McGregor, Peter Lamarque, and Peter Kivy to frame an (...) approach to the form-content distinction, and to offer a brief overview of the paraphrase paradox. Sections III-IV summarize Deacon’s model of aesthetic experience, and argue that this model implies that poetic experience both triggers an impulse towards paraphrase, and frustrates this impulse. Section V looks at implications for the poetry teacher’s attempts to navigate the paraphrase paradox. Section VI tests these implications through an analysis of Philip Larkin’s poem ‘Faith Healing’. (shrink)

The phrase 'here be monsters' or 'here be dragons' is commonly believed to have been used on ancient maps to indicate unexplored territories which might hide unknown beasts. This book maps and explores places between science and politics that have been left unexplored, sometimes hiding in plain sight - in an era when increased emphasis was put on 'openness'. The book is rooted in a programme of research funded by the Leverhulme Trust entitled: 'Making Science Public: Challenges and opportunities, which (...) runs from 2014 to 2017. One focus of our research was to critically question the assumption that making science more open and public could solve various issues around scientific credibility, trust, and legitimacy. Chapters in this book explore the risks and benefits of this perspective with relation to transparency, responsibility, experts and faith. (shrink)

Driving simulators are becoming increasingly common in driver training and assessment. Since virtual reality is generally regarded as an appropriate environment for measuring risk behavior, simulators are also used to assess hazard perception, which is considered to be one of the most important skills for safe driving. Simulators, which offer challenges that are indeed comparable to driving in real traffic, but at a very low risk of physical injury, have the potential to complement theoretical and practical driver trainings and tests. (...) Although configurations and fidelity differ considerably between driving simulators, studies comparing the impact of their distinct features on driving performance and test validity remain rare. In this context, prior research demonstrated that a wider field of view led to earlier speed adjustments in response to potential hazards—especially for experienced drivers. The wider field of view was assumed to cause the drivers to be more present in the virtual world, which in turn provoked more natural scanning of the road and therefore, earlier hazard detection in experienced drivers. Research on spatial presence in other contexts support this assumption. The present experiment investigated whether this effect could be enhanced by an even more immersive presentation technique for driving simulation: a head-mounted display. Moreover, we studied the interplay between display mode, sense of presence and simulation sickness. Eighty experienced and less experienced drivers completed six simulation-based hazard perception scenarios, which were displayed either via a triple-monitor set-up or an HMD. Results indicate that the experienced drivers showed very similar driving and risk behavior as the inexperienced drivers in both experimental conditions. However, there were significant differences between the two display conditions. The use of an HMD resulted in a clearer and more abrupt speed reduction, more virtual presence, and a higher degree of simulation sickness. However, the interrelation between these three variables could not be conclusively clarified in the present study and thus represents a research aim that could be addressed in future studies. (shrink)

Plato's account of the making of the world by a supreme divinity has often been felt to foreshadow the natural theology associated with orthodox western religion. This paper examines some significant ways (having more than merely antiquarian interest, it is hoped) in which the Timaeus scheme differs from more familiar orthodoxy.

À l'orée du xvme siècle, Wilhelm Gottfried Leibniz et Friedrich Hoffmann critiquent la théorie médicale de Georg Ernst Stahl. Ils trient le vrai du faux. En l'occurrence, ils reprennent à leur compte la définition stahlienne de la respiration en l'extirpant de ses fondements animistes pour la placer dans une épistémologie soumise au principe de raison suffisante et au modèle mécanique. La découverte stahlienne consiste à penser la respiration comme ventilation calorifique à l'encontre de la conception antique ; les iatromécaniciens reconnaissent (...) la justesse de la notion stahlienne, ils essaient alors de la transposer dans un modèle mécanique de la ventilation. Cette reprise dans un contexte épistémologique différent implique une analyse critique de l'idée de découverte« vraie» dans son contenu, mais « fausse» dans ses hypothèses. Elle oblige en outre à interroger l'épistémologie de la connaissance médicale, en tant que science et thérapeutique, et ses liens avec les autres disciplines. En effet, si Leibniz philosophe et Hoffmann médecin prennent au sérieux la théorie animiste de Stahl, c'est que l'importance de ses découvertes met en cause les fondements de la médecine. (shrink)

The legitimacy of embryo research, use, and destruction is among the most important issues facing contemporary bioethics. In the preceding paper, Ingmar Persson and Julian Savulescu took up an argument of John Harris and tried to find some new ways of avoiding its dramatic consequences. They noted that: “John Harris has argued that if … it is morally permissible to engage in reproduction … despite knowledge that a large number of embryos will fail to implant and quickly die, then … (...) it is morally permissible to produce embryos for other purposes that involve killing them, for instance, to harvest stem cells” and suggest that this argument fails. (shrink)

On an initial read, neither A.A. Milne's Winnie the Pooh Adventures or Hugh Lofting's The Story of Dr. Dolittle come across as literature written about trauma, and yet both stories derived from authors who were at the front lines of World War I and who put their war experiences into their stories. Evoking nostalgia and drawing on simple lore, both of these works continue to touch the human psyche. Both writers reinvented the way we see trauma and pain, whilst advocating (...) for broader access to holistic healthcare. This, in turn, has impacted our relationship with trauma texts and healthcare forever. (shrink)

A central theme in the Christian contemplative tradition is that knowing God is much more like ‘unknowing’ than it is like possessing rationally acceptable beliefs. Knowledge of God is expressed, in this tradition, in metaphors of woundedness, darkness, silence, suffering, and desire. Philosophers of religion, on the other hand, tend to explore the possibilities of knowing God in terms of rational acceptability, epistemic rights, cognitive responsibility, and propositional belief. These languages seem to point to very different accounts of how it (...) is that we come to know God, and a very different range of critical concepts by which the truth of such knowledge can be assessed. In this paper, I begin to explore what might be at stake in these different languages of knowing God, drawing particularly on Alvin Plantinga’s epistemology of Christian belief. I will argue that his is a distorted account of the epistemology of Christian belief, and that this has implications for his project of demonstrating the rational acceptability of Christian faith for the 21st century. (shrink)

The Hunter, the Stag, and the Mother of Animals: Image, Monument, and Landscape in Ancient North Asia. By Esther Jacobson-Tepfer. Oxford: Oxford University Press, 2015. Pp. xxxiii + 413. $85.

I reconstruct Buber’s conception of personhood and identify in his work four criteria for personhood— uniqueness, wholeness, goodness, and a drive to relation—and an account of three basic degrees of personhood, stretching, as a kind of “chain of being,” from plants and animals, through humans, to God as the absolute person. I show that Buber’s “new” conception of personhood is rooted in older Neoplatonic notions, such the goodness of all being and the principle of plenitude. While other philosophers have used (...) reason and memory to distinguish persons, I find that Buber instead takes these to be specific to humanity, and I explore Buber’s account of a “fall” from a state of nature into a historical mode, such that our humanity threatens our personhood. (shrink)

Synthetic biology has generated extensive discussion about a wide range of risks and potential benefits, the intrinsic value of the technology, and the soci­etal distribution of its risks and benefits. However, be­fore these questions can be resolved, it is important to first ask a critical question: Is synthetic biology different enough from the technologies that came before it that it raises new questions or concerns? By putting synthetic biology into context, we gain a better understanding of the issues, both old (...) and new, that it raises. We can then consider practical governance questions, including ways to improve current practices. (shrink)

Fort, da. Loin, ici. L’enfant joue avec la bobine de fil qui s’éloigne et disparaît, puis revient. Enracinement, déracinement, certaines expériences ancrent mon corps dans une présence à soi, au monde et aux autres, tandis que d’autres me rendent étrangère à moi-même, aux autres et au monde. Les modalités du jeu ou de l’existence se cristallisent dans le corps, qui oscille entre ces deux pôles : il s’affirme et se nie, il s’impose et se retire, il procure plaisir et peine, (...) il se donne et se r... (shrink)