Due to the historic separation of cognition and emotion, the affective aspects of learning are often seen as trivial in comparison to the more ‘essential’ cognitive qualities—particularly in science. We are taught that science should objectively scrutinize the world in search of answers, and science educators have been taught to look to scientists to guide their teaching of content and processes.2 As a result, science pedagogy characteristically instructs students to step back from objects and events in order to dispassionately observe (...) and analyze them. In an attempt to guide students towards thinking like scientists, the process of scientific inquiry is typically the focus in science. What is left out, of course .. (shrink)

T. A. Cavanaugh's Hippocrates' Oath and Asclepius' Snake: The Birth of the Medical Profession articulates the Oath as establishing the medical profession's unique internal medical ethic - in its most basic and least controvertible form, this ethic mandates that physicians help and not harm the sick. Relying on Greek myth, drama, and medical experience (e.g., homeopathy), the book shows how this medical ethic arose from reflection on the most vexing medical-ethical problem -- injury caused by a physician -- and (...) argues that deliberate iatrogenic harm, especially the harm of a doctor choosing to kill (physician assisted suicide, euthanasia, abortion, and involvement in capital punishment), amounts to an abandonment of medicine as an exclusively therapeutic profession. The book argues that medicine as a profession necessarily involves stating before others what one stands for: the good one seeks and the bad one seeks to avoid on behalf of the sick, and rejects the view that medicine is purely a technique lacking its own unique internal ethic. It concludes noting that medical promising (as found in the White Coat Ceremony through which U. S. medical students matriculate) implicates medical autonomy which in turn merits respect, including honoring professional conscientious objections. (shrink)

The current linkages between ethical theory and management behavior are investigated in the wake of the much-publicized convictions of Enron executives. The vignettes used in this investigation represent ethical dilemmas in the areas of coercion and control, conflict of interest, physical environment, and personal integrity. Since 2003, and after the successful prosecution of Enron executives, the link between ethical philosophy and management behavior has shifted somewhat dramatically. There has been a significant change in the rational basis for managerial decision making. (...) In 2003, even after the Enron scandal was publicized, practitioners still relied heavily on both act and rule utilitarian ethical philosophies when making business decisions. Currently, the majority of respondents are likely to select ethically appropriate actions based on either rule utilitarian or rights rationales. It appears that ethical behavior is now more in line with ethical rhetoric, which may positively impact the ethical climate of business decision making. Apparently, business scandals of the past did not really impact actual ethical behavior much, but the high-profile prosecutions, convictions, and jail sentences may have impressed on managers that now is the time to incorporate ethics into business decisions. (shrink)

T. A. Cavanaugh defends double-effect reasoning (DER), also known as the principle of double effect. DER plays a role in anti-consequentialist ethics (such as deontology), in hard cases in which one cannot realize a good without also causing a foreseen, but not intended, bad effect (for example, killing non-combatants when bombing a military target). This study is the first book-length account of the history and issues surrounding this controversial approach to hard cases. It will be indispensable in theoretical ethics, (...) applied ethics (especially medical and military), and moral theology. It will also interest legal and public policy scholars. (shrink)

Social Constructivism about the disease concept has generally been taken to ignore the fundamental biological reality underlying diseases, as well as to fall foul of several apparently compelling objections. In this paper, I explain how the metaphysical relation of grounding can be used to tie a socially constructed account of diseases and their classification to their underlying biological and behavioural states. I then generalize the position by disambiguating several varieties of normativism, including a particularly strong ‘placeholder’ version of social constructivism, (...) and showing that the grounding approach is available to each. I go on to provide what I believe to be the first attempt at a full semantics for disease-talk and disagreement, before using the placeholder to demonstrate on that basis that the most troublesome objections to normativism can be avoided even by very strong versions of the position. (shrink)

Work on dispositions focuses chiefly on dispositions that are manifested in dynamic causal processes. Williams, Neil. 2005. “Static and Dynamic Dispositions.” Synthese 146: 303–24 has argued that the focus on dynamic dispositions has been at the expense of a richer ontology of dispositions. He contends that we ought to distinguish between dynamic and static dispositions. The manifestation of a dynamic disposition involves some change in the world. The manifestation of a static disposition does not involve any change in the world. (...) In this paper, we concede that making a conceptual distinction between dynamic and static dispositions is useful and we allow that we can truthfully represent objects as manifesting static dispositions. However, we argue that the distinction is not ontologically deep. Rather, the truthmakers for our representations of static dispositions are actually dynamic dispositions to whose manifestations we may fail to be sensitive. (shrink)

Educators studied are: Francis Parker, John Dewey, Rudolf Steiner, Hugh Mearns, and Laura Zirbes.

The forty‐ninth annual IRAS conference on Star Island pursued the science‐religion dialogue primarily in terms of two concepts: nature and transcendence. Robust Yes responses and likewise robust No responses were presented by both scientists and theologians to the theme question, “Is Nature Enough? The Thirst for Transcendence.” After this introductory survey of the definitional landscape, representative papers from the conference are presented.

Can corporations remain socially responsible in today's fiercely competitive global economy? For several decades after World War II, companies like IBM, which exemplified what journalist Robert J. Samuelson called the 'good corporation,' poured forth material comforts and technological ideas while guaranteeing full employment and adequate retirement. In the 1980s all of that changed, as corporations moved to 'downsize' and become lean, mean global competitors. In this collection, thirteen prominent scholars in business ethics, finance, management, and religion and six corporate leaders (...) respond to a new essay by Samuelson that sounds the death knell of the 'good corporation.' They propose new approaches to corporate integrity and social responsibility in the global economy. The book will be useful in corporate workshops and will make an excellent business ethics text in philosophy departments and business schools. (shrink)

In what follows, I reply to critical appraisals of my book entitled Hippocrates’ Oath and Asclepius’ Snake: The Birth of the Medical Profession. Professors Tollefsen, McPherson, and Potts separately offer these thoughtful critiques. Professor Tollefsen approaches the work from the standpoint of the physician-patient relationship. Professors McPherson and Potts both address it in terms of virtues. Potts treats the theme of virtue generally while McPherson focuses on the virtue of piety. Since virtues attend relationships, in what follows, I discuss, first, (...) the physician-patient relationship ; second, virtue generally ; and third, and finally, the virtue of piety specifically. (shrink)

Dewey and Russell's debate over the status of logic in the twentieth-century is, by now, well-trodden ground for scholarly inquiry. However, Dewey's novel theory of propositions, first articulated in his 1938 Logic: The Theory of Inquiry, has received comparatively less attention than the debate that touched upon it. The paucity of interest among philosophers of language is probably due to a variety of reasons, such as the theory's unorthodox character and, what at least appears to be, its naive simplicity when (...) compared to other more common (syntactic and pragmatic) theories of propositions. In this paper, I would like to examine the three most extensive treatments, one by the late H.S. Thayer, another by Tom Burke, and the most recent exposition by Larry Hickman, with the intention of reviving scholarly interest in Dewey's theory of propositional form. Another objective of the present project is to situate Dewey's theory relative to more contemporary theories and debates about propositional form in the philosophy of language literature. (shrink)

If mental illnesses are externally constituted, then so are somatic illnesses. Will Davies makes a persuasive case for externalism in psychiatry; as I show here, parallel examples exist in somatic medicine.

Despite numerous ethical examinations of automated vehicles, philosophers have neglected to address how these technologies will affect vulnerable people. To account for this lacuna, researchers must analyze how driverless cars could hinder or help social justice. In addition to thinking through these aspects, scholars must also pay attention to the extensive moral dimensions of automated vehicles, including how they will affect the public, nonhumans, future generations, and culturally significant artifacts. If planners and engineers undertake this task, then they will have (...) to prioritize their efforts to avoid additional harm. The author shows how employing an approach called a “complex moral assessment” can help professionals implement these technologies into existing mobility systems in a just and moral fashion. (shrink)

A fundamental problem in artificial intelligence is that nobody really knows what intelligence is. The problem is especially acute when we need to consider artificial systems which are significantly different to humans. In this paper we approach this problem in the following way: we take a number of well known informal definitions of human intelligence that have been given by experts, and extract their essential features. These are then mathematically formalised to produce a general measure of intelligence for arbitrary machines. (...) We believe that this equation formally captures the concept of machine intelligence in the broadest reasonable sense. We then show how this formal definition is related to the theory of universal optimal learning agents. Finally, we survey the many other tests and definitions of intelligence that have been proposed for machines. (shrink)

Requirements for business ethics education and organizational ethics trainings mark an important step in encouraging ethical behavior among business students and professionals. However, the lack of specificity in these guidelines as to how, what, and where business ethics should be taught has led to stark differences in approaches and content. The present effort uses meta-analytic procedures to examine the effectiveness of current approaches across organizational ethics trainings and business school courses. to provide practical suggestions for business ethics interventions and research. (...) Thus, the primary questions driving this research are as follows: what course characteristics moderate the effectiveness of ethics instruction?, and have ethics education and training efforts improved? Findings suggest that professional, focused, and workshop-based training programs are especially effective for improving business ethics. However, results also reveal considerable problems with many of the criteria used to evaluate the effectiveness of business ethics interventions. Practical suggestions for course design and evaluation in business ethics efforts are discussed along with future research needs. (shrink)

In February 1975, a group of leading scientists, physicians, and policymakers convened at Asilomar, California, to consider the safety of proceeding with recombinant DNA research. The excitement generated by the promise of this new technology was counterbalanced by concerns regarding dangers that might arise from it, including the potential for accidental release of genetically modified organisms into the environment. Guidelines developed at the conference to direct future research endeavors had several consequences. They permitted research to resume, bringing to an end (...) the voluntary moratorium that the National Academy of Sciences had instituted several months earlier. They also served to illustrate that the scientific community was capable of self-governance, thereby securing public trust and persuading Congress not to institute legislative restrictions. Finally, they underscored the importance of weighing unforeseen risks inherent in some research against potential benefits that may arise from these same endeavors. (shrink)

This paper explores the relationship of various trait emotions to the ethical choices of 189 college students who completed a managerial decision-making task as part of an in-basket exercise in a laboratory setting. Prior research regarding emotion influences on ethical decision-making and linkages between emotions and cognition informed hypotheses about how different types of emotions impact ethical choices. Findings supported our expectations that positive and negative emotions classified as active would be more strongly related to interpersonally-directed ethical choices than to (...) organizationally-directed ones, and that passive emotions would be less related to ethical choices than active emotions. Implications for ethical decision-making research and organizational practices are discussed. (shrink)

Nihilists cannot square their position with common sense simply by paraphrasing away apparent ontological commitments in ordinary language. I argue for this claim by analogy. Paraphrase atheism says there is no God, but tries to square the truth of atheism with ordinary religious sentences by paraphrasing away apparent ontological commitments. Obviously, paraphrase does not reconcile atheism with ordinary language about God. I discuss two different reasons that paraphrase can fail and suggest that both reasons afflict paraphrase nihilism. Hence, paraphrase nihilism (...) cannot reconcile nihilism and common sense, and so nihilists must look for some other strategy that can evade the force of the Atheism Case. (shrink)

In this paper, I evaluate three views of philosophical pragmatism’s practical implications for academic and non-academic or public discourses, as well as offer my own view of those implications. The first view is that of George Novack. In an underappreciated tract, Pragmatism versus Marxism, the American Trotskyite and union organizer launched a vicious attack on John Dewey’s career as a professional philosopher. He alleged that Dewey’s ideas were inaccessible to all but a small community of fellow academicians. While Novack conceded (...) that Dewey’s philosophical inquiries had a cross-pollinating influence on other academic fields, he doubted that the beneficial products of those inquiries traveled far beyond the walls of the so-called ‘ivory tower.’ Larry Hickman offers a second view. He understands Dewey’s claim in Experience and Nature that philosophy serves as a “liaison officer” to mean that philosophers should provide a common lexicon that translates between the languages of distinct disciplines. In other words, for Dewey, the role of philosophy, including philosophical pragmatism, is to facilitate interdisciplinarity. Since interdisciplinary sharing is usually confined to academic discourse, Novack’s challenge is perfectly compatible with Hickman’s interpretation of Dewey’s ‘liaison officer’ claim. Both Novack and Hickman are mistaken, though in different degrees and for different reasons. The third, and more promising, view is advanced by Robert Talisse. He cites the life and works of Sidney Hook, one of Dewey’s better-known students, as an exemplary case of a pragmatist who consistently realized his pragmatic commitments in public discourse. The most important reason for qualifying Hickman’s interpretation of Dewey’s ‘liaison officer’ claim is that the measure of pragmatism’s value is not solely the ability of pragmatists to facilitate interdisciplinary collaboration, but their ability to also insert their ideas into public discourse. In my view, philosophical pragmatists, and philosophers generally, should both facilitate interdisciplinarity in academic discourse and introduce philosophical notions into public discourse—that is, serving in the dual capacity of interdisciplinary scholar and public intellectual. (shrink)

The question of whether medical and psychiatric judgements involve a normative or evaluative component has been a source of wide and vehement disagreement. But among those who think such a component is involved, there is considerable further disagreement as to its nature. In this article, I consider several versions of Aristotelian normativism, as propounded by Christopher Megone, Michael Thompson and Philippa Foot, and Martha Nussbaum. The first two, I claim, can be persuasively rebutted by different modes of liberal pluralist challenge (...) — respectively, pluralism about structures of social organisation and pluralism about biological forms. Nussbaum's version, by contrast, is alert to the need for pluralism; I argue, however, that the Aristotelian aspects of her theory hamper her pursuit of those pluralistic aims. (shrink)

Boredom is a frequently experienced and unpleasant state (Bench & Lench, 2019; Danckert et al., 2018; Eastwood et al., 2012) that people are experiencing more frequently (Weybright et al., 2020). W...

A popular argument for a right to ectogenic abortions appeals to a right to avoid the obligations associated with parenthood. A common objection to this argument questions whether there are any sufficiently great harms associated with parenthood to ground such a right. I propose a novel formulation of this argument that avoids these objections. I then defend it against important objections.

Juergensmeyer's interviews of ex-fighters—Muslims in Iraq and Mindanao, Sikhs in Punjab—illustrate how stubbornly they refuse to conform to Western narratives about “religious violence.” Among the Sikhs, “almost none of the militants surveyed... were said to be noticeably religious”; in ISIS, “many in the movement were attracted not by the ideology or the ideals, but by the excitement of being involved in an alternative culture, one of largely male militancy.” For the Moros in Mindanao, likewise, Islamic theology is one factor among (...) many, and one of relatively minor importance for the majority. These are all, nevertheless, treated as exemplars of religious violence, as Juergensmeyer puzzles through how to end it. His final chapter is called “How Imagined Wars End,” though we have been informed in the first chapter that “every war is an imagined war.” War is an “alternative reality,” “an inversion of ordinary reality where differences are negotiated through civil discourse.” Religion—whatever that is; no definition is offered—is also an alternative reality, one based on fear of one's own death. When these two alternative realities are joined, and “religion is thought to be war, and war religion,” the result is “cosmic war,” which is the worst. The book seeks to understand how cosmic war fades into more mundane conflict (and eventually peace).The internal factors that bring cosmic war to an end—fighters lose faith in their movement when it loses battles, when there is infighting, when new alternatives offer hope—and the external factors—a strong military or police response, concessions by the government, gestures of respect from opponents—do not seem different from the factors that bring all wars to an end. Juergensmeyer never convincingly distinguishes cosmic from other kinds of war. But the book exudes a bias toward the status quo, such that the violence of armed anticolonial movements is of a fundamentally different order than the everyday violence of established governments. It is hard to resist the conclusion that cosmic wars are simply wars that we “secular” Westerners find distasteful. We puzzle over cosmic religious violence to assure ourselves that our “ordinary” violence does not really count as violence. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Was Hume An Atheist? Shane Andre Hume's philosophy of religion, as expressed in the Dialogues Concerning Natural Religion, the Natural History of Religion, and sections 10 and 11 ofthe Enquiry ConcerningHuman Understanding,1 invites a number of diverse interpretations. At one extreme are those who see Hume as an "atheist"2 or "anti-theist."3 At the other extreme are those who see Hume as some kind of theist, though not a (...) classical or orthodox one.4 In between are others for whom Hume is an "agnostic* or "ironic skeptic."6 Still a fourth interpretation can be found, according to which Hume "seems to vacillate hopelessly" in his view ofreligion;7 in other words, no coherent philosophy ofreligion can be found in his work and so it is futile to look for one. Ofthe four alternatives, it seems to me that the fourth, being less interesting philosophically and less to Hume's credit as a major philosopher, should be rejected unless by default no coherent case can be made for one of the other three. Since I believe that Hume's views about the nature and existence of God are complex, somewhat unconventional, but still coherent, I will concentrate on the title question. Before tackling that question directly, however, we need to clarify the meaning of the term "atheist" and its cognates. While an atheist is popularly defined as one who does not believe in God, this definition is inadequate for two reasons. First, while the absence of belief is sometimes treated as a synonym for disbelief, it is clear that the two are not the same. An infant does not believe in God, but that does not make him an atheist,8 for, as yet, he does not have the linguistic competence to reflect on the question, Does God exist? Neither is the agnostic an atheist, for, though he has reflected on the question, he has not found reason to answer it affirmatively, Uke the theist, or negatively, like the atheist. For this reason, the atheist must be characterized more strongly, as one who disbelieves that God exists. But even this stronger characterization is insufficient, for, as is well-known but perhaps less widely takeninto account, there are many different conceptions ofGod, ranging from monotheism to polytheism, from beUef in a perfect being to belief in a being who shares some human limitations, from deism to pantheism, and so on. Accordingly, it has become commonplace in philosophy to recognize at least two senses ofthe term "God": a narrow sense, signifying "a supremely good being, creator of but separate from and independent of the world, omnipotent, omniscient, eternal and self-existent";9 and a wide sense, Volume XLX Number 1 141 SHANE ANDRE signifying one or more divine beings, personal or otherwise, manifesting extraordinarybut perhaps not superlative properties. For short, we could call the narrow sense the standard concept ofGod, and beliefin the existence ofsuch a being standard theism.10 And we could call the broad sense, applicable to any concept of the divine, the extended concept of God, and belief in the existence of such a being(s) extendedtheism. On this account, standard theists will alsobe extended theists, but of course someone could be an extended theist without being a standard theist. Let us call such a person (for example, Epicurus, who denied, not that the Gods exist, but that they intervene in human affairs) a limited theist. It is important to note that the limited theist rejects standard theism but is not an atheist simpliciter. How does recognition of these different forms oftheism affect our understanding of atheism? There seem to be two major possibilities. One is to characterize atheism in the narrow sense as disbeUef in standard theism; the other is to characterize it in the broad sense as disbeliefin any form of theism, including limited theism. While either option is open, it seems to me that the latter is preferable. For ifwe say that anyone who rejects standard theism is an atheist, we will end up with the paradoxical result that many distinguished theists will turn out to be atheists. For example, while Charles Hartshorne is not a standard theist, insofar as he rejects the... (shrink)

Mackinlay, Shane The opening of the legal year is marked by many events, including a range of religious celebrations. These celebrations are part of a long tradition, dating back nearly eight hundred years. The first religious ceremony recorded as marking the start of the legal year was a Mass celebrated in Notre Dame Cathedral in Paris in 1245. Then, it would have been a completely obvious thing to do, as it was unquestioned that those holding civic authority did so (...) only because it had been entrusted to them from God, and that they exercised it on his behalf. A range of powerful symbols made this relation very evident. The religious character of weighty ceremonies such as coronations was complemented by the integral place of faith in the broader culture; religious belief was not so much chosen as an expression of individual commitment, but was simply one characteristic among many others of national culture and identity. (shrink)

Developing a way to address troublesome issues in areas such as urban planning is a chal-lenging undertaking. It includes making decisions that involve humans, nonhumans, future generations, and historical and cultural artifacts. All of these groups deserve consideration, but not equally. Figuring out how to approach this topic involves overcoming the problem of moral prioritization. The structure of weak anthropocentrism can help with this problem, suggesting that future research on the environmental aspects of metropolitan regions should make use of its (...) applicability. Despite its strengths, weak anthropocentrism must be expanded to address complicated urban issues. A multitiered weak-anthropocentric measure, a “complex moral assessment,” is needed to address these concerns. (shrink)

Although Eugene Hargrove did not invent weak anthropocentrism, his version lacks adequate representation in several pedagogical and research venues in environmental ethics. In turn, weak anthropocentrism is one of the lesser-appreciated approaches when compared to areas such as ecocentrism. The author argues Hargrove’s version remains highly applicable to several of today’s ecological issues and advances in neighboring subfields, such as philosophy of technology, philosophy of food, and the emerging area of philosophy of the city. These points suggest weak anthropocentrism could (...) require additional study to understand how it could enhance environmental thought and could benefit philosophy’s future in classrooms and research explorations. (shrink)

The Oxford Handbook of Positive Psychology is the seminal reference in the field of positive psychology, which in recent years has transcended academia to capture the imagination of the general public. The handbook provides a roadmap for the psychology needed by the majority of the population -- those who don't need treatment but want to achieve the lives to which they aspire. These 65 chapters summarize all of the relevant literature in the field. The content's breadth and depth provide an (...) unparalleled cross-disciplinary look at positive psychology from diverse fields and all branches of psychology, including social, clinical, personality, counseling, school, and developmental psychology. Topics include not only happiness but also hope, strengths, positive emotions, life longings, creativity, emotional creativity, courage, and more, plus guidelines for applying what has worked for people across time and cultures. (shrink)

Scholars have typically regarded Confucius as an ethical thinker broadly construed and not as an epistemological thinker. This chapter seeks to overturn that view and, in doing so, has three basic goals. The first goal is to make the case that Confucian thought is of epistemological significance. Goal two is to locate the significance of Confucian thought within epistemology while accounting for the past overlooking of this significance. The third goal is to show that Confucian thought is not only of (...) epistemological significance, but that it can make a contribution to progressing contemporary epistemology. (shrink)

In this paper, I outline and defend a commonly-held moral view which has received surprisingly little sustained philosophical attention. This view, which I call the ‘authority of conscience,’ states that believing ourselves to have moral obligations to act in a certain way does in fact create an obligation to act in that way. Although I do not provide a positive case for the principle of authoritative conscience, beyond its popularity and intuitive force, I defend it against several prima facie objections. (...) I then go on to demonstrate that the principle does not entail any anti-realist metaethical commitments, and is therefore compatible in particular, and contrary to appearances, with plausible formulations of moral realism. (shrink)

A path-breaking collection launching a new series of books on the senses in antiquity. Synaesthesia and the Ancient Senses presents a radical reappraisal of antiquity's textures, flavours, and aromas, sounds and sights. It offers both a fresh look at society in the ancient world and an opportunity to deepen the reading of classical literature. The book will appeal to readers in classical society and literature, philosophy and cultural history. All Greek and Latin is translated and technical matters are explained for (...) the non-specialist. The introduction sets the ancient senses within the history of aesthetics and the subsequent essays explore the senses throughout the classical period and on to the modern reception of classical literature. (shrink)

Moral issues in urban planning involving technology, residents, marginalized groups, ecosystems, and future generations are complex cases, requiring solutions that go beyond the limits of contemporary moral theory. Aside from typical planning problems, there is incongruence between moral theory and some of the subjects that require moral assessment, such as urban infrastructure. Despite this incongruence, there is not a need to develop another moral theory. Instead, a supplemental measure that is compatible with existing moral positions will suffice. My primary goal (...) in this paper is to explain the need for this supplemental measure, describe what one looks like, and show how it works with existing moral systems. The secondary goal is to show that creating a supplemental measure that provides congruency between moral systems that are designed to assess human action and non-human subjects advances the study of moral theory. (shrink)

The current linkages between ethical theory and management behavior are investigated. The vignettes used in this investigation represent ethical dilemmas in the areas of coercion and control, conflict of interest, physical environment, and personal integrity. Overall, even with heightened ethical awareness the link between ethical philosophy and management behavior remains similar to that of the early 1990s. Generally, practitioners still rely heavily on the utilitarian ethical philosophy when making business decisions. However, more managers are now likely to select ethically appropriate (...) actions either because it is ethical to do so, or because the consequences or risk of not doing so are too great. This shift could positively impact the ethical climate of business decision-making. (shrink)

Corrective measures and remediation efforts aimed at alleviating the conditions of environmental injustice usually depend on federal or state funding. However, such resources could disappear, leavi...

The type II phosphatidylinositol 4-kinases produce the lipid phosphatidylinositol 4-phosphate and participate in a confusing variety of membrane trafficking and signaling roles. This review argues that both historical and contemporary evidence supports the function of the PI4KIIs in numerous trafficking pathways, and that the key to understanding the enzymatic regulation is through membrane interaction and the intrinsic membrane environment. By summarizing new research and examining the trafficking roles of the PI4KIIs in the context of recently solved molecular structures, I highlight (...) how mechanisms of PI4KII function and regulation are providing insights into the development of cancer and in neurological disease. I present an integrated view connecting the cell biology, molecular regulation, and roles in whole animal systems of these increasingly important proteins. The type II phosphatidylinositol 4-kinases are versatile mediators of membrane trafficking, controlling pathways that impact on disease. Recent advances suggest that the membrane lipid environment regulates enzyme activity and that the complexity of trafficking routes can be explained by the ability of these kinases to promote membrane trafficking in different directions. (shrink)