Results for 'incidental findings'

979 found
Order:
  1.  22
    Reporting incidental findings from non-biological assessments in human subject research.Alyssa Pingitore, Ashley Mack, Justin Zhang, Eric G. Devine, Jackson Doerr & Caroline Denneen - 2022 - Research Ethics 18 (3):241-249.
    Incidental findings in research with human participants may have implications for a person’s present health or future health outcomes. Current guidelines focus on methods for handling and reporting incidental findings from biological test data but incidental findings might also arise from non-biological tests. This article presents three examples in which the results from non-biological test data can be predictive of future disease and should be disclosed to research participants. It is intended to increase awareness (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  2.  76
    Understanding Incidental Findings in the Context of Genetics and Genomics.Mildred K. Cho - 2008 - Journal of Law, Medicine and Ethics 36 (2):280-285.
    Human genetic and genomic research can yield information that may be of clinical relevance to the individuals who participate as subjects of the research. However, no consensus exists as yet on the responsibilities of researchers to disclose individual research results to participants in human subjects research. “Genetic and genomic research” on humans varies widely, including association studies, examination of allele frequencies, and studies of natural selection, human migration, and genetic variation. For the purposes of this article, it is defined broadly (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   11 citations  
  3.  5
    Incidental Findings In Neuroscience Research: A Fundamental Challenge To The Structure Of Bioethics And Health Law.Susan M. Wolf - 2013 - In Judy Illes & Barbara J. Sahakian (eds.), Oxford Handbook of Neuroethics. Oxford University Press.
    The problem of incidental findings in human subjects research—findings of potential health importance to the research participant that the researcher stumbles upon while pursuing the aims of the research—may at first seem of minor significance. The number and potential gravity of incidental findings force researchers to face difficult questions. The most fundamental of these is whether researchers have any duty to identify, evaluate, and disclose these findings to the research participant. This is a profound (...)
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  4.  27
    Incidental Findings in CT Colonography: Literature Review and Survey of Current Research Practice.Hassan Siddiki, J. G. Fletcher, Beth McFarland, Nora Dajani, Nicholas Orme, Barbara Koenig, Marguerite Strobel & Susan M. Wolf - 2008 - Journal of Law, Medicine and Ethics 36 (2):320-331.
    Incidental fndings of potential medical signifcance are seen in approximately 5-8 percent of asymptomatic subjects and 16 percent of symptomatic subjects participating in large computed tomography colonography studies, with the incidence varying further by CT acquisition technique. While most CTC research programs have a well-defned plan to detect and disclose IFs, such plans are largely communicated only verbally. Written consent documents should also inform subjects of how IFs of potential medical signifcance will be detected and reported in CTC research (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  5.  40
    Incidental Findings in Low‐Resource Settings.Haley K. Sullivan & Benjamin E. Berkman - 2018 - Hastings Center Report 48 (3):20-28.
    Much new global genetic research employs whole genome sequencing, which provides researchers with large amounts of data. The quantity of data has led to the generation and discovery of more incidental or secondary findings and to vigorous theoretical discussions about the ethical obligations that follow from these incidental findings. After a decade of debate in the genetic research community, there is a growing consensus that researchers should, at the very least, offer to return incidental (...) that provide high‐impact, medically relevant information, when it is not unduly burdensome to the research enterprise to do so. Much as genetic research has been limited to U.S. and European settings, the incidental findings debate has primarily focused on research conducted in high‐income countries. In a 2015 paper, Alberto Ortiz‐Osorno, Linda Ehler, and Judith Brooks note salient differences between the circumstances of research participants in low‐ and high‐resource settings that alter the analysis of when and why incidental findings should be offered to research participants. In this article, we expand on their analysis and present a framework for thinking about how investigators’ obligations to return genomic data might change in low‐resource settings, particularly in settings where participants do not have access to the medical care needed to treat, assess, or monitor incidental findings that are actionable in settings with plentiful resources. (shrink)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   11 citations  
  6.  51
    Incidental Finding of Tumor While Investigating Subarachnoid Hemorrhage: Ethical Considerations and Practical Strategies.Doniel Drazin, Kevin Spitler, Milos Cekic, Ashish Patel, George Hanna, Ali Shirzadi & Ray Chu - 2013 - Science and Engineering Ethics 19 (3):1107-1120.
    High-resolution neuroimaging modalities are used often in studies involving healthy volunteers. Subsequently, a significant increase in the incidental discovery of asymptomatic intracranial abnormalities raised the important ethical issues of when follow-up and treatment may be necessary. We examined the literature to establish a practical set of criteria for approaching incidental findings. Our objective is to develop an algorithm for when follow-up may be important and to provide recommendations that would increase the likelihood of follow-up. A systematic literature (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  7.  45
    Incidental Findings in Genetics Research Using Archived DNA.Ellen Wright Clayton - 2008 - Journal of Law, Medicine and Ethics 36 (2):286-291.
    There are countless variations on this theme. The call can come from one of your own physicians who was called by the investigator. Your physician may or may not be well informed on what the reported finding about Disease Y means or how to respond. DNA testing can reveal more than susceptibility to disease. People can learn that they do not have the biological connections — parentage or evidence of ethnic origin — that they thought they did.Colleagues who serve on (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  8.  18
    Incidental Findings from Deep Phenotyping Research in Psychiatry: Legal and Ethical Considerations.Amanda Kim, Michael Hsu, Amanda Koire & Matthew L. Baum - 2022 - Cambridge Quarterly of Healthcare Ethics 31 (4):482-486.
    Substantial advancement in the diagnosis and treatment of psychiatric disorders may come from assembling diverse data streams from clinical notes, neuroimaging, genetics, and real-time digital footprints from smartphones and wearable devices. This is called “deep phenotyping” and often involves machine learning. We argue that incidental findings arising in deep phenotyping research have certain special, morally and legally salient features: They are specific, actionable, numerous, and probabilistic. We consider ethical and legal implications of these features and propose a practical (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  9. Managing Incidental Findings in Human Subjects Research: Analysis and Recommendations.Susan M. Wolf, Frances P. Lawrenz, Charles A. Nelson, Jeffrey P. Kahn, Mildred K. Cho, Ellen Wright Clayton, Joel G. Fletcher, Michael K. Georgieff, Dale Hammerschmidt, Kathy Hudson, Judy Illes, Vivek Kapur, Moira A. Keane, Barbara A. Koenig, Bonnie S. LeRoy, Elizabeth G. McFarland, Jordan Paradise, Lisa S. Parker, Sharon F. Terry, Brian Van Ness & Benjamin S. Wilfond - 2008 - Journal of Law, Medicine and Ethics 36 (2):219-248.
    No consensus yet exists on how to handle incidental fnd-ings in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are fndings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   123 citations  
  10.  91
    Incidental Findings and Ancillary-Care Obligations.Henry S. Richardson - 2008 - Journal of Law, Medicine and Ethics 36 (2):256-270.
    This paper explores the convergence of two recent and growing streams of bioethical work and concern. Each has originated independently, but each arises from the fact that the Common Rule that has shaped medical research ethics, as institutionalized in the United States and also abroad, is largely silent about what needs to be done in response to researchers’ positive obligations. One stream concerns what to do about the sometimes vast range of findings that may arise incidentally to performing research (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   31 citations  
  11.  55
    Incidental Findings in the Era of Whole Genome Sequencing?Erik Parens, Paul Appelbaum & Wendy Chung - 2013 - Hastings Center Report 43 (4):16-19.
    The rise of technologies that can inexpensively sequence entire genomes means that researchers and clinicians have access to ever vaster stores of genomic data, some of which could be of great use to research participants or patients, and most of which, at least for today, will be of little, uncertain, or no use. Those facts are essential features of a new ethical territory we are now entering with genetics research. As we explore that territory, we should try to be as (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  12.  43
    Incidental Findings in Human Subjects Research: What Do Investigators Owe Research Participants?Franklin G. Miller, Michelle M. Mello & Steven Joffe - 2008 - Journal of Law, Medicine and Ethics 36 (2):271-279.
    The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental fndings discovered in the course of research. In this article, we argue that investigators have an obligation to respond to incidental fndings in view of their entering into a professional relationship with research participants in which they are granted privileged access to private information with potential relevance to participants' health. We discuss the scope and (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   33 citations  
  13.  25
    Returning Incidental Findings in Low‐Resource Settings: A Case of Rescue?Douglas Mackay - 2018 - Hastings Center Report 48 (3):28-30.
    In a carefully argued article, Haley K. Sullivan and Benjamin E. Berkman address the important question of whether investigators have a duty to report incidental findings to research participants in low‐resource settings. They suggest that the duty to rescue offers the most plausible justification for the duty to return incidental findings, and they explore the implications of this duty for the context of research in low‐resource settings. While I think they make valuable headway on an important (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  14.  45
    Incidental Findings in Magnetic Resonance Imaging (MRI) Brain Research.Charles A. Nelson - 2008 - Journal of Law, Medicine and Ethics 36 (2):315-319.
    Magnetic resonance imaging is a noninvasive imaging tool that utilizes a strong magnetic field and radio frequency waves to visualize in great detail organs, soft tissue, and bone. Unlike conventional x-rays, there is no exposure to ionizing radiation and at most field strengths the procedure is considered safe for nearly every age group. Because it is non-invasive and possesses excellent spatial resolution, the use of MRI as a research tool has increased exponentially over the past decade. Uses have ranged from (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  15.  52
    Freedom of Choice About Incidental Findings Can Frustrate Participants' True Preferences.Jennifer Viberg, Pär Segerdahl, Sophie Langenskiöld & Mats G. Hansson - 2015 - Bioethics 30 (3):203-209.
    Ethicists, regulators and researchers have struggled with the question of whether incidental findings in genomics studies should be disclosed to participants. In the ethical debate, a general consensus is that disclosed information should benefit participants. However, there is no agreement that genetic information will benefit participants, rather it may cause problems such as anxiety. One could get past this disagreement about disclosure of incidental findings by letting participants express their preferences in the consent form. We argue (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  16.  67
    Incidental Findings in Pediatric Research.Benjamin S. Wilfond & Katherine J. Carpenter - 2008 - Journal of Law, Medicine and Ethics 36 (2):332-340.
    Incidental research findings, as defined in this symposium’s consensus paper, are unexpected findings discovered in the course of research but “beyond the aims of the study.” These include findings generated by research methodology, such as imaging or genetic analysis, findings related to clinical screening for inclusion or exclusion, or direct observations of physical abnormalities or behavior. Decisions about managing incidental research findings involve important ethical considerations regarding a researcher’s obligations to provide care, minimize (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   7 citations  
  17.  20
    A Just Standard: The Ethical Management of Incidental Findings in Brain Imaging Research.Mackenzie Graham, Nina Hallowell & Julian Savulescu - 2021 - Journal of Law, Medicine and Ethics 49 (2):269-281.
    Neuroimaging research regularly yields “incidental findings”: observations of potential clinical significance in healthy volunteers or patients, but which are unrelated to the purpose or variables of the study.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  18.  30
    Genomic Incidental Findings: Reducing the Burden to Be Fair.Velizara Anastasova, Alessandro Blasimme, Sophie Julia & Anne Cambon-Thomsen - 2013 - American Journal of Bioethics 13 (2):52-54.
  19.  73
    Returning incidental findings from genetic research to children: views of parents of children affected by rare diseases.Erika Kleiderman, Bartha Maria Knoppers, Conrad V. Fernandez, Kym M. Boycott, Gail Ouellette, Durhane Wong-Rieger, Shelin Adam, Julie Richer & Denise Avard - 2014 - Journal of Medical Ethics 40 (10):691-696.
  20.  42
    The Challenge of Incidental Findings.Susan M. Wolf - 2008 - Journal of Law, Medicine and Ethics 36 (2):216-218.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   10 citations  
  21.  46
    (2 other versions)Incidental findings of uncertain significance: To know or not to know - that is not the question.Bjørn Hofmann - forthcoming - Most Recent Articles: Bmc Medical Ethics.
    Although the “right not to know” is well established in international regulations, it has been heavily debated. Ubiquitous results from extended exome and genome analysis have challenged the right not to know...
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  22.  1
    Far from Home: Managing Incidental Findings in Field Research with Portable MRI.Susan M. Wolf & Judy Illes - 2024 - Journal of Law, Medicine and Ethics 52 (4):805-815.
    Portable MRI for neuroimaging research in remote field settings can reach populations previously excluded from research, including communities underrepresented in current brain neuroscience databases and marginalized in health care. However, research conducted far from a medical institution and potentially in populations facing barriers to health care access raises the question of how to manage incidental findings (IFs) that may warrant clinical workup. Researchers should not withhold information about IFs from historically excluded and underserved population when members consent to (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  23.  71
    Disclosing neuroimaging incidental findings: a qualitative thematic analysis of health literacy challenges.Caitlin E. Rancher, Jody M. Shoemaker, Linda E. Petree, Mark Holdsworth, John P. Phillips & Deborah L. Helitzer - 2016 - BMC Medical Ethics 17 (1):58.
    BackgroundReturning neuroimaging incidental findings may create a challenge to research participants’ health literacy skills as they must interpret and make appropriate healthcare decisions based on complex radiology jargon. Disclosing IF can therefore present difficulties for participants, research institutions and the healthcare system. The purpose of this study was to identify the extent of the health literacy challenges encountered when returning neuroimaging IF. We report on findings from a retrospective survey and focus group sessions with major stakeholders involved (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  24.  23
    Incidental Findings in Public Health Research: The Importance of Maintaining Trust.Tabitha E. H. Moses - 2020 - American Journal of Bioethics 20 (10):70-72.
    Volume 20, Issue 10, October 2020, Page 70-72.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  25.  52
    The Law of Incidental Findings in Human Subjects Research: Establishing Researchers' Duties.Susan M. Wolf, Jordan Paradise & Charlisse Caga-Anan - 2008 - Journal of Law, Medicine and Ethics 36 (2):361-383.
    Technology has outpaced the capacity of researchers performing research on human participants to interpret all data generated and handle those data responsibly. This poses a critical challenge to existing rules governing human subjects research. The technologies used in research to generate images, scans, and data can now produce so much information that there is significant potential for incidental findings, findings generated in the course of research but beyond the aims of the study. Neuroimaging scans may visualize the (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   11 citations  
  26.  29
    The Impact of Incidental Findings Detected During Brain Imaging on Research Participants of the Rotterdam Study: An Interview Study.Charlotte H. C. Bomhof, Lisa van Bodegom, Meike W. Vernooij, Wim Pinxten, Inez D. de Beaufort & Eline M. Bunnik - 2020 - Cambridge Quarterly of Healthcare Ethics 29 (4):542-556.
    This interview study investigates the short- and long-term implications of incidental findings detected through brain imaging on research participants’ lives and their surroundings. For this study, nine participants of the Rotterdam Scan Study with an incidental finding were approached and interviewed. When examining research participants’ narratives on the impact of the disclosure of incidental findings, the authors identified five sets of tensions with regard to motivations for and expectations of research participation, preferences regarding disclosure, short- (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  27.  62
    Managing Incidental Findings: Lessons From Neuroimaging.Emily Borgelt, James A. Anderson & Judy Illes - 2013 - American Journal of Bioethics 13 (2):46-47.
  28.  51
    Models of Consent to Return of Incidental Findings in Genomic Research.Paul S. Appelbaum, Erik Parens, Cameron R. Waldman, Robert Klitzman, Abby Fyer, Josue Martinez, W. Nicholson Price & Wendy K. Chung - 2014 - Hastings Center Report 44 (4):22-32.
    Genomic research—including whole genome sequencing and whole exome sequencing—has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research—historically referred to as “incidental findings”—has generated considerable discussion as to how this information should be handled—that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of “the procedures to (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   7 citations  
  29.  25
    Disclosing Incidental Findings in Mental Health Research.Tamra Lysaght - 2013 - Asian Bioethics Review 5 (3):271-273.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  30.  11
    Management of Incidental Findings from Genetic Tests: Perspectives of Ethics Committee Members.Leigh Jackson Lesley Goldsmith - 2015 - Journal of Clinical Research and Bioethics 6 (3).
    Direct download  
     
    Export citation  
     
    Bookmark  
  31.  51
    Genomic Research and Incidental Findings.Brian Van Ness - 2008 - Journal of Law, Medicine and Ethics 36 (2):292-297.
    Medical practice is poised to incorporate genomescale testing into treatment decisions. However, broad genome testing in laboratories may lead to discoveries not anticipated, yet highly significant to the health of the patient. Understanding the complexity of our genome and its relationship to our health is an overwhelming task. Currently, much of the effort to unravel this complexity is in the realm of research. However, researchers are often neither qualified nor prepared to deal with incidental findings of genetic abnormalities (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  32.  39
    Ethical signposts for clinical geneticists in secondary variant and incidental finding disclosure discussions.Gabrielle M. Christenhusz, Koenraad Devriendt, Hilde Van Esch & Kris Dierickx - 2015 - Medicine, Health Care and Philosophy 18 (3):361-370.
    While ethical and empirical interest in so-called secondary variants and incidental findings in clinical genetics contexts is growing, critical reflection on the ethical foundations of the various recommendations proposed is thus far largely lacking. We examine and critique the ethical justifications of the three most prominent disclosure positions: briefly, the clinical geneticist decides, a joint decision, and the patient decides. Subsequently, instead of immediately developing a new disclosure option, we explore relevant foundational ethical values and norms, drawing on (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  33.  27
    Incidental Findings: Patients’ Knowledge, Rights, and Preferences.Lisa S. Parker & Rachel Ankeny Majeske - 1995 - Journal of Clinical Ethics 6 (2):176-179.
  34.  52
    An implementation framework for the feedback of individual research results and incidental findings in research.Adrian Thorogood, Yann Joly, Bartha Maria Knoppers, Tommy Nilsson, Peter Metrakos, Anthoula Lazaris & Ayat Salman - 2014 - BMC Medical Ethics 15 (1):88.
    This article outlines procedures for the feedback of individual research data to participants. This feedback framework was developed in the context of a personalized medicine research project in Canada. Researchers in this domain have an ethical obligation to return individual research results and/or material incidental findings that are clinically significant, valid and actionable to participants. Communication of individual research data must proceed in an ethical and efficient manner. Feedback involves three procedural steps: assessing the health relevance of a (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   7 citations  
  35.  32
    The views of ethics committee members and medical researchers on the return of individual research results and incidental findings, ownership issues and benefit sharing in biobanking research in a South Indian city.Manjulika Vaz, Mario Vaz & Srinivasan K. - 2018 - Developing World Bioethics:321-330.
    The return of individual research results and incidental findings from biobanking research is a much debated ethical issue globally but has extensive relevance in India where the burden of out of pocket health care expenses is high for the majority. The views of 21 ethics committee (EC) members and 22 researchers from Bengaluru, India, concerning the ethics of biobanking research were sought through in‐depth interviews using an unfolding case vignette with probes. A shared view among most was that (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   5 citations  
  36.  63
    The Management of Incidental Findings in Neuro-Imaging Research: Framework and Recommendations.Erica K. Rangel - 2010 - Journal of Law, Medicine and Ethics 38 (1):117-126.
    This paper addresses the question of how incidental findings in clinical research should be managed by researchers, focusing in detail on IFs discovered in neuroimaging research. It begins by engaging the larger research ethics issue of whether researchers have any obligations of clinical care to participants, and assesses the content and merits of one particular framework for answering this question, Richardson and Belsky's ancillary care model. From here the paper develops an organizational structure for integrating the ancillary care (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  37. A New Challenge for Research Ethics: Incidental Findings in Neuroimaging.Bert Heinrichs - 2011 - Journal of Bioethical Inquiry 8 (1):59-65.
    It has become evident that neuroimaging raises new normative questions that cannot be addressed adequately within the (in this regard unspecific) frameworks of existing research ethics. Questions that are especially troubling are, among others, provoked by incidental findings. Two questions are particularly intricate in view of incidental findings: (1) How can the research subject’s right not to know be guaranteed? And (2) should a diagnostic check of scans by a neuroradiologist become an obligatory part of neuroscientific (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  38.  47
    The Future of Incidental Findings: Should They be Viewed as Benefits?Lisa S. Parker - 2008 - Journal of Law, Medicine and Ethics 36 (2):341-351.
    This paper argues against considering incidental fndings as potential benefts of research when assessing the social value of proposed research, determining the appropriateness of a study's risk/beneft ratio, and identifying and disclosing the risks and benefts of participation during informed consent. The possibility of generating IFs should be disclosed during informed consent as neither a risk nor beneft, but as a possible outcome collateral to participation. Whether specifc IFs will be disclosed when identifed is a separate question whose answer (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   8 citations  
  39.  49
    Critical social theory approach to disclosure of genomic incidental findings.Jeffrey L. Bevan, Julia N. Senn-Reeves, Ben R. Inventor, Shawna M. Greiner, Karen M. Mayer, Mary T. Rivard & Rebekah J. Hamilton - 2012 - Nursing Ethics 19 (6):819-828.
    Technology has expanded genomic research and the complexity of extracted gene-related information. Health-related genomic incidental findings pose new dilemmas for nurse researchers regarding the ethical application of disclosure to participants. Consequently, informed consent specific to incidental findings is recommended. Critical Social Theory is used as a guide in recognition of the changing meaning of informed consent and to serve as a framework to inform nursing of the ethical application of disclosure consent in genomic nursing research practices.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  40.  32
    Ubuntu philosophy and the consensus regarding incidental findings in genomic research: a heuristic approach.Cornelius Ewuoso - 2020 - Medicine, Health Care and Philosophy 23 (3):433-444.
    This study adopts a heuristic technique to argue the thesis that a set of norms rooted in the African philosophy of Ubuntu can usefully supplement current research guidelines for dealing with incidental findings discovered in genomic research. The consensus regarding incidental findings is that there is an ethical obligation to return individual genetic incidental findings that meet the threshold of analytic and clinical validity, have clinical utility, and are actionable, provided that research contributors have (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   6 citations  
  41.  53
    Do Researchers Have an Obligation to Actively Look for Genetic Incidental Findings?Catherine Gliwa & Benjamin E. Berkman - 2013 - American Journal of Bioethics 13 (2):32-42.
    The rapid growth of next-generation genetic sequencing has prompted debate about the responsibilities of researchers toward genetic incidental findings. Assuming there is a duty to disclose significant incidental findings, might there be an obligation for researchers to actively look for these findings? We present an ethical framework for analyzing whether there is a positive duty to look for genetic incidental findings. Using the ancillary care framework as a guide, we identify three main criteria (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   21 citations  
  42. Empirical Analysis of Current Approaches to Incidental Findings.Frances Lawrenz & Suzanne Sobotka - 2008 - Journal of Law, Medicine and Ethics 36 (2):249-255.
    Researchers in the health sciences regularly discover information of potential health importance unrelated to their object of study in the course of their research. However, there appears to be little guidance available on what researchers should do with this information, known in the scientific literature as incidental findings. The study described here was designed to determine the extent of guidance available to researchers from public sources. This empirical study was part of a larger two-year project funded by the (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   10 citations  
  43.  76
    Ethical framework for the detection, management and communication of incidental findings in imaging studies, building on an interview study of researchers’ practices and perspectives.Eline M. Bunnik, Lisa van Bodegom, Wim Pinxten, Inez D. de Beaufort & Meike W. Vernooij - 2017 - BMC Medical Ethics 18 (1):10.
    As thousands of healthy research participants are being included in small and large imaging studies, it is essential that dilemmas raised by the detection of incidental findings are adequately handled. Current ethical guidance indicates that pathways for dealing with incidental findings should be in place, but does not specify what such pathways should look like. Building on an interview study of researchers’ practices and perspectives, we identified key considerations for the set-up of pathways for the detection, (...)
    Direct download (8 more)  
     
    Export citation  
     
    Bookmark   5 citations  
  44.  40
    Stakeholder Opinions and Ethical Perspectives Support Complete Disclosure of Incidental Findings in MRI Research.John P. Phillips, Caitlin Cole, John P. Gluck, Jody M. Shoemaker, Linda E. Petree, Deborah L. Helitzer, Ronald M. Schrader & Mark T. Holdsworth - 2015 - Ethics and Behavior 25 (4):332-350.
    How far does a researcher’s responsibility extend when an incidental finding is identified? Balancing pertinent ethical principles such as beneficence, respect for persons, and duty to rescue is not always straightforward, particularly in neuroimaging research where empirical data that might help guide decision making are lacking. We conducted a systematic survey of perceptions and preferences of 396 investigators, research participants, and Institutional Review Board members at our institution. Using the partial entrustment model as described by Richardson, we argue that (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  45.  22
    Considering Actionability at the Participant's Research Setting Level for Anticipatable Incidental Findings from Clinical Research.Alberto Ortiz-Osorno, Linda A. Ehler & Judith Brooks - 2015 - Journal of Law, Medicine and Ethics 43 (3):619-632.
    Determining what constitutes an anticipatable incidental finding from clinical research and defining whether, and when, this IF should be returned to the participant have been topics of discussion in the field of human subject protections for the last 10 years. It has been debated that implementing a comprehensive IF-approach that addresses both the responsibility of researchers to return IFs and the expectation of participants to receive them can be logistically challenging. IFs have been debated at different levels, such as (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   7 citations  
  46.  21
    Shining a Light also Casts a Shadow: Neuroimaging Incidental Findings in Neuromarketing Research.Owen M. Bradfield - 2021 - Neuroethics 14 (3):459-465.
    Rapid growth in structural and functional brain research has led to increasing ethical discussion of what to do about incidental findings within the brains of healthy neuroimaging research participants that have potential health importance, but which are beyond the original aims of the study. This dilemma has been widely debated with respect to general neuroimaging research but has attracted little attention in the context of neuromarketing studies. In this paper, I argue that neuromarketing researchers owe participants the same (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  47.  48
    The Risks and Benefits of Searching for Incidental Findings in MRI Research Scans.Jason M. Royal & Bradley S. Peterson - 2008 - Journal of Law, Medicine and Ethics 36 (2):305-314.
    The question of how to handle incidental findings has sparked a heated debate among neuroimaging researchers and medical ethicists, a debate whose urgency stems largely from the recent explosion in the number of imaging studies being conducted and in the sheer volume of scans being acquired. Perhaps the point of greatest controversy within this debate is whether the magnetic resonance imaging scans of all research participants should be reviewed in an active search for pathology and, moreover, whether this (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   11 citations  
  48.  18
    To disclose, or not to disclose? Perspectives of clinical genomics professionals toward returning incidental findings from genomic research.Saleh AlGhamdi, Amani Abu-Shaheen, Mohamad Al-Tannir & Isamme AlFayyad - 2021 - BMC Medical Ethics 22 (1):1-8.
    BackgroundClinical genomic professionals are increasingly facing decisions about returning incidental findings (IFs) from genetic research. Although previous studies have shown that research participants are interested in receiving IFs, yet there has been an argument about the extent of researcher obligation to return IFs. We aimed in this study to explore the perspectives of clinical genomics professionals toward returning incidental findings from genomic research.MethodsWe conducted a national survey of a sample (n = 113) of clinical genomic professionals (...)
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  49.  23
    A Social Constructivism Decision-Making Approach to Managing Incidental Findings in Neuroimaging Research.Marcie L. King - 2018 - Ethics and Behavior 28 (5):393-410.
    Functional magnetic resonance imaging is a powerful tool used in cognitive neuroscientific research. fMRI is noninvasive, safe, and relatively accessible, making it an ideal method to draw inferences about the brain–behavior relationship. When conducting fMRI research, scientists must consider risks associated with brain imaging. In particular, the risk of potentially identifying an abnormal brain finding in an fMRI research scan poses a complex problem that researchers should be prepared to address. This article illustrates how a social constructivism decision-making model can (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  50.  40
    On the Justifiability of ACMG Recommendations for Reporting of Incidental Findings in Clinical Exome and Genome Sequencing.Thomas May - 2015 - Journal of Law, Medicine and Ethics 43 (1):134-142.
    This paper examines three possible justifications for original ACMG recommendations to return incidental findings from whole exome or genome sequencing independent of patient preferences. The first two potential justifications, based on a patient's authentic values, then on harms to others, are founding lacking as a basis of justification for these recommendations. The third, grounded in analogous professional practices, might serve as a potential justification if several controversies can be avoided. However, given the nature of these controversies and the (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
1 — 50 / 979