Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the formation of dilated, dysfunctional blood vessels in the dermis, eyes, and/or brain. Cutaneous PWBs can be treated by current dermatologic therapy, like laser intervention, to lighten the lesions and diminish nodules that occur in the lesion. Involvement of the eyes and/or brain can result in serious complications and this variation is termed Sturge-Weber syndrome (...) (SWS). Some of the biggest hurdles preventing development of new therapeutics are unanswered questions regarding disease biology and lack of models for drug screening. In this review, we discuss the current understanding of GNAQ signaling, the standard of care for patients, overlap with other GNAQ-associated or phenotypically similar diseases, as well as deficiencies in current in vivo and in vitro vascular malformation models. (shrink)

The last two decades have seen two significant trends emerging within the philosophy of science: the rapid development and focus on the philosophy of the specialised sciences, and a resurgence of Aristotelian metaphysics, much of which is concerned with the possibility of emergence, as well as the ontological status and indispensability of dispositions and powers in science. Despite these recent trends, few Aristotelian metaphysicians have engaged directly with the philosophy of the specialised sciences. Additionally, the relationship between fundamental Aristotelian concepts—such (...) as "hylomorphism", "substance", and "faculties"—and contemporary science has yet to receive a critical and systematic treatment. _Neo-Aristotelian Perspectives on Contemporary Science _aims to fill this gap in the literature by bringing together essays on the relationship between Aristotelianism and science that cut across interdisciplinary boundaries. The chapters in this volume are divided into two main sections covering the philosophy of physics and the philosophy of the life sciences. Featuring original contributions from distinguished and early-career scholars, this book will be of interest to specialists in analytical metaphysics and the philosophy of science. (shrink)

Two strategies for using a model as “null” are distinguished. Null modeling evaluates whether a process is causally responsible for a pattern by testing it against a null model. Baseline modeling measures the relative significance of various processes responsible for a pattern by detecting deviations from a baseline model. When these strategies are conflated, models are illegitimately privileged as accepted until rejected. I illustrate this using the neutral theory of ecology and draw general lessons from this case. First, scientists cannot (...) draw certain conclusions using null modeling. Second, these conclusions follow using baseline modeling, but doing so requires more evidence. (shrink)

According to deontic justice theory, individuals often feel principled moral obligations to uphold norms of justice. That is, standards of justice can be valued for their own sake, even apart from serving self-interested goals. While a growing body of evidence in business ethics supports the notion of deontic justice, skepticism remains. This hesitation results, at least in part, from the absence of a coherent framework for explaining how individuals produce and experience deontic justice. To address this need, we argue that (...) a compelling, yet still missing, step is to gain further understanding into the underlying neural and psychological mechanisms of deontic justice. Here, we advance a theoretical model that disentangles three key processes of deontic justice: The use of justice rules to assess events, cognitive empathy, and affective empathy. Together with reviewing neural systems supporting these processes, broader implications of our model for business ethics scholarship are discussed. (shrink)

This generous omnium-gatherum brings together all the writings William James published that have not appeared in previous volumes of this definitive edition of ...

There is now a considerable literature that goes under the heading of “phenomenal intentionality.” But it features a number of distinct issues. What they have in common is the claim that intentionality bears a closer relation to phenomenology than had previously been recognized. There is a basic thesis, which is controversial, and there are further arguments attempting to draw more exciting morals from the basic thesis. My purpose in this paper is to survey these issues, see what may be at (...) stake, and adjudicate. (shrink)

The purpose of retracting published papers is to maintain the integrity of academic research. Recent work in research ethics has devoted important attention to how to improve the system of paper retraction. In this context, the focus has primarily been on how to handle fraudulent or flawed research papers and how to encourage the retraction of papers based on honest mistakes. Less attention has been paid to whether papers that report unethical research—for example, research performed without appropriate concern for the (...) moral rights and interests of the research participants—should be retracted. The aim of this paper is to examine to what extent retraction policies of academic journals and publishers address retractions of unethical research and to discuss critically various policy options and the reasons for accepting them. The paper starts by reviewing retraction policies of academic publishers. The results show that many journals do not have explicit policies for how to handle unethical research. Against this background, we then discuss four normative arguments for why unethical research should be retracted. In conclusion, we suggest a retraction policy in light of our empirical and normative investigations. (shrink)

The background of these remarks is that in 1967, in ‘’Constructive reasoning” [27], I sketched an argument that finitist arithmetic coincides with primitive recursive arithmetic, P RA; and in 1981, in “Finitism” [28], I expanded on the argument. But some recent discussions and some of the more recent literature on the subject lead me to think that a few further remarks would be useful.

Toby Handfield has advanced a subtle form of dispositionalism that purports to reconcile the concept of causal powers with broadly Humean convictions by dissolving the requirement for objectively modal relations between powers and their manifestations. He suggests we should identify manifestations with certain types of causal processes, and identify powers with properties that are parts of their structures. The modal features of causal powers can then be explained in terms of internal relations between a power and the property of being (...) a certain type of causal process, but these relations are supervenient and do not add anything to the basic ontology. In this way, causal powers may be ‘connected’ to their manifestations without admitting objectively modal relations. I disagree with this characterisation of causal powers and its identification of manifestations with types of causal processes: I question the assumption that causal processes can be isolated in quantum physics in the way Handfield requires and confront Humean dispositionalism with the problem of individuating powers in an entangled world. (shrink)

Between the opposing claims of reason and religious subjectivity may be a middle ground, William J. Wainwright argues. His book is a philosophical reflection on the role of emotion in guiding reason. There is evidence, he contends, that reason functions properly only when informed by a rightly disposed heart. The idea of passional reason, so rarely discussed today, once dominated religious reflection, and Wainwright pursues it through the writings of three of its past proponents: Jonathan Edwards, John Henry Newman, (...) and William James. He focuses on Edwards, whose work typifies the Christian perspective on religious reasoning and the heart. Then, in his discussion of Newman and James, Wainwright shows how the emotions participate in non-religious reasoning. Finally he takes up the challenges most often posed to notions of passional reason: that such views justify irrationality and wishful thinking, that they can't be defended without circularity, and that they lead to relativism. His response to these charges culminates in an eloquent and persuasive defense of the claim that reason functions best when influenced by the appropriate emotions, feelings, and intuitions. (shrink)

There is currently an important debate about whether philosophical intuitions are intended as evidence for the theories philosophers promote. On one side are those who argue that philosophers do rely on intuitions as evidence; on the other side are those who deny any such role for philosophical intuitions. This paper argues that both sides of this debate are partially right and partially wrong. Intuitive judgments do not, as psychological states, function as evidence in most well-known philosophical thought experiments. Philosophers nevertheless (...) strongly depend upon these intuitive judgments. Where both sides go awry is in assuming that the importance of intuitive judgments rests solely upon their role as evidence. We need to distinguish between evidence, as such, from various nonevidential psychological states that are needed for something else to serve as evidence. The paper calls these latter conditions “evidence facilitators” and argues that intuitive judgments belong in this category. (shrink)

Three concepts—authority, obedience and obligation—are central to understanding law and political institutions. The three are also involved in the legitimation of the state: an apology for the state has to make a normative case for the state’s authority, for its right to command obedience, and for the citizen’s obligation to obey the state’s commands. Recent discussions manifest a cumulative scepticism about the apologist’s task. Getting clear about the three concepts is, of..

Ludwig Wittgenstein was, famously, not a fan of William Shakespeare. He wrote in 1946 that “Shakespeare's similes are, in the ordinary sense, bad.” But Wittgenstein’s opinion was not only one fueled by aesthetic dislike. This short website article argues that Wittgenstein sees in Shakespeare a fellow explorer of skepticism, but one willing to travel down dark alleys that Wittgenstein himself sought to avoid. (This article is a journalistic version of "To Not Understand, but Not Misunderstand: Wittgenstein on Shakespeare," in (...) Wittgenstein Reading, edited by Sascha Bru, Wolfgang Huemer, and Daniel Steuer [De Gruyter, 2013, 39-53].). (shrink)

P. T. Geach, notoriously, holds the Relative Identity Thesis, according to which a meaningful judgment of identity is always, implicitly or explicitly, relative to some general term. ‘The same’ is a fragmentary expression, and has no significance unless we say or mean ‘the same X’, where ‘X’ represents a general term (what Frege calls a Begriffswort or Begriffsausdruck). (P. T. Geach, Mental Acts (London: Routledge and Kegan Paul, 1957), p. 69. I maintain that it makes no sense to judge whether (...) things are ‘the same’, or remain ‘the same’, unless we add or understand some general term - ‘the same F’. (P. T. Geach, Reference and Generality, third Edition (Ithaca, N.Y.: Cornell University Press, 1980), pp. 63f. I am arguing for the thesis that identity is relative. When one says ‘x is identical with y’, this, I hold, is an incomplete expression; it is short for ‘x is the same A as y’, where ‘A’ represents some count noun understood from the context of utterance - or else, it is just a vague expression of a half-formed thought. (P. T. Geach, ‘Identity,’ Review of Metaphysics 21 (1967-8), p. 3.) One of the ways Geach seeks to support this is by tying it to the well nigh universally admired Fregean thesis about cardinality. (shrink)

Most accounts of mechanism discovery have focused on mechanisms that perform the work required to produce a phenomenon. These mechanisms are often subject to regulation by control mechanisms. Using the example of the molecular motor dynein, this paper examines one process by which such control mechanisms are discovered—the process by which researchers, after identifying additional components required to produce the phenomenon but not directly involved in the work of producing that phenomenon, investigate both how these components act on the original (...) mechanism and how they do so in response to measurements of conditions relevant to the operation of the controlled mechanism. (shrink)

Digital technology, including artificial intelligence, is having a dramatic impact on the professions of medicine, law, journalism, finance, and others. Some suggest that clergy will also be affected. We describe recent progress in designing artificially intelligent systems, suggesting that this is possible, perhaps even likely. We investigate ways in which technology currently is affecting ministry and outline some plausible scenarios in which digital systems could supplement or supplant clergy in some areas, specifically preaching and pastoral care. We also raise some (...) theological issues raised by the use of digital systems in ministry. (shrink)

Taking an analytic and historical approach, this work develops and defends Althusserian critical theory. This theory, it is argued, produces knowledge of how a particular class of people, in a particular time, in a particular place, is dominated, oppressed, or exploited. Moreover, without relying on a general notion of human emancipation, concrete critical theory can suggest political means for the alleviation of these conditions. Because it puts Althusser’s ideas in dialogue with contemporary social science and philosophy, the book as a (...) whole makes contributions to Althusser studies, to Anglo-American political philosophy, and to current debates in the philosophy of the social sciences. (shrink)

Film is the supreme medium for mythmaking. The gods and heroes of mythology are both larger than life and deeply human; they teach us about the world, and they tell us a good story. Similarly, our experience of film is both distant and intimate. Cinematic techniques--panning, tracking, zooming, and the other tools in the filmmaker's toolbox--create a world that is unlike reality and yet realistic at the same time. We are passive spectators, but we also have a personal relationship with (...) the images we are seeing. In Cinematic Mythmaking, Irving Singer explores the hidden and overt use of myth in various films and, in general, the philosophical elements of a film's meaning. Mythological themes, Singer writes, perform a crucial role in cinematic art and even philosophy itself. Singer incisively disentangles the strands of different myths in the films he discusses. He finds in Preston Sturges's The Lady Eve that Barbara Stanwyck's character is not just the biblical Eve but a liberated woman of our times; Eliza Doolittle in the filmed versions of Shaw's Pygmalion is not just a statue brought to life but instead a heroic woman who must survive her own dark night of the soul. The protagonist of William Wyler's The Heiress and Anieszka Holland's Washington Square is both suffering Dido and an awakened Amazon. Singer reads Cocteau's films--including La Belle et la Bête, Orphée, and The Testament of Orpheus--as uniquely mythological cinematic poetry. He compares Kubrickean and Homeric epics and analyzes in depth the self-referential mythmaking of Federico Fellini in many of his movies, including 8½. The aesthetic and probing inventiveness in film, Singer shows us, restores and revives for audiences in the twenty-first century myths of creation, of the questing hero, and of ideals--both secular and religious--that have had enormous significance throughout the human search for love and meaning in life. (shrink)

It is commonly supposed that citizens of a reasonably just state have a prima facie duty to obey its laws. In recent years, however, a number of influential political philosophers have concluded that there is no such duty. But how can the state be a legitimate authority if there is no general duty to obey its laws? This article is an attempt to explain how we can make sense of the idea of legitimate political authority without positing the existence of (...) a general duty to obey the law. The explanation makes use of a distinction between laws of general application, on one hand, and on the other the particularized, directed efforts by state officials to channel and resolve disputes (including those arising from violations of the law). A state's legitimate authority entails a general duty to cooperate in the latter type of effort, rather than upon a dubious general duty to obey the law. (shrink)

This book is a study of Plato’s most elementary dialogues, arranged in relation to Reading Order as opposed to order of composition. Beginning with the theatrical Protagoras and reaching a mountaintop in Symposium, the dialogues between them—Alcibiades, Lovers, Hippias, Ion, and Menexenus—introduce the student to both philosophy and Platonism.

The nineteenth century background -- Kant, God, and immortality -- Newman and the argument from conscience -- The argument from the objectivity of value -- The euthyphro problem -- Two recent divine command theories -- Objections to divine command theory -- The case for divine command theory -- Religious ethics and rational morality -- Abraham and the binding of Isaac -- Mysticism and morality.

In the fall of 1869, the first of eight students set off from the tiny Sadowara Domain in southeastern Kyushu to pursue study in America and Europe. Overshadowed by more famous peers from other domains, the Sadowara students have been all but forgotten, and their lives abroad remain an untold story. Yet they played an important role in the early development of Japanese studies in the United States. Enrolling at diverse institutions mostly in the Northeast, six of the students came (...) to form a close relationship with Yale’s university librarian, a philologist named Addison Van Name. Inspired by his new friends to study the Japanese language, within a year Van Name was offering America’s first college course in Japanese, and he quickly began to produce scholarship on Japan and its language, literature, and history. By the mid-1870s, the Sadowara students had returned to their home country, where their subsequent careers constituted a microcosm of the paradox and transformation of the early Meiji period. Van Name maintained contact with his Japanese friends, and through this long-distance relationship succeeded in building America’s first significant Japanese library collection: a 3,000-volume collection of Edo and early Meiji titles that still survives today. (shrink)

Journal of Political Philosophy, EarlyView.

ABSTRACT In this paper, I outline two concerns regarding Avner de Shalit’s proposal for a public reflective equilibrium. Firstly, de Shalit's work suggests a division between the philosopher and the people. We, therefore, need to clarify what the relation between the philosopher and the public is. Secondly, who is the ‘public’ that de Shalit is discussing? By bringing de Shalit's work into contact with the work of Jacques Rancière, this paper will deepen the question who the ‘people’ or ‘public’ in (...) de Shalit's work are, and how would a public reflective equilibrium allow for the implicit democratic vision that de Shalit believes it has. (shrink)

To avoid potential abuse and respect patient autonomy, physicians have a moral obligation to obtain informed consent before performing any significant medical intervention. To give informed consent, a patient must be competent, understand her condition, options and their expected risks and benefits and must freely and expressly consent to one of those options. Shlomo Cohen challenges this conception of informed consent by constructing cases based on Edmund Gettier’s classic counterexamples to traditional theories of knowledge. In this paper, I argue Cohen-style (...) cases are not genuine threats to the concept of informed consent, however they provide an interesting challenge to theories of conscientious objection. (shrink)

First published in 1840, this two-volume treatise by Cambridge polymath William Whewell remains significant in the philosophy of science. The work was intended as the 'moral' to his three-volume History of the Inductive Sciences, which is also reissued in this series. Building on philosophical foundations laid by Immanuel Kant and Francis Bacon, Whewell opens with the aphorism 'Man is the Interpreter of Nature, Science the right interpretation'. Volume 1 contains the majority of Whewell's section on 'ideas', in which he (...) investigates the philosophy underlying a range of different disciplines, including pure, classificatory and mechanical sciences. Whewell's work upholds throughout his belief that the mind was active and not merely a passive receiver of knowledge from the world. A key text in Victorian epistemological debates, notably challenged by John Stuart Mill and his System of Logic, Whewell's treatise merits continued study and discussion in the present day. (shrink)

Récurrente sous différentes formes dans le domaine de la lexicométrie, l’analyse cooccurrentielle vise à dévoiler les attractions lexicales qui opèrent dans un texte en restituant un état intermédiaire entre la séquence textuelle et l’inventaire lexical, état qui doit combiner l’explicitation syntagmatique de l’une avec la hiérarchisation statistique de l’autre. Pour dépasser les résultats des méthodes de cooccurrence classiques et identifier des systèmes cooccurrentiels plus complexes à l’oeuvre dans le texte, il s’avère nécessaire de substituer à l’approche analytique des associations lexicales (...) une vue synthétique de ces attractions prééminentes en contexte. (shrink)

This article analyses the depiction of mental and physical pain in Sophoclean tragedy, showing how Sophocles uses medical imagery to explore fundamental problems in the personality and behaviour of his protagonists. It argues that the concentration of medical language at certain moments in particular plays not only makes the scenes more graphic and credible, but also articulates the causes and consequences of the characters’ predicament. Particular attention is given to Ajax’s delusions and maddening shame, Heracles’ agony and Deianeira’s mistake, and (...) Philoctetes’ intransigence and resentment. Sophocles’ sustained and detailed engagement with medical language and thought reveals him to be (no less than Aeschylus or Euripides) deeply interested in the wider intellectual and scientific issues of his time. (shrink)

This paper traces the intellectual development of the workplace privacy construct in the course of American thinking. The role of technological development in this process is examined, particularly in regard to the information gathering/dissemination dilemmas faced by employers and employees alike. The paper concludes with some preliminary considerations toward a theory of workplace privacy.

In this paper, I approach the trolley problem from a different angle, and align the perspective with non-Western models of philosophy as instruction for life. I argue that the trolley problem is an...

At the end of the 1990s, Brazil was faced with a potentially explosive HIV/AIDS epidemic. Through an innovative and multifaceted campaign, and despite initial resistance from multinational pharmaceutical companies, the government of Brazil was able to negotiate price reductions for HIV medications and develop local production capacity, thereby averting a public health disaster. Using interview data and document analysis, the authors show that the exercise of corporate social responsibility can be viewed in practice as a dynamic negotiation and an interaction (...) between multiple actors. Action undertaken in terms of voluntary CSR alone may be insufficient. This finding highlights the importance of a strong role for national governments and international organizations to pressure companies to perform better. (shrink)

This article seeks to develop an under-appreciated aspect of spectator activity: the way in which viewers make use of film to enter or sustain a project of bad faith. Based on Jean-Paul Sartre's account of bad faith in Being and Nothingness (1943), the article explains the aspects of bad faith that are pertinent to viewer activity, then explores the way viewers can make use of filmic depictions to facilitate self-denial. For example, spectators may emphasize the fact that persons are depicted (...) in narrow terms as corroboration for their belief that human nature is just as its depicted, thereby denying that we have the freedom to be otherwise. Or spectators may deny the relevance of problematic aspects of themselves when they find it depicted in characters who are admirable in other ways. I then consider whether films themselves can be described as being in bad faith. While technically they cannot, I identify ways that a film may encourage or discourage bad faith in viewers. I also examine how the immersive aspect of film enables viewers to turn attention away from themselves while they engage in self-denial. The case for this approach to viewer activity and film analysis is supplemented by a distinction between traits that do apply to film, e.g., being racist, sexist, or homophobic, and the resources it gives persons to be in bad faith about these social attitudes. I argue that a film can have traits like these while not encouraging bad faith and vice versa, demonstrating the unique perspective offered by approaching film and spectator activity in terms of bad faith. (shrink)

In recent years, there has been a panoply of new forms of ‘social’ government, as manifest in ‘social enterprise’ and ‘social media’. This follows an era of neoliberalism in which social logics were apparently being eliminated, through the expansion of economic rationalities. To understand this, the article explores the critique of the very notion of the ‘social’, as manifest in neoliberal contributions to the socialist calculation debate from the 1920s onwards. Understood as a zone lying between market and state, the (...) social was accused by Mises and Hayek of being both unaccountable (lacking any units of measurement) and formless (lacking instruments of explication). The article then asks to what extent these critiques still retain their purchase, following recent developments in hedonic measurement and data analytics. The argument is made that new post-neoliberal forms of ‘social government’ may now be entirely plausible, though focusing on the corporation rather than the state. (shrink)