Mitochondrial respiration is the predominant source of ATP. Excessive rates of electron transport cause a higher production of harmful reactive oxygen species (ROS). There are two regulatory mechanisms known. The first, according to Mitchel, is dependent on the mitochondrial membrane potential that drives ATP synthase for ATP production, and the second, the Kadenbach mechanism, is focussed on the binding of ATP to Cytochrome c Oxidase (CytOx) at high ATP/ADP ratios, which results in an allosteric conformational change to CytOx, causing inhibition. (...) In times of stress, ATP‐dependent inhibition is switched off and the activity of CytOx is exclusively determined by the membrane potential, leading to an increase in ROS production. The second mechanism for respiratory control depends on the quantity of electron transfer to the Heme aa3 of CytOx. When ATP is bound to CytOx the enzyme is inhibited, and ROS formation is decreased, although the mitochondrial membrane potential is increased. (shrink)

What is attention? How does attention shape consciousness? In an approach that engages with foundational topics in the philosophy of mind, the theory of action, psychology, and the neurosciences this book provides a unified and comprehensive answer to both questions. Sebastian Watzl shows that attention is a central structural feature of the mind. The first half of the book provides an account of the nature of attention. Attention is prioritizing, it consists in regulating priority structures. Attention is not another (...) element of the mind, but constituted by structures that organize, integrate, and coordinate the parts of our mind. Attention thus integrates the perceptual and intellectual, the cognitive and motivational, and the epistemic and practical. The second half of the book concerns the relationship between attention and consciousness. Watzl argues that attentional structure shapes consciousness into what is central and what is peripheral. The center-periphery structure of consciousness cannot be reduced to the structure of how the world appears to the subject. What it is like for us thus goes beyond the way the world appears to us. On this basis, a new view of consciousness is offered. In each conscious experience we actively take a stance on the world we appear to encounter. It is in this sense that our conscious experience is our subjective perspective. (shrink)

The thesis of Weak Unrestricted Composition says that every pair of objects has a fusion. This thesis has been argued by Contessa and Smith to be compatible with the world being junky and hence to evade an argument against the necessity of Strong Unrestricted Composition proposed by Bohn. However, neither Weak Unrestricted Composition alone nor the different variants of it that have been proposed in the literature can provide us with a satisfying answer to the special composition question, or so (...) we will argue. We will then go on to explore an alternative family of purely mereological rules in the vicinity of Weak Unrestricted Composition, Cardinal Composition: A plurality of pairwise non-overlapping objects composes an object iff the objects in the plurality are of cardinality smaller than $$\kappa $$ κ. As we will show, all the instances for infinite $$\kappa $$ κ s determine fusion and are compatible with junk, and every instance for a $$\kappa > \aleph _0$$ κ > ℵ 0 is furthermore compatible with gunk and dense chains of parthood. (shrink)

My aim in this paper is to explore the limits of a conception of metaphysical explanation based on the Principle of Sufficient Reason (PSR). For this purpose, I will focus on one of the alleged counter-intuitive consequences of an unrestricted application of the PSR, namely: Radical Monism. First, I will articulate such a conception of metaphysical explanation. Then, I will explain how is it that from a famous argument that rests on the PSR (i.e., Bradley’s regress) Radical Monism indeed seems (...) to follow. Right away, I will argue against the natural reaction that such argument triggers, namely: that we shall accept pluralism and relations as brute facts. Finally, I will sketch a qualified version of the PSR that allows us to avoid Radical Monism without compromising the essential content of the PSR. (shrink)

The exploration of chemical periodicity over the past 250 years led to the development of the Periodic System of Elements and demonstrates the value of vague ideas that ignored early scientific anomalies and instead allowed for extended periods of normal science where new methodologies and concepts are developed. The basic chemical element provides this exploration with direction and explanation and has shown to be a central and historically adaptable concept for a theory of matter far from the reductionist frontier. This (...) is explored in the histories of Prout’s hypothesis, Döbereiner Triads, element inversions necessary when ordering chemical elements by atomic weights, and van den Broeck’s ad-hoc proposal to switch to nuclear charges instead. The development of more accurate methods to determine atomic weights, Rayleigh and Ramsey’s gas separation and analytical techniques, Moseley’s X-ray spectroscopy to identify chemical elements, and more recent accelerator-based cold fusion methods to create new elements at the end of the Periodic Table point to the importance of methodological development complementing conceptual advances. I propose to frame the crossover from physics to chemistry not as a loss of accuracy and precision but as an increased application of vague concepts such as similarity which permit classification. This approach provides epistemic flexibility to adapt to scientific anomalies and the continued growth of chemical compound space and rejects the Procrustean philosophy of reductionist physics. Furthermore, it establishes chemistry with its explanatory and operational autonomy epitomized by the periodic system of elements as a gateway to other experimental sciences. (shrink)

Some recent interpretations of his philosophy of mind argue that Hegel endorses one or both of a pair of Aristotelian ideas about human reason: first, that our responsiveness to reasons is a capacity we acquire through the development of our second nature; second, that our rationality is not merely one more capacity alongside those capacities we appear to share with nonrational animals but rather transforms the latter qualitatively. In this paper I argue, through an interpretation of Hegel’s discussion of gestation (...) and childbirth, that he endorses these ideas only in a negatively united form in which both the naturalism of the first and the rationalism of the second are sublated. The result is a uniquely Hegelian understanding of our rational animality. (shrink)

Dispositional Essentialism, as commonly conceived, consists in the claims that at least some of the fundamental properties essentially confer certain causal-nomological roles on their bearers, and that these properties give rise to the natural modalities. As such, the view is generally taken to be committed to a realist conception of properties as either universals or tropes, and to be thus incompatible with nominalism as understood in the strict sense. Pace this common assumption of the ontological import of Dispositional Essentialism, the (...) aim of this paper is to explore a nominalist version of the view, Austere Nominalist Dispositional Essentialism. The core features of the proposed account are that it eschews all kinds of properties, takes certain predicative truths as fundamental, and employs the so-called generic notion of essence. As I will argue, the account is significantly closer to the core idea behind Dispositional Essentialism than the only nominalist account in the vicinity of Dispositional Essentialism that has been offered so far—Ann Whittle’s Causal Nominalism—and is immune to crucial problems that affect this view. (shrink)

Despite his commitment to universal explicability, a case can be made that Hegel is better labelled an idealist than a naturalist. As an analysis of his three syllogisms of philosophy reveals, he strictly differentiates between the domains of nature and Geist, suggesting in sequence that Geist replaces nature, Geist comprehends nature and that Geist and nature are comprehended as forms of the metaphysical idea and determine and mediate each other. Since Hegel grounds his accounts of the metaphysical idea and its (...) forms nature and Geist in concept-metaphysics and these include a supernatural notion of undetermined, self-positing universality, Hegel’s entire ontological edifice is ultimately supernatural. This stands in stark contrast to the metaphysics of naturalism, which are based on categories Hegel associates with the logics of being and essence or which fail to sufficiently emancipate universality from its immediate connection to particularity. (shrink)

In his article ‘Making semantics for essence’ (Inquiry, 2019), Justin Zylstra proposed a truthmaker semantics for essence and used it to evaluate principles regarding the explanatory role of essence. The aim of this article is to show that Zylstra's semantics has implausible implications and thus cannot adequately capture essence.

Abstract: Science and emerging technologies should not be predominantly tasked with furnishing us with more sustainable societies. Continuous short-term technological bail outs without taking into account the longer socio-cultural incubation times required to transition to ‘weakly sustainable’ economies squander valuable resources and time. Emerging technologies need to be deployed strategically to buy time in order to have extended political, social and ethical discussions about the root-causes of unsustainable economies and minimize social disruptions on the path towards global sustainability. Keywords: Nanoscience; (...) nanotechnology; expanded materials design space; dematerialization; sustainability; permanent resource crises . (shrink)

The Stoics’ theory of kataleptic impressions looks different once we attend to their analysis of the Sorites paradox. In defending this view, I reject the long-standing assumption that the Stoics develop their theory by focusing on sensory impressions. The Stoic approach to vagueness shows, for example, that non-sensory impressions can be seemingly indistinguishable by belonging to a series. It also draws attention to an understudied dimension of Stoic theory: in aiming to assent only to kataleptic impressions, one aims to avoid (...) not only assent to false impressions but also assent to those that are neither true nor false. (shrink)

What is the explanatory role of ‘status-truths’ such as essence-truths, necessity-truths and law-truths? A plausible principle, suggested by various authors, is Ground by Status, according to which status truths ground their prejacents. For instance, if it is essential to a that p, then this grounds the fact that p. But Ground by Status faces a forceful objection: it is inconsistent with widely accepted principles regarding the logic of grounding (Glazier in Philos Stud 174(11):2871–2889, 2017a, Synthese 174(198):1409–1424, 2017b; Kappes in Synthese (...) 199(1–2):2575–2595, 2020, Philos Stud 178(4):1267–1284, 2021). I defend Ground by Status against this objection. (shrink)

The Stoics identify the law with the active principle, which is corporeal, pervades the universe, individuates each part of the world, and causes all its movements. At the same time, the law is normative for all reasoners. The very same law shapes the movements of the cosmos and governs our actions. With this reconstruction of Stoic law, I depart from existing scholarship on whether Stoic law is a set of rules. The question of whether ethics involves a set of rules (...) is rich and fascinating. In the 1970s and 80s, the observation that ancient ethics might do without rules was part of philosophy’s rediscovery of virtue ethics. This debate, however, neglects that Stoic law is a corporeal principle pervading the world. The key puzzle regarding Stoic law, I argue, is how it is possible that the very same law is a corporeal principle in the world and normative for us. (shrink)

After introducing the concept of compressed sensing as a complementary measurement mode to the classical Shannon-Nyquist approach, I discuss some of the drivers, potential challenges and obstacles to its implementation. I end with a speculative attempt to embed compressed sensing as an enabling methodology within the emergence of data-driven discovery. As a consequence I predict the growth of non-nomological sciences where heuristic correlations will find applications but often bypass conventional pure basic and use-inspired basic research stages due to the lack (...) of verifiable hypotheses. (shrink)

. Human capabilities theory has emerged as an important framework for measuring whether various social systems promote human flourishing. The premise of this theory is that human beings share some nearly universal capabilities; what makes a human life fulfilling is the opportunity to exercise these capabilities. This essay proposes that the use of human capabilities theory can be expanded to assess whether a company has organized the work environment in such a way that allows workers to develop a variety of (...) human capabilities. This mode of analysis is put forward as a complement to the work of Mihaly Csikszentmihalyi, who has suggested that the key to promoting human well-being in the workplace is the maximization of flow experiences. (shrink)

Contrary to their predecessors, the Stoics put forward a unified notion of cause: a cause is a bodily because-of-which. Against the backdrop of Plato’s and Aristotle’s influential views, this is an original proposal. It involves the rejection of an earlier trend, according to which causes and explanations are closely associated. It also involves a pulling apart of causes and principles. And it comes with a charge against Plato and Aristotle, namely that they introduce a swarm of causes, a turba causarum.

The article discusses the link between freedom, crime and punishment. According to some theorists, crime does not only cause a person to have less freedom; it constitutes, _in and of itself_, a breach of the freedom of others. Punishment does not only cause people to have more freedom, for instance by preventing crimes; it constitutes, _in and of itself_, respect for mutual freedom. If the latter claims are true, crime and punishment must have certain _meanings_ that make them denials/affirmations of (...) freedom irrespective of their consequences. My aim is to show that such an immanent connection between crime/punishment and freedom exists. I do so by explicating the “natural meaning” of crime and punishment. This way of addressing the topic is inspired by Jean Hampton’s use of H. P. Grice’s concept of natural meaning. Expanding on Hampton’s theory, drawing on both H. L. A. Hart and Kant, I argue that crime has the natural meaning of denying freedom, and punishment has the natural meaning of affirming freedom. The paper presents an ideal theory, not a justification for actual criminal justice practices, which in most countries unfortunately fail to instantiate the value of mutual freedom. (shrink)

The surplus of impulses is a key category in Gehlen’s anthropobiology to understand the process of hominisation and humanisation. From the dedifferentiation of human instincts and the primitivisation of man’s anatomy, to the role of experience, institutions, and speech, the surplus of impulses is a source that flows between the inner and the outer, by feeding the action circle that whether translates in activity or is redirected inwards in order to become a movement of volitional constitution. The ambivalence in which (...) Gehlen deals with this function of freedom gives rise to a pessimistic and sacrificial idea of man. However, he posits certain basic elements of a hedonistic theory of speech from which we can better understand the stabilizing task of language as cornerstone of institutions. (shrink)

The thesis discusses the justice of state punishment in response to criminal wrongs. The introductory chapter explores the logic of the concept of justice itself, proposing that we understand justice as the function of remedying injustice. This negative approach – studying justice through injustice – allows us to critically evaluate theories of retributive justice via the conceptions of the wrong in crime that they entail, and for which punishment is perceived as a remedy. Examples of the conceptions of the wrong (...) in crime considered in the first part of the thesis are: ‘infringement of mutual freedom’, ‘freeloading’, ‘undermining the mutual benefits of law’, ‘undeserved profit’, ‘harm to the victim’ and ‘material imbalance’. Punishment, upon each of these conceptions, is just to the extent that it remedies the particular wrong of the crime, for instance by cancelling its undeserved profits or by alleviating the harm of the victim. The first part of the thesis culminates in a prolonged discussion of what is deemed the most suitable theory of punishment in a modern democratic state, the ‘Freedom Perspective’ based on a Kantian-Hegelian framework, whereupon crime is wrong because it infringes upon mutual freedom. The second part discusses the possible injustice of punishing severely socially deprived offenders. Specifically, it considers four reasons for the justice of lowering or abstaining from punishment of this group of offenders. These reasons relate to the material, cultural and psychological factors which increase this group’s likelihood of committing crimes and of being punished. These factors are to some extent the result of unjust social structures in society. Hence, this part discusses the links between social justice and criminal justice. Finally, the thesis examines the justice of an alternative way of remedying the wrong in crime: restorative justice processes between victim, offender and other parties to the crime. The concluding remarks are devoted to the meta-issue of how to conceive of justice when facing competing, yet plausible claims of justice. (shrink)

English title: The Right to be Punished: On Kant and Hegel's theories of punishment as respect for the criminal -/- The article discusses Kant and Hegel's theories of punishment in light of their broader legal philosophies. The purpose of punishment, and law in general, is to secure mutual freedom and mutual recognition. Punishment is a way of expressing respect for the freedom of the criminal, as well as the freedom of victims and all members of society. Though it might seem (...) odd that imprisoning somebody means respecting their freedom, Hegel famously insists that punishment is a right for the criminal. The article explains how punishment may respect mutual freedom, and defends the claim that this is a necessary condition for just punishment. However, the purpose of re-establishing mutual freedom may possibly be achieved by other methods than punishment. The article discusses the potential of restorative justice processes for expressing the kind of mutual recognition that Hegel ascribes to punishment. Punishment is therefore not necessary for achieving the just purpose that Kant and Hegel ascribe to it. We may thus accept the Kantian-Hegelian framework for the just sanctioning of crime while challenging their more controversial claim that punishment is a categorical imperative. (shrink)

The Moral Equality Account of Hypocrisy (ME) is a prominent theory of why hypocrites lack moral standing to blame. Hypocrites make exceptions for themselves and thereby implicitly deny moral equality, which is an essential premise of moral standing to blame. ME has recently faced challenges from philosophers who deny that it is the hypocrite’s rejection of moral equality that causes her to lose moral standing to blame. I have distinguished three main challenges which I discuss and rebut in this article: (...) “The Internal Blame and Blame of Fictional Characters Challenge”, which I attribute to Todd ( 2019 ), and “The Hypercrite Challenge” and “The Inegalitarian Norm Challenge”, which are due to Lippert-Rasmussen ( 2021 ). The article begins by offering an account of ME. It fills in a few gaps in the theory, by explaining why it is necessary for a blamer to invoke a special right to blame and by determining the type of right that standing to blame is. It also distinguishes between the question of why hypocrisy is wrong or bad, and the question of why it undermines moral standing to blame. I hold that several theories provide plausible answers to the first question, but only ME has so far given a good answer to the second question. When distinguishing properly between these two questions, we see that ME can respond satisfactorily to the three challenges. (shrink)

English title: Kant and the Right to Vote The article is a contribution to the ongoing debate in NFT about the moral responsibility of voters. Kristian Skagen Ekeli has argued that politically ignorant citizens have a duty to abstain from voting. He argues that such a duty fol- lows from Kant’s duty to respect other persons. I analyze Ekeli’s proposed duties by considering how they might fit into Kant’s system of duties. I conclude, contra Ekeli, that the Kantian duty to (...) respect persons does not give rise to a duty for politically ignorant voters to abstain from voting. -/- Denne artikkelen er et bidrag til debatten om velgeres moralske ansvar. Kristian Skagen Ekeli har i to artikler argu- mentert for at uvitende borgere har en plikt til ikke å stemme, noe han begrunner ut fra en kantiansk pliktetikk. Det er imidlertid uklart hvordan en uvitende borgers plikt til å avstå fra å stemme skulle følge av Kants plikt til å respek- tere personer, noe Cornelius og Herman Cappelen kort antyder i sin kommentar til Ekeli. I denne artikkelen foretar jeg en analyse av de pliktene som Ekeli tar til orde for, og undersøker hvordan disse eventuelt kunne passe inn i Kants system av plikttyper. Jeg konkluderer motsatt av Ekeli, med at den kantianske plikten til å respektere personer ikke gir grunnlag for en plikt for uvitende borgere til å avstå fra å stemme i valg. (shrink)

Microscopy allows us to observe objects we cannot see with our eyes alone. With a light microscope, we can distinguish objects at the scale of the wavelengths of visible light just under a micrometer. Around 1870 Ernst Abbe, who laid the foundation of modern optics, suggested that the resolution of a microscope would improve by using some yet-unknown radiation with shorter wavelengths than visible light, that is, below 390 nanometers (1 nm = 10−9 m). Electrons can have wavelengths near 1 (...) picometer (1 pm = 10−12 m) and should therefore allow atoms to be distinguished since they are typically at least a few hundred pm apart. In this oversimplified view, further decreasing the wavelength of the radiation should allow us to increase the resolution of electron microscopy even more. However, this can only be done by increasing the energy of the radiation, which would ultimately destroy the samples. Other factors also affect the resolution of electron microscopes, among them non-ideal imaging properties of electromagnetic lenses, which result in false images. It took more than half a century to understand and control these aberrations and separate objects less than 1 Ångstrom (1 Å = 10−10 m) apart. (shrink)

This paper illustrates how external symbol grounding can be studied in simulations with large populations. We discuss how we can simulate language evolution in a relatively complex environment which has been developed in the context of the New Ties project. This project has the objective of evolving a cultural society and, in doing so, the agents have to evolve a communication system that is grounded in their interactions with their virtual environment and with other individuals. A preliminary experiment is presented (...) in which we investigate the effect of a number of learning mechanisms. The results show that the social symbol grounding problem is a particularly hard one; however, we provide an ideal platform to study this problem. (shrink)

Cross-situational learning has recently gained attention as a plausible candidate for the mechanism that underlies the learning of word-meaning mappings. In a recent study, Blythe and colleagues have studied how many trials are theoretically required to learn a human-sized lexicon using cross-situational learning. They show that the level of referential uncertainty exposed to learners could be relatively large. However, one of the assumptions they made in designing their mathematical model is questionable. Although they rightfully assumed that words are distributed according (...) to Zipf's law, they applied a uniform distribution of meanings. In this article, Zipf's law is also applied to the distribution of meanings, and it is shown that under this condition, cross-situational learning can only be plausible when referential uncertainty is sufficiently small. It is concluded that cross-situational learning is a plausible learning mechanism but needs to be guided by heuristics that aid word learners with reducing referential uncertainty. (shrink)

Plato’s Euthyphro, I argue, lays out a metaethics that responds to persistent and unresolved value disagreement. The dialogue’s analysis of disagreement leads to the distinction between three kinds of value, exemplified by the good, the god-loved, and the pious. With this proposal, I reject centuries of scholarship, which ascribe a realist metaethics to the Plato of the Euthyphro. But only the good and the just require a ‘realist’ analysis: we relate to them as features of the world to which we (...) have attitudes, not as features of the world that are conferred by our attitudes. The god-loved is overtly attitudinal, thus calling for an anti-realist account. A compelling account of the pious has both realist and anti-realist dimensions. All three kinds of value, I argue, are to be found in the domain of law. Here, too, the good and the just require a realist, the legal an anti-realist, and the lawful a realist and anti-realist analysis. As important as piety was for millennia, it is a non-issue in today’s metaethics. But its analogue in the domain of the law, the lawful, plays a crucial role in our lives today. While we recognize legality as potentially flawed, respect for the law is an indispensable attitude if we are to strive towards improved lives and improved societies. (shrink)

Many later thinkers in the Islamic world pick up on, and further expand, the idea of intuition (ḥads) as they react to Avicenna (Ibn Sīnā). Focusing on figures from the twelfth–thirteenth century, in this paper we will focus especially on the following points of debate: (1) Avicenna’s idea that intuition is distingiushed from normal (discursive) thought by lacking ‘motion’, (2) The question of how and why different individuals differ in the extent of their intuition, (3) The role of intuitive thought (...) in grounding knowledge: is intuition needed every time a certain item of knowledge is grasped for the first time, and hence without a teacher; and further, is intuition needed as an ultimate justification for all non-intuitive knowledge? (shrink)

En este artículo se presentan las reflexiones epistemológicas del filósofo Francisco Fernández Buey (1943-2012), las cuales, han estado continuamente presentes en la obra del autor al menos desde la publicación en 1991 de La ilusión del método, y culminan en su obra póstuma Para la tercera cultura (2013) en una apuesta por la complementariedad entre ciencias positivas y reflexión humanística. Partiendo de un marxismo heterodoxo tanto en el plano ético-político como en el epistemológico, Fernández Buey apuesta por una idea de (...) ciencia alejada del positivismo, a la vez que critica las filosofías contrarias a aquella en la medida en que la consideran como un conocimiento meramente reductor de una realidad que no puede ser aprehendida por la ciencia. Desde el concepto de dialéctica de Manuel Sacristán; el reconocimiento a la figura de Einstein como ejemplo de científico que no renuncia a otros modos de conocimiento; y la reflexión sobre la filosofía de la ciencia en la segunda mitad del siglo XX, el autor nos muestra la necesidad de un diálogo entre cultivadores de la ciencia y las humanidades para afrontar los desafíos del siglo XXI. (shrink)

Recent investigations with non‐model species and whole‐genome approaches have challenged several paradigms in animal epigenetics. They revealed that epigenetic variation in populations is not the mere consequence of genetic variation, but is a semi‐independent or independent source of phenotypic variation, depending on mode of reproduction. DNA methylation is not positively correlated with genome size and phylogenetic position as earlier believed, but has evolved differently between and within higher taxa. Epigenetic marks are usually not completely erased in the zygote and germ (...) cells as generalized from mouse, but often persist and can be transgenerationally inherited, making them evolutionarily relevant. Gene body methylation and promoter methylation are similar in vertebrates and invertebrates with well methylated genomes but transposon silencing through methylation is variable. The new data also suggest that animals use epigenetic mechanisms to cope with rapid environmental changes and to adapt to new environments. The main benefiters are asexual populations, invaders, sessile taxa and long‐lived species. (shrink)

We outline a view of imitative behaviour as largely internally driven and discuss, based on experimental research, the distinction between program versus action level imitation, the role of organismic constraints, observational learning as vicarious exploration, and imitation as selection in speeded response paradigms.

The Theory of Multidimensional Reality is the latest development of this information theory of existence by the Author. The book applies the theory to explain what causes light, gravity, time, Planck's constant, and other phenomena found in physics. The Theory provides a foundation philosophy for all of science to explain some of the hardest phenomenon found.