The rapid evolution of drug resistance remains a major obstacle for HIV therapy. The capacity of the virus for recombination is widely believed to facilitate the evolution of drug resistance. Here, we challenge this intuitive view. We develop a population genetic model of HIV replication that incorporates the processes of mutation, cellular superinfection, and recombination. We show that cellular superinfection increases the abundance of low fitness viruses at the expense of the fittest strains due to the mixing of viral proteins (...) during virion assembly. Moreover, we argue that whether recombination facilitates the evolution of drug resistance depends critically on how resistance mutations interact to determine viral fitness. Contrary to the commonly held belief, we find that, under the most plausible biological assumptions, recombination is expected to slow down the rate of evolution of multi‐drug‐resistant virus during therapy. BioEssays 26:180–188, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Acknowledging his indebtedness to Tillich, Bultmann, and Bonhoeffer, Dr. Smith reviews the changes in man's estimate of his own relation to history and Christianity, and describes a "new man" who can find God through other people and the community they comprise.--E. T.

The paper explicates Bonhoeffer's dense statement, made in a 1932 lecture, that `Reality is the sacrament of [the ethical] command'. It begins with a summary of William T. Cavanaugh's rich description of the Eucharist as that act which makes the Church Christ's body, thereby constituting the true res publica. A comparison is drawn with Bonhoeffer's account of the sacramental foundation of the Church's public proclamation of God's ethical command. Bonhoeffer differs from Cavanaugh, I suggest, not only in (...) his conviction that the Church speaks God's command penultimately and with humility, but in regarding the state as one of the means by which God acts within the penultimate to preserve creation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Why Can't a First Mover Be Accidentally Moveable?Bolstering Aquinas's Case for Divine Immutability in the Face of Objections from Theistic PersonalistsMats WahlbergIntroductionIn his book An Introduction to the Philosophy of Religion, Brian Davies coined the term "theistic personalism" in order to have a name for a kind of monotheism that is quite widespread, but that differs significantly from the "classical theism" of the Church Fathers, the great medieval theologians, (...) and the Reformers.1 Theistic personalists claim that the personal nature of the biblical God cannot be reconciled with some of the core tenets of classical theism, in particular the doctrines of divine immutability, timelessness, and simplicity. Although personalists typically agree with the classical tradition that God exists necessarily and is the ultimate explanatory principle, they also claim that he is changeable and metaphysically composed. God's attributes or properties are distinct from each other and from God himself, and God can be causally affected by events in the created world. Some of the most influential figures within contemporary analytic philosophy of religion—thinkers like Richard Swinburne, Alvin Plantinga, and William Lane Craig—defend personalism of various shades.Within contemporary systematic theology, theistic personalism is also [End Page 1305] dominant. The long-standing tendency to contrast (unfavorably) a "Hellenistic," "static" conception of God with a "biblical," "dynamic" conception is evidence of this, as is the common tendency to historicize God's being along Hegelian lines. Karl Barth, Dietrich Bonhoeffer, Wolfhart Pannenberg, Robert Jenson, Eberhart Jüngel, Jürgen Moltmann, and many other theologians have rejected core elements of classical theism, such as God's immutability and impassibility. It is fair to say that most contemporary theologians regard the idea that God suffers alongside his creation as almost axiomatically true, and this view entails that God can change.2In book I of the Summa contra gentiles [SCG], St. Thomas Aquinas attempts to build a philosophical case for classical theism. He starts with two Aristotelian arguments from motion, presented in chapter 13, whereby he claims to establish that there is an immutable First Mover. Taking himself to have proved this, Aquinas then systematically unfolds the other doctrines of classical theism, using divine immutability as a key premise. In chapter 14, St. Thomas describes his modus operandi: "In order to proceed by the way of remotion about knowledge of God, let us take as principle that which is already manifest by what we have said above, namely that God is altogether unchangeable [quod Deus sit omnino immobilis]."3Prima facie, this seems to be a promising method. If divine changelessness can be proved at the outset from the mere fact that there is motion, then the road to classical theism lies open. Given divine immutability, it readily follows that God lacks beginning and end, and perhaps also that God is eternal in the sense of being altogether timeless, as Aquinas argues in chapter 15. At the very least it follows that God lacks passive potentiality, since change is the actualization of some potential (ch. 16). From the lack of potentiality, furthermore, it follows that God is pure act, and from this it follows that he lacks any kind of composition whatsoever, so he is altogether simple.This is basically how Aquinas argues in SCG I. The success of Aquinas's case for classical theism depends, however, on whether the crucial premise of divine immutability can be proved without reliance on any of the other divine attributes that I have just mentioned. Theistic personalists claim that [End Page 1306] this cannot be done, and that the controversial divine attributes of classical theism can be proved only in a circular way, relying on one attribute (such as divine simplicity) in order to prove another (such as divine immutability), and vice versa.In this article, I will try to show that this accusation is false, and that God's changelessness can be demonstrated without assuming divine simplicity, eternity, or any other divine attribute that is at issue between classical theists and personalists. Immutability can, if this is true, function as the cornerstone in a case for classical theism, in the way that Aquinas suggests. In what follows, I will do... (shrink)

Bishop John A.T. Robinson's Honest to God was exceptionally successful. In the decade following its publication more than a million copies were sold in seventeen different languages. Robinson was aware that numerous awkward questions were being asked about traditional Christian beliefs, which it was no longer possible to ignore. His purpose was not so much to question traditional ideas of God as to suggest alternatives for those who found them unsatisfactory . He wanted to convince such persons that an inability (...) to believe what is stated in the Bible or the prayer book does not disqualify them from calling themselves Christians and presenting themselves at church. He speaks of traditional Christian beliefs, as stated in the New Testament, as a ‘language’ and thinks that Christianity should be conveyed to people in a variety of languages. By employing, as he does, the language of such Christian scholars as Bonhoeffer, Tillich and Bultmann, an atheist may find himself able to call himself a Christian. But the old familiar language of the Bible remains more pleasing to most of God's children, particularly to his ‘older children’ , so we must not give it up, although he allows that it is becoming increasingly unpopular, so that without ‘the kind of revolution’ he is advocating, ‘Christian faith and practice … will come to be abandoned’. (shrink)

Spiritualist ethics: The problem of evil, by L. Lavelle. On conscience, or On the pain of having-done-it, by V. Jankélévitch. Value and immortality; and, Dangerous situation of ethical values, by G. Marcel. The concept of fallibility, by P. Ricoeur.--Axiological ethics: Ethics and metaphysics, by R. Le Senne. Good and evil, by H. Reiner. Values and truths, by R. Polin. Values as principles of action, by G. Gusdorf.--Three contemporary conceptions of humanism: Jean-Paul Sartre: Sartre on humanism, by J. J. Kockelmans. Moral (...) perspectives in Sartre's thought, by F. Jeanson. Ambiguity, by S. de Beauvoir. Albert Camus: Albert Camus and the ethic of absurdity, by H. Hochberg. On humanism, by M. Heidegger. Existentialism's basic ethical position, by O. Bollnow.--Situation ethics: Systematic essentialist ethics and existential situation ethics, by T. Steinbüchel. The question of the Single One, by M. Buber. What is a Christian ethic? By D. Bonhoeffer. Meaning and analysis of the borderline situation, by H. Thielicke. (shrink)

This series will include monographs and collections of studies devoted to the investigation and exploration of knowledge, information, and data-processing systems of all kinds, no matter whether human, (other) animal, or machine. Its scope is intended to span the full range of interests from classical problems in the philosophy of mind and philosophical psychology through issues in cognitive psychology and sociobiology (concerning the mental capabilities of other species) to ideas related to artificial intelligence and computer science. While primary emphasis will (...) be placed upon theoretical, conceptual, and epistemological aspects of these problems and domains, empirical, experimental, and methodological studies will also appear from time to time. While most philosophers and psychologists tend to believe that the rise of cognitive psychology has occurred concomitant with the decline of operant psychology, Terry L. Smith contends that nothing could be further from the truth. He maintains that operant psychology has discovered (and continues to discover) reasonably well-confirmed causal principles of intentional behavior, which go beyond what cognitive psychology can provide, while cognitive psychology, in tum, has the potential to supply analyses (and explanations) that account for them. Smith thus advances a surprising but nonetheless illuminating perspective for appreciating the place of operant conditioning within the discipline of psychology in this rich and fascinating work. J. H. F. (shrink)

This book offers an important study of Aristotle's theory of the sense-organs. It aims to answer two questions central to Aristotle's psychology and biology: why does Aristotle think we have sense-organs, and why does he describe the sense-organs in the way he does? The author looks at all the Aristotelian evidence for the five senses and shows how pervasively Aristotle's accounts of the sense-organs are motivated by his interest in form and function. The book also engages with the celebrated problem (...) of whether perception for Aristotle requires material changes in the perceiver. It argues that, surprisingly to the modern philosopher, nothing in Aristotle's description of the sense-organs requires us to believe in such changes. (shrink)

A beautifully executed limning of the men doing some of the freshest theological thinking today. With Bishop Robinson's Honest to God as his starting point, Mehta interviews Paul Tillich, Paul van Buren, Reinhold Niebuhr, Bishop Robinson, A. R. Vidler, H. A. Williams, Donald MacKinnon, A. M. Ramsey, I. T. Ramsey, Nicholas Stacey, Rudolf Bultmann, and Karl Barth. Almost half of the book is devoted to the portrait of Dietrich Bonhoeffer which emerges from Mehta's stay in Germany with Bonhoeffer's (...) closest friend, Pastor Eberhard Bethge. The book is reporting rather than a probing of the philosophic issues, but, taken as such, it constitutes a tantalizing gateway into a world in which insight, courage, honesty, and immense confusion flourish together like plants in an untended garden.—S. A. S. (shrink)

This article reviews contributions to The Volitional Brain, some of which defend a libertarian, contra-causal account of free will, while others take a so-called compatibilist view, in which adequate conceptions of human liberty and moral responsibility are claimed to be compatible with naturalistic causality. Siding with compatibilism, this review finds that defenders of libertarian free will place undue weight on the first person feeling of freedom, while discounting scientific evidence that human choices are fully a function of antecedent causes at (...) various levels of description. It is argued that morality, justice, and personal responsibility and efficacy do not require the assumption that persons are first causes, so that we need not fear mechanism when applied to human agency. (shrink)

Open peer commentary on the article “Communication Emerging? On Simulating Structural Coupling in Multiple Contingency” by Manfred Füllsack. Upshot: Our criticism aims at the premises of Füllsack’s simulation model, i.e., we claim that his interpretation of the Luhmannian concept of double contingency contradicts the systems theoretical approach in fundamental ways. Neither the view of communication as an emergent system, nor the theory of double contingency is addressed in an adequate manner. Thus Füllsack in fact does not simulate a systems theoretical (...) approach to double contingency but simulates a mere reduction of the social to the individual psyches. (shrink)

Not only today, but also in the 18th century the question whether human history reveals moral progress, is widely discussed. In one of his last writings, the second part of The Contest of Faculties: 'A Renewed Attempt to Answer the Question: Is the Human Race Continually Improving?' (1797), Kant answers this question affirmatively. His main reason for this answer resides in the so-called 'historical sign' (Geschichtszeichen), which proves, as Kant writes, the moral tendency of the human race. In this ‘historical (...) sign’ both the French Revolution and the enthusiasm displayed by those who witnessed this event, play an important role. In this article the author evaluates these two elements and tries to assess their value. Contrary to the interpretation of Arendt and Lyotar,he argues that according to Kant there can only be progress in history by establishing legal relations among citizens and nations. In view of this process the principles of the French Revolution are crucially important. (shrink)