Results for 'phosphatase inhibition'

982 found
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  1.  21
    Cracking the ANP32 whips: Important functions, unequal requirement, and hints at disease implications.Patrick T. Reilly, Yun Yu, Ali Hamiche & Lishun Wang - 2014 - Bioessays 36 (11):1062-1071.
    The acidic (leucine‐rich) nuclear phosphoprotein 32 kDa (ANP32) family is composed of small, evolutionarily conserved proteins characterized by an N‐terminal leucine‐rich repeat domain and a C‐terminal low‐complexity acidic region. The mammalian family members (ANP32A, ANP32B, and ANP32E) are ascribed physiologically diverse functions including chromatin modification and remodelling, apoptotic caspase modulation, protein phosphatase inhibition, as well as regulation of intracellular transport. In addition to reviewing the widespread literature on the topic, we present a concept of the ANP32s as having (...)
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  2. What's Old Is New Again: Kemeny-Oppenheim Reduction at Work in Current Molecular Neuroscience.Kari Theurer & John Bickle - 2013 - Philosophia Scientiae 17 (2):89-113.
    We introduce a new model of reduction inspired by Kemeny and Oppenheim’s model [Kemeny & Oppenheim 1956] and argue that this model is operative in a “ruthlessly reductive” part of current neuroscience. Kemeny and Oppenheim’s model was quickly rejected in mid-20th-century philosophy of science and replaced by models developed by Ernest Nagel and Kenneth Schaffner [Nagel 1961], [Schaffner 1967]. We think that Kemeny and Oppenheim’s model was correctly rejected, given what a “theory of reduction” was supposed to account for at (...)
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  3.  27
    Good fungi gone bad: The corruption of calcineurin.Deborah S. Fox & Joseph Heitman - 2002 - Bioessays 24 (10):894-903.
    Calcineurin is a Ca2+/calmodulin‐activated protein phosphatase that is conserved in eukaryotes, from yeast to humans, and is the conserved target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. Genetic studies in yeast and fungi established the molecular basis of calcineurin inhibition by the cyclophilin A–CsA and FKBP12–FK506 complexes. Calcineurin also functions in fungi to control a myriad of physiological processes including cell cycle progression, cation homeostasis, and morphogenesis. Recent investigations into the molecular mechanisms of pathogenesis in Candida (...)
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  4.  14
    Protein Phosphorylation Dynamics: Unexplored Because of Current Methodological Limitations.Alain Robichon - 2020 - Bioessays 42 (4):1900149.
    The study of intrinsic phosphorylation dynamics and kinetics in the context of complex protein architecture in vivo has been challenging: Method limitations have prevented significant advances in the understanding of the highly variable turnover of phosphate groups, synergy, and cooperativity between P‐sites. However, over the last decade, powerful analytical technologies have been developed to determine the full catalog of the phosphoproteome for many species. The curated databases of phospho sites found by mass spectrometry analysis and the computationally predicted sites based (...)
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  5.  40
    Peptide drugs accelerate BMP‐2‐induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling. [REVIEW]Yasutaka Sugamori, Setsuko Mise-Omata, Chizuko Maeda, Shigeki Aoki, Yasuhiko Tabata, Ramachandran Murali, Hisataka Yasuda, Nobuyuki Udagawa, Hiroshi Suzuki, Masashi Honma & Kazuhiro Aoki - 2016 - Bioessays 38 (8):717-725.
    Both W9 and OP3‐4 were known to bind the receptor activator of NF‐κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor, which was recently demonstrated to be an important serine/threonine kinase for bone formation, inhibited the peptide‐induced alkaline phosphatase activity. Furthermore, both peptides promoted the phosphorylation of Akt and S6K1, an upstream (...)
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  6.  12
    Inhibition modulated by self-efficacy: An event-related potential study.Hong Shi - 2022 - Frontiers in Psychology 13.
    Inhibition, associated with self-efficacy, enables people to control thought and action and inhibit disturbing stimulus and impulsion and has certain evolutionary significance. This study analyzed the neural correlates of inhibition modulated by self-efficacy. Self-efficacy was assessed by using the survey adapted from the Motivated Strategies for Learning Questionnaire. Fifty college students divided into low and high self-efficacy groups participated in the experiments. Their ability to conduct inhibitory control was studied through Go/No-Go tasks. During the tasks, we recorded students’ (...)
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  7.  40
    Conditioned inhibition of the rabbit's nictitating membrane response.Horace G. Marchant, Frederick W. Mis & John W. Moore - 1972 - Journal of Experimental Psychology 95 (2):408.
  8.  32
    Proactive inhibition of a Maze position habit.Richard J. Koppenaal & Eleanor Jagoda - 1968 - Journal of Experimental Psychology 76 (4p1):664.
  9.  26
    Mechanisms regulating phosphatase specificity and the removal of individual phosphorylation sites during mitotic exit.Samuel Rogers, Rachael McCloy, D. Neil Watkins & Andrew Burgess - 2016 - Bioessays 38 (S1):24-32.
    Entry into mitosis is driven by the activity of kinases, which phosphorylate over 7000 proteins on multiple sites. For cells to exit mitosis and segregate their genome correctly, these phosphorylations must be removed in a specific temporal order. This raises a critical and important question: how are specific phosphorylation sites on an individual protein removed? Traditionally, the temporal order of dephosphorylation was attributed to decreasing kinase activity. However, recent evidence in human cells has identified unique patterns of dephosphorylation during mammalian (...)
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  10.  6
    Inhibition in the emotional Hayling task: can hypnotic suggestion enhance cognitive control on a prepotent negative word?Jeremy Brunel, Sandrine Delord & Stéphanie Mathey - forthcoming - Cognition and Emotion.
    Recent studies suggest that instrumental hypnosis is a useful experimental tool to investigate emotional and language processing effects. However, the capacity of hypnotic suggestions to intervene during the response inhibition of emotional words remains elusive. This study investigated whether hypnotic suggestion can improve the inhibition of prepotent negative word responses in an emotional Hayling sentence completion task. High-suggestible participants performed a computerised emotional Hayling task. They were first asked to select the appropriate words ending highly predictable sentences among (...)
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  11.  40
    Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors.Ashley A. George, Sara Hayden, Gail R. Stanton & Susan E. Brockerhoff - 2016 - Bioessays 38 (S1):119-135.
    Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected in vivo the role of SynJ1 in endolysosomal trafficking in zebrafish cone photoreceptors using a SynJ1‐deficient zebrafish mutant, nrca14. We found that loss of SynJ1 leads to specific accumulation of late endosomes (...)
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  12.  37
    Retroactive inhibition with different patterns of interpolated lists.Judith Goggin - 1968 - Journal of Experimental Psychology 76 (1p1):102.
  13.  25
    Reactive inhibition as a factor in maze learning: III. Effects in the human stylus maze.Merrell E. Thompson - 1952 - Journal of Experimental Psychology 43 (2):130.
  14. Saccadic Inhibition in Reading.Eyal M. Reingold & Dave M. Stampe - unknown
    In 5 experiments, participants read text that was briefly replaced by a transient image for 33 ms at random intervals. A decrease in saccadic frequency, referred to as saccadic inhibition, occurred as early as 60 –70 ms following the onset of abrupt changes in visual input. It was demonstrated that the saccadic inhibition was influenced by the saliency of the visual event (Experiment 3) and was not produced in response to abrupt but irrelevant auditory stimuli (Experiment 1). Display (...)
     
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  15.  23
    SHIP2 phosphatase domain structure suggests sites of regulation (retrospective on DOI 10.1002/bies.201100195).Frank Wang, Sylvia Cheung & Alice Mui - 2014 - Bioessays 36 (11):1019-1019.
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  16. Inhibition and the right inferior frontal cortex.Adam R. Aron, Trevor W. Robbins & Russell A. Poldrack - 2004 - Trends in Cognitive Sciences 8 (4):170-177.
  17.  17
    Retroactive inhibition as a function of the relative serial positions of the original and interpolated items.Arthur L. Irion - 1946 - Journal of Experimental Psychology 36 (3):262.
  18.  14
    Reactive inhibition as a function of number of response evocations.Paul S. Siegel - 1950 - Journal of Experimental Psychology 40 (5):604.
  19.  15
    Retroactive inhibition: the temporal position of interpolated activity.E. D. Sisson - 1939 - Journal of Experimental Psychology 25 (2):228.
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  20.  33
    Retroactive inhibition with bilinguals.Robert K. Young & M. Isabelle Navar - 1968 - Journal of Experimental Psychology 77 (1):109.
  21.  30
    Contact inhibition in the failure of mammalian CNS axonal regeneration.Alan R. Johnson - 1993 - Bioessays 15 (12):807-813.
    Anamniote animals, such as fish and amphibians, are able to regenerate damaged CNS nerves following injury, but regeneration in the mammalian CNS tracts, such as the optic nerve, does not occur. However, severed adult mammalian retinal axons can regenerate into peripheral nerve segments grafted into the brain and this finding has emphasized the importance of the environment in explaining regenerative failure in the adult mammalian CNS. Following lesions, regenerating axons encounter the glial cells, oligodendrocytes and astro‐cytes, and their derivatives, respectively (...)
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  22.  12
    Collaborative Inhibition: A Phenomenological Perspective.Daniel Gyollai - forthcoming - Review of Philosophy and Psychology:1-19.
    The tendency for people to remember less as members of a group than they would be capable of were they to remember alone is a phenomenon known as collaborative inhibition. The article offers a phenomenological account of this highly counterintuitive effect of group remembering. It argues that the mutual failure to live up to one’s potential does not warrant the standard, strongly negative views about the role of others in recall. Rather, the phenomenon may imply that sharedness itself becomes (...)
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  23.  22
    Inhibition: History and Meaning in the Sciences of Mind and Brain.Roger Smith - 1992 - University of California Press.
    In everyday parlance, "inhibition" suggests repression, tight control, the opposite of freedom. In medicine and psychotherapy the term is commonplace, its definition understood. Relating how inhibition—the word and the concept—became a bridge between society at large and the natural sciences of mind and brain, Smith constructs an engagingly original history of our view of ourselves. Not until the late nineteenth century did the term "inhibition" become common in English, connoting the dependency of reason and of civilization itself (...)
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  24. Cognitive Inhibition and the Conscious Assent to Truth: A Newmanian Perspective.Javier Sánchez-Cañizares - 2016 - Newman Studies Journal 13 (2):40-52.
    When must a specific cognitive habit be called upon to solve a problem? In the subject’s learning process, “knowing-to” is connected with a conscious particular judgment of truth or “aha” moment enacting a new behavioral schema. This paper comments on recent experiments supporting the view that a shift from automatic to controlled forms of inhibition, involving conscious attention, is crucial for detecting errors and activating a new strategy in complex cognitive situations. The part that consciousness plays in this process (...)
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  25.  44
    Retroactive inhibition in free recall as a function of first- and second-list organization.Graeme H. Watts & Richard C. Anderson - 1969 - Journal of Experimental Psychology 81 (3):595.
  26.  40
    The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction.Julie A. Frearson & Denis R. Alexander - 1997 - Bioessays 19 (5):417-427.
    Phosphotyrosine phosphatases (PTPases) are the enzymes which remove phosphate groups from protein tyrosine residues. An enormous number of phosphatases have been cloned and sequenced during the past decade, many of which are expressed in haematopoietic cells. This review focuses on the biochemistry and cell biology of three phosphatases, the transmembrane CD45 and the cytosolic SH2‐domain‐containing PTPases SHP‐1 and SHP‐2, to illustrate the diverse ways in which PTPases regulate receptor signal transduction. The involvement of these and other PTPases has been demonstrated (...)
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  27.  32
    Beyond inhibition: GABA synapses tune the neuroendocrine stress axis.Wataru Inoue & Jaideep S. Bains - 2014 - Bioessays 36 (6):561-569.
    We recently described a novel form of stress‐associated bidirectional plasticity at GABA synapses onto hypothalamic parvocellular neuroendocrine cells (PNCs), the apex of the hypothalamus‐pituitary‐adrenal axis. This plasticity may contribute to neuroendocrine adaptation. However, this GABA synapse plasticity likely does not translate into a simple more and less of inhibition because the ionic driving force for Cl−, the primary charge carrier for GABAA receptors, is dynamic. Specifically, stress impairs a Cl− extrusion mechanism in PNCs. This not only renders the steady‐state (...)
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  28. Inhibition in Huntington's disease.M. F. Beal, D. W. Ellison & J. B. Martin - 1987 - Journal of Mind and Behavior 8 (4):635-642.
     
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  29.  96
    Retroactive inhibition in free recall: Inaccessibility of information available in the memory store.Endel Tulving & Joseph Psotka - 1971 - Journal of Experimental Psychology 87 (1):1.
  30.  9
    Assumptions inhibiting progress in comparative biology.Brian I. Crother & Lynne R. Parenti (eds.) - 2017 - Boca Raton: CRC Press, Taylor & Francis Group.
    This book is a thought-provoking assessment of assumptions inhibiting progress in comparative biology. The volume is inspired by a list generated years earlier by Donn Rosen, one of the most influential, innovative and productive comparative biologists of the latter 20th century. His list has assumed almost legendary status among comparative evolutionary biologists. Surprisingly many of the obstructing assumptions implicated by Rosen remain relevant today. Any comparative biologist hoping to avoid such assumptions in their own research will benefit from this introspective (...)
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  31.  10
    Music, tendencies, and inhibitions: reflections on a theory of Leonard Meyer.Renee Cox Lorraine - 2001 - Lanham, Md.: Scarecrow Press.
    Leonard B. Meyer has proposed that when musical tendencies or expectations are inhibited by musical ambiguity or the unexpected, those inhibitions and their subsequent resolutions are likely to be provocative or engaging. Music, Tendencies and Inhibitions will explore the relevance of this theory to music and various other disciplines, and to psychological and natural processes. Each chapter consists of two parts: a presentation and consideration of an aspect of Meyer's theory, and a more associative or rhapsodic section of "Reflections" on (...)
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  32. GABAergic inhibition in the neocortex.K. Krnjevic - 1987 - Journal of Mind and Behavior 8 (4):537-547.
  33. Saccadic Inhibition in Voluntary and Reflexive Saccades.Eyal M. Reingold & Dave M. Stampe - unknown
    & The present study investigated saccadic inhibition in both voluntary and stimulus-elicited saccades. Two experiments examined saccadic inhibition caused by an irrelevant flash occurring subsequent to target onset. In each trial, participants were required to perform a single saccade following the presentation of a black target on a gray background, 48 to the left or to the right of screen center. In some trials (flash trials), after a variable delay, a 33-msec flash was displayed at the top and (...)
     
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  34.  37
    Retroactive inhibition of verbal associations as a multiple function of temporal point of interpolation and degree of interpolated learning.E. James Archer & Benton J. Underwood - 1951 - Journal of Experimental Psychology 42 (5):283.
  35.  16
    Latent inhibition: No effect of intertrial interval of the preexposure trials.Terry L. DeVietti & Owen V. Barrett - 1986 - Bulletin of the Psychonomic Society 24 (6):453-455.
  36. Inhibition of return-effects of attentional cueing on eye-movement latencies (vol 30, pg 483, 1992).Rs Dobkin - 1993 - Bulletin of the Psychonomic Society 31 (1):85-85.
  37.  19
    Inhibition and Updating, but Not Switching, Predict Developmental Dyslexia and Individual Variation in Reading Ability.Caoilainn Doyle, Alan F. Smeaton, Richard A. P. Roche & Lorraine Boran - 2018 - Frontiers in Psychology 9.
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  38.  21
    Conditioned inhibition of the rabbit nictitating membrane response as a function of CS-UCS interval.William J. Mahoney, Suzanne E. Kwaterski & John W. Moore - 1975 - Bulletin of the Psychonomic Society 5 (2):177-179.
  39. Presynaptic inhibition and information transmission in neuronal populations.P. Rudomin - 1992 - Behavioral and Brain Sciences 15 (4):793-794.
     
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  40.  33
    Inhibition effects of intralist repetition in free recall.Endel Tulvig & Reid Hastie - 1972 - Journal of Experimental Psychology 92 (3):297.
  41.  16
    Molecular mechanisms of durg inhibition of DNA gyrase.Richard J. Lewis, Francis T. F. Tsai & Dale B. Wigley - 1996 - Bioessays 18 (8):661-671.
    DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X‐ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA (...)
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  42.  12
    Intraserial inhibition as measured by reproduction.H. E. Peixotto - 1942 - Journal of Experimental Psychology 31 (1):17.
  43.  25
    Proactive inhibition in the recognition of nonsense syllables.Helen E. Peixotto - 1947 - Journal of Experimental Psychology 37 (1):81.
  44.  29
    Proactive inhibition in free recall.Fergus I. Craik & John Birtwistle - 1971 - Journal of Experimental Psychology 91 (1):120.
  45. Inhibition, local excitatory interactions and synchronization of epileptiform activity in hippocampal slices.F. E. Dudek & E. P. Christian - 1987 - Journal of Mind and Behavior 8 (4):619-633.
  46.  46
    Retroactive inhibition of R-S associations.Geoffrey Keppel & Benton J. Underwood - 1962 - Journal of Experimental Psychology 64 (4):400.
  47.  60
    Stimulus-category competition, inhibition, and affective devaluation: a novel account of the uncanny valley.Anne E. Ferrey, Tyler J. Burleigh & Mark J. Fenske - 2015 - Frontiers in Psychology 6:92507.
    Stimuli that resemble humans, but are not perfectly human-like, are disliked compared to distinctly human and nonhuman stimuli. Accounts of this “Uncanny Valley” effect often focus on how changes in human resemblance can evoke different emotional responses. We present an alternate account based on the novel hypothesis that the Uncanny Valley is not directly related to ‘human-likeness’ per se, but instead reflects a more general form of stimulus devaluation that occurs when inhibition is triggered to resolve conflict between competing (...)
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  48.  23
    Proactive inhibition as an effect of handedness in mirror drawing.Charles W. Simon - 1948 - Journal of Experimental Psychology 38 (6):697.
  49.  32
    Retroactive inhibition of connected discourse as a function of practice level.Norman J. Slamecka - 1960 - Journal of Experimental Psychology 59 (2):104.
  50.  22
    Studies in retroactive inhibition: XI. The influence of the relative serial positions of interpolated synonyms in twenty-item lists.J. A. McGeoch & E. D. Sisson - 1938 - Journal of Experimental Psychology 22 (6):547.
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