Gene regulation involves various cis-regulatory elements that can act at a distance. They may physically interact each other or with their target genes to exert their effects. Such interactions are beginning to be uncovered in the imprinted Igf2/H19 domain.1 The differentially methylated regions (DMRs), containing insulators, silencers and activators, were shown to have physical contacts between them. The interactions were changeable depending on their epigenetic state, presumably enabling Igf2 to move between an active and a silent chromatin domain. The study (...) gives us a novel view on how regulatory elements influence gene expression and how epigenetic modifications modulate their long-range effects. (shrink)

Nearly all philosophers refer to Kant when debating the concept of dignity, and many approve of Kant’s conception, unaware of the tensions between Kant’s conception and the modern idea of dignity intimately connected to the idea of human rights. What exactly is Kant's conception of dignity? Is there a connecting tie between dignity and the legal sphere of human rights at all? Does Kant’s concept refer to a superior status human beings seem to own in comparison to non-rational beings? Or (...) does it refer to an absolute value? The contributions of this volume are organised in five broader topics. In the first section tensions within the Kantian conception of dignity are discussed (C. Horn, D. Birnbacher, G. Schönrich). The second group of articles illuminates the intimate connections between dignity and human rights (R. Mosayebi, M. Kettner). The third group discusses the prevailing moral conception of dignity (S. Yamatsuta, S. Shell, O. Sensen). The fourth group focuses on the relation of dignity and end in itself (T. Hill, D. Sturma, A. Wood). The central theme of the fifth group of contributions are the social, political, and cultural dimensions of dignity (Y. Kato, K. Ameriks, K. Flikschuh, T. Saito). (shrink)

科学が自然を破壊した今、人間は人工的に反人工的な自然を保持するべく努力しなければなりません。科学技術は、この逆説に耐え抜かねばならないのでしょう。.

Coping flexibility, as defined by the dual-process theory, refers to one’s ability to relinquish a coping strategy recognized as ineffective—abandonment—and to devise and implement an alternative and more effective strategy—re-coping. The coping flexibility hypothesis dictates that richer coping flexibility produces more adaptive outcomes caused by stress responses, such as reduced psychological and physical dysfunction. We tested the reliability and validity of the Coping Flexibility Scale-Revised and the CFH using the CFS-R, which was developed to measure coping flexibility. In total, we (...) performed three studies involving 6,752 participants. Study 1 provided the psychometric properties of the CFS-R and tested this factorial structure by a confirmatory factor analysis. Study 2 estimated the validity of the CFS-R by examining the associations between its three subscales and variables that were conceptually similar to them. Study 3 tested the CFH using a longitudinal design after controlling for the effects of typical coping strategies and other types of coping flexibility. Overall, the CFH was supported by the use of the CFS-R, and the findings in Studies 2 and 3 showed that it had acceptable validity and reliability. Our findings implied that abandonment and re-coping can predict reduced depressive symptoms more than other types of theoretical framings for coping flexibility. Additionally, a meta-analysis of the Cronbach’s alphas for all samples in this study showed that they were 0.87 for abandonment, 0.92 for re-coping, and 0.86 for meta-coping. (shrink)

In Plato's "Hippias Major" 292e6-7, we can find a self-predication sentence; "The fine is always fine." (We have similar expressions in "Protagoras" 330c4-6, 330d8-el, "Lysis" 220b6-7.) How should we interpret this sentence? We cannot give it any metaphysical meaning drawn from Plato's own theory of Form, which is explicit in his middle dialogues. "The fine" here should be the logical cause, not the one of the metaphysical essentials (cf. Paul Woodruff's "Plateo Hippias Major", p. 150). So taking a sentence like (...) "parthenos kale kalon" (287e4), we can safely paraphrase it in Woodruff's manner: "a fine girl is a fine thing." This can avoid reading the metaphysical meaning into the text. And I would like to make a new proposal for reading of 292e6-7: "the fine thing is what is to be called fine." This is to emphasize the unique character of the self-predication sentences in the early dialogues. In the Socratic way of discourse, Socrates and his partner get involved into "trial and error" during their pursuit of the knowledge. What they can do then is to give their opinions which seem to them true (so-called alethes doxa", cf. "Meno" 85c), and to get close examinations of them. And in this way they are getting closer to the knowledge. My interpretation well describes these activities. (shrink)

We examine the possible role played by field angular momentum in two systems of vastly different sizes: (i) the nucleon and (ii) highly magnetic white dwarf stars. For the nucleon we study the restrictions on the nucleon's structure that arise from the requirement that the total field angular (spin, orbital and field angular momentum) should satisfy the standard angular momentum commutation relationship. For the magnetic white dwarfs we argue that the magnetic field may alter the statistics of some fraction of (...) the white dwarf's electrons from fermionic to bosonic. This would effect the stars structure, giving it a smaller than expected radius, and a lower than expected temperature. In some extreme cases one could imagine that this effect could lead to the collapse of the white dwarf into a neutron star despite being below the Chandreshekar limit. (shrink)

This article investigates differences in structural tendencies between Japanese newspaper editorials and front-page columns. Although intuitively recognized by Japanese people, such differences have tended to be empirically overlooked in discourse or rhetoric research. This study compares the two text types, specifically focusing on the location of the main topic in the text item rather than the main thesis, the former of which has received less empirical attention than the latter in Japanese discourse research. The study analyzed 30 editorials and 30 (...) front-page columns from three major Japanese newspapers. The results show that the editorials have an early placement pattern, whereas the columns tend to have delayed introductions. These differences were statistically significant, empirically demonstrating how the intuitively recognized structural tendencies between the two text types crucially differ. The finding that there is a systematic early placement of the main topic in Japanese editorials is indicative of a basic common feature among languages in the editorial genre. From a methodological perspective, the study demonstrates the validity of the index of the main topic location as an analytical tool to distinguish different textual structures. (shrink)

The aim of this presentation is to show that philosophy of education must seriously engage itself with horizons of education. After a brief explanation of the term “horizon”, the horizon of modern pedagogy, which was inaugurated by Pestalozzi and Herbart, is examined. Modern pedagogy with its special emphasis on method unravels itself as one of the major streams of modern epistemology, for which inspection of inner ideas is crucial. The modern epistemology, on the other hand, presupposes the atomistic self represented (...) by the Lockian dark room. This is the horizon of modern pedagogy. One of the deficiencies of this horizon is that it is not capable of articulating the educational aim on its own terms. Thus, dealing with the aim of education, modern pedagogy was obliged to use terms such as God or Nature, the terms, of which philosophical origin goes back to the Cave metaphor of Plato. This takes us to the second part of the presentation: the examination of the Cave metaphor in order to unravel the horizon of the classical education, paideia. The comparison of the two horizons will show the importance of horizon, about which philosophy of education must be sensitive. (shrink)

In the past decades, research has raised the idea of a theology of the Septuagint on various occasions. Important works were recently published on this topic in the Handbuch zur Septuaginta and the Septuagint and Cognate Studies series. The general theological tendencies of the LXX are identified by scholars in eschatology, messianism, anti-anthropomorphism and angelology. These tend to all be regarded as further developments of the theology of the Hebrew Bible. However, one can trace the evolution of these and other (...) main topics of the LXX in the New Testament and in the later apostolic writings as well. Based on three concise case studies, I point out the evolution of theological ideas from the HB through the LXX up to the NT in this paper. First, I will discuss the importance of the 'Name of God'-theology which is increasingly present in the LXX and has a key role in the messianic passages of the NT. Then in two points it will be argued that addressing Jesus as κύριος implies theological accents which can be detected in the LXX. These observations aim to show that the development of the religious ideologies of the HB can be followed not only in the LXX but in the NT and beyond as well. The importance of a theology of the LXX goes beyond the HB research, having significant implications for the NT as well. In fact, such theology could build the bridge between the HB and the NT, and should not only be written from the viewpoint of the HB but also considering the NT. CONTRIBUTION: This contribution traces the routes of three theological concepts originating in the Hebrew Bible developed further in the LXX and finally adopted by the New Testament. Based on these three examples, it is suggested here as a novel idea that a theology of the LXX should not be written only with the Hebrew Bible in mind but also considering the New Testament. (shrink)

The emerging critique of alternative food networks (AFNs) points to several factors that could impede the participation of low-income, minority communities in the movement, namely, spatial and temporal constraints, and the lack of economic, cultural, and human capital. Based on a semi-experimental study that offers 6 weeks of free produce to 31 low-income African American households located in a New Orleans food desert, this article empirically examines the significance of the impeding factors identified by previous scholarship, through participant surveys before, (...) during, and after the program. Our results suggest economic constraints are more influential in determining where the participants shop for food than spatial and temporal constraints, and the study participants exhibit high levels of human and cultural capital regarding the purchase and consumption of locally grown produce. We also find them undeterred by the market’s predominantly White, middle-class cultural social space, which leads us to question the extent to which cultural exclusivity discourages their participation in AFNs. For all five factors we find that the constraints posed to accessing the local food market were not universal but varied among the participants. Finally, the study reveals some localized social constraints, fragmented social ties in particular, as a possible structural hurdle to engaging these residents in the alternative market in their neighborhood. Conclusions point to the need for a multi-dimensional and dynamic conceptualization of “food access.”. (shrink)

The psychological gap based on distrust and mutual ignorance between the Islamic world and the rest of the world, including Japan, has never been wider than it is today. Some might think that Islamic and other civilizations share little common ground in terms of basic values concerning humanity. Some even claim that “the clash of civilizations” is inevitable. However, it is too early to conclude that these civilizations will always be in conflict with each other. Although their theological interpretations of (...) God and the teachings of their religions show clear contrasts, there might be some common values that they can share in social life. One of the most prestigious and well-known Islamic boarding schools or Pesantren in Indonesia, Al-Mukumin of Solo in Central Java, offers fundamentalist education. Yet, the students in this school still learn about the importance of co-existence with non-Muslims through social activities and classroom instructions. Multiculturalism and the appreciation of non-Muslims are clearly emphasised in the curriculum. Based on the field research conducted in January 2013, I will attempt to picture the state of Islamic education in Indonesia and identify some values common to Islamic and other civilizations, such as Western and Japanese. (shrink)