In this paper we examine the following problems: How many concepts of function are there in biology, social science, and technology? Are they logically related and if so, how? Which of these function concepts effect a functional explanation as opposed to a mere functional account? What are the consequences of a pluralist view of functions for functionalism? We submit that there are five concepts of function in biology, which are logically related in a particular way, and six function concepts in (...) social science and technology. Only two of them may help effect a genuine functional explanation. Finally, our synthetic approach allows us to distinguish four different varieties of functionalism in biology, psychology, social science, and technology: formalist, black boxist, adaptationist, and teleological. And only one of them is explanatory in the strong sense defended here. (shrink)

I examine the positive and negative features of synthetic biology (‘SynBio’) from a utilitarian ethical perspective. The potential beneficial outcomes from SynBio in the context of medicine are substantial; however it is not presently possible to predict precise outcomes due to the nascent state of the field. Potential negative outcomes from SynBio also exist, including iatrogenesis and bioterrorism; however it is not yet possible to quantify these risks. I argue that the application of a ‘precautionary’ approach to SynBio (...) is ethically fraught, as is the notion that SynBio-associated knowledge ought to be restricted. I conclude that utilitarians ought to support a broadly laissez-faire stance in respect of SynBio. (shrink)

This volume launches a new series of contemporary conversations about scientific classification. Most philosophical conversations about kinds have focused centrally or solely on natural kinds, that is, kinds whose existence is not dependent on the scientific process of synthesis. This volume refocuses conversations about classification on unnatural, or synthetic, kinds via extensive study of three paradigm cases of unnatural kinds: nanomaterials, stem cells, and synthetic biology.

Synthetic biologists are extremely concerned with responsible research and innovation. This paper critically assesses their culture of responsibility. Their notion of responsibility has been so far focused on the identification of risks, and in their prudential attitude synthetic biologists consider that the major risks can be prevented with technological solutions. Therefore they are globally opposed to public interference or political regulations and tend to self-regulate by bringing a few social scientists or ethicists on board. This article emphasizes that (...) ethics lies beyond prudence and requires a cultural evaluation of the modes of existence of the various microorganisms designed by synthetic biologists, independently of their potential applications. (shrink)

Although the emerging field of synthetic biology looks back on barely a decade of development, the stakes are high. It is a multidisciplinary research field that aims at integrating the life sciences with engineering and the physical/chemical sciences. The common goal is to design and construct novel biological components, functions and systems in order to implement, in a controlled way, biological devices and production systems not necessarily found in nature. Among the many potential applications are novel drugs and pesticides, (...) cancer treatments, biofuels, and new materials. According to the most optimistic visions, synthetic biology may thus lead to a biotechnological revolution by transforming microorganisms into ‘factories’ of sorts, which could eventually displace conventional industrial methods. (shrink)

This article aims to make an analysis of the cultural and anthropological issues raised by synthetic biology. The novelty of the field makes it relatively difficult to compose a comprehensive analysis, even for philosophers with experience, but who are not familiar with the specifics of the field. The article will follow the synthesis of the models of ethical decision applicable in the field of ethical evaluation of technologies from a cultural and anthropological perspective, their critical analysis and will (...) highlight the limitations of each model, as well as a possible synthesis of a model of ethical evaluation of technologies. Afterwords, it can be decided whether a particular technology - such as those involved in synthetic biology - poses risks to the environment, to those involved in research, to future generations, to humanity as a whole or to present or future ecosystems. (shrink)

Synthetic biology emerged around 2000 as a new biological discipline. It shares with systems biology the same modular vision of organisms, but is more concerned with applications than with a better understanding of the functioning of organisms. A herald of this new discipline is Craig Venter who aims to create an artificial microorganism with the minimal genome compatible with life and to implement into it different 'functional modules' to generate new micro-organisms adapted to specific tasks. Synthetic biology is (...) based on the possibilities raised by genetic engineering, but it aims to engineer organisms, and not simply to modify them, mimicking the practice of computer engineers. Three points will be discussed: In what regard does synthetic biology represent a new epistemology of the life sciences? What are the relations between synthetic biology and evolutionary biology? What is the raison d'être of synthetic biology as a discipline independent of nanotechnologies? (shrink)

Synthetic biology opens up the possibility of producing new entities not found in nature, whose classification as organisms or machines has been debated. In this paper we are focusing on the delimitation of the moral value of synthetic products, in order to establish the ethically right way to behave towards them. In order to do so, we use personalism as our ethical framework. First, we examine how we can distinguish between organisms and machines. Next, we discuss whether the (...) products of synthetic biology can be considered organisms at all and assess what their moral value is and how should we behave towards them. Finally, we discuss the hypothetical case of synthetic humans. (shrink)

The short experimental film Shifting Perspectives stems from a collaborative research project initiated in 2019 in Sydney, Australia, during the 'Choreographic Hack Lab-a week-long laboratory co-presented by Critical Path and Sydney Festival in partnership with the Museum of Applied Arts and Sciences (MAAS), which asked artists and academics to rethink and respond to the idea of the Anthropocene (Pini & George, 2019). The film was later developed in 2020 during a Responsive Residency at Critical Path, Sydney, awarded to anthropologist and (...) choreographer Sarah Pini in collaboration with Jestin George, biotechnologist and visual artist, and Melissa Ramos, visual artist and filmmaker. This work aims to open a multivocal interdisciplinary dialogue across screendance, performance and synthetic biology. Inspired by a recent conversation between two leaders in the field of synthetic biology (Sarah Richardson and Tom Knight) and their divergent approaches to working with microbial life (Agapakis, 2019), the film invites to consider how collaborating with microorganisms can reshape our future in a more-than-human world. (shrink)

Zalamea’s book is as original as it is belated. It is indeed surprising, if we give it a moment’s thought, just how greatly behind schedule philosophical reflection on contemporary mathematics lags, especially considering the momentous changes that took place in the second half of the twentieth century. Zalamea compares this situation with that of the philosophy of physics: he mentions D’Espagnat’s work on quantum mechanics, but we could add several others who, in the last few decades, have elaborated an extremely (...) timely philosophy of contemporary physics (see for example Bitbol 2000; Bitbol et al. 2009). As was the case in biology, philosophy – since Kant’s crucial observations in the Critique of Judgment, at least – has often “run ahead” of life sciences, exploring and opening up a space for reflections that are not derived from or integrated with its contemporary scientific practice. Some of these reflections are still very much auspicious today. And indeed, some philosophers today are saying something truly new about biology... (shrink)

This article presents the problem of a person skilled in the field of synthetic biology. The person skilled in the art is one of the notions which have to be revisited due to the multidisciplinary nature of synthetic biology which involves numerous fields. The article studies this problem from the perspectives of Iraqi and Malaysian patent laws. First, it conceptualizes synthetic biology and person skilled in the art. The Iraqi and Malaysian attitudes regarding person skilled in the (...) art are then addressed. Afterwards, the paper points out the multidisciplinary nature of synthetic biology. In its last part, it discusses the person skilled in synthetic biology and how patent offices and courts deal with this point. Finally, the authors submit that the use of a team of skilled persons to substitute for a single technician would render the obviousness test a subjective assessment dependent on the inventor. The level of non-obviousness would differ in similar cases simply because of the number of inventors. Consequently, the suggestion of having a hypothetical team instead of one person is irrelevant because skills that are attributed to the skilled notional person are not real skills. Thus, replacing him is easy, but the replacement would be fruitless because the skills attributed to a person or a team will be similar. (shrink)

In this essay, I discuss Dennett’s From Bacteria to Bach and Back: The Evolution of Minds and Godfrey Smith’s Other Minds: The Octopus and The Evolution of Intelligent Life from a methodological perspective. I show that these both instantiate what I call ‘synthetic philosophy.’ They are both Darwinian philosophers of science who draw on each other’s work. In what follows I first elaborate on synthetic philosophy in light of From Bacteria and Other Minds; I also explain my (...) reasons for introducing the term; and I close by looking at the function of Darwinism in contemporary synthetic philosophy. (shrink)

Through the relatively new science and technology known as synthetic biology, scientists are attempting to create useful new life forms. Any attempt to “create life” inevitably prompts some to ask whether man is trespassing into areas properly reserved for a divine creator. The potential creative power of synthetic biology raises this concern to a level that has not been known before. Thus a new chapter in the history of the relationship between science and religion is being written. This (...) article presents some of the scholarly perspectives on that chapter. (shrink)

This article is concerned with two interrelated questions: what, if anything, distinguishes synthetic from natural organisms, and to what extent, if any, creating the former is of moral significance. These are ontological and ethical questions, respectively. As the title indicates, I address both from a broadly neo-Aristotelian perspective, i.e. a teleological philosophy of life and virtue ethics. For brevity’s sake, I shall not argue for either philosophical position at length, but instead hope to demonstrate their legitimacy through their (...) explanatory power. I firstly argue that synthetic organisms differ in kind from natural organisms and machines, and differ only by degree from genetically modified organisms. I then suggest that this is nevertheless sufficient to give us specific ethical reservations about synthetic biology: namely, that more than any other widely used biotechnology, it is characterised by a drive to mastery that stands opposed to due appreciation of the giftedness of life. (shrink)

Synthetic biology presents a challenge to traditional accounts of biology: Whereas traditional biology emphasizes the evolvability, variability, and heterogeneity of living organisms, synthetic biology envisions a future of homogeneous, humanly engineered biological systems that may be combined in modular fashion. The present paper approaches this challenge from the perspective of the epistemology of technoscience. In particular, it is argued that synthetic-biological artifacts lend themselves to an analysis in terms of what has been called ‘thing knowledge’. As (...) such, they should neither be regarded as the simple outcome of applying theoretical knowledge and engineering principles to specific technological problems, nor should they be treated as mere sources of new evidence in the general pursuit of scientific understanding. Instead, synthetic-biological artifacts should be viewed as partly autonomous research objects which, qua their material-biological constitution, embody knowledge about the natural world—knowledge that, in turn, can be accessed via continuous experimental interrogation. (shrink)

The NeoSynthesis Research Centre (NSRC) was organized to promote sustainable agriculture and resource conservation in the island nation of Sri Lanka. Staffed by people with varied life and cultural backgrounds, NSRC has attempted to develop frameworks or ways of understanding agriculture from more than a single perspective. It is assumed that even a partial understanding of agriculture requires many perspectives because no single set of opinions or discourse based upon a narrow range of life experiences can account for the (...) life processes that capture and process energy through many species,H. Sapiens included. NSRC participants are expected to relate their respective disciplinary paradigms toward a synthetic approach of resource management to be demonstrated under specific environmental and social conditions. Using ecological and energetic perspectives as baseline conceptual frameworks, both scientific and non-scientific descriptions have been incorporated to provide greater understanding of the functioning of Sri Lanka's living communities. Sustainability is not promoted through sound empirical description alone. Broad community participation is required if resource and management is to be modified in any significant way. The notion of sustainability is again translated into a more political and policy language and the forums involved include the public media, administrative and legislative branches of the national government, and the civil service. Is Sri Lanka on a collision course with disaster because of heavy population pressure and irresponsible and unwise landscape management? From experiences over the past 11 years at the NSRC, the steps toward sustainability seem best cast in terms of a discovery and learning process rather than something to be invented in the abstract. (shrink)

Synthetic biology is an emerging technology that aims to design and engineer DNA and molecular structures of single cell organisms. Existing organisms can be altered, novel organisms can be created. In doing so, synthetic biology makes use of specific technoscientific understandings of living beings. This volume sets out to explore and assess synthetic biology and its notions of life from philosophical, ethical, social, and legal perspectives. Contents Concepts, Metaphors, Worldviews.- Public Good and Private Ownership.Social and Legal Ramifications.- (...) Opportunities, Risks, Governance. Target Groups Scholars of sociology, philosophy, theory of science, history of science, biology, engineering Politicians and policymakers The Editor Dr. Joachim Boldt is Deputy Director at the Institut für Ethik und Geschichte der Medizin in Freiburg, Germany. (shrink)

It has become commonplace to say that with the advent of technologies like synthetic biology the line between artifacts and living organisms, policed by metaphysicians since antiquity, is beginning to blur. But that line began to blur 10,000 years ago when plants and animals were first domesticated; and has been thoroughly blurred at least since agriculture became the dominant human subsistence pattern many millennia ago. Synthetic biology is ultimately only a late and unexceptional offshoot of this prehistoric development. (...) From this perspective, then, synthetic biology is a red herring, distracting us from more thorough philosophical consideration of the most truly revolutionary human practice—agriculture. In the first section of this paper I will make this case with regard to ontology, arguing that synthetic biology crosses no ontological lines that were not crossed already in the Neolithic. In the second section I will construct a parallel case with regard to cognition, arguing that synthetic biology as biological engineering represents no cognitive advance over what was required for domestication and the new agricultural subsistence pattern it grounds. In the final section I will make the case with regard to human existence, arguing that synthetic biology, even if wildly successful, is not in a position to cause significant existential change in what it is to be human over and above the massive existential change caused by the transition to agriculture. I conclude that a longer historical perspective casts new light on some important issues in philosophy of technology and environmental philosophy. (shrink)

In this article I discuss the ethics of synthetic biology from a broadly deontological perspective, evaluating its morality in terms of the integrity of nature, the dignity of life and the relationship between God and his creation. Most ethical analyses to date have been largely consequentialist in nature; they reveal a dual use dilemma, showing that synbio has potential for great good and great evil, possibly more so than any step humanity has taken before. A deontological analysis may (...) help to resolve this dilemma, by evaluating whether synbio is right or wrong in itself. I also assess whether deontology alone is a sufficient methodological paradigm for the proper evaluation of synbio ethics. (shrink)

This editorial introduces a special issue of Bioethics focusing on the ethical implications of synthetic biology for human health. It highlights the proactive approach of synthetic biology researchers in engaging with ethical considerations early on, hoping to avoid public backlash similar to that experienced with genetically modified foods. The editorial outlines the key ethical questions raised by synthetic biology, including its implications for the moral status of life, conceptualization of risks and benefits, and potential impacts on future (...) generations. The editorial summarizes the contributions of various authors who explore different ethical perspectives on synthetic biology. These perspectives range from examining issues of social justice and biodiversity to philosophical debates about the creation of life and the nature of health and disease. The editors aim to provide a multifaceted analysis of synthetic biology's potential benefits and concerns, ultimately hoping to inform future policy-making and public discourse about this emerging technology. (shrink)

With the development of new procedures in the production of synthetic human gametes it has become important to re-examine the manner in which reproductive cells, taking part in the generation of children, can be understood. Though this can be attempted from many different perspectives, the present study will examine the possibility of considering gametes as representing the persons from whom they originated. From this perspective, it is possible to suggest that, in procreation, the entirety of each human sperm (...) cell may represent and reveal the man from whom it was produced and the entirety of each human egg cell may represent and reveal the woman from whom it was produced.The possible ethical consequences of using synthetic gametes for those who hold this perspective together with their understanding of relational identity will also be examined. (shrink)

The aim of synthetic biology is to rationally design devices, systems, and organisms with desired innovative and useful functions (Slusarczyk, Lin, and Weiss 2012). To achieve this aim, synthetic biology uses a concept similar to engineering sciences: well-characterized and standardized modular biological building blocks are reassembled in a systematic and rational manner to generate complex devices and systems with a predicted function. In the past, molecular biological research in combination with intense work in new research areas like systems (...) biology and functional genomics revealed a large inventory of multifaceted modular biological parts that are now in the toolboxes of synthetic biologists. Due to .. (shrink)

It is a most commonly accepted hypothesis that life originated from inanimate matter, somehow being a synthetic product of organic aggregates, and as such, a result of some sort of prebiotic synthetic biology. In the past decades, the newly formed scientific discipline of synthetic biology has set ambitious goals by pursuing the complete design and production of genetic circuits, entire genomes or even whole organisms. In this paper, I argue that synthetic biology might also shed some (...) novel and interesting perspectives on the question of the origin of life, and that, in addition, it might challenge our most commonly accepted definitions of life, thereby changing the ways we might think about life and its origin. (shrink)

Synthetic biology is a new biotechnology that is developing at an impressive pace and attracting a considerable amount of attention from outside the scientific community as well. In this article, two main philosophically and ethically relevant characteristics of this field of research will be laid bare, namely its reliance on mechanistic metaphors to denominate simple forms of life and its appeal to the semantic field of creativity. It is argued that given these characteristics synthetic biology can be understood (...) as a prime example of a kind of human interference with reality that German philosopher Hannah Arendt called “fabrication.” This kind of self-world-relation contrasts to “action,” a relation that introduces, among other things, the idea of an inherent value of the object acted upon. Taking up this latter perspective, one scientific and two ethical challenges to synthetic biology’s take on the realm of life are identified. (shrink)

A recurrent theme in the characterization of synthetic biology is the role of engineering. This theme is widespread in the accounts of scholars studying this field and the biologists working in it, in those of the biologists themselves, as well as in policy documents. The aim of this article is to open this black-box of engineering that is supposed to influence and change contemporary life sciences. Too often, both synthetic biologists and their critics assume a very narrow understanding (...) of what engineering is about, resulting in an unfruitful debate about whether synthetic biology possesses genuine engineering methodologies or not. By looking in more detail to the diversity of engineering conceptions in debates concerning synthetic biology, a richer perspective can be developed. In this article, I will examine five influential ways in which engineering is understood in these debates, namely engineering as applied science, as rational methodology, context-sensitive practice, cunning activity or design. The claim is first of all thus to argue that engineering must not be seen as something stable or characterized by a fixed essence. It rather has multiple meanings and interpretations. Secondly, the claim is that most of the debates on synthetic biology cannot be indifferent towards the question which conception of engineering is at play, since the specific questions and concerns that pop up depend to a great extent on the precise conception of engineering one has in account. Many of the existing debates around synthetic biology can thus be reinterpreted and readdressed once one is aware of which conception of engineering is at play. (shrink)

To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 extracts (...) from about 200 Chinese herbs, and tested them against a mouse model of malaria. She found one extract, of the Artemisia plant, effective in mice, but she could not reproduce the results consistently. So she .. (shrink)

:This article analyzes the ethics of synthetic biology from a consequentialist perspective, examining potential effects on food and agriculture, and on medicine, fuel, and the advancement of science. The issues of biosafety and biosecurity are also examined. A consequentialist analysis offers an essential road map to policymakers and regulators as to how to deal with synbio. Additionally, the article discusses the limitations of consequentialism as a tool for analysing synbioethics. Is it possible to predict, with any degree of (...) plausibility, what the consequences of synthetic biology will be in 50 years, or in 100, or in 500? Synbio may take humanity to a place of radical departure from what is known or knowable. (shrink)

The juvenile hormones of insects regulate an unusually large diversity of processes during postembryonic development and adult reproduction. It is a long‐standing puzzle in insect developmental biology and physiology how one hormone can have such diverse effects. The search for molecular mechanisms of juvenile hormone action has been guided by classical models for hormone–receptor interaction. Yet, despite substantial effort, the search for a juvenile hormone receptor has been frustrating and has yielded limited results. We note here that a number of (...) lipid‐soluble signaling molecules in vertebrates, invertebrates and plants show curious similarities to the properties of juvenile hormones of insects. Until now, these signaling molecules have been thought of as uniquely evolved mechanisms that perform specialized regulatory functions in the taxon where they were discovered. We show that this array of lipid signaling molecules share interesting properties and suggest that they constitute a large set of signal control and transduction mechanisms that include, but range far beyond, the classical steroid hormone signaling mechanism. Juvenile hormone is the insect representative of this widespread and diverse system of lipid signaling molecules that regulate protein activity in a variety of ways. We propose a synthetic perspective for understanding juvenile hormone action in light of other lipid signaling systems and suggest that lipid activation of proteins has evolved to modulate existing signal activation and transduction mechanisms in animals and plants. Since small lipids can be inserted into many different pathways, lipid‐activated proteins have evolved to play a great diversity of roles in physiology and development. BioEssays 25:994–1001, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

We study a contemporary need to complement analytic philosophy with pendular, synthetic approaches. We provide new definitions of the dyad analytics/synthetics and complete it with a natural third, horotics. Some historical trends to support a synthetic/horotic paradigm are studied: (i) Peirce’s ideas around his logic of continuity – non Cantorian continuum and existential graphs – emphasizing the importance of mathematical gestures, (ii) Gödel’s understanding of intuitionism as a synthetic counterpart of classical logic, along with a new horotic (...) approach to his work, (iii) Contemporary mathematical achievements (1950-2000), difficult to understand from analytical philosophy perspectives. Finally, we indicate some main features that a systematical synthetic/horotic reasoning should enforce, in order to fulfill its historic sequence. (shrink)

Following Hans-Jörg Rheinberger’s epistemological concept we show how a generic element of synthetic biology, the “biological switch”, can be integrated into an experimental system. Here synthetic biology is assumed to be a technoscience. Hence, the biological switch becomes a technoscientific research object. Consequently, the experimental system has to be analyzed in a technoscientific experimental setting, showing differences in comparison with the former. To work out the specific properties of the technoscientific experimental system, biological switching behavior is compared with (...) the scientific research object laser light in its classical setting. For the analyses, both the laser light and bistability, enabling a biological switch, are considered as epistemic things connected by the same theoretical concept of phase transitions. The so-called Schlögl model is used to model both biological switching behavior and induced emission of radiation and becomes an epistemic thing in itself. It becomes clear that the answer, whether one is dealing with the emission of laser light or with bistable switching behavior, is linked to the perspective taken. The technoscientific orientation towards applications and the development of basic scientific theories require different perspectives on one and the same epistemic thing, here also represented by the model. The research objects of synthetic biology as a technoscience thus also enter into the corresponding experimental systems as techno-epistemic objects. Their analysis leads to a more complete understanding of what constitutes synthetic biology. (shrink)

Within French epistemology the question is central whether the present can be a reference point for the history of science or whether scientific practices should be understood within their own historical context. Both positions are linked with problems: either it results in a ‘whig history’ written from the perspective of the victors or it leads to the accusation of relativism and to resistance from the scientists themselves. Isabelle Stengers claims that this resistance by scientists must be considered as an (...) essential element in the historiography of the sciences. She is part of a more recent generation of French philosophers of science, who build on the work of the earlier generation but with significant differences. Stengers interprets the scientist’s work as ‘in the service of history’: everyone must be forced to recognize their work not as the product of personal construction but as a necessary discovery in the history of science. The work of the historian of science is in conflict with the aims of the scientists themselves, who want to be seen as the norm of the present by which one should read the history of science. This service of history is not some external ideological factor, but an internal part of the scientific practice itself. The construction of the difference between the discovery of a pre-given fact and the construction of a fiction is for Stengers the core of the scientific practices. This use of history will be illustrated by the case of synthetic biology, as described by Bernadette Bensaude-Vincent. Synthetic biologists are invoking specific past or future scenario’s, such as that of synthetic chemistry or computer engineering, to legitimatize their current research projects and ambitions. From this perspective, the problematic tension between the past and the present is so hard to cope with because it is not merely a struggle among historians and philosophers of science, but also among the scientists themselves. (shrink)

Ethical dilemmas raised by the use of nanotechnology in medical practice can be viewed from several perspectives: religious spiritualist perspective, the perspective of human dignity (nanotechnologies can be thought of as an affront to human dignity), the issue of controversial choice. The article aims to expose some bioethical dilemmas in using synthetic biology and nanotechnologies. Nowadays is often brought into discussion the fact it is possible to appear in the future new human species resulted not via natural (...) selection and evolution, but through the demiurgic effect of technology development in areas such as: synthetic biology, genetics, neurobiology and neurosciences, prosthesis technology and not least of artificial intelligence research. We will also refer into this paper at the possible raised challenges to ethicists who are oriented towards an ethics of species. Those challenges are raised right from the dawn of a consciousness of species, a social construction generated by changes of the meaning of belonging to humanity. During our article we argue that medical technology, especially genetics, medical assisted human reproduction and not least synthetic biology, require a rethinking ethical meanings of applying those technologies in everyday practices. (shrink)

Crossing the boundaries - between nature and artifact and between inanimate and living matter - is a major feature of the convergence between nanotechnology and biotechnology. This paper points to two symmetric ways of crossing the boundaries: chemists mimicking nature's structures and processes, and synthetic biologists mimicking synthetic chemists with biological materials. However to what extent are they symmetrical and do they converge toward a common view of life and machines? The question is addressed in a historical (...) class='Hi'>perspective. Both biomimetic chemistry and synthetic biology can be described as descendants of an ambitious program developed by Stéphane Leduc who coined the phrase 'synthetic biology' in the early twentieth century. The main intention of this genealogy is to emphasize that although making life in a test tube is a recurrent project there are subtle nuances in the underlying metaphysical assumptions. This comparison is meant to contribute to a better understanding of the cultural issues at stake in the convergence between nano and biotechnologies. It suggests that the demarcation line between life and inanimate matter remains a hot issue, and that all traffics across the borders do not proceed from the same metaphysical assumptions. (shrink)

Synthetic biology, an emerging field of science and technology, intends to make of the natural world a substrate for engineering practice. Drawing inspiration from conventional engineering disciplines, practitioners of synthetic biology hope to make biological systems standardized, calculable, modular, and predictably functional. This essay develops a Heideggerian reading of synthetic biology as a useful perspective with which to identify and explore key facets of this field, its knowledge, its practices, and its products. After overviews of (...) class='Hi'>synthetic biology and Heidegger’s account of technology, I discuss calculability, utility, function, setting-upon, and ordering, with the aim of discussing the manner in which synthetic biology works to render the biological world intelligible as something to be used, rather than something that is in and of itself. Having developed this Heideggerian reading, I proffer a number of corrections to his account that enable a more accurate, nuanced understanding of synthetic biology. Specifically, I discuss the notion of Ge-stell and submit that multiple systems of “enframing” may help to make Heidegger’s argument more robust. I suggest that synthetic biology may work to reveal the natural world as a standing-reserve of function. (shrink)

The topic of synthetic life has long been a subject for science fiction writers, philosophers, and even scientists. With the announcement in 2010 by renowned biologist J. Craig Venter that he and a team of scientists from the J. Craig Venter Institute (JCVI) had created a bacterial cell with chemically synthesized genome, discussions of synthetic life were no longer just conjecture.Humans had assembled nonliving components to make a living cell (Gibson et al. 2010). I was one of the (...) leaders of that endeavor, and this article will be a first-person account of how we made our cell, along with my conjectures about what will come next in the new fields of synthetic biology and synthetic genomics.Scanning electron .. (shrink)

Different applications of synthetic biology are alike in that their possible negative consequences are highly uncertain, potentially catastrophic, and perhaps irreversible; therefore, they are also alike in that public attitudes about them are fertile ground for behavioral economic phenomena. Findings from behavioral economics suggest that people may not respond to such applications according to the normal rules of economic evaluation, by which the value of an outcome is multiplied by the mathematical probability that the outcome will occur. Possibly, then, (...) synthetic biology applications challenge the normative postulates of the standard approach, too.I want to first consider how some of the phenomena described by behavioral economists—and behavioral scientists more broadly—might affect people's perceptions of the uncertainties associated with synthetic biology. My analysis will be far from complete, however, because behavioral economics is essentially the study of human behavior, and thus its reach is potentially vast and its development longstanding and ongoing. Nonetheless, I hope to give an indicative perspective on how some aspects of behavioral economics might affect the assessment and perceived acceptability of synthetic biology. I will then consider the issue of agency. Should policy‐makers respect people's reactions to synthetic biology when those reactions are known to be driven by behavioral economic phenomena rather than following the normative postulates of rational choice theory? Or should policy‐makers dismiss these reactions as inherently biased? I will argue that the normative force of these human reactions (probably) depends on phenomenon and context. (shrink)

As an introduction to the special issue on Perspectives on Strategic Maneuvering, this article provides a synthetic recapitulation of the various steps that were taken in developing the pragma-dialectical theory of strategic maneuvering. First, the concept of strategic maneuvering is described as a means to reconcile the simultaneous pursuit of dialectical and rhetorical aims. Second, strategic maneuvering is related to the various kinds of argumentative activity types in which it takes place. Third, the concept of dialectical profiles is discussed (...) and the parameters that are pertinent to distinguishing between different types of strategic maneuvering. Fourth, the fallacies are viewed as derailment of strategic maneuvering. Fifth, as a case in point, strategic maneuvering with inconsistency is examined. (shrink)

The construction of synthetic life might appear to be the natural objective of the emerging discipline of synthetic biology. The situation, though, is not that simple. Plans to synthesize life appeared quite early, at the beginning of the 20th century (Bensaude-Vincent 2009; Deichmann 2009; Fox Keller 2002; Pereto and Catala 2007). Nor can synthetic biology be identified with work on the origin of life. Nevertheless, it is remarkable that a new, more integrated approach to the origin of (...) life appeared exactly when synthetic biology was emerging (Szostak, Bartel, and Luisi 2001).Most synthetic biologists have the more limited ambition of modifying existing organisms by giving them new functionalities. Synthetic .. (shrink)

Combining the communicative language competence model and the perspective of multimodal research, this research proposes a research framework for oral communicative competence under the multimodal perspective. This not only truly reflects the language communicative competence but also fully embodies the various contents required for assessment in the basic attributes of spoken language. Aiming at the feature sparseness of the user evaluation matrix, this paper proposes a feature weight assignment algorithm based on the English spoken category keyword dictionary and (...) user search records. The algorithm is mainly based on the self-built English oral category classification dictionary and converts the user’s query vector into a user-English-speaking type vector. Through the calculation rules proposed in this paper, the target user’s preference score for a specific type of spoken English is obtained, and this score is assigned to the unrated item of the original user’s feature matrix as the initial starting score. At the same time, in order to solve the problem of insufficient user similarity calculation accuracy, a user similarity calculation algorithm based on “Synonyms Cilin Extended Edition” and search records is proposed. The algorithm introduces “Synonyms Cilin” to calculate the correlation between the semantic items, vocabulary, and query vector in the user query record to obtain the similarity between users and finally gives a user similarity calculation that integrates user ratings and query vectors method. For the task of Chinese grammar error correction, this article uses two methods of predicting the relationship between words in the corpus, Word2Vec and GloVe, to train the word vectors of different dimensions and use the word vectors to represent the text features of the experimental samples, avoiding sentences brought by word segmentation. On the basis of word vectors, the advantages and disadvantages of CNN, LSTM, and SVM models in this shared task are analyzed through experimental data. The comparative experiment shows that the method in this paper has achieved relatively good results. (shrink)

Humans have long wondered whether they can survive the death of their physical bodies. Some people now look to technology as a means by which this might occur, using terms such 'whole brain emulation', 'mind uploading', and 'substrate independent minds' to describe a set of hypothetical procedures for transferring or emulating the functioning of a human mind on a synthetic substrate. There has been much debate about the philosophical implications of such procedures for personal survival. Most participants to that (...) debate assume that the continuation of identity is an objective fact that can be revealed by scientific enquiry or rational debate. We bring into this debate a perspective that has so far been neglected: that personal identities are in large part social constructs. Consequently, to enable a particular identity to survive the transference process, it is not sufficient to settle age-old philosophical questions about the nature of identity. It is also necessary to maintain certain networks of interaction between the synthetic person and its social environment, and sustain a collective belief in the persistence of identity. We defend this position by using the example of the Dalai Lama in Tibetan Buddhist tradition and identify technological procedures that could increase the credibility of personal continuity between biological and artificial substrates. (shrink)

Metaphors allow us to come to terms with abstract and complex information, by comparing it to something which is structured, familiar and concrete. Although modern science is “iconoclastic”, as Gaston Bachelard phrases it, scientists are at the same time prolific producers of metaphoric images themselves. Synthetic biology is an outstanding example of a technoscientific discourse replete with metaphors, including textual metaphors such as the “Morse code” of life, the “barcode” of life and the “book” of life. This paper focuses (...) on a different type of metaphor, however, namely on the archetypal metaphor of the mandala as a symbol of restored unity and wholeness. Notably, mandala images emerge in textual materials related to one of the new “frontiers” of contemporary technoscience, namely the building of a synthetic cell: a laboratory artefact that functions like a cell and is even able to replicate itself. The mandala symbol suggests that, after living systems have been successfully reduced to the elementary building blocks and barcodes of life, the time has now come to put these fragments together again. We can only claim to understand life, synthetic cell experts argue, if we are able to technically reproduce a fully functioning cell. This holistic turn towards the cell as a meaningful whole also requires convergence at the “subject pole”: the building of a synthetic cell as a practice of the self, representing a turn towards integration, of multiple perspectives and various forms of expertise. (shrink)

The extent to which machine metaphors are used in synthetic biology is striking. These metaphors contain a specific perspective on organisms as well as on scientific and technological progress. Expressions such as “genetically engineered machine”, “genetic circuit”, and “platform organism”, taken from the realms of electronic engineering, car manufacturing, and information technology, highlight specific aspects of the functioning of living beings while at the same time hiding others, such as evolutionary change and interdependencies in ecosystems. Since these latter (...) aspects are relevant for, for example, risk evaluation of uncontained uses of synthetic organisms, it is ethically imperative to resist the thrust of machine metaphors in this respect. In addition, from the perspective of the machine metaphor viewing an entity as a moral agent or patient becomes dubious. If one were to regard living beings, including humans, as machines, it becomes difficult to justify ascriptions of moral status. Finally, the machine metaphor reinforces beliefs in the potential of synthetic biology to play a decisive role in solving societal problems, and downplays the role of alternative technological, and social and political measures. (shrink)

Not only the public debate about science but even the way scientists conceive their own work is to some extent determined by cultural images. In the case of synthetic biology, literary figures like the Golem of Prague and its successors, such as Frankenstein’s monster, seem to suggest themselves. This article reconstructs some cognitive structures underlying the surface of metaphorical thinking and shows how talking about synthetic biology as similar to Golem-making obscures important onto- logical, pragmatic, and ethical differences.

In the first part of this paper I contend that Michael Dummett’s works contain a distinction between analytic and synthetic (logical) deductions. Dummett does not use Kant’s terminology. Nevertheless, based on general considerations about theories of meaning, Dummett shows how one can distinguish between deductions whose validity is recognised by merely grasping the concepts and deductions whose validity can be recognised only by “going beyond the concepts”, as Kant wrote. The latter are synthetic deductions, through which we can (...) increase our knowledge. A special merit of Dummett’s distinction is its theoretical flexibility and generality. He does not propose a single clear-cut distinction between analytic and synthetic deductions; rather in his works we find an indication of how to draw a distinction once a theory of meaning is adopted. In the second part of the paper I consider possible developments within an inferentialist theory of meaning and draw some conclusions concerning the fallibility of deductions. (shrink)

: This essay addresses the difficulties that sociology as a discipline continues to experience in grasping the relations between technology, science and the social. I argue that these difficulties stem from a resolute centering of sociology on the social, which follows a generically Durkheimian blueprint. I elaborate a response to these difficulties which derives from recent lines of work in science and technology studies, and which entails a decentering of the social relative to the material and the conceptual, in terms (...) of both objects of analysis and explanatory formats. In order to display the direct sociological relevance of this approach, I move to the macro level, developing the conceptual apparatus of a decentered social theory via the discussion of a historical example of major sociological significance—the systematic gearing together of scientific research, technological innovation and industrial production that originated in the synthetic dye industry in the second half of the nineteenth century. Besides the interest of the topic itself, the aim is thus to exemplify in some detail what a decentered sociology might look like, both empirically and conceptually. (shrink)

Systems and synthetic biology promise to revolutionize our understanding of biology, blur the boundaries between the living and the engineered in a vital new bioengineering, and transform our daily relationship to the living world. Their emergence thus deserves to be understood in a wider intellectual perspective. Close attention to their relationship to the larger scientific intellectual frameworks within which they function reveals that systems and synthetic biology raise fundamental challenges to scientific orthodoxy, but stand in the vanguard (...) of an emerging new complex dynamical systems paradigm now sweeping across science. (shrink)

According to Viveiros de Castro, comparison as ontology defines the ontological turn in anthropology. It presents a necessity for philosophy to approach the matter with comparative strategy. Morten Pedersen claims that ontological turn should be interpreted as a fulfillment of an anthropological version of Husserl’s method. Thus, phenomenology enters the field of interest along with its critique in Speculative Realism. In this article, we will see clearly why this selection is not accidental but rather unavoidable. Amerindian perspectivism necessitates the philosophical (...) reconceptualization of perspective in general, which is to be taken as a challenge for the established discourses. The need arises to rethink the problematic of Kantian perspectivism and its offspring. Amerindian perspectivism proposes cosmological deictics that hold a spatiality of the perspective of the other, of the in-itself, thus it comes into an opposition to Kant’s system. Phenomenological perspective, as one of the Kantian offspring, faces a predicament that is interwoven with the critique of correlationism arriving from Speculative Realisms. The synthetic character of phenomenology allows enough flexibility for it to traverse these recent charges. We will draw a comparative picture of dynamic co-evolution of strains of recent thought, striving for a synthetic multiplicity, permeated by a common perspectival thread. (shrink)