What produces emotions? Why do we have emotions? How do we have emotions? Why do emotional states feel like something? This book considers these questions, going beyond examining brain mechanisms of emotion, by proposing a theory of what emotions are, and an evolutionary, Darwinian, theory of the adaptive value of emotion.

The topics treated in The brain and emotion include the definition, nature, and functions of emotion (Ch. 3); the neural bases of emotion (Ch. 4); reward, punishment, and emotion in brain design (Ch. 10); a theory of consciousness and its application to understanding emotion and pleasure (Ch. 9); and neural networks and emotion-related learning (Appendix). The approach is that emotions can be considered as states elicited by reinforcers (rewards and punishers). This approach helps with understanding the functions of emotion, with (...) classifying different emotions, and in understanding what information-processing systems in the brain are involved in emotion, and how they are involved. The hypothesis is developed that brains are designed around reward-and punishment-evaluation systems, because this is the way that genes can build a complex system that will produce appropriate but flexible behavior to increase fitness (Ch. 10). By specifying goals rather than particular behavioral patterns of responses, genes leave much more open the possible behavioral strategies that might be required to increase fitness. The importance of reward and punishment systems in brain design also provides a basis for understanding the brain mechanisms of motivation, as described in Chapters 2 for appetite and feeding, 5 for brain-stimulation reward, 6 for addiction, 7 for thirst, and 8 for sexual behavior. Key Words: amygdala; brain evolution; consciousness; dopamine; emotion; hunger; orbitofrontal cortex; punishment; reward; taste. (shrink)

The traditional distinction between basic and applied science has been much criticized in recent decades. The criticism is based on a combination of historical and systematic epistemic argument. The present paper is mostly concerned with the historical aspect. I argue that the critics impose an understanding at odds with the way the distinction was understood by its supporters in debates on science education and science policy in the nineteenth and twentieth centuries. And I show how a distinction that refers to (...) difference on several epistemic and social dimensions makes good sense of representative historical cases. If this argument is tenable it suggests more continuity in the epistemology and politics of science than has been claimed by a new paradigm of science studies and politics during recent decades. (shrink)

I call an experiment “crucial” when it makes possible a decisive choice between conflicting hypotheses. Joharmsen's selection for size and weight within pure lines of beans played a central role in the controversy over continuity or discontinuity in hereditary change, often known as the Biometrician-Mendelian controversy. The “crucial” effect of this experiment was not an instantaneous event, but an extended process of repeating similar experiments and discussing possible objections. It took years before Johannsen's claim about the genetic stability of pure (...) lines was accepted as conclusively demonstrated by the community of geneticists. The paper also argues that crucial experiments thus interpreted contradict certain ideas about the underdetermination of theories by facts and the theory-ladenness of facts which have been influential in recent history and sociology of science. The acceptance of stability in the pure lines did not rest on prior preference for continuity or discontinuity. And this fact permitted a final choice between the two theories. When such choice is characterized as “decisive” or “final”, this is not meant in an absolute philosophical sense. What we achive in these cases is highly reliable empirical knowledge. The philosophical possibility of drawing (almost) any conclusion in doubt should be distinguished from reasonable doubt in empirical science. (shrink)

This paper describes the historical background and early formation of Wilhelm Johannsen's distinction between genotype and phenotype. It is argued that contrary to a widely accepted interpretation his concepts referred primarily to properties of individual organisms and not to statistical averages. Johannsen's concept of genotype was derived from the idea of species in the tradition of biological systematics from Linnaeus to de Vries: An individual belonged to a group - species, subspecies, elementary species - by representing a certain underlying type. (...) Johannsen sharpened this idea theoretically in the light of recent biological discoveries, not least those of cytology. He tested and confirmed it experimentally combining the methods of biometry, as developed by Francis Galton, with the individual selection method and pedigree analysis, as developed for instance by Louis Vilmorin. The term "genotype" was introduced in W. Johannsen's 1909 treatise, but the idea of a stable underlying biological "type" distinct from observable properties was the core idea of his classical bean selection experiment published 6 years earlier. The individual ontological foundation of population analysis was a self-evident presupposition in Johannsen's studies of heredity in populations from their start in the early 1890s till his death in 1927. The claim that there was a "substantial but cautious modification of Johannsen's phenotype-genotype distinction" from a statistical to an individual ontological perspective derives from a misreading of the 1903 and 1909 texts. The immediate purpose of this paper is to correct this reading of the 1903 monograph by showing how its problems and results grow out of Johannsen's earlier work in heredity and plant breeding. Johannsen presented his famous selection experiment as the culmination of a line of criticism of orthodox Darwinism by William Bateson, Hugo de Vries, and others. They had argued that evolution is based on stepwise rather than continuous change in heredity. Johannsen's paradigmatic experiment showed how stepwise variation in heredity could be operationally distinguished from the observable, continuous morphological variation. To test Galton's law of partial regression, Johannsen deliberately chose pure lines of self-fertilizing plants, a pure line being the descendants in successive generations of one single individual. Such a population could be assumed to be highly homogeneous with respect to hereditary type, and Johannsen found that selection produced no change in this type. Galton, he explained, had experimented with populations composed of a number of stable hereditary types. The partial regression which Galton found was simply an effect of selection between types, increasing the proportion of some types at the expense of others. (shrink)

There are many advantages to defining emotions as states elicited by reinforcers, with the states having a set of different functions. This approach leads towards an understanding of the nature of emotion, of its evolutionary adaptive value, and of many principles of brain design. It also leads towards a foundation for many of the processes that underlie evolutionary psychology and behavioral ecology. It is shown that recent as well as previous evidence implicates the amygdala and orbitofrontal cortex in positive as (...) well as negative emotions. The issue of why emotional states feel like something is part of the much larger problem of phenomenal consciousness. It is argued that thinking about one's own thoughts would have adaptive value by enabling first order linguistic thoughts to be corrected. It is suggested that reflecting on and correcting one's own thoughts and plans would feel like something, and that phenomenal consciousness may occur when this type of monitoring process is taking place. (shrink)

Dans cet article, je montre que les neurosciences computationnelles fournissent une nouvelle approche pertinente à des problèmes traditionnels en philosophie tels que la relation entre les états mentaux et cérébraux (le problème esprit–corps ou corps–esprit), le déterminisme et le libre arbitre, et peut nous aider à traiter le problème « difficile » des aspects phénoménaux de la conscience. Un des thèmes de cet article et de mon livre Neuroculture: on the Implications of Brain Science ([Rolls 2012c]) est qu’en comprenant les (...) calculs effectués par les neurones et les réseaux neuronaux, et les effets du bruit dans le cerveau sur ceux-ci, nous gagnerons une vraie compréhension des mécanismes qui sous-tendent le fonctionnement du cerveau. Une partie de notre solution au problème esprit–corps est que l’esprit et le cerveau sont différents niveaux d’explication du traitement de l’information, leur relation pouvant être appréhendée par la compréhension des mécanismes en jeu à l’aide de l’approche fournie par les neurosciences computationnelles. Mais cette solution ne traite pas certains problèmes « difficiles » tels que le problème de la conscience phénoménale, et, même si j’ai fourni de nouvelles suggestions sur ce point dans cet article, il faut reconnaître qu’il y a toujours une brèche dans notre compréhension entre les événements dans le cerveau et les expériences subjectives qui peuvent les accompagner. L’explication que je propose est que, lorsque cela « fait quelque chose », il ne s’agit que d’une propriété d’un processus computationnel qui a des pensées sur ses propres pensées (pensées d’ordre supérieur), les pensées étant ancrées dans le monde. (shrink)

Memory, attention, and decision-making are three major areas of cognitive neuroscience. They are however frequently studied in isolation, using a range of models to understand them. This book brings a unified approach to understanding these three processes, showing how these fundamental functions can be understood in a common and unifying framework.

This chapter considers the functions of the orbitofrontal cortex. It shows that the orbitofrontal cortex is involved in decoding and representing some primary reinforcers such as taste and touch; in learning and reversing associations of visual and other stimuli to these primary reinforcers; in controlling and correcting reward-related and punishment-related behavior; and, thus, in emotion.

Why do we have emotions? What is the relationship between mind and brain? Why do we appreciate art? How do we make decisions? Why do so many people follow religions? Neuroculture considers the implications of our modern understanding of how the brain works, and how it can help us understand many mental issues central to everyday life.

What produces emotions? Why do we have emotions? How do we have emotions? Why do emotional states feel like something? The Brain, Emotion, and Depression addresses these issues and more, providing a unified approach to emotion, reward value, economic value, decision-making, and their brain mechanisms.

An approach to emotion is described in which emotions are defined as states elicited by instrumental reinforcers, that is, by stimuli that are the goals for action. This leads to a theory of the evolutionary adaptive value of emotions, which is that different genes specify different goals in their own self-interest, and any actions can then be learned and performed by instrumental learning to obtain the goals. The brain mechanisms for emotion in brain regions such as the orbitofrontal and anterior (...) cingulate cortex provide a foundation for understanding the neural basis of emotion. Classically conditioned effects may modulate the actions initiated by this system. In addition to this instrumental learning system, some stimuli may elicit responses, for example approach, withdrawal, or fixed action patterns, but intervening states are not required for this type of adaptive response. In addition, a rational thought system involved in multistep planning can allow gene-specified goals to be deferred or avoided in order to achieve longer-term types of goals that may be more advantageous to the individual than to the genes. (shrink)

This systematic review aims to examine the existing literature concerning the association between father involvement and the development children's cognitive skills during early and middle childhood. Specifically, it analyzes: (1) how the number of researches developed across years; (2) which are the main socio-demographic characteristics of the samples; (3) which are the main focuses examined; and (4) which operational definitions were used to assess father involvement and children cognitive skills. Following the guidelines of the Preferred Reporting Items for Systematic Reviews (...) and Meta-Analyses (PRISMA) statement, the articles were searched through PubMed and EBSCO (PsycInfo, PsycArticles, Education Source, Social Sciences Abstract, Family Studies Abstracts, Gender Studies Database and CINAHL complete). The findings suggest that, although each research used a different operational definition of the father involvement construct, in recent years there was a wide and constant interest increase about this issue. Most of the empirical studies utilized quantitative methods, whereas relatively few used qualitative and only one mixed methods. As regards the analysis of socio-demographic characteristics of the samples there is a great evidence that most of them included biological and residential fathers: it may reflect that this type of sample is easier to recruit than non-residential and non-biological fathers. Regarding the socio-economic status and the ethnicity of families, the data highlighted how in recent years the literature on father involvement is starting to look at differences in ethnic and cultural backgrounds, in contrast to past researches. The findings revealed that the main focus is the impact of father involvement on children's cognitive skills and the most of the studies highlighted that it is positive and statistically significant. Regarding to the assessment of father involvement and children's cognitive skills, the literature is quite heterogeneous. (shrink)

A neuroscience-based approach has recently been proposed for the relation between the mind and the brain. The proposal is that events at the sub-neuronal, neuronal, and neuronal network levels take place simultaneously to perform a computation that can be described at a high level as a mental state, with content about the world. It is argued that as the processes at the different levels of explanation take place at the same time, they are linked by a non-causal supervenient relationship: causality (...) can best be described in brains as operating within but not between levels. This mind-brain theory allows mental events to be different in kind from the mechanistic events that underlie them; but does not lead one to argue that mental events cause brain events, or vice versa: they are different levels of explanation of the operation of the computational system. Here, some implications are developed. It is proposed that causality, at least as it applies to the brain, should satisfy three conditions. First, interventionist tests for causality must be satisfied. Second, the causally related events should be at the same level of explanation. Third, a temporal order condition must be satisfied, with a suitable time scale in the order of 10 ms. Next, although it may be useful for different purposes to describe causality involving the mind and brain at the mental level, or at the brain level, it is argued that the brain level may sometimes be more accurate, for sometimes causal accounts at the mental level may arise from confabulation by the mentalee, whereas understanding exactly what computations have occurred in the brain that result in a choice or action will provide the correct causal account for why a choice or action was made. Next, it is argued that possible cases of “downward causation” can be accounted for by a within-levels-of-explanation account of causality. This computational neuroscience approach provides an opportunity to proceed beyond Cartesian dualism and physical reductionism in considering the relations between the mind and the brain. (shrink)

This book engages in an analysis of the ideals of freedom and social justice. Rolle examines and questions Appeal to the Colored Citizens of the World by David Walker, which encourages slaves to embrace a theologically-based understanding of freedom and participate in insurrectionist activities to overthrow slavery.

In lieu of an abstract, here is a brief excerpt of the content:Figuring Myself Out:Certainty, Injury, and the Poststructuralist Repositioning of Bodies of IdentityJames Haywood Rolling Jr. (bio)CertaintyI have been attempting to figure myself out. Out of chaos and incompletion, toward increased certainty. I have been at this task of construction for quite some time now. I have just proposed my dissertation and my intentions are once again uncertain. My dissertation is to be a self-study. It is also a story (...) about uncertainty and my attempts to redeem a clear definition, to be named a peer and a colleague among artists, writers, and teachers. I have been uncertain as a little boy; uncertain as a son; uncertain as a student of architecture; uncertain as an artist and writer; uncertain as a teacher; uncertain as a black man. To compensate, I have sought the conferral of certainty, a name among leaders in many fields of inquiry. Still, it is not easy to forget that certainty has also been the cause of great injury to my body, to my mind.On sunny afternoons after school all the kids came outside to play. The air would fill with echoes going back and forth between the red brick and stone buildings on both sides of our narrow street. Pounding rubber balls, the taps and scratches of shoe heels, and the slapping of sneakers on the cement and asphalt.Sometimes white chalk would appear and hopscotch boxes were quickly drawn on the neat squares of cement pavement in front of my Grandma's house. Grandma lived next door to us. Houses on our block were side by side, sharing each other's walls.On a particular day, similar to other days, I watched as a small flat stone was tossed to bounce across the cement into a numbered box. I watched the one foot, two feet, one foot hops from box to box to stop and balance on one small hopping foot, steadying itself, to drop a hand to pick up the stone. Some little girl came to sit beside me and asked me to look at her. We were sitting on one of Grandma's two wooden benches, just inside the front gate. [End Page 46] Two steps down was the sidewalk and other kids. I ignored the girl. I made sure my body had no contact with hers on the bench. Why was she talking to me anyway? Didn't she see I didn't have anything I wanted to say?"Look at me!" she said, tugging at my arm."Will you stop it!" I snapped back, jerking my arm away. Being touched was not natural to me. My family didn't touch. I tightened the skin of my eyebrows and the bridge of my nose into a frown."Smile!" the little girl said slyly, trying to tickle me."Leave me alone!" I yelled. I tried to move away from the touching.I must have grinned. Grinning relaxes the frowns on faces. The girl clapped a hand over her mouth, all giggles. I asked what she was laughing so loud for. The kids out in front of us now had our attention. I felt like I was now being watched. I can't remember the faces, just the noise and voices that seemed to stop. The little girl stood up, pointed at my face and declared, finger in my face, pointing, speaking out loud, "Look! He only has one dimple! See?! Look at his face!""No I don't," I said, dropping my face, my eyes, my voice. My head was down and I didn't want to see if anyone was looking. The attention made my face warm and I needed to move away fast. "No I don't," I repeated, stiffly. My whole head seemed to glow brightly, very hot, drawing lots of attention. I was beneath windows, very near, on both sides of the street, always with onlookers. I rushed through the painted iron gate, going quickly next door, upstairs to "our house," to the second floor apartment we lived in, down the hallway so dark after the bright outside, around a curve and a corner, into the bathroom, closing the door behind me. Locking the door... (shrink)

Maintaining two full-time careers has required sacrifice, of course. On a recent Saturday Night Live, as an obvious plug, one of the actors carried a copy of The Chomsky Reader throughout a skit. Albert telephoned Chomsky to say, "Hey, you're on television!" and found himself having to explain what Saturday Night Live is. So Chomsky doesn't know anything about popular culture. He doesn't watch TV. He doesn't listen to rock & roll. He goes to maybe one movie a year. (...) He has little time for a private life. (shrink)

The study of the autonomic nervous system (ANS) function has shown to provide useful indicators for risk stratification and early detection on a variety of cardiovascular pathologies. However, data gathered during different tests of the ANS are difficult to analyse, mainly due to the complex mechanisms involved in the autonomic regulation of the cardiovascular system (CVS). Although model-based analysis of ANS data has been already proposed as a way to cope with this complexity, only a few models coupling the main (...) elements involved have been presented in the literature. In this paper, a new model of the CVS, representing the ventricles, the circulatory system and the regulation of the CVS activity by the ANS, is presented. The models of the vascular system and the ventricular activity have been developed using the Bond Graph formalism, as it proposes a unified representation for all energetic domains, facilitating the integration of mechanic and hydraulic phenomena. In order to take into account the electro-mechanical behaviour of both ventricles, an electrophysiologic model of the cardiac action potential, represented by a set of ordinary differential equations, has been integrated. The short-term ANS regulation of heart rate, cardiac contractility and peripheral vasoconstriction is represented by means of continuous transfer functions. These models, represented in different continuous formalisms, are coupled by using a multi-formalism simulation library. Results are presented for two different autonomic tests, namely the Tilt Test and the Valsalva Manoeuvre, by comparing real and simulated signals. (shrink)

The representation of objects and faces by neurons in the temporal lobe visual cortical areas of primates has the property that the neurons encode relatively independent information in their firing rates. This means that the number of stimuli that can be encoded increases exponentially with the number of neurons in an ensemble. Moreover, the information can be read by receiving neurons that perform just a synaptically weighted sum of the firing rates being received. Some ways in which these representations become (...) grounded in the world are described. The issue of syntactic binding in representations, and of its value for a higher order thought system, is discussed. (shrink)

We are living in a time of social and cultural changes. As in other disciplines, the foundations of music education are being increasingly challenged. Thus, it is no longer possible to specify reliably the aims and contents of music education and their implementation in school by simply basing them on lasting musical traditions and changeless forms of life. It has been said that such an assessment leads us to a pluralistic—if not relativistic—view of music education. But it does not help (...) us when we have to make a decision on "What is to be done?" How can we orientate ourselves in our actions and whereupon should we base our judgements when negotiating decisions and trying to convince others? If we are not ready to accept that the decision-making process in the field of music education is just a matter of power, we have to be content with the arguments we can offer. We need to have the courage of independent critical thinking in terms of Didaktik involving all concerned. The situation is similar to that of aesthetic arguing: there is no sure footing; our criteria for evaluation are always up for discussion. (shrink)

Problems are raised with the global workspace hypothesis of consciousness, for example about exactly how global the workspace needs to be for consciousness to suddenly be present. Problems are also raised with Carruthers’s (2019) version that excludes conceptual (categorical or discrete) representations, and in which phenomenal consciousness can be reduced to physical processes, with instead a different levels of explanation approach to the relation between the brain and the mind advocated. A different theory of phenomenal consciousness is described, in which (...) there is a particular computational system involved in which Higher Order Syntactic Thoughts are used to perform credit assignment on first order thoughts of multiple step plans to correct them by manipulating symbols in a syntactic type of working memory. This provides a good evolutionary reason for the evolution of this kind of computational module, with which, it is proposed, phenomenal consciousness is associated. Some advantages of this HOST approach to phenomenal consciousness are then described with reference not only to the global workspace approach, but also to Higher Order Thought (HOT) theories. It is hypothesized that the HOST system which requires the ability to manipulate first order symbols in working memory might utilize parts of the prefrontal cortex implicated in working memory, and especially the left inferior frontal gyrus, which is involved in language and probably syntactical processing. Overall, the approach advocated is to identify the computations that are linked to consciousness, and to analyze the neural bases of those computations. (shrink)

Present science policy discourse is focused on a broad concept of “techno-science” and emphasizes practical economic goals and gains. At the same time scientists are worried about the freedom of research and the autonomy of science. Half a century ago the difference between basic and applied science was widely taken for granted and autonomy was a value in high esteem. Most recent accounts of the history of science policy start abruptly from World War II, emphasize the Cold War context, and (...) neglect the pioneering role of the Soviet Union in forming todays “big science.” This paper claims that a closer look into the intellectual heritage from the early twentieth century will be helpful in navigating present issues of science policy. The “Lysenko affair” was a paradigmatic case in forming Cold War views on science and politics. (shrink)

Throughout the history of genetics, the concept of the gene has been a hot topic. Theories of the gene as a coherent structured particle, a large molecule, or part of such molecule, were prominent from the 1920s until well after the discovery of DNA structure and its function in the production of proteins in the 1950s and 1960s. As knowledge of the material basis of heredity advanced, new and more sophisticated definitions were proposed (see, for example, Gerstein et al. 2007; (...) Müller-Wille and Rheinberger 2012). But rapid growth of knowledge about the molecular basis of biological heredity and individual development during the last half-century has made the idea of a particulate “gene” more and more elusive. Or .. (shrink)

Zhores Medvedev and Mark Popovsky have both drawn attention to the positive response on the part of the scientific community to the early work of Lysenko on the phasic development of plants. This aspect of the Lysenko Affair is explored more fully in this paper. Vavilov's sponsorship of Lysenko is set in the intellectual context of plant physiology circa 1930, and in the political climate of the pressing needs of Russian agriculture at that time. Lysenko's rise was also favoured by (...) the Marxist philosophy of science then current in which the traditional distinction between basic and applied science was discarded and an opposition between proletarian and bourgeois science introduced. It is claimed that an understanding of the intellectual history must lie at the core of a social history of the Lysenko Affair if it is to prove adequate. (shrink)

During the first half of the twentieth century there was a marked decline in biological conceptions of man and society. This paper describes the development of the views concerning eugenics held by the Norwegian scientific expertise, from open racism before World War I to a moderate nonracist eugenic program in the 1930's. It is claimed that public criticism of the popular eugenics movement by the experts came earlier in Norway than in most other countries, including the United States. The first (...) attack in 1915 was directed at dilettantic and irresponsible handling of scientific ideas, data and arguments. The conflict was over different views of science and its social role rather than over different aims for social development. The strict methodological demands that the scientific expertise wanted to enforce, provided a barrier against extreme eugenic views and proposals, and a source for critical arguments against eugenics in general. The experts differed considerably in their political views, but united in the crusade against dilettantism. They all feared premature applications of science to social problems. John Alfred Mjøen was leader of the popular eugenics movement in Norway. He learned about race-hygiene in Germany and started a public campaign in Norway around 1908. Mjøen formulated the so-called « Norwegian program for racehygiene » and played a prominent role in the international eugenics movement, but he was ostracized by Norwegian genetic scientists. Mjøen's strongest critic was Otto Lous Mohr, medical doctor and biologist, trained in genetics under T. H. Morgan. Mohr led the attack on Mjøen in 1915. Besides being a human geneticist of international prominence Mohr was strongly involved in campaigns for birth control and sexual instruction. Important supporters of a moderate eugenic program were Ragnar Vogt, founder of modern Norwegian psychiatry, and Johan Scharffenberg, psychiatrist and central public figure. Both were clearly on Mohr's side in the conflict with Mjøen. (shrink)

The study of the autonomic nervous system (ANS) function has shown to provide useful indicators for risk stratification and early detection on a variety of cardiovascular pathologies. However, data gathered during different tests of the ANS are difficult to analyse, mainly due to the complex mechanisms involved in the autonomic regulation of the cardiovascular system (CVS). Although model-based analysis of ANS data has been already proposed as a way to cope with this complexity, only a few models coupling the main (...) elements involved have been presented in the literature. In this paper, a new model of the CVS, representing the ventricles, the circulatory system and the regulation of the CVS activity by the ANS, is presented. The models of the vascular system and the ventricular activity have been developed using the Bond Graph formalism, as it proposes a unified representation for all energetic domains, facilitating the integration of mechanic and hydraulic phenomena. In order to take into account the electro-mechanical behaviour of both ventricles, an electrophysiologic model of the cardiac action potential, represented by a set of ordinary differential equations, has been integrated. The short-term ANS regulation of heart rate, cardiac contractility and peripheral vasoconstriction is represented by means of continuous transfer functions. These models, represented in different continuous formalisms, are coupled by using a multi-formalism simulation library. Results are presented for two different autonomic tests, namely the Tilt Test and the Valsalva Manoeuvre, by comparing real and simulated signals. (shrink)

The study of the autonomic nervous system (ANS) function has shown to provide useful indicators for risk stratification and early detection on a variety of cardiovascular pathologies. However, data gathered during different tests of the ANS are difficult to analyse, mainly due to the complex mechanisms involved in the autonomic regulation of the cardiovascular system (CVS). Although model-based analysis of ANS data has been already proposed as a way to cope with this complexity, only a few models coupling the main (...) elements involved have been presented in the literature. In this paper, a new model of the CVS, representing the ventricles, the circulatory system and the regulation of the CVS activity by the ANS, is presented. The models of the vascular system and the ventricular activity have been developed using the Bond Graph formalism, as it proposes a unified representation for all energetic domains, facilitating the integration of mechanic and hydraulic phenomena. In order to take into account the electro-mechanical behaviour of both ventricles, an electrophysiologic model of the cardiac action potential, represented by a set of ordinary differential equations, has been integrated. The short-term ANS regulation of heart rate, cardiac contractility and peripheral vasoconstriction is represented by means of continuous transfer functions. These models, represented in different continuous formalisms, are coupled by using a multi-formalism simulation library. Results are presented for two different autonomic tests, namely the Tilt Test and the Valsalva Manoeuvre, by comparing real and simulated signals. (shrink)

Two questions will receive special attention in this account, namely the political location of eugenics and the role of genetic science in its development. I will show that moderate eugenic policies had broad political support. For instance, the Scandinavian sterilization laws which were introduced in the 1930s were supported by the Social Democratic Parties, who were partly in position of government. I will argue that the effect of genetic research was to make eugenics more moderate, mainly because the fears and (...) hopes were shown to be exaggerated. Degeneration was much slower than feared at first, if it took place at all, and the expectation of rapid and large effects of eugenic policies on the gene pool likewise proved to be quite unrealistic. (shrink)

There is at present uneasiness about the conceptual basis of genetics. The gene concept has become blurred and there are problems with the distinction between genotype and phenotype. In the present paper I go back to their role in the creation of modern genetics in the early twentieth century. The terms were introduced by the Danish botanist and geneticist Wilhelm Johannsen in his big textbook of 1909. Historical accounts usually concentrate on this book and his 1911 paper “The Genotype Conception (...) of Heredity.” His bean selection experiment of 1900–1903 is generally assumed to be the source of his genotype theory. The present paper examines the scientific context and meaning of this experiment, how it was received, and how the genotype theory became securely established by the early 1910s. I argue in conclusion that the genotype/phenotype distinction, which provides the empirical basis for Johannsen's gene, was scientifically well founded when introduced and still is. Keith Baverstock's criticism does not consider the force of the bean selection experiment at the time and as a paradigm for following investigations of heredity. (shrink)