The solution structures of several small proteins have recently been determined from high‐resolution nuclear magnetic resonance data. The principal features of the methods available to do this are outlined here, together with the advantages, limitations and future prospects of the technique.

Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction and restricted/repetitive behavior. We performed a large-scale retrospective analysis of 1,996 clinical neurological structural magnetic resonance imaging (MRI) examinations of 781 autistic and 988 control subjects (aged 0 to 32 years), and extracted regionally distributed cortical thickness measurements, including average measurements as well as standard deviations which supports the assessment of intra-regional cortical thickness variability. The youngest autistic participants (< 2.5 years) were diagnosed after imaging and (...) were identified retrospectively. The largest effect sizes and the most common findings not previously published in the scientific literature involve abnormal intra-regional variability in cortical thickness affecting many (but not all) regions of the autistic brain, suggesting irregular gray matter development in autism that can be detected with MRI. Atypical developmental patterns have been detected as early as 0 years old in individuals who would later be diagnosed with autism. (shrink)

Magic angle spinning (MAS) NMR methods provide a means of obtaining high resolution structural data on rhodopsin and its photoin termediates. Current work has focused on the structure of the retinal chromophore and its interactions with surrounding protein charges. The recent development of MAS NMR methods for measuring internuclear distances with a resolution of ∼0.2 will complement diffraction methods for addressing key mechanistic questions.

Critical studies in higher education often embrace the ideas of the slowness movement to address time pressure. However, this desirable horizon presents some limitations. On the one hand, by emphasizing solutions at the individual level, boosting slowness may promote tactics incapable of producing changes to the underlying structural dynamics of time pressure. On the other hand, approaches based on slowness may also inadvertently foster a form of ethical paternalism within the context of ethical pluralism by prescribing substantive models of practice (...) ultimately based on ‘do this quickly or do it slowly.’ This theoretical research moves away from the temporal paradigm to that of the way of relating. Building upon the ethical concept of resonance, the approach focuses on a formal critique of the current socioeconomic and ethical dynamics of social acceleration, growth, and innovation that can contribute to projecting non-alienated relationships in higher education. (shrink)

Democratic conceptions of politics are tacitly or explicitly predicated upon a functioning arena for the formation of public opinion in an associated media-space. Policy-making thus requires a reliable connection to processes of ‘public’ will formation. These processes formed the focus for Habermas’s influential study on the public sphere. This contribution presents a look at more recent ‘structural transformation’, the causes of which are by no means limited to social media communication, and examines its consequences. It proceeds in three steps: 1) (...) in some proximity to Habermas, but also by means of the theory of resonance, it seeks to determine the kind of public sphere that a democratic polity requires; 2) an analysis of problems within the contemporary public sphere will feed into 3) a discussion of the conditions for the restoration of a ‘functioning political public sphere’. These include changes in the realms of participation, representation and spaces of encounter. (shrink)

Magnetic resonance imaging (MRI) can provide a number of measurements relevant to sport-related concussion (SRC) symptoms; however, most studies to date have used a single MRI modality and whole-brain exploratory analyses in attempts to localize concussion injury. This has resulted in highly variable findings across studies due to wide ranging symptomology, severity and nature of injury within studies. A multimodal MRI, symptom-guided region-of-interest (ROI) approach is likely to yield more consistent results. The functions of the cerebellum and basal ganglia (...) transcend many common concussion symptoms, and thus these regions, plus the white matter tracts that connect or project from them, constitute plausible ROIs for MRI analysis. We performed diffusion tensor imaging (DTI), resting-state functional MRI, quantitative susceptibility mapping (QSM), and cerebral blood flow (CBF) imaging using arterial spin labeling (ASL), in youth aged 12-18 years following SRC, with a focus on the cerebellum, basal ganglia and white matter tracts. Compared to controls similar in age, sex and sport (N= 20), recent SRC youth (N= 29; MRI at 8 ± 3 days post injury) exhibited increased susceptibility in the cerebellum (p= 0.032), decreased functional connectivity between the caudate and each of the pallidum (p= 0.035) and thalamus (p= 0.021), and decreased diffusivity in the mid-posterior corpus callosum (p< 0.038); no changes were observed in recovered asymptomatic youth (N= 16; 41 ± 16 days post injury). For recent symptomatic-only SRC youth (N= 24), symptom severity was associated with increased susceptibility in the superior cerebellar peduncles (p= 0.011) and reduced activity in the cerebellum (p= 0.013). Fewer days between injury and MRI were associated with reduced cerebellar-parietal functional connectivity (p< 0.014), reduced activity of the pallidum (p= 0.002), increased CBF in the caudate (p= 0.005), and reduced diffusivity in the central corpus callosum (p< 0.05). Youth SRC is associated with acute cerebellar inflammation accompanied by reduced cerebellar activity and cerebellar-parietal connectivity, as well as structural changes of the middle regions of the corpus callosum accompanied by functional changes of the caudate, all of which resolve with recovery. Early MRI post-injury is important to establish objective MRI-based indicators for concussion diagnosis, recovery assessment and prediction of outcome. (shrink)

When physical structures resonate in proximity to each other they will under certain circumstances 'sync up' in a shared resonance frequency. This is the phenomenon of spontaneous selforganization. General resonance theory (GRT), a theory of consciousness developed by Hunt and Schooler, suggests that consciousness is a product of various shared resonance frequencies at different physical scales. I suggest a heuristic for calculating the boundaries and resulting capacity for phenomenal consciousness in such resonating structures. Shared resonance results (...) in phase transitions in the speed and bandwidth of information exchange and thus richer and more complex consciousness. This approach is a solution to the 'combination problem' and 'boundary problem' of consciousness. The proposed mathematical heuristic is a practical approach for identifying potential conscious structures and the spatial and temporal boundaries of such structures over time, and also for calculating the capacity for phenomenal consciousness of any putative conscious entity. The slowest-frequency shared resonance -- the 'slowest common denominator'-- is the limiting factor for the spatial extent of any macro-consciousness. Various synchrony indexes are discussed. I describe some limitations of the proposed framework, and how it compares to Tononi's integrated information theory. IIT's constellation- qualia characterization framework is compatible with GRT and may be a useful tool in conjunction with GRT's quantification framework. (shrink)

Hemispherical Resonator Gyro is a new type gyro with high precision, high reliability, shock resistance, no need of preheating, short start time, and long life. It is a kind of vibrating gyro with standing wave rotating along the sensitive base of annular precession, has a unique application prospect in the field of high precision inertial sensors, and is widely used in unmanned aerial vehicle control in complex environments. Based on the theory of the structure characteristics of the hemispherical resonator, the (...) mathematical model of energy of the resonator is established to research the rule of resonant frequency when the hemispherical resonator is rotated around the central axis. In this paper, the influence of precession factor, which are the top angle, the bottom angle, and wall unevenness of the hemispherical resonator, are analyzed. A series of hemispherical resonator models are constructed by ANSYS software to prove the results of theoretical research. The simulation results show that precession factor of the hemispherical resonator is more sensitive of the top angle than the bottom angle, and the error of angular velocity which is caused by the change of the top angle is larger than that which is caused by the change of the bottom angle. (shrink)

In this paper, I argue that the recent work on mirror neurons illuminates the character of our capacities for a politics of resonant receptivity in ways that both help us to comprehend the damages of our contemporary order and suggest indispensable alternative ethical-strategic registers and possible directions for organising a powerful movement towards radical democracy. In doing so, neuroscience simultaneously contributes to our understanding of the possibility and importance of a more durable radically democratic habitus. While the trope, ‘radically democratic (...) habitus’, may seem oxymoronic in light of Bourdieu’s extensive rendering of ‘habitus’, I suggest that research on mirror neurons discloses ways in which iterated practices and dispositional structures are crucial for democratic freedom.Keywords: radical democracy; mirror neurons; receptivity; political resonance; habitus; resonance machine; mimesis; affect. (shrink)

This paper explores corporate charitable giving disclosures in order to question the extent to which corporations can claim that their philanthropy activities are charitable at all. Exploration of these issues is carried out by means of a tropological analysis that focuses on the different linguistic tropes within the philanthropy disclosures of 52 companies, namely metaphor and synecdoche. The results reveal a number of complex and contradictory things. Primarily, the master metaphor of 'altruism' projected by the corporate disclosures is ideologically at (...) odds with the more business case-oriented discourse that shapes the disclosures. This contradiction is put into starker contrast by the existence of a root metaphor, whereby the recipients of corporate philanthropy are presented as the 'deserving poor'. Synecdochal devices are present within the corporate disclosures, whereby employee initiatives that are independent of corporate strategies are used to confer attributes onto the disclosures that bolster the master metaphor of 'altruism'. As such, corporate philanthropy is presented by the paper as a structurally incoherent discourse and yet one that has implications for both extracting greater value from various societal groups and in defining, on behalf of civil society, what is a worthy cause. (shrink)

Child trauma plays an important role in the etiology of Bordeline Personality Disorder. Of all traumas, sexual trauma is the most common, severe and most associated with receiving a BPD diagnosis when adult. Etiologic models posit sexual abuse as a prognostic factor in BPD. Here we apply machine learning using Multiple Kernel Regression to the Magnetic Resonance Structural Images of 20 BPD and 13 healthy control to see whether their brain predicts five sources of traumas: sex abuse, emotion neglect, (...) emotional abuse, physical neglect, physical abuse. We also applied the same analysis to predict symptom severity in five domains: affective, cognitive, impulsivity, interpersonal for BPD patients only. Results indicate that CTQ sexual trauma is predicted by a set of areas including the amygdala, the Heschl area, the Caudate, the Putamen, and portions of the Cerebellum in BPD patients only. Importantly, interpersonal problems only in BPD patients were predicted by a set of areas including temporal lobe and cerebellar regions. Notably, sexual trauma and interpersonal problems were not predicted by structural features in matched healthy controls. This finding may help elucidate the brain circuit affected by traumatic experiences and connected with interpersonal problems BPD suffer from. (shrink)

Rapidly advancing studies on rhodopsin have focused on new strategies for crystallization of this integral membrane protein for x-ray analysis and on alternative methods for structural determination from nuclear magnetic resonance data. Functional studies of the interactions between the apoprotein and its chromophore have clarified the role of the chromophore in deactivation of opsin and in photoactivation of the pigment.

Confronting the uncertain environment, this article adopts a case research approach to resonate with the studies of hybridity. It aims to explain how the perception of uncertainty in the institutional environment affects the adaptation of organizational structure in pursuing legitimacy for hybrid organizations. Based on the empirical data collected from a two-staged fieldwork and in-depth interviews, the case analysis concentrates on the correlation between the evolution of institutional logics and organizational structure change from a diachronic perspective. The findings indicate that (...) in the face of competing and changing institutional logics, Chinese mass media organizations have gradually shifted from a dominated blending strategy in the exploration stage to a deeply compartmentalizing strategy in the stable stage. The hybrids can deal with the uncertainty of the institutional environment by enhancing the uncertainty of the organizational structure. Consequently, the case evolves an organizational integration through internal legitimacy. It manifests a possibility for hybrids of combining the two major response mechanisms in one process. (shrink)

Consciousness has always been linked to the nervous system or rather the brain, but there recorded conscious behaviors in organisms without nerve cells have changed the perspective of consciousness. A living cell is a blend of resonant frequencies, due to degrees of freedom that make it vibrate as a harmonic oscillator supporting the progression of vibrations as waves in and out of the system; to the neighboring cells, to the body, to other bodies and ultimately to the Universe; all of (...) which connects. Quantum generated consciousness is energy; emerges in each and every living cell and traverses by means of resonating vibrations; which utilizes the cellular structures to flow by means of a coherent, obscured, robust, recoverable process. (shrink)

Fractals are built from patterns generated from immense complexity within the resonant frequencies that connect and tune the universe. Play of such frequencies would result in the exchange of energy and coupling of informational systems at various levels and scales. The present essay serves as a small ride into life’s association with such phenomenon. At a fundamental level communication happens via process called ‘resonance’, and this in turn manifests at a physical level as self-replicating and self-resonating patterns called ‘fractals.’ (...) This could be the reason why at a physical level every structure carries this fractal imprint nature, making it the cosmic signature. The fractal patterns popping out in the natural world surrounding us could be thought of as frozen energy or resonant life patterns. Thus, we hypothesize life could have emerged or appeared as a ‘fracto-resonant’ phenomenon, resulting from the play of interference between material and non-material aspects. In this regard, we propose frequencies or vibrations to be more fundamental to life and call for scientific studies that aim at understanding the effect of various frequencies and vibrations on life forms and consciousness. (shrink)

In 1950, Alan Turing proposed his iconic imitation game, calling it a ‘test’, an ‘experiment’, and the ‘the only really satisfactory support’ for his view that machines can think. Following Turing’s rhetoric, the ‘Turing test’ has been widely received as a kind of crucial experiment to determine machine intelligence. In later sources, however, Turing showed a milder attitude towards what he called his ‘imitation tests’. In 1948, Turing referred to the persuasive power of ‘the actual production of machines’ rather than (...) that of a controlled experiment. Observing this, I propose to distinguish the logical structure from the rhetoric of Turing’s argument. I argue that Turing’s proposal of a crucial experiment may have been a concession to meet the standards of his interlocutors more than his own, while his construction of machine intelligence rather reveals a method of successive idealizations and exploratory experiments. I will draw a parallel with Galileo’s construction of idealized fall in a void and the historiographical controversies over the role of experiment in Galilean science. I suggest that Turing, like Galileo, relied on certain kinds of experiment, but also on rhetoric and propaganda to inspire further research that could lead to convincing scientific and technological progress. (shrink)

Rapid technological advances have produced a variety of novel techniques that allow a comprehensive assessment of brain function to be combined with detailed information about brain structure and connectivity. Any assessment that is based on exhibited behavior after brain injury will be prone to error for a number of reasons. These questions are explored in the context of recent studies in both healthy populations and brain injured patients that have sought to investigate covert awareness through the use of functional neuroimaging. (...) Those circumstances in which functional magnetic resonance imaging data can be used to infer awareness in the absence of a behavioral response are contrasted with those circumstances in which it cannot. This distinction is fundamental for understanding and interpreting patterns of brain activity following acute brain injury and has implications for clinical care, diagnosis, prognosis, and medicolegal decision-making after serious brain injury. (shrink)

Whether designing animals, insects, or plants, Nature draws upon symmetry and periodicity to play a fundamental role in defining the body plan. When implemented with the proper chemical mechanisms, these principles guide our bodies from single-celled embryos to bilaterally symmetric creatures with intricate periodic structures, such as the spine and rib cage. The properties of symmetry and periodicity also appear to be fundamental to visual perception. We will show that this is no coincidence, but is a consequence of the fact (...) that these properties are generated by the same underlying phenomenon, standing wave patterns formed from harmonic resonances. The symmetry in life forms arises from chemical harmonic resonances, whereas the symmetry in visual perception arises from harmonic resonances in the visual system. We will show that harmonic resonances have very interesting properties for the representation of geometrical form that make them eminently suitable for encoding geometric form for body plans as well as for visual perception. In particular, we will show that by being simultaneously invariant to perspective transformation and robust to deformation, such resonant representations have fundamental advantages over more traditional techniques. (shrink)

Transcultural dialogue and research are often bedeviled by a range of divergences in the use and resonances of key terms defining the focus of the conversation; social understandings; ways of dealing with the life situations involved; and traditional protocols in relation to the ethical challenges in the areas of research. A simple example from research into genetics will illustrate the problem. A team from two New Zealand universities comprising both Māori and NZ European academics examined indigenous attitudes to genetic technologies. (...) A breakdown of trust became evident such that many of the Māori members of the team felt they could no longer participate because they felt their views... (shrink)

This study examines the similarities and differences in pre- and post-Sarbanes-Oxley corporate ethics codes and codes of conduct using the framework of structuration theory. Following the passage of the Sarbanes-Oxley (SOX) legislation in 2002 in the United States, publicly traded companies there undertook development and revision of their codes of ethics in response to new regulatory requirements as well as incentives under the U.S. Corporate Sentencing Guidelines, which were also revised as part of the SOX mandates. Questions that remain are (...) whether these new or revised codes are effective means of communicating changed ethical foci and attitudes in organizations. Centering resonance analysis (CRA) is used to identify differences and similarities across time and industries by analyzing word networks of 46 pre- and post-SOX corporate codes of ethics. Analyses focus on content and structure of generated word networks as well as resulting factors that emerged from the texts. Results are interpreted from the structuration perspective that content and structure of codes are constrained and enabled by system structures while they function to produce and reproduce those structures. Results indicate that corporate codes of ethics are formal discourses of ethics, laws, and control. Code structure has changed across time, with an increased emphasis on compliance in post-SOX codes. Implications for research and practice are discussed in light of findings. (shrink)

In this paper we elaborate a conception of what we call integrational creativity, which aims both to capture the richest kinds of human creativity and to bring together certain existing conceptions of creativity in a way that we hope will resonate with what people have had in mind in talking of creativity. These conceptions are those offered by Arthur Koestler, Margaret Boden, and two conceptual blending theorists, Gilles Fauconnier and Mark Turner; and we show how these conceptions and the criticisms (...) that have been made of them can be accommodated within our integrational account. We also argue, drawing on the work of Immanuel Kant and Hartmut Rosa, that the integrating character of creativity is complemented by the resonating character of its appreciation. On our view, the heart of creativity lies in its integrating–resonating structure, and in the final part we note some of the implications for recent debates about creativity. (shrink)

One innovation in this paper is its identification, analysis, and description of a troubling ambiguity in the word ‘argument’. In one sense ‘argument’ denotes a premise-conclusion argument: a two-part system composed of a set of sentences—the premises—and a single sentence—the conclusion. In another sense it denotes a premise-conclusion-mediation argument—later called an argumentation: a three-part system composed of a set of sentences—the premises—a single sentence—the conclusion—and complex of sentences—the mediation. The latter is often intended to show that the conclusion follows from (...) the premises. The complementarity and interrelation of premise-conclusion arguments and premise-conclusion-mediation arguments resonate throughout the rest of the paper which articulates the conceptual structure found in logic from Aristotle to Tarski. This 1972 paper can be seen as anticipating Corcoran’s signature work: the more widely read 1989 paper, Argumentations and Logic, Argumentation 3, 17–43. MR91b:03006. The 1972 paper was translated into Portuguese. The 1989 paper was translated into Spanish, Portuguese, and Persian. (shrink)

This essay seeks to scrutinize Kierkegaard’s critical philosophical theology. The intent is to demonstrate how his religious thought, especially on God’s relation to the world and to the human being, can contribute to generating a cogent response to the challenges presented by our accelerating secular world. Apart from the narrative on the Dane’s passionate reflections, I employ two other narratives to facilitate this inquiry into Kierkegaard. The first of these facilitating narratives comes from highlighting the work on the concept of (...) resonance by the social theorist Hartmut Rosa. Rosa’s rich analysis of our contemporary situation provides a persuasive case for the accelerating pace of our secular world, the complex dynamics of alienation that are at play within it, and the need for social transformation that creates space for increasing resonance within personal and social relationships and structures. The second facilitating narrative centers on the notion of dancing in God, which I believe holds promise for effectively communicating moving, bodily, rhythmic, passionate, and responsive thoughts and actions concerning God’s engagement in our contemporary world. I hope to show that these three complementary discourses together provide a provocative religious discourse and vision that can prove helpful in addressing many of the challenges of our time. (shrink)

Recent studies have provided evidence of associations between neurochemistry and reading (dis)ability (Pugh et al., 2014). Based on a long history of studies indicating that fluent reading entails the automatic convergence of the written and spoken forms of language and our recently proposed Neural Noise Hypothesis (Hancock et al., 2017), we hypothesized that individual differences in cross-modal integration would mediate, at least partially, the relationship between neurochemical concentrations and reading. Cross-modal integration was measured in 231 children using a two-alternative forced (...) choice cross-modal matching task with three language conditions (letters, words, and pseudowords) and two levels of difficulty within each language condition. Neurometabolite concentrations of Choline (Cho), Glutamate (Glu), gamma-Aminobutyric (GABA), and N- acetyl-aspartate (NAA) were then measured in a subset of this sample (n = 70) with Magnetic Resonance Spectroscopy (MRS). A structural equation mediation model revealed that the effect of cross-modal word matching mediated the relationship between increased Glu (which has been proposed to be an index of neural noise) and poorer reading ability. In addition, the effect of cross-modal word matching fully mediated a relationship between increased Cho and poorer reading ability. Multilevel mixed effects models confirmed that lower Cho predicted faster cross-modal matching reaction time, specifically in the hard word condition. These Cho... (shrink)

Electromagnetic field oscillations produced by the brain are increasingly being viewed as causal drivers of consciousness. Recent research has highlighted the importance of the body’s various endogenous rhythms in organizing these brain-generated fields through various types of entrainment. We expand this approach by examining evidence of extracerebral shared oscillations between the brain and other parts of the body, in both humans and animals. We then examine the degree to which these data support one of General Resonance Theory’s principles: the (...) Slowest Shared Resonance principle, which states that the combination of micro- to macro-consciousness in coupled field systems is a function of the slowest common denominator frequency or resonance. This principle may be utilized to develop a spatiotemporal hierarchy of brain-body shared resonance systems. It is predicted that a system’s SSR decreases with distance between the brain and various resonating structures in the body. The various resonance relationships examined, including between the brain and gastric neurons, brain and sensory organs, and brain and spinal cord, generally match the predicted SSR relationships, empirically supporting this principle of GRT. (shrink)

To model behavioral and neural correlates of language comprehension in naturalistic environments, researchers have turned to broad‐coverage tools from natural‐language processing and machine learning. Where syntactic structure is explicitly modeled, prior work has relied predominantly on context‐free grammars (CFGs), yet such formalisms are not sufficiently expressive for human languages. Combinatory categorial grammars (CCGs) are sufficiently expressive directly compositional models of grammar with flexible constituency that affords incremental interpretation. In this work, we evaluate whether a more expressive CCG provides a better (...) model than a CFG for human neural signals collected with functional magnetic resonance imaging (fMRI) while participants listen to an audiobook story. We further test between variants of CCG that differ in how they handle optional adjuncts. These evaluations are carried out against a baseline that includes estimates of next‐word predictability from a transformer neural network language model. Such a comparison reveals unique contributions of CCG structure‐building predominantly in the left posterior temporal lobe: CCG‐derived measures offer a superior fit to neural signals compared to those derived from a CFG. These effects are spatially distinct from bilateral superior temporal effects that are unique to predictability. Neural effects for structure‐building are thus separable from predictability during naturalistic listening, and those effects are best characterized by a grammar whose expressive power is motivated on independent linguistic grounds. (shrink)

In this paper, I compare all three editions of Bennett Reimer’s A Philosophy of Music Education with early Chinese philosophy, in particular, classical Chinese aesthetics. I structure my analysis around a quartet of interrelated themes: aesthetic education, education of feeling, aesthetic experience, and ethics and aesthetics. This paper suggests that Reimer’s philosophical writings have some degree of transcultural applicability beyond Western thought, counterpointing criticisms that his philosophy is narrow, ethnocentric, and culturally limited. It also serves as a plausible point of (...) departure towards a transcultural theory of aesthetics for music education relevant to the pluralistic and globalized world in which we live. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 (...) participants (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Summary The resonator and the tuning fork were major instruments in acoustics in the latter half of the nineteenth-century. In particular, the third Baron Rayleigh made extensive use of these instruments throughout his long career as an experimentalist. These instruments underwent a number of alterations during their use as central experimental tools in acoustics. Functional and structural alterations were introduced in the adaptation of these instruments to several major acousticians’ experimental settings. Rayleigh not only adopted the two instruments as objects (...) of mathematical and experimental investigation but also employed them ingeniously for various purposes. His continuing creation of a variety of uses and forms of these instruments contributed to focusing acoustics on pure tones and musical sounds until the early twentieth century. (shrink)

This study examines the formation and development of the Xiangxi Miao Drum Dance (XMDD) through a philosophical and religious lens, situating its evolution within the broader discourse of cultural ecology and spiritual practice. The research seeks to uncover how the interplay between the Miao people's ancestral environment, cosmological beliefs, and socio-cultural traditions has shaped this unique ritualistic art form. Employing a qualitative research design, the study integrates ethnographic methods—including participant observation, interviews with local practitioners, and analysis of historical texts—to explore (...) the sacred and symbolic dimensions of XMDD. Key findings reveal that the dance originates from agricultural rituals and clan-based, matriarchal structures of Miao society, dating back to the Zhou and Qin dynasties. More significantly, the research highlights how XMDD functions as a conduit for spiritual expression, invoking divine protection, ancestral reverence, and cosmic harmony. Over time, this ritual dance has transformed from a sacred communal practice into a performative cultural heritage, yet it continues to carry profound religious and philosophical significance. The study underscores the necessity of preserving XMDD within both traditional and contemporary contexts, not merely as an artistic expression but as a vehicle for transmitting religious worldviews and philosophical reflections on identity, harmony, and transcendence. Future research should further investigate the dance’s role in shaping Miao religious thought, its contribution to interethnic philosophical discourse, and its pedagogical potential in fostering spiritual and cultural awareness. (shrink)

The poor denoising effect for noisy grayscale images with traditional processing methods would be obtained under strong noise condition, and some image details would be lost. In this paper, a parallel array model of Fitzhugh–Nagumo neurons was proposed, which can restore noisy grayscale images well with low peak signal-to-noise ratio conditions and the image details are better preserved. Firstly, the row-column scanning method was used to convert the 2D grayscale image into a 1D signal, and then the 1D signal was (...) converted into a binary pulse amplitude modulation signal by signal modulation. The modulated signal was input to an FHN parallel array for stochastic resonance. Finally, the array output signal was restored to a 2D gray image, and the image restoration effect was analyzed based on the PSNR and Structural SIMilarity index. It is shown that the SR effect can be exhibited in an array of FHN neuron nonlinearities by increasing the array size, and the image restoration effect is significantly better than the traditional image restoration method, and larger PSNR and SSIM can be obtained. It provides a new idea for grayscale image restoration in a low PSNR environment. (shrink)

Beyond the eras a dialogue seems to have been established between Bruegel the Elder (1525-1569) and Antonin Artaud (1896-1948). The poet’s wonder at the « painting of the North », both realistic and emblematic, reveals his deepest ideal as an artist : painting, a « magical » operation, deploys a power of expression based on signs and no longer on words, which the theatre is also called upon to seize. The juxtaposition of Bruegel’s Triumph of Death and a famous drawing (...) by Artaud, Le Théâtre de la cruauté [The Theatre of Cruelty], highlights the striking convergences between the two artists. Through their pictorial works, both of them renew over the centuries the funerary and mythical symbolism of death, inherited from the macabre scenes of medieval paintings, but also from ancient times. Studying the references to theatrical iconography in Bruegel’s painting, where carnival and crudity of death reinforce each other, allows us to deepen the meaning of these resonances. For the two artists, form and poetic momentum meet so that representation, as a structure common to painting and theatre, fixes a moment of the world, while animating that moment to infinity, thanks to signs conceived as « true hieroglyphs » (Artaud), a problem that Michel Foucault associated with the strongest truth that the experience of madness carries. (shrink)

Understanding the neural basis of schizophrenia (SZ) is important for shedding light on the neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, and medial prefrontal cortex (MPFC) have been implicated in the neurobiology of SZ. However, the effective connectivity among them in SZ remains unclear. The current study investigated how neuronal pathways involving these regions were affected in first-episode SZ using functional magnetic resonance imaging (fMRI). Forty-nine (...) patients with a first-episode of psychosis and diagnosis of SZ—according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision—were studied. Fifty healthy controls (HCs) were included for comparison. All subjects underwent resting state fMRI. We used spectral dynamic causal modeling (DCM) to estimate directed connections among the bilateral ACC, DLPFC, hippocampus, and MPFC. We characterized the differences using Bayesian parameter averaging (BPA) in addition to classical inference (t-test). In addition to common effective connectivity in these two groups, HCs displayed widespread significant connections predominantly involved in ACC not detected in SZ patients, but SZ showed few connections. Based on BPA results, SZ patients exhibited anterior cingulate cortico-prefrontal-hippocampal hyperconnectivity, as well as ACC-related and hippocampal-dorsolateral prefrontal-medial prefrontal hypoconnectivity. In summary, spectral DCM revealed the pattern of effective connectivity involving ACC in patients with first-episode SZ. This study provides a potential link between SZ and dysfunction of ACC, creating an ideal situation to associate mechanisms behind SZ with aberrant connectivity among these cognition and emotion-related regions. (shrink)

Patients with Wilson’s disease suffer from prospective memory impairment, and some of patients develop cognitive impairment. However, very little is known about how brain structure and function changes effect PM in WD. Here, we employed multimodal neuroimaging data acquired from 22 WD patients and 26 healthy controls who underwent three-dimensional T1-weighted, diffusion tensor imaging, and resting state functional magnetic resonance imaging. We investigated gray matter volumes with voxel-based morphometry, DTI metrics using the fiber tractography method, and RS-fMRI using the (...) seed-based functional connectivity method. Compared with HC, WD patients showed GM volume reductions in the basal ganglia and occipital fusiform gyrus, as well as volume increase in the visual association cortex. Moreover, whiter matter tracks of WD were widely impaired in association and limbic fibers. WM tracks in association fibers are significant related to PM in WD patients. Relative to HC, WD patients showed that the visual association cortex functionally connects to the thalamus and hippocampus, which is associated with global cognitive function in patients with WD. Together, these findings suggested that PM impairment in WD may be modulated by aberrant WM in association fibers, and that GM volume changes in the association cortex has no direct effect on cognitive status, but indirectly affect global cognitive function by its aberrant functional connectivity in patients with WD. Our findings may provide a new window to further study how WD develops into cognitive impairment, and deepen our understanding of the cognitive status and neuropathology of WD. (shrink)

In this chapter, I argue that care ethics offers useful resources for developing alternative models of responsibility for of structural injustice. I begin in Section 2 by providing an overview of what 'structural injustice' is and of the ‘forward-looking’ models of responsibility that have been developed for dealing with it. In Section 3, I give an overview of (my interpretation of) care ethics. This will reveal several points of resonance between care ethics and existing forward-looking theories of responsibility for (...) structural injustice. In Section 4, I weave these two threads together, explicitly enumerating several care ethical insights that can be brought to bear on forward-looking theories of responsibility for structural injustice. (shrink)

In this paper, we review the history of quasicrystals from their sensational discovery in 1982, initially “forbidden” by the rules of classical crystallography, to 2011 when Dan Shechtman was awarded the Nobel Prize in Chemistry. We then discuss the discovery of quasicrystals in philosophical terms of anomalies behavior that led to a paradigm shift as offered by philosopher and historian of science Thomas Kuhn in ‘The Structure of Scientific Revolutions’. This discovery, which found expression in the redefinition of the concept (...) crystal from being periodically arranged to producing sharp peaks in the Bragg diffraction pattern, is analyzed according to the Kuhn Cycle. We relate the quasicrystal revolution to the non-Euclidean geometry revolution and argues that since “great minds think alike” there is a diffusion of ideas between scientific revolutions, or a resonance between different disciplines at different times. The story behind quasicrystals is an excellent example of a paradigm shift, demonstrating the nature of scientific discoveries and breakthroughs. (shrink)

Objective: Patients with hypochondriasis hold unexplainable beliefs and a fear of having a lethal disease, with poor compliances and treatment response to psychotropic drugs. Although several studies have demonstrated that patients with hypochondriasis demonstrate abnormalities in brain structure and function, gray matter volume and functional connectivity in hypochondriasis still remain unclear.Methods: The present study collected T1-weighted and resting-state functional magnetic resonance images from 21 hypochondriasis patients and 22 well-matched healthy controls. We first analyzed the difference in the GMV between (...) the two groups. We then used the regions showing a difference in GMV between two groups as seeds to perform functional connectivity analysis. Finally, a support vector machine was applied to the imaging data to distinguish hypochondriasis patients from HCs.Results: Compared with the HCs, the hypochondriasis group showed decreased GMV in the left precuneus, and increased GMV in the left medial frontal gyrus. FC analyses revealed decreased FC between the left medial frontal gyrus and cuneus, and between the left precuneus and cuneus. A combination of both GMV and FC in the left precuneus, medial frontal gyrus, and cuneus was able to discriminate the hypochondriasis patients from HCs with a sensitivity of 0.98, specificity of 0.93, and accuracy of 0.95.Conclusion: Our study suggests that smaller left precuneus volumes and decreased FC between the left precuneus and cuneus seem to play an important role of hypochondriasis. Future studies are needed to confirm whether this finding is generalizable to patients with hypochondriasis. (shrink)

Birth asphyxia is the most common single cause of death in term newborn infants. The majority of deaths in developed countries follow decisions to withdraw intensive care. Recent technological advances, particularly the use of magnetic resonance imaging (MRI) of the brain, may affect the process of prognostication and decision-making. There is little existing evidence about how prognosis is determined in newborn infants and how this relates to treatment withdrawal decisions.An exploratory qualitative study was performed using in-depth semi-structured interviews (...) with a sample of ten neonatologists from tertiary intensive care units in the UK. Participants were purposively selected to ensure a range of experience and type of unit. They were asked about the process of prognostication for infants with birth asphyxia and decisions about treatment withdrawal. Interviews were transcribed and thematically analysed.MRI played a significant role in decision-making about life-sustaining treatment for a number of clinicians. Clinicians did not identify particular ethical concerns related to MRI, though wider discussion revealed issues relating to uncertainty around predictions, the timing of prognostication and decision-making, and difficulty in predicting quality of life. (shrink)

Male sexual arousal (SA) has been known as a multidimensional experience involving closely interrelated and coordinated neurobehavioral components that rely on widespread brain regions. Recent functional neuroimaging studies have shown relation between abnormal/altered dynamics in these circuits and male sexual dysfunction. However, alterations in the topological1 organization of structural brain networks in male sexual dysfunction are still unclear. Here, we used graph theory2 to investigate the topological properties of large-scale structural brain networks, which were constructed using inter-regional correlations of cortical (...) thickness between 78 cortical regions (subcortical regions were not included due to the used cortical surface model) in 40 patients with psychogenic erectile dysfunction (pED) and 39 normal controls. Compared with normal controls, pED patients exhibited a less optimal global topological organization with reduced global and increased local efficiencies. Our results suggest disrupted neural integration among distant brain regions in pED patients, consistent with previous reports of impaired white matter structure and abnormal functional integrity in pED. Additionally, disrupted global network topology in pED was observed to be primarily relevant to altered subnetwork and nodal properties within the networks mediating the cognitive, motivational and inhibitory processes of male SA, possibly indicating disrupted integration of these networks in the whole brain networks and might account for pED patients’ abnormal cognitive, motivational and inhibitory processes for male SA. In total, our findings provide evidence for disrupted integrity in large-scale brain networks underlying the neurobehavioral processes of male SA in pED and provide new insights into the understanding of the pathophysiological mechanisms of pED. (shrink)

This article examines the reception of Roy Bhaskar amongst some contemporary Deleuzians. It proceeds by rejecting the all too often predilection of opposing realism to ‘postmodernism’ or ‘post-structuralism’ arguing instead for the need to bring one into dialogue with the other. To this end, the paper explores the resonances and points of departure between the work of Gilles Deleuze and Roy Bhaskar. In particular, it examines the language of causation, object-oriented versus process-oriented ontologies, as well as the charge by Deleuzians (...) that Bhaskar is an essentialist. Through this engagement it attempts to develop and rethink explanation and causation in terms of a more chaotic ontology of machines, centered around the concept of structure, process, and production in an open, heterogeneous, and dynamic world. The end result is a more chaotic concept of realism. (shrink)

Single-sided deafness (SSD) or profound unilateral hearing loss obligates the only serviceable ear to capture all acoustic information. This loss of binaural function taxes cognitive resources for accurate listening performance, especially under adverse environments or challenging tasks. We hypothesized that adults with SSD would manifest both functional and structural brain plasticity compared to controls with normal binaural hearing. We evaluated functional alterations using magnetoencephalographic imaging (MEGI) of brain activation during performance of a moderately difficult auditory syllable sequence reproduction task and (...) assessed structural integrity using diffusion tensor magnetic resonance imaging (DTI). MEGI showed the SSD cohort to have increased induced oscillations in the theta band over the left superior temporal cortex and decreased induced gamma band oscillations over the frontal and parietal cortices between 175-475 ms following stimulus onset. DTI showed the SSD cohort to have extensive fractional anisotropy reduction in both auditory and non-auditory tracts and regions. Overlaying functional and structural changes revealed by the two imaging techniques demonstrated close registration of cortical areas and white matter tracts that expressed brain plasticity. Hence, complete loss of input from one ear in adulthood triggers both functional and structural alterations to dorsal temporal and frontal-parietal areas. (shrink)