Gene therapy has emerged from the idea of inserting a wild‐type copy of a gene in order to restore the proper expression and function of a damaged gene. Initial efforts have focused on finding the proper vector and delivery method to introduce a corrected gene to the affected tissue or cell type. Even though these first attempts are clearly promising, seveal problems remain unsolved. A major problem is the influence of chromatin structure on transgene expression. To overcome chromatin‐dependent repressive transgenic (...) states, researchers have begun to use chromatin regulatory elements to drive transgene expression. Insulators or chromatin boundaries are able to protect a transgene against chromatin position effects at their genomic integration sites, and they are able to maintain transgene expression for long periods of time. Therefore, these elements may be very useful tools in gene therapy applications for ensuring high‐level and stable expression of transgenes. BioEssays 26:796–807, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Based on Michel Foucault's 1978 and 1979 lectures at the Collège de France on governmental rationalities and his 1977 interview regarding his work on imprisonment, this volume is the long-awaited sequel to Power/Knowledge.

What does it take for one proposition to be closer to the truth than another. In this, the first published monograph on the topic, Oddie develops a comprehensive theory that takes the likeness in truthlikeness seriously.

Why should a Bayesian bother performing an experiment, one the result of which might well upset his own favored credence function? The Ramsey-Good theorem provides a decision theoretic answer. Provided you base your decision on expected utility, and the the experiment is cost-free, performing the experiment and then choosing has at least as much expected utility as choosing without further ado. Furthermore, doing the experiment is strictly preferable just in case at least one possible outcome of the experiment could alter (...) your choice of options. That is, you should pursue the information just in case it could make a difference to what you do. The problem remains, however, why one should do an experiment when nothing of much practical consequence hangs in the balance. One possibility here is to invoke the pure cognitive utility of states. It is shown that one constraint on cognitive value (what I call cogency) guarantees the value of learning: from a cognitive point of view you are justified in performing an experiment if the outcome of the experiment could make a different to what you think. A bonus of the basic framework is that it provides a new decision theoretic argument for the rationality of conditionalization. (shrink)

The goal of this research is to know and compare the emotions and reactions to confinement due to the COVID-19 pandemic in children and adolescents with high abilities and community samples. This is a mixed study with an exploratory reach that is descriptive, and which combines survey and qualitative methodologies to examine the emotions and reactions to confinement experiences of children and adolescents aged between 5 and 14 years. An online poll was designed with 46 questions, grouped into three sections: (...) General Data, Reactions to the health contingencies of COVID-19, and Positive and negative emotions. This last section was included the Oros’ positive emotions questionnaire and the scales of the negative effect of the PANAS Schedule positive and negative affect on children and adolescents between 8 and 14 years old. Data were collected online with a convenience sample. Quantitative data were analyzed with the SPSS statistics program and qualitative data with Alceste software. Among the main findings is the fact that there are no significant differences between the groups by ability in terms of reactions and emotions; however, there are differences between age groups and sex. The study discusses the implications for educational intervention in situations like the current pandemic. (shrink)

Proper functionalism explicates epistemic warrant in terms of the function and normal functioning of the belief-forming process. There are two standard substantive views of the sources of functions in the literature in epistemology: God (intelligent design) or Mother Nature (evolution by natural selection). Both appear to confront the Swampman objection: couldn’t there be a mind with warranted beliefs neither designed by God nor the product of evolution by natural selection? Is there another substantive view that avoids the Swampman objection? There (...) are two. The first is the generalized selected-effects theory of functions. The second is the organizational theory of functions. Both, however, require some history to assign functions, for both are etiological theories of functions: past effects help explain current function. Swampman can then acquire functions, perhaps soon after creation, though he has none at the moment of inception. (shrink)

‘What is philosophy?’ is a question that every professional philosopher must ask themself sometimes. In a sense, of course, they know: they spend much time doing it. But in another sense, the answer to the question is not at all obvious. In the same way, any person knows by acquaintance what breathing is; but this does not mean that they know the nature of breathing: its mechanism and function. The nature of breathing, in this sense, is now well understood; the (...) nature of philosophy, by contrast, is still very much an open question. One of the reasons this is so is that the nature of philosophy is itself a philosophical question, so uncontentious answers are not to be expected—if philosophers ever ceased disagreeing with one another our profession would be done for. Moreover, it is a hard philosophical question. Many great philosophers, including Plato, Hegel, and others, have suggested answers to it. But their answers would now be given little credence. In the thirty or so years that I have been doing philosophy there have been two views about the nature of philosophy which have had wide acceptance. These are the views of the later Wittgenstein and of Derrida. In the first two parts of this paper I will describe these views and explain why I find them unsatisfactory. I will then go on, in the final part of paper, to outline a view that inspires more confidence in me. (shrink)

Alvin Goldman’s paper “What Is Justified Belief" and his book Epistemology and Cognition pioneered reliabilist theories of epistemic justifiedness. In light of counterexamples to necessity and counterexamples to sufficiency, Goldman has offered a number of refinements and modifications. This paper focuses on those refinements that relativize the justification conferring force of a belief-forming process to its reliably producing a high ratio of true beliefs over falsehoods in special circumstances: reliability in the actual world, in normal worlds, and in nonmanipulated environments. (...) This paper argues that Goldman’s refinements fall short and suggests instead the relativization to reliability in normal circumstances. Normal circumstances are those where the belief-forming process acquired the etiological function of reliably inducing true beliefs. This theory invites the Swampman objection. Two lines of response are pursued. (shrink)

IntroductionCurry’s paradox is well known.See, e.g., Priest , ch. 6. It comes in both set theoretic and semantic versions. Here we will concentrate on the semantic versions. Historically, these have deployed the notion of truth. Those who wish to endorse an unrestricted T-schema have mainly endorsed a logic which rejects the principle of Absorption, \\models A\rightarrow B\). High profile logics of this kind are certain relevant logics; these have semantics which show how and why this principle is not valid. Of (...) more recent times, paradoxes which are clearly in the same family have been appearing; but these concern the notion of validity itself. The standard semantics of relevant logics seem powerless to address these. But they can. This note shows how. The upshot can be seen as a return to the roots of relevant logic, in a sense to become clear.BackgroundThe Usual Curry ParadoxesLet us start with a couple of standard forms of the paradox. I .. (shrink)

I argue that there is nothing about truth as such that prevents contradictions from being true. I argue this by considering the main standard accounts of truth, and showing that they are quite compatible with the existence of true contradictions. Indeed, in many cases, they are actually friendly to the idea.

Does epistemic justification aim at truth? The vast majority of epistemologists instinctively answer 'Yes'; it's the textbook response. Joseph Cruz and John Pollock surprisingly say no. In 'The Chimerical Appeal of Epistemic Externalism' they argue that justification bears no interesting connection to truth; justification does not even aim at truth. 'Truth is not a very interesting part of our best understanding' of justification (C&P 2004, 137); it has no 'connection to the truth.' A 'truth-aimed ... epistemology is not entitled to (...) carry the day' (C&P 2004, 138, emphasis added).Pollock and Cruz's argument for this surprising conclusion is of general interest for it is 'out of step with a very common view on the .. (shrink)

In Pascal's Wager: A Study Of Practical Reasoning In Philosophical Theology ,[1] Nicholas Rescher aims to show that, contrary to received philosophical opinion, Pascal's Wager argument is "the vehicle of a fruitful and valuable insight--one which not only represents a milestone in the development of an historically important tradition of thought but can still be seen as making an instructive contribution to philosophical theology".[2] In particular, Rescher argues that one only needs to adopt a correct perspective in order to see (...) that Pascal's Wager argument is a good argument. Moreover, there seems to be a certain amount of contemporary support for Rescher's claim that Pascal's Wager argument can be seen to be a good argument when properly construed .[3] However, despite this recent trend to adopt a more sympathetic stance towards Pascal's Wager argument, I propose to defend the traditional view that Pascal's Wager argument is almost entirely worthless--at least from the theological standpoint. (No doubt, it has historical significance from the standpoint of decision theory; but that's a separate matter.). (shrink)

This paper provides a survey of philosophical discussion of the "the Turing Test". In particular, it provides a very careful and thorough discussion of the famous 1950 paper that was published in Mind.

I argue for an evaluative theory of desire—specifically, that to desire something is for it to appear, in some way or other, good. If a desire is a non-doxastic appearance of value then it is no mystery how it can rationalize as well as cause action. The theory is metaphysically neutral—it is compatible with value idealism (that value reduces to desire), with value realism (that it is not so reducible), and with value nihilism (all appearances of value are illusory). Despite (...) this metaphysical neutrality the thesis opens up an epistemological gold mine. Non-doxastic value appearances can provide defeasible reasons for value judgements, in roughly the same way that perceptual appearances provide defeasible reasons for perceptual judgements. The paper presents a new line of argument for the evaluative theory—drawing on recent work on fitting attitudes—and rebuts some of the most pressing criticisms. (shrink)

Hylomorphism is the theory that objects are composites of form and matter. Recently it has been argued that form is structure, or the arrangement of an object's parts. This paper shows that the principle of form cannot be ontologically exhausted by structure. That is, I deny form should be understood just as the arrangement of an object's parts. I do so by showing that structure cannot play the role form is supposed to in a certain domain of objects, specifically, in (...) mereological simples. Thus, I show that Hylomorphism does not reduce to Structuralism. I also draw out some important consequences from my argument for Hylomorphism in general. (shrink)

The case of very young children is a test case for the plausibility of reductionism about testimonial warrant. Reductionism requires reductive reasons, reductively justified and actively deployed for testimonial justification. Though nascent language-users enjoy warranted testimony based beliefs, they do not meet these three reductionist demands. This paper clearly formulates reductionism and the infant/child objection. Two rejoinders are discussed: an influential conceptual argument from Jennifer Lackey’s paper “Testimony and the Infant/Child Objection” and the growing empirical evidence from developmental psychology on (...) selective trust in children. Neither Lackey’s argument nor the empirical evidence vindicate reductionism. (shrink)

This paper articulates Sylvan's theory of mathematical objects as non-existent, by improving (arguably) his treatment of the Characterisation Postulate. It then defends the theory against a number of natural objections, including one according to which the account is just platonism in disguise.

Over the past three decades, economic sociology has been revealing how culture shapes economic life even while economic facts affect social relationships. This work has transformed the field into a flourishing and increasingly influential discipline. No one has played a greater role in this development than Viviana Zelizer, one of the world's leading sociologists. Economic Lives synthesizes and extends her most important work to date, demonstrating the full breadth and range of her field-defining contributions in a single volume for (...) the first time. Economic Lives shows how shared cultural understandings and interpersonal relations shape everyday economic activities. Far from being simple responses to narrow individual incentives and preferences, economic actions emerge, persist, and are transformed by our relations to others. Distilling three decades of research, the book offers a distinctive vision of economic activity that brings out the hidden meanings and social actions behind the supposedly impersonal worlds of production, consumption, and asset transfer. Economic Lives ranges broadly from life insurance marketing, corporate ethics, household budgets, and migrant remittances to caring labor, workplace romance, baby markets, and payments for sex. These examples demonstrate an alternative approach to explaining how we manage economic activity--as well as a different way of understanding why conventional economic theory has proved incapable of predicting or responding to recent economic crises. Providing an important perspective on the recent past and possible futures of a growing field, Economic Lives promises to be widely read and discussed. (shrink)

In many philosophical traditions, it is held that reality is non-dual. Of course, to be non-dual, as opposed to dual, is itself to partake of a certain duality. If reality really is non-dual, it must transcend this duality too. But what could this mean? Can one make coherent sense of it? To keep the discussion focussed, I will locate it in one specific tradition: the Mahāyāna Buddhist tradition. The idea that ultimate reality is non-dual goes back to the earliest Mahāyāna (...) sūtras at the turn of the Common Era. Thereafter, the question of what it means to transcend duality plays a central role in Buddhist philosophy. The point that reality must transcend even the duality between duality and non-duality plays a significant role in the Chinese Sanlun philosopher Jizang (, 549–623). His discussion points the way to an answer to our problem which may be articulated with the techniques of contemporary paraconsistent logic, as we will see. (shrink)

Richard Gale and Alexander Pruss contend that their ‘new cosmological argument’ is an improvement over familiar cosmological arguments because it relies upon a weaker version of the Principle of Sufficient Reason than that used in those more familiar arguments. However, I note that their ‘weaker’ version of the Principle of Sufficient Reason entails the ‘stronger’ version of that principle which is used in more familiar arguments, so that the alleged advantage of their proof turns out to be illusory. Moreover, I (...) contend that, even if their argument did rely on a weaker version of the Principle of Sufficient reason, nontheists would still be perfectly within their rights to refuse to accept the conclusion of the argument. (shrink)

Logic, in one of the many sense of that term, is a theory about what follows from what and why. Arguably, the correct theory has to be determined by abduction. Over recent years, so called logical anti-exceptionalists have investigated this matter. Current discussions have been restricted to deductive logic. However, there are also, of course, various forms of non-deductive reasoning. Indeed, abduction itself is one of these. What is to be said about the way of choosing the best theory of (...) non-deductive inferences? It would seem clear that an anti-exceptionalist should hold that essentially the same method of choice should apply to non-deductive logic. A number of issues need to be faced in the process, not the least of which is the circularity involved in an abductive justification for a theory of abduction. This paper discusses matters. (shrink)

Hylomorphism is the Aristotelian theory according to which substances are composed of matter and form. If a house is a substance, then its matter would be a collection of bricks and timbers, and its form is something like the structure of those bricks and timbers. It is widely agreed that matter bears a mereological relationship to substance; the bricks and timbers are parts of the house. But with form things are more controversial. Is the structure of the bricks and timbers (...) best conceived as a part of the house, or is it related to the house in some non‐mereological fashion? Kathrin Koslicki argues that substances have formal parts and that forms are best conceived as bearing a mereological relation to substances. This paper shows that her argument fails, given the traditional and plausible distinction between substances and accidental unities. I close with a brief suggestion for a non‐mereological construal of forms. (shrink)

Moral dilemmas can arise from uncertainty, including uncertainty of the real values involved. One interesting example of this is that of experimentation on human embryos and foetuses, If these have a moral stauts similar to that of human persons then there will be server constraitns on what may be done to them. If embryous have a moral status similar to that of other small clusters of cells, then constraints will be motivated largely by consideration for the persons into whom the (...) embryos may develop. If the truth lies somewhere between these two extremes, the embryo having neither the full moral weight of persons, nor a completely negligible moral weight, then different kinds of constraints will be appropriate. On the face of it, in order to know what kinds of experiements, if any, we are morally justified in performing on embryos we have to know what the moral weight of the embryo is. But then an impasse threatens, for it seems implausible that we can settle with certainty the exact moral status of the human embryo. It is the purpose of this paper to show that moral uncertainty need not make rational moral justification impossible. I develop a framework which distinguishes between what is morally right/wrong, and what is morally justified/unjustified, and applies standard decision theoretic tools to the case of moral uncertainties. (This was the first published account of what has subsequently become known as Expected Moral Value Theory. An earlier version of the paper, "A decision theoretic argument against human embryo experimentation", was published in M. Fricke (ed.), Essays in honor of Bob Durrant. (University of Otago Press, 1986) 111-27.). (shrink)

In Metaphysics III, Chapter 4, Aristotle sets out and defends the Law of Non-Contradiction. The arguments are, however, rather less satisfactory than one might have expected, given the enormous historical influence the text has had. His major argument is a particularly tangled one, and the others are often little more than throw-away remarks. This essay is a commentary on the chapter, but its aim is less to interpret the text , than to see whether there is anything that Aristotle could (...) have meant that would have served his purpose. Whilst other commentators have sometimes attempted this, they have always taken his conclusion to be correct, even if his arguments were not; I do not. The commentary is therefore a confrontation between Aristotle and modern dialetheism. (shrink)

In ‘Professor Mackie and the Kalam Cosmological Argument’ , 367–75), Professor William Lane Craig undertakes to demonstrate that J. L. Mackie's analysis of the kalam cosmological argument in The Miracle of Theism is ‘superficial’, and that Mackie ‘has failed to provide any compelling or even intuitively appealing objection against the argument’ . I disagree with Craig's judgement; for it seems to me that the considerations which Mackie advances do serve to refute the kalam cosmological argument. Consequently, the purpose of this (...) paper is to reply to Craig's criticisms on Mackie's behalf. (shrink)

David Lewis has offered a reply to the standard argument for the claim that the truth of determinism is incompatible with anyone’s being able to do otherwise than she in fact does. Helen Beebee has argued that Lewis’s compatibilist strategy is untenable. In this paper I show that one recent attempt to defend Lewis’s view against this argument fails and then go on to offer my own defense of Lewis’s view.

Only too often critical realist contributions to understanding and explaining social phenomena fall into one of two discrete categories: exercises in philosophy or social theory, or empirical research that strikes as more or less atheoretical. This paper continues a long-term project to build bridges between abstruse issues of philosophy and theory and attempts to grasp the ‘how’ and ‘why’ of actual social events. The topic selected is elite professional rugby union and the principal theme is its emergence as an extreme (...) sport and the risk of serious injury. It is argued that the injurious nature of elite rugby has its causal genesis in the professionalization of the sport and that a critical realist-oriented sociology has an important contribution to make in framing and gasping how and why this is. (shrink)

In Contradiction advocates and defends the view that there are true contradictions (dialetheism), a view that flies in the face of orthodoxy in Western philosophy since Aristotle. The book has been at the center of the controversies surrounding dialetheism ever since its first publication in1987. This second edition of the book substantially expands upon the original in various ways, and also contains the author's reflections on developments over the last two decades. Further aspects of dialetheism are discussed in the companion (...) volume, Doubt Truth to be a Liar, also published byOxford University Press in 2006. (shrink)

Here are three (rough) theories of testimonial knowledge. (1) Speaker's knowledge: a hearer acquires the knowledge that P though testimony because of the speaker's knowledge that P--testimony "transfers" knowledge. This is the popular view, defended by Elizabeth Fricker and Paul Faulkner, among others. (2) Speaker's assertion: a hearer acquires the knowledge that P through testimony because the speaker's assertion that P is reliable that P in the right way (safe or sensitive). That's Jennifer Lackey's view. (3) Speaker's comprehension state: a (...) hearer acquired the knowledge that P through comprehending as of a speaker's assertion that P where the comprehension state is reliable in the right way (safe). That's my view. Lackey would reject such a view for it allows cases of testimonial knowledge that P from a speaker who did not assert that P. But Faulkner might reject Lackey's view on the grounds that it allows cases of testimonial knowledge that P from a speaker who did not know that P. Lackey replies that her account is better unified. But for the same reason, my account is even better unified. This paper runs through a series of cases and shows that my account--the Unified Account--is superior to the others. (shrink)

This article defends a new sense of “formalism” in philosophy and the arts, against recent materialist fashion. Form has three key opposite terms: matter, function, and content. First, I respond to Jane Bennett’s critique of object-oriented philosophy in favor of a unified matter-energy, showing that Bennett cannot reach the balanced standpoint she claims to obtain. Second, I show that the form/function dualism in architecture gives us two purely relational terms and thus cannot do justice to the topic of form. Third, (...) I argue against Greenberg, Heidegger, and McLuhan that content cannot be trivialized in favor of deeper form. I close with a new conception of mimesis as performance rather than as the fabrication of copies. The form underlying any work’s content is provided by the spectator herself as the only real object that does not withdraw from the aesthetic scene. (shrink)

Jennifer Lackey argues that “testimony” in philosophy has one sense, but that sense—the concept expressed—is disjunctive. One disjunct she calls speaker-testimony and the other disjunct she calls hearer-testimony. A speaker then testifies simpliciter iff the speaker either speaker-testifies or hearer-testifies. Inadequate views of testimony, she argues, fail to recognize, distinguish and then disjoin these two “aspects” of testimony. I argue that her view about the semantics of “testimony” is mistaken and that her criticisms of two other views—mine included —are ineffective. (...) I argue that instead of one disjunctive concept, the word “testimony” expresses more than one concept; “testimony” means many things. In ordinary English, it names two distinct kinds of constative speech acts. In epistemology, it gets used a synonym for “assertion”. In epistemology, it also refers to the process whereby we form beliefs on the basis of comprehending assertions—to communication or interlocution. (shrink)

The year 1992 is a year for reflection, because whether or not the quincentenary celebration of the arrival of the Europeans to this continent seems justified, one cannot escape thinking about the impact of this event on our land.As archeology is my area of study, my reflections are directed toward the changes that came about in the relationship between man and animals after 1492, specifically toward what occurred in Mexico once the Spaniards established themselves in this territory.

Are things good because we desire them or do we desire them because they are good? Theories that countenance only desire-dependent values are idealist, those that countenance desire-independent values are realist. A value can be either subject-relative or subject-neutral. Subjectivism countenances only subject-relative and desire-dependent values. Subject-neutral idealism countenances at least some subject-neutral values. Realism repudiates the dependence of value on actual desires, but endorses an important relation between value and the fittingness of desires. Normative realism takes normative facts about (...) the fittingness of desires to ground the value facts, while axiological realism takes value facts to ground facts about fittingness. An important variant of axiological realism, namely representational realism, holds that desires are appearances of value, and that the fittingness of a desire is simply a matter of accurate representation. (shrink)