The polarized organization of epithelial cells is expressed in many ways including the morphology of the cell surface or cytocortex, the molecular composition of membrane domains and the distribution of cytoplasmic organelles. The differentiation of mouse trophectoderm is described with particular attention given to the maturation of the endocytic system in an attempt to define how the complex assembly of an epithelium may be generated.

To develop a theoretical framework for drawing moral distinctions between instances of sexual misconduct, I defend the “Ameliorative View” of consent, according to which there are three possibilities for what effect, if any, consent has: “fully valid consent” eliminates a wronging, “fully invalid consent” has no normative effect, and “partially valid consent” has an ameliorative effect on a wronging in the respect that it makes the wronging less grave. I motivate the view by proposing a solution to the problem of (...) characterizing the moral effect of consent that is given in response to minor coercion. (shrink)

Can humans get arbitrarily capable reinforcement learning agents to do their bidding? Or will sufficiently capable RL agents always find ways to bypass their intended objectives by shortcutting their reward signal? This question impacts how far RL can be scaled, and whether alternative paradigms must be developed in order to build safe artificial general intelligence. In this paper, we study when an RL agent has an instrumental goal to tamper with its reward process, and describe design principles that prevent instrumental (...) goals for two different types of reward tampering. Combined, the design principles can prevent reward tampering from being an instrumental goal. The analysis benefits from causal influence diagrams to provide intuitive yet precise formalizations. (shrink)

'By identifying the extent to which Aristotle's thinking about ethics was shaped by notions drawn from the crafts Angier has thrown new light on a surprising number of topics and has deepened our understanding of tensions within Aristotle's thought. It is by now a rare achievement to have said something new, true and important about Aristotle.' -- Alasdair MacIntyre, Emeritus Professor of Philosophy, University of Notre Dame, USA.

Le Fragment 47[5] constitue un point aveugle dans la recherche sur Nietzsche. Ce texte est pourtant capital pour saisir le fond de la critique de la philosophie schopenhauerienne, dans la mesure où Nietzsche y dévoile ce qu’il nomme la «grande erreur fondamentale de Schopenhauer» qui, selon lui, réside dans une fausse compréhension du rapport entre la «volonté» et la «connaissance». La comparaison de ce fragment avec d’autres permet d’une part de souligner que Nietzsche est en désaccord non seulement avec les (...) conclusions de la philosophie schopenhauerienne (pessimisme, attitude ascétique face à la vie, éthique de la compassion), mais aussi avec son fondement, la primauté métaphysique de la volonté sur la connaissance. Nous suggérons, d’autre part, que le concept plus tardif de volonté de puissance chez Nietzsche peut précisément être compris comme une réponse critique à cette idée schopenhauerienne d’une subordination du connaître au vouloir qui ne sont, pour Nietzsche, que deux aspects différents de ce même rapport de forces appelé «volonté de puissance». (shrink)

There are many questions we can ask about time, but perhaps the most fundamental is whether there are metaphysically interesting differences between past, present and future events. An eternalist believes in a block universe: past, present and future events are all on an equal footing. A gradualist believes in a growing block: he agress with the eternalist about the past and the present but not about the future. A presentist believes that what is present has a special status. My first (...) claim is that the familiar ways of articulating these views result in there being no substantive disagreement at all between the three parties. I then show that if we accept the controversial truthmaking principle, we can articulate a substantive disagreenment. Finally, I apply this way of formulating the debate to related questions such as the open future and determinism, showing that these do not always line up in quite the way one would expect. (shrink)

[R]eflection is a system of thought no less closed than insanity, with this difference that it understands itself and the madman too, whereas the madman does not understand it.– Merleau-Ponty, Phen...

The research importance of biobanked biological materials and their derived data is growing, especially as these are increasingly linked with individual and population‐level medical and health information. The number, diversity, and size of biobanks are growing in tandem. So, too, is the number of individuals whose donations are being used in biobank‐supported research, with or without their knowledge. Pretty soon, we all will be “participants” in a variety of research projects we know nothing about. Until recently, our leftover tissue or (...) deidentified medical information could be used for research without our consent or even our knowledge. Even if we've been asked–as the current regulations require when research uses are anticipated‐we were most likely asked to give a blanket consent to any future use, with no prospect of learning about or controlling how our material is later used. This is an ethically problematic state of affairs, but there are options for improving it. (shrink)

Book reviewed in this article: Life and Death: Philosophical Essays in Biomedical Ethics. By Dan W. Brock.

This paper examines the extent to which the voluntary adoption of codes of conduct by multinational corporations (MNCs) renders MNCs accountable for the performance of actions specified in a code of conduct. In particular, the paper examines the ways in which codes of conduct coordinate the expectations of relevant parties with regard to the provision of assistance by MNCs on grounds of rescue or justice. The paper argues that this coordinative role of codes of conduct renders MNCs more accountable for (...) the performance of actions specified in a code of conduct than they would be without a code of conduct. This interpretation of the significance of codes of conduct is contrasted with the view that codes of conduct render MNCs accountable for performing actions specified in a code of conduct by grounding contractual obligations for the performance of such actions. (shrink)

Researchers working on drug addiction may, for a variety of reasons, want to carry out research which involves giving addicts their drug of choice. In carrying out this research consent needs to be obtained from those addicts recruited to participate in it. Concerns have been raised about whether or not such addicts are able to give this consent. Despite their differences, however, both sides in this debate appear to be agreed that the way to resolve this issue is to determine (...) whether or not addicts have irresistible cravings for drugs – if they do, then they cannot consent to this type of research; if they do not, then they can. This I will argue is a mistake. Determining whether or not addicts can say 'No' to offers of drugs will not help us to make much progress here. Instead we need to look at the various ways in which different types of research may undermine an addict's competence to give consent. What we will find is that the details of the research make a big difference here and that, as such, we need to steer a course between, on the one hand, painting all addicts as being unable to consent to research which involves providing them with drugs, and, on the other, maintaining that there are no problems in obtaining consent from addicts to take part in such research. (shrink)

German Idealism as Constructivism is the culmination of many years of research by distinguished philosopher Tom Rockmore—it is his definitive statement on the debate about German idealism between proponents of representationalism and those of constructivism that still plagues our grasp of the history of German idealism and the whole epistemological project today. Rockmore argues that German idealism—which includes iconic thinkers such as Kant, Fichte, Schelling, and Hegel—can best be understood as a constructivist project, one that asserts that we cannot know (...) the mind-independent world as it is but only our own mental construction of it. Since ancient Greece philosophers have tried to know the world in itself, an effort that Kant believed had failed. His alternative strategy—which came to be known as the Copernican revolution—was that the world as we experience and know it depends on the mind. Rockmore shows that this project was central to Kant’s critical philosophy and the later German idealists who would follow him. He traces the different ways philosophers like Fichte, Schelling, and Hegel formulated their own versions of constructivism. Offering a sweeping but deeply attuned analysis of a crucial part of the legacy of German idealism, Rockmore reinvigorates this school of philosophy and opens up promising new avenues for its study. (shrink)

Hume wrote about fundamental similarities and dissimilarities between human and nonhuman animals. His work was centered on the cognitive and emotional lives of animals, rather than their moral or legal standing, but his theories have implications for issues of moral standing. The historical background of these controversies reaches to ancient philosophy and to several prominent figures in early modern philosophy. Hume develops several of the themes in this literature. His underlying method is analogical arg ument and his conclusions are generally (...) favorable regarding the abilities in animals. Hume does not attribute a moral sense or capacity of judgment to animals, but he does suggest that their actions exhibit moral qualities, such as other-regarding instincts. Hume allows in-kind differences in both demonstrative reason and moral judgment, but in the domains of both causal reason and moral agency he believes there are differences of degree rather than of kind. Hume's most significant philosophical contribution was to move as far as anyone before him to a naturalistic explanation of human and nonhuman minds that invited psychological and epistemological examination of minds by using the identical methods and categories for man and beast. (shrink)

After expressing our gratitude to the commentators for their valuable analyses and assessments of Principles of Biomedical Ethics, we respond to several particular critiques raised by the commentators under the following rubrics: the compatibility of different sets of principles and rules; challenges to the principle of respect for autonomy; connecting principles to cases and resolving their conflicts; the value of and compatibility of virtues and principles; common morality theory; and moral status. We point to areas where we see common agreement (...) with our commentators and respond to their critical evaluations. (shrink)

Contrasting brain states when subjects are aware compared to unaware of a presented stimulus has allowed researchers to isolate candidate neural correlates of consciousness. Here we propose that an important next step in this research program is to investigate, perhaps paradoxically, brain states that covary with reports of absences of awareness. Specifically, we propose that in order to distinguish content-specific and content-invariant neural correlates of consciousness, a distinction needs to be made between the neural correlates of awareness of stimulus absence, (...) and the neural correlates of absence of awareness. We ground this distinction in higher-order computational models of consciousness, where the state of higher-order nodes is invariant to the specific contents of awareness. To map the different levels of these models to neurophysiological correlates, we suggest two empirical approaches – inverted designs and two-dimensional awareness reports – in which reports about awareness and stimulus presence can be dissociated. (shrink)

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Bankers have been slow to claim responsibility or apologise for the seismic damage of the 2008 financial crisis. How is this shortcoming to be spelled out? One possibility is by saying that the bankers failed to display what Susan Wolff calls "the nameless virtue" --the disposition to take responsibility for untoward events that occur in one's area of influence, even if we did not intend them or directly cause them. I think this diagnosis is unduly generous to leaders of banks (...) at the centre of the crisis. Even where the nameless virtue has arguably been displayed, it is no substitute for submitting to criminal proceedings for recklessness in financial markets. (shrink)

A comparative study of the literature on party changes shows that there are many different views on why and how parties change. The existing literature is rather theoretical. Most authors have based their model on a survey of a limited number of parties. The only general conclusion one can draw is that both external and internal factors can provoke party changes. In this contribution, we concentrate on the role of the internal factors. We find that change is less likely to (...) happen when the party is divided in several factions. Furthermore the party organisation influences the changes. In highly institutionalised parties changes wil be more difficult than in less organised parties. Finally the role of the party president cannot be neglected. He has to analyse and interpret the external challenges. Only if he thinks that a change is necessary, the party is likely to change. In brief, party change is a dynamic process that is led by the party elite. (shrink)

A personable teenager with Down's syndrome became a Canadian cause célèbre a few months ago when University Hospital in Edmonton, Alberta, denied him a position on the organ transplantation waiting list. Terry Urquart lacked “reasonable” intelligence, hospital officials said, a criterion for all transplant candidates at that hospital. Protests by the boy's family, and by groups active in the cause of those with developmental disabilities, became well-photographed stories on the nightly television news and in the nation's newspapers. It did not (...) hurt the Urquart cause one bit that the 17-year-old teenager had won a gold medal in skiing at the International Special Olympics. (shrink)

Wenmackers and Romeijn (2016) formalize ideas going back to Shimony (1970) and Putnam (1963) into an open-minded Bayesian inductive logic, that can dynamically incorporate statistical hypotheses proposed in the course of the learning process. In this paper, we show that Wenmackers and Romeijn’s proposal does not preserve the classical Bayesian consistency guarantee of merger with the true hypothesis. We diagnose the problem, and offer a forward-looking open-minded Bayesians that does preserve a version of this guarantee.

Nuffield Council on Bioethics, London * Corresponding author: Nuffield Council on Bioethics, 28 Bedford Square, London WC1B 3JS, UK. Email: hschmidt{at}nuffieldbioethics.org ' + u + '@' + d + ' '//--> Abstract In November 2007, the Nuffield Council on Bioethics published the report Public Health: Ethical Issues . While the report has been welcomed by a wide range of stakeholders, there has also been some criticism. First, it has been suggested that it is not clear why, in developing its ‘stewardship (...) model’, the Council felt the need to go beyond the liberal position developed by John Stuart Mill—what is it that the stewardship model adds? Second, it is suggested that the Report is confused about the concept of paternalism. Third, it is argued that the discussion of the concept of stewardship is lacking in detail and substance. We clarify the Working Party's thinking regarding these three areas, which demonstrates the robustness of the framework set out in the report. CiteULike Connotea Del.icio.us What's this? (shrink)

Freud’s fascination with the ruins of ancient Rome was an element in the formation and development of psychology. This article concerns the intersection of psychoanalysis with archaeology and history in the study of that city. Its substantive content is an analysis of the life and career of Andrea Carandini, the best-known Roman archaeologist of the past 40 years. He has said and written much about his changing views of himself and about what he is trying to do in his approach (...) to the recuperation of the Roman past. His scholarly publications and autobiographical testimonies are at the core of this article. After an early commitment to Marxism that ended in disenchantment and a crisis in his personal life, Carandini spent a decade undergoing psychoanalysis with the Chilean-born expatriate Ignacio Matte-Blanco. The latter gained a following as a theorist who built upon Freud’s ideas about the unconscious by producing a set of mathematically inspired concepts concerning the workings of temporality in human history in which emotional intuition took priority over the rational(izing) logic of empiricism. Much influenced by his psychoanalyst, Carandini developed a highly personal approach to the writing of archaeology and history. These writings are explored here in terms of Roman historiography, and in the wider arena of formulations of how the past is to be addressed and written about. (shrink)

On 28 October 2018 the far-right candidate Jair Bolsonaro won the presidential elections in Brazil with 55% of the vote. This result has been viewed by many as yet another instance of the global rise of authoritarian populist leaders, grouping Bolsonaro alongside the likes of Hungary’s Viktor Orbán, Turkey’s Recep Tayyip Erdoğan, India’s Narendra Modi, or Donald Trump in the USA – indeed, Bolsonaro has been dubbed the “Trump of the Tropics.” The focus on Bolsonaro himself reflects the strong emphasis (...) on executives in a rapidly expanding literature suggesting the emergence of a new form of would-be autocrat who is democratically elected but who hollows out democratic rule over time. However, this Article argues that, far beyond Bolsonaro, the Brazilian experience is an important case-study as it prompts reflection on three fundamental propositions. First, any analysis of liberal democracy as the perceived object of attack must be highly cognizant of the democratic “starting point” and history of a given state. Second, an excessive focus on executive-led assaults on democratic rule can impede fuller analysis of a broader suite of actors and factors relevant to the (declining) health of the democratic system. Third, authoritarianism is a more appropriate analytical lens than populism for identifying potential democratic threats, especially in the Brazilian context. (shrink)

With this first part of the eleventh volume, Bruce Kirmmse et al.’s monumental task of translating Søren Kierkegaard’s journals and notebooks begins to draw to a close. The journals and notebooks t...

The online panel discussion following the 2021 Boyle Lecture, “The Re‐discovery of Contemplation through Science” was very rich, both in terms of the topics raised by the panel members, and the extensive list of questions and suggestions posed by the online participants. Here, I record some initial thoughts in response, grouped under the following headings: Overall Rationale and Purpose, Contemplative Methodologies in Scientific Insight and Broader Practice, Science Culture and Politics, Psychological and Meditative Consequences, Natural Theology of Old and New (...) Kinds, New Atheism, Education, Christian Practice, and Lessons from the History of Science and Technology. (shrink)

Let it be granted that Buddhism has, e.g., in its logical literature, detailed canons and explicit rules of right reason that, amongst other things, ban inconsistency as irrational. This is the normative dimension of how people should think according to many major Buddhist authors. But do important Buddhist writers ever recognize any interesting or substantive role for inconsistency and forms of irrationality in their account of how people actually do think and act? The article takes as its point of departure (...) a recurring theme in the writings of the 8th Century Indian Buddhist thinker, Śāntideva, who subjects his own behaviour and thought to minute scrutiny in argumentation with himself, only to be puzzled at his own seemingly irrational persistence in ways of thinking that he knows to be wrong and actions that he knows to be worse courses. The Buddhist’s situation is profitably comparable to issues of akrasia, weakness of the will, that are taken up by Plato, Aristotle and many modern philosophers, including notably Donald Davidson and David Wiggins. (shrink)

This series celebrates the Bodleian Library's acquisition of Tom Phillips's archive of over 50,000 photographic postcards dating from the first half of the twentieth century, a period in which, thanks to the ever cheaper medium of photography, 'ordinary' people could afford to own their portraits. Each title in this series is thematically assembled and designed by the artist, the covers featuring a linked painting specially created for each title from Tom Phillips's signature work, A Humument.With an illuminating foreword by Eric (...) Musgrave, 'Menswear' presents postcards of men in all manner of outfits, whether formal, practical or casual, dating from around 1900 up to c. 1949. Most of the subjects are posing for portraits, displaying both their individual style and an interpretation of the fashions of the time. The rich variety of accessories on display includes ties, gloves, pocket squares, walking sticks, canes, boutonnières and spats. (shrink)

Affirmative action refers to positive steps taken to hire persons from groups previously and presently discriminated against. Considerable evidence indicates that this discrimination is intractable and cannot be eliminated by the enforcement of laws. Numerical goals and quotas are justified if and only if they are necessary to overcome the discriminatory effects that could not otherwise be eliminated with reasonable efficiency. Many past as well as present policies are justified in this way.

The whole brain-death criterion of death now enjoys a wide acceptance both within the medical profession and among the general public. That acceptance is in large part the product of the contention that brain death is the proper criterion for even a conservative definition of death – the irreversible loss of the integrated functioning of the organism as a whole. This claim – most recently made in the report of the Presidential Commission and in a comprehensive article by James Bernat (...) and others – is based upon a series of fallacious arguments. Chief among these is the argument that whole brain-death is the proper criterion for the conservative definition because the brain is the organ that integrates the rest of the organism. A central part of the paper shows that this argument rests upon a confusion between a function and the mechanism that performs it, and replies to the defenses that the Presidential Commission makes on this point. The concluding portion of the paper argues that this issue is not merely of academic interest, but has the potential for undermining the present consensus that supports the use of whole brain-death criteria. * Keywords: brain-death, definition of death, determination of death * I would like to thank Howard Brody and Bruce Miller for helpful suggestions and criticisms. CiteULike Connotea Del.icio.us What's this? (shrink)

The Reeh-Schlieder theorem asserts the vacuum and certain other states to be spacelike superentangled relative to local quantum fields. This motivates an inquiry into the physical status of various concepts of localization. It is argued that a covariant generalization of Newton-Wigner localization is a physically illuminating concept. When analyzed in terms of nonlocally covariant quantum fields, creating and annihilating quanta in Newton-Wigner localized states, the vacuum is seen to not possess the spacelike superentanglement that the Reeh-Schlieder theorem displays relative to (...) local fields, and to be locally empty as well as globally empty. Newton-Wigner localization is then shown to be physically interpretable in terms of a covariant generalization of the center of energy, the two localizations being identical if the system has no internal angular momentum. Finally, some of the counterintuitive features of Newton-Wigner localization are shown to have close analogues in classical special relativity. (shrink)

The paper looks at how Tsong kha pa, mKhas grub, and Go rams pa understood the third and fourth lemmas in the tetralemma, “both A and B” and “neither A nor B,” respectively.