The timeliness of the problem of reduction is due above all to the successes of application of the techniques of the exact sciences in biology. To the extent that molecular biology "gets down to" the initial, fundamental mechanisms of the processes of life, it is impossible for it to remain purely in the realm of statement of facts; it cannot but affect methodological principles of the study of life. "The history of biology clearly demonstrates the striking regularity (...) with which the problem of reductionism arises each time biological knowledge advances to a new level." The counterposing of mechanism and vitalism, elementarism and organicism, etc., was replaced by new forms of methodological discussion born of the achievements of experimental knowledge of life and the demands that this be formulated into theory. To separate the principle of reduction, productive in current biological research, from biological reductionism based on the elevation of this principle to an absolute is the meaning of the current struggle against mechanistic trends in biology. The mechanicism of the present day rests primarily on the productiveness of the methods of physical chemistry in adding to knowledge of life; and therefore when people speak of the problem of reductionism, discussion of the potentials of the investigation of life by molecular biology and the limits of those potentials takes pride of place. (shrink)

Open peer commentary on the article “Homeostats for the 21st Century? Simulating Ashby Simulating the Brain” by Stefano Franchi. Upshot: The target article proposes that Ashby’s investigations of the homeostat and ultrastability lead to a view of living systems as heteronomous, passive “sleeping” machines and thus are in fundamental conflict with concepts of autonomy developed by Jonas, Varela and others. I disagree, arguing that (1) the maintenance of essential variables within viability limits is not a passive process for living (...) systems and (2) the purpose of Ashby’s investigations of the homeostat was to investigate adaptivity, a subject that is related to, but clearly distinct from, autonomy. As such, I find Ashby’s work on adaptivity to be neither in opposition to nor in direct support of modern concepts of biological autonomy and suggest that a productive way forward involves the investigation of the intersection between these two fundamental properties of living systems. (shrink)

After the discovery of the structure of DNA in 1953, scientists working in molecular biology embraced reductionism—the theory that all complex systems can be understood in terms of their components. Reductionism, however, has been widely resisted by both nonmolecular biologists and scientists working outside the field of biology. Many of these antireductionists, nevertheless, embrace the notion of physicalism—the idea that all biological processes are physical in nature. How, Alexander Rosenberg asks, can these self-proclaimed physicalists also be (...) antireductionists? With clarity and wit, Darwinian Reductionism navigates this difficult and seemingly intractable dualism with convincing analysis and timely evidence. In the spirit of the few distinguished biologists who accept reductionism—E. O. Wilson, Francis Crick, Jacques Monod, James Watson, and Richard Dawkins—Rosenberg provides a philosophically sophisticated defense of reductionism and applies it to molecular developmental biology and the theory of natural selection, ultimately proving that the physicalist must also be a reductionist. (shrink)

_Conservative Reductionism_ sets out a new theory of the relationship between physics and the special sciences within the framework of functionalism. It argues that it is wrong-headed to conceive an opposition between functional and physical properties and to build an anti-reductionist argument on multiple realization. By contrast, all properties that there are in the world, including the physical ones, are functional properties in the sense of being causal properties, and all true descriptions that the special sciences propose can in principle (...) be reduced to physical descriptions by means of functional reduction, despite multiple realization. The book develops arguments for from the metaphysics of properties and the philosophy of physics. These arguments lead to a conservative ontological reductionism. It then develops functional reduction into a fully-fledged, conservative theory reduction by means of introducing functional sub-types that are coextensive with physical types, illustrating that conservative reductionism by means of case studies from biology. (shrink)

The extensive philosophical discussions and analyses in recent decades of function-talk in biology have done much to clarify what biologists mean when they ascribe functions to traits, but the basic metaphysical question—is there genuine teleology and design in the natural world, or only the appearance of this?—has persisted, as recent work both defending, and attacking, teleology from a Darwinian perspective, attest. I argue that in the context of standard contemporary evolutionary theory, this is for the most part a verbal, (...) rather than a substantive dispute: the disputants are talking past one another. To justify this claim I develop a general framework within which reductionist views, such as the standard ‘etiological’ account of biofunctions, occupy an intermediate position between what I call full-blooded realism and full-blooded anti-realism, and suggest that whether such views count as ‘realist’ views has no objective, theory-neutral answer. (shrink)

Reductionism concerns a set of ontological and epistemological claims, and methodological strictures based on them, about the relationship between two different scientific domains. The critical assumption is that one of these domains is privileged over the other in the sense that the concepts, rules, laws, and other elements of the privileged domain can be used to specify, constitute, or account for those of the other “reduced” domain. This specification often consists of explanation, such that the “reducing” domain is epistemically (...) privileged over the reduced one. Explanations of this type are “reductionist” (or, are “reductions”) and reductionism is then the thesis that such explanations will always be forthcoming or at least are possible in principle. Reductionism is most plausible if the entities of the reduced domain can be interpreted as arising from (e.g., as aggregates of) entities of the reduced domain. This ontological claim is controversial but motivates many reductionist theses and associated scientific research programs. Thus, epistemological and ontological claims about reductionism have the methodological implication that they should govern and guide scientific research. When such research proves to be fruitless over a period of time, the associated reductionist claims themselves become suspect. Although issues connected with reductionism arise in the physical and social sciences, most attention to reductionism in philosophy of science over the last few decades has focused on the biological sciences, especially after the advent of molecular biology made it plausible to believe that biological phenomena can be uniformly explained (in detail) from their physical basis. However, the program of finding such explanations has a long philosophical history often couched in terms of seeking “mechanical,” “mechanistic,” or “materialistic” explanations. The contrast here is with traditional vitalism and various forms of teleology and holism. (shrink)

During the past few decades, philosophers of biology have debated the issue of reductionism versus anti-reductionism, with both sides often claiming a ‘pluralist’ position. However, both sides also tend to focus on a single research paradigm, which analyzes living things in terms of certain macromolecular components. I offer a case study where biologists pursue other analytic pathways, in a tradition of quantitative genetics that originates with the initially purely mathematical theories of R. A. Fisher, J. B. S. (...) Haldane, and Sewall Wright in the 1930s. Aster Models offers a class of statistical models designed for studying the fitness of plant and animal populations, by integrating the measurements of separate, sequential, non-normally distributed fitness components in novel ways. Their work generates important theoretical and practical results that do not require elaboration by molecular biology, and thus serves as a counterexample to the claims of philosophers whose ‘pluralism’ still harbors reductionist assumptions. (shrink)

Alexander Rosenberg recently claimed (1997) that developmental biology is currently being reduced to molecular biology. cite several concrete biological examples that are intended to impugn Rosenberg's claim. I first argue that although Laubichler and Wagner's examples would refute a very strong reductionism, a more moderate reductionism would escape their attacks. Next, taking my cue from the antireductionist's perennial stress on the importance of spatial organization, I describe one form an empirical finding that refutes this moderate (...) class='Hi'>reductionism would take. Finally, I point out an actual example, anterior-posterior axis determination in the chick, that challenges the reductionist's belief that all developmental regularities can be explained by molecular biology. In short, I argue that Rosenberg's position can be saved from Laubichler and Wagner's criticisms and putative counter-examples, but it would not survive a different kind of counter-example. (shrink)

This is an extended review of John Dupré's _Processes of Life_, a collection of essays. It clarifies Dupré's concepts of reductionism and anti-reductionism, and critically examines his associated discussions of downward causation, and both the context sensitivity and multiple realization of categories. It reviews his naturalistic monism, and critically distinguishes between his realism about categories and constructivism about classification. Challenges to his process ontology are presented, as are arguments for his pluralism about scientific categories. None of his main (...) conclusions are rejected; rather it is main arguments for them that are the focus. (shrink)

Causal reductionism is the widespread assumption that there is no room for additional causes once we have accounted for all elementary mechanisms within a system. Due to its intuitive appeal, causal reductionism is prevalent in neuroscience: once all neurons have been caused to fire or not to fire, it seems that causally there is nothing left to be accounted for. Here, we argue that these reductionist intuitions are based on an implicit, unexamined notion of causation that conflates causation (...) with prediction. By means of a simple model organism, we demonstrate that causal reductionism cannot provide a complete and coherent account of ‘what caused what’. To that end, we outline an explicit, operational approach to analyzing causal structures. (shrink)

The present disarray of psychoanalytic criticism is no doubt a cause for satisfaction among people who never cared for "deep" interpretation and who now feel confirmed in their resolution to allow literature to speak for itself. The only way to do that, however, is to remain silent—a sacrifice beyond the saintliest critic's power. To be a critic is precisely to take a stance different from the author's and to pursue a thesis of one's own. Among the arguments it is possible (...) to make, reductive ones are without a doubt the trickiest, promising Faustian knowledge but often misrepresenting the object of inquiry and deluding the critic into thinking he has cracked the author's code. To forswear all reductions, however, is not the answer: that is the path of phobia. A critic can avoid reductionism, yet still give his intellect free rein, only by keeping his skepticism in working order. If psychoanalysis, originally the most distrustful of psychologies, has by its worldly success and conceptual elaboration become a positive impediment to skepticism, we need be no more surprised than Freud himself would have been at such all-too-human backsliding. A critic's sense of limits, like Freud's own, must come not from the fixed verities of a doctrine but from his awe at how little he can explain. And that awe in turn must derive from his openness to literature—from his sense that the reader in him, happily, will never be fully satisfied by what the critic in him has to say. Frederick Crews has written books on James, Forster, Hawthorne, and Christopher Robin. He is professor of English at the University of California at Berkeley. The present essay is a chapter from a new book, Out of My System: Psychoanalysis, Ideology, and Critical Method. (shrink)

In this essay I argue that Ernst Mayr's idea that the emergence of evolutionary biology in Western thought was delayed by the pernicious influence of the false ideologies of Platonism, Christianity, and physicalism is ahistorical and anti-evolutionary, that similar ideas, especially his antipathy to physicalism, prejudice his account of the transformation of natural history and medical science into biology, that his organicist resolution of the perennial conflict between mechanism and vitalism is an unstable compound of semi-holism and semi-mechanism, (...) that his conception of biology as the true bridge between the sciences and the humanities, ethics, and social theory is open to question (especially as to the adequacy of the theory of natural selection to account for every aspect of human nature), and that his depiction of science as the sovereign key to understanding everything known to exist or happen in this universe cannot be justified at the bar of reason. (shrink)

First published in 1982. Routledge is an imprint of Taylor & Francis, an informa company.

Reductionism--understanding complex processes by breaking them into simpler elements--dominates scientific thinking around the world and has certainly proved a powerful tool, leading to major discoveries in every field of science. But reductionism can be taken too far, especially in the life sciences, where sociobiological thinking has bordered on biological determinism. Thus popular science writers such as Richard Dawkins, author of the highly influential The Selfish Gene, can write that human beings are just "robot vehicles blindly programmed to preserve (...) the selfish molecules known as genes." Indeed, for many in science, genes have become the fundamental unit for understanding human existence: genes determine every aspect of our lives, from personal success to existential despair: genes for health and illness, genes for criminality, violence, and sexual orientation. Others would say that this is reductionism with a vengeance. In Lifelines, biologist Steven Rose offers a powerful alternative to the ultradarwinist claims of Dawkins, E.O. Wilson, Daniel Dennett and others. Rose argues against an extreme reductionist approach that would make the gene the key to understanding human nature, in favor of a more complex and richer vision of life. He urges instead that we focus on the organism and in particular on the organism's lifeline: the trajectory it takes through time and space. Our personal lifeline, Rose points out, is unique--even identical twins, with identical genes at birth, will differ over time. These differences are obviously not embedded in our genes, but come about through our developmental trajectory in which genes, as part of the biochemical orchestra of trillions of cells in each human body, have an important part--but only a part--to play. To illustrate this idea, Rose examines recent research in modern biology, and especially two disciplines--genetics (which looks at the impact of genes on form) and developmental biology (which examines the interaction between the organism and the environment)--and he explores new ideas on biological complexity proposed by scientists such as Stuart Kauffman. He shows how our lifelines are constructed through the interplay of physical forces--such as the intrinsic chemistry of lipids and proteins, and the self-organizing and stabilizing properties of complex metabolic webs--and he reaches a startling conclusion: that organisms are active players in their own fate, not simply the playthings of the gods, nature, or the inevitable workings out of gene-driven natural selection. The organism is both the weaver and the pattern it weaves. Lifelines will be a rallying point for all who seek an alternative to the currently fashionable, deeply determinist accounts which dominate popular science writing and, in fact, crowd the pages of some of the major scientific journals. Based on solid, state-of-the-art research, it not only makes important contributions to our understanding of Darwin and natural selection, but will swing the pendulum back to a richer, more complex view of human nature and of life. (shrink)

Biological atomism postulates that all life is composed of elementary and indivisible vital units. The activity of a living organism is thus conceived as the result of the activities and interactions of its elementary constituents, each of which individually already exhibits all the attributes proper to life. This paper surveys some of the key episodes in the history of biological atomism, and situates cell theory within this tradition. The atomistic foundations of cell theory are subsequently dissected and discussed, together with (...) the theory’s conceptual development and eventual consolidation. This paper then examines the major criticisms that have been waged against cell theory, and argues that these too can be interpreted through the prism of biological atomism as attempts to relocate the true biological atom away from the cell to a level of organization above or below it. Overall, biological atomism provides a useful perspective through which to examine the history and philosophy of cell theory, and it also opens up a new way of thinking about the epistemic decomposition of living organisms that significantly departs from the physicochemical reductionism of mechanistic biology. (shrink)

Recent developments toward a more holistic biology do not eliminate reductionism and determinism, but they do suggest more complex forms of them, in which there are multiple, interacting influences, as there are in complex or chaotic systems. Though there is a place in biology for both systemic and atomistic modes of explanation, for those with a theological perspective the shift to complex explanations in biology is often welcome. It suggests a more subtle view of divine action (...) in which God's purposes are affected through engagement with the complex systems of creation rather than by discrete interventions. It also invites us to connect the biological interdependence with the interdependence in the nature and purposes of God, and it is consonant with a mystical vision of the unity of all things. (shrink)

From the perspective of nonlinear science, it is argued that one may accept physicalism and reject substance dualism without being forced into reductionism. This permits a property dualism under which biological and mental phenomena may emerge from intricate positive feedback networks, involving many levels of both the biological and cognitive hierarchies.

. Humans can be described as existing somewhere on a descriptive continuum between the poles expressed by the metaphors “humans are machines” and “humans are animals.” Arguments for these metaphors are examined, and the metaphors are rejected as absolute descriptions of humans. After a brief examination of the nature of metaphor, all metaphors are discovered to mediate between biological and cultural evolution. Contrary to the reductionist program of sociobiologists, religious metaphors that generate transcendent meaning offer a legitimate description of humans.

Paul Thompson argues that current synthetic biology amounts to synthetic genomics, comprising a ‘platform’ technology, and that Christopher Preston's deontological objections based on its supposed rejection of the historical process of evolution miscarry. This makes it surprising that Thompson's normative ethic consists in a deontological appeal to Kantian duties of imperfect obligation. Construed as obligations subject to choice, such constraints risk being excessively malleable where the ethical objections to deployment of this technology concern land rights and/or exploitation. Thompson's advocacy (...) of processes ‘more beneficial’ well illustrates another vulnerability; processes more beneficial than ones that undermine livelihoods could be best avoided themselves, although ones more beneficial than the status quo may not. He well argues that non-deontological arguments should not be confined to human survival, but neglects stances that are either biocentric, consequentialist, or both. Yet a truly synthetic bioethics would be likely to embody these characteristics. (shrink)

I argue (1) that Searle's reductive stance about mental causation is unwarranted on evolutionary, logical, and neuroscientific grounds; and (2) that his theory of weak emergence, called biological naturalism, fails to provide a satisfactory account of objectual unity and subject unity. Finally I propose a stronger variety of emergence called emergent subject dualism (ESD) to fill the gaps in Searle's account, and support ESD on grounds of recent evidence in neuroscience. Hence I show how it is possible, if not also (...) theoretically preferable, to go from Searle's biological naturalism to emergent subject dualism. (shrink)

In this paper the common association between ontological reductionism and a methodological position called 'Mechanism' is discussed. Three major points are argued for: (1) Mechanism is not to be identified with reductionism in any of its forms; in fact, mechanism leads to a non-reductionist ontology. (2) Biological methodology is thoroughly mechanistic. (3) Mechanism is compatible with at least one form of teleology. Along the way the nature and value of scientific explanations, some recent controversies in biology and (...) why reductionism has proven to be such an attractive position are discussed. (shrink)

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