Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organization coordinated and supported research to expedite identification of interventions that could control the outbreak and improve future control efforts. Consequently, the World Health Organization Research Ethics Review Committee was heavily involved in reviews and ethics discussions. It reviewed 24 new and 22 amended protocols for research studies including interventional (...) and observational studies. WHO-ERC provided the reviews within on average 6 working days. The WHO-ERC often could not provide immediate approval of protocols for reasons which were not Ebola Virus Disease specific but related to protocol inconsistencies, missing information and complex informed consents. WHO-ERC considerations on Ebola Virus Disease specific issues are presented. To accelerate study approval in future public health emergencies, we recommend: internally consistent and complete submissions with information documents in language participants are likely to understand, close collaboration between local and international researchers from research inception, generation of template agreements for data and sample sharing and use during the ongoing global consultations on bio-banks, formation of Joint Scientific Advisory and Data Safety Review Committees for all studies linked to a particular intervention or group of interventions, formation of a Joint Ethics Review Committee with representatives of the Ethics Committees of all institutions and countries involved to strengthen reviews through the different perspectives provided without the ‘opportunity costs’ for time to final approval of multiple, independent reviews, direct information exchange between the chairs of advisory, safety review and ethics committees, more Ethics Committee support for investigators than is standard and a global consultation on criteria for inclusion of pregnant women and children in interventional studies for conditions which put them at particularly high risk of mortality or other irreversible adverse outcomes under standard-of-care. (shrink)

Brian Epstein has argued (in The Ant Trap and ‘Anchoring versus grounding’) that social kinds ‘export’ across worlds. Although the conditions for war criminality are not ‘fixed’ in the Empire, for instance, Darth Vader is a war criminal there. And, according to Epstein, an account of social construction should imply that he is. Ultimately, he argues that ‘grounding-only’ accounts of social construction – like those proposed by Jonathan Schaffer and Aaron Griffith – imply that social kinds do not export across (...) worlds. As a result, he argues that we need more than grounding; in particular, we need both grounding and what he calls ‘anchoring’ to account for it. In this paper, I argue that, once we draw a distinction between what I call ‘thick’ and ‘thin’ social kinds, Epstein’s argument is either invalid or irrelevant. (shrink)

Just as contemporary metaphysics, in general, is marked by an interest in ground, contemporary social metaphysics, in particular, is marked by an interest in social construction. It’s no surprise, then, that some contemporary metaphysicians have come to understand social construction in terms of ground. In this paper, I argue that this is a mistake. In particular, I argue that any otherwise plausible account of construction as ground is objectionably revisionary. First, I discuss an argument for the view that construction is (...) ground that is endorsed by its proponents, and identify its weaknesses. I then consider, and dispense with, different versions of the view that construction is ground, and argue that these either overgeneralize, undergeneralize, or both. After responding to the objection that my arguments presuppose monism with respect to construction, I conclude that though ground is relevant to construction, extant ground-theoretic accounts of its relevance fail to capture it. (shrink)

Compared to other animals, humans appear to have a special motivation to share experiences and mental states with others (Clark, 2006;Grice, 1975), which enables them to enter a condition of ‘we’ or shared intentionality (Tomasello & Carpenter, 2005). Shared intentionality has been suggested to be an evolutionary response to unique problems faced in complex joint action coordination (Levinson, 2006;Tomasello, Carpenter, Call, Behne, & Moll, 2005) and to be unique to humans (Tomasello, 2014). The theoretical and empirical bases for this claim, (...) however, present several issues and inconsistencies. Here, we suggest that shared intentionality can be approached as an interactional achievement, and that by studying how our closest relatives, the great apes, coordinate joint action with conspecifics, we might demonstrate some correlate abilities of shared intentionality, such as the appreciation of joint commitment. We provide seven examples from bonobo joint activities to illustrate our framework. (shrink)

From Italian physician Hieronymus Mercurialis’s contention that the stomach was ‘the king of the belly’, to its promotion by the end of the nineteenth century to the ‘monarch of humanity’ in patent medicine, to Byron Robinson’s discovery of the enteric nervous system in 1907 (a mesh of neural connectivity that led him to dub the gut ‘the second brain’), there has historically been a longstanding awareness of the expansive reach of the gut in the functions of the body. In the (...) nineteenth century, the authority of the gut and its allyship with the brain became a focus for writers thinking about the intersections of illness and ‘modern life’. In medical texts, domestic health manuals, patent medicine, and fiction, the electric telegraph in particular became a way of envisaging what we would now call the ‘gut-brain axis’. The telegraphic metaphor enabled a view of digestion as not simply a mechanical or chemical process, but one that was understood in terms of time, space, and communication. However, such a framework also suggested problems of connection that were common to both systems, emphasising not only the healthy body’s quasi-telegraphic networks but also its vulnerability to delay, disruption, and pathological incoherence. This article will explore the use of telegraphic technologies as proxies for theorising gastric connection and more broadly the concept of ‘gastric time’ as a key conceit for understanding digestion as a process that was and is subject to the idiosyncrasies of bodily rhythms. (shrink)

La capacité des êtres humains à obéir aux ordres, même si ceux-ci sont jugés atroces, n’a plus à être prouvée. Comme l’a souligné Howard Zinn, « D’un point de vue historique, les évènements les plus terribles – tels que la guerre, les génocides et l’esclavage – ont résulté non pas de la désobéissance, mais de l’obéissance» (Zinn, 1997). Mais la question de savoir « comment» les individus peuvent commettre des atrocités lorsqu’ils suivent des ordres reste ouverte. Les études de Milgram (...) sont célèbres pour avoir montré une forte soumission aux ordres de l’expérimentateur. Mais ces études n’ont révélé que les facteurs situationnels et sociaux favorisant l’obéissance. Elles n’ont pas permis de comprendre comment tant de personnes ont accepté d’envoyer des chocs douloureux et potentiellement mortels à une autre personne. Dans cet article, j’opposerai les entretiens qualitatifs réalisés avec d’anciens génocidaires au Rwanda et la recherche expérimentale en neurosciences pour tenter de faire émerger un élément de réponse à cette question critique. Je soutiendrai que le dépassement des frontières entre différentes disciplines scientifiques est la clé d’une meilleure compréhension de la façon dont l’obéissance modifie la prosocialité. Je défendrai également l’idée provocatrice que les chercheurs devraient saisir l’opportunité de quitter leur laboratoire pour étudier la question de l’obéissance. (shrink)

There are an increasing number of cell therapy approaches being studied and employed world‐wide. An emerging area in this field is the use of human pluripotent stem cell (hPSC) products for the treatment of injuries/diseases that cannot be effectively managed through current approaches. However, as with any cell therapy, vast numbers of functional and safe cells are required. Bioreactors provide an attractive avenue to generate clinically relevant cell numbers with decreased labour and decreased batch to batch variation. Yet, current methods (...) of performing quality control are not readily scalable to the cell densities produced during bioreactor scale‐up. One potential solution is the application of inducible/controllable suicide genes that can trigger cell death in unwanted cell types. These types of approaches have been demonstrated to increase the quality and safety of the resultant cell products. In this review, we will provide background on these approaches and how they could be used together with bioreactor technology to create effective bioprocesses for the generation of high quality and safe hPSCs for use in regenerative medicine approaches. (shrink)

Au sein des séparations parentales conflictuelles, l’enfant peut adopter un rôle de parent. La parentification est une conséquence fréquente de ces situations. L’article présente le cas clinique d’une jeune fille de 12 ans illustrant l’articulation entre sa situation familiale et le phénomène de parentification. Marie est prise en charge en centre-médico-psychologique suite à une injonction de soin émise par le juge des enfants. Au sein de la séparation conflictuelle de ses parents, elle apparaît comme la soignante et la confidente de (...) sa mère. Elle cherche à aider cette dernière par divers moyens tels que le soutien moral, le rejet du père ou encore la rupture de liens avec sa famille. Des programmes éducatifs mandatés par les tribunaux, des programmes de prévention ou des discussions avec les parents dans les écoles sembleraient pertinents afin de diminuer la parentification. (shrink)

Strategies based on performance measurement and feedback are commonly used to support quality improvement among nurses. These strategies require practice change, which, for nurses, rely to a large extent on their capacity to coordinate with each other effectively. However, the levers for coordinated action are difficult to mobilize. This discussion paper offers a theoretical reflection on the challenges related to coordinating nurses' actions in the context of practice changes initiated by performance measurement and feedback strategies. We explore how Jürgen Habermas' (...) theory of Communicative Action may shed light on the issues underlying nurses' collective actions and self‐determination in practice change and the implications for the design of strategies based on performance measurement and feedback. Based on this theory, we propose differences between communicative and functional coordination according to the nature of the actions and the purposes involved. The domains of action underlying these coordination processes, which Habermas referred to as the lifeworld and the system, are then used to draw a parallel with aspects of nursing practice. Further exploration of these concepts allows us to consider the tensions between the demands of the system and the self‐determination of nurses within their practice. (shrink)

The continued rise of populism and authoritarianism throughout the world has witnessed an alarming attack on basic democratic freedoms and led to a divided political and social world. Few thinkers have done as much as Jürgen Habermas to understand and critique these problems, perhaps most famously through his notions of the public sphere, deliberative democracy and discourse ethics. In this fascinating book, Emilie Prattico considers the crisis of democracy from a Habermasian standpoint via engaging interviews with an outstanding line up (...) of leading philosophers and thinkers. The following key topics are unpacked and explored: Can some basic rights and liberties be given up to safeguard democracy? With Hauke Brunkhorst, How does actual deliberation confer legitimacy to democratic decisions? With Cristina Lafont, Why is "fake news" a crisis of democracy? With Michael Lynch, How can we build a public sphere together and share it in a world characterized by divisiveness and tribalism? With Barbara Fultner, Can democracy survive without the voice of experts? With Kenneth Baynes, How dangerous are the current forms of authoritarianism we are seeing take hold all over the world? With Maria Pia Lara, What does the public sphere look like with new technologies? With Gertrud Koch, What duties do we owe descendants of slaves and how do we reckon with our antidemocratic and oppressive past? With Lorenzo Simpson. Also including a Foreword by Habermas himself, this book is essential reading for anyone seeking to understand the challenges facing democracy and liberalism today. It will be of great interest to those in philosophy, sociology and politics as well as related fields such as religion and law. (shrink)

Résumé Aux années soixante-dix, Roland Barthes désigne le Zen japonais par « L’empire des signes », alors que la culture chinoise par la « fadeur des signes ». François Jullien reprend ultérieurement l’idée de la « fadeur » au niveau de son sens « non dualiste » dans le cadre de la philosophie comparée. Depuis les courants poststructuraliste et déconstructionniste, de plus en plus de recherches sémiotiques et philosophiques portent sur l’étude bouddhique, dont le point nodal se situe alors dans (...) un parallélisme au bénéfice des échanges interculturels. En vue d’une déspécialisation du jargon propre à chaque domaine, il semble impératif de mettre en relation les concepts de base en commun. Pour mettre en évidence l’apport de l’étude terminologique et méthodologique, cet article commence par les travaux philologiques sur la « traduction » des textes bouddhiques. Ensuite, la discussion se concentre sur la « dualité » à partir de la « réception » de l’exégétique saussurienne. Il s’agit concrètement d’une étude embryonnaire sur le terme propre couple « signifiant/signifié »: l’exégétique saussurienne s’est répandue efficacement en Chine grâce aux emprunts à la terminologie bouddhique, ce qui offrirait une perspective positive vis-à-vis du dialogue interculturel. En même temps, il serait aussi possible de traduire les termes bouddhiques par le biais sémiotique en regard d’une osmose transdisciplinaire. (shrink)

This paper examines Irish campaigns for condom access in the early 1990s. Against the backdrop of the AIDS crisis, activists campaigned against a law which would not allow condoms to be sold from ordinary commercial spaces or vending machines, and restricted sale to young people. Advancing a conception of ‘transformative illegality’, we show that illegal action was fundamental to the eventual legalisation of commercial condom sale. However, rather than foregrounding illegal condom sale as a mode of spectacular direct action, we (...) show that tactics of illegal sale in the 1990s built on 20 years of everyday illegal sale within the Irish family planning movement. Everyday illegal sale was a long-term world-making practice, which gradually transformed condoms’ legal meanings, eventually enabling new forms of provocative and irreverent protest. Condoms ‘became legal’ when the state recognised modes of condom sale, gradually built up over many years and publicised in direct action and in the courts. (shrink)

Background Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organization coordinated and supported research to expedite identification of interventions that could control the outbreak and improve future control efforts. Consequently, the World Health Organization Research Ethics Review Committee was heavily involved in reviews and ethics discussions. It reviewed 24 new and 22 amended protocols for research studies including (...) interventional and observational studies. WHO-ERC reviews WHO-ERC provided the reviews within on average 6 working days. The WHO-ERC often could not provide immediate approval of protocols for reasons which were not Ebola Virus Disease specific but related to protocol inconsistencies, missing information and complex informed consents. WHO-ERC considerations on Ebola Virus Disease specific issues are presented. Conclusions To accelerate study approval in future public health emergencies, we recommend: internally consistent and complete submissions with information documents in language participants are likely to understand, close collaboration between local and international researchers from research inception, generation of template agreements for data and sample sharing and use during the ongoing global consultations on bio-banks, formation of Joint Scientific Advisory and Data Safety Review Committees for all studies linked to a particular intervention or group of interventions, formation of a Joint Ethics Review Committee with representatives of the Ethics Committees of all institutions and countries involved to strengthen reviews through the different perspectives provided without the ‘opportunity costs’ for time to final approval of multiple, independent reviews, direct information exchange between the chairs of advisory, safety review and ethics committees, more Ethics Committee support for investigators than is standard and a global consultation on criteria for inclusion of pregnant women and children in interventional studies for conditions which put them at particularly high risk of mortality or other irreversible adverse outcomes under standard-of-care. (shrink)

This paper draws on an in-depth phenomenological analysis of some interviews taken from volunteers, inviting them to reflect on their lived experiences of meaningfulness in the context of volunteering and citizenship. It is found that while some testimonies reinforce the standard conceptions of meaningfulness, other testimonies vary from it. The main challenge of this contribution consists in phenomenologically describing this alternative picture of meaningfulness, depicted as the event of wit(h)nessing. In a final part, the authors consider how volunteering is at (...) times especially prone to further experiences of wit(h)nessing. (shrink)

This paper draws on an in-depth phenomenological analysis of some interviews taken from volunteers, inviting them to reflect on their lived experiences of meaningfulness in the context of volunteering and citizenship. It is found that while some testimonies reinforce the standard conceptions of meaningfulness, other testimonies vary from it. The main challenge of this contribution consists in phenomenologically describing this alternative picture of meaningfulness, depicted as the event of witnessing. In a final part, the authors consider how volunteering is at (...) times especially prone to further experiences of witnessing. (shrink)

Dans son ouvrage La libération animale, Peter Singer développe trois grandes idées : le principe d'égale considération des intérêts, le rejet du spécisme et la nécessité de mettre un terme à certains types d'exploitation des animaux, notamment ceux qui ont trait à la recherche et à l'élevage industriel. Cette oeuvre phare a connu un retentissement immense, à tel point que sa publication, en 1975, a été présentée comme le moment clef dans l'émergence du mouvement éponyme. Cependant, le mouvement de libération (...) animale ne saurait se réduire à la seule pensée singerienne. Ce mouvement extrêmement protéiforme a fait l'objet de débats intenses à l'interne, entre les défenseurs des animaux eux-mêmes qui privilégient des approches diverses, comme à l'externe, entre ceux qui défendent le statu quo ou contestent les arguments animalistes. L'objet de ce recueil est de revenir sur le lien entre le mouvement de libération animale et les théories de Peter Singer qui, à tort ou à raison, en est perçu comme le père fondateur. Comment l'éthique animale de l'auteur a-t-elle été accueillie depuis la publication de La libération animale, et comment a-t-elle évolué? Quelle place la doctrine utilitariste occupe-t-elle dans le travail de Singer et dans les débats qu'il a engendrés? C'est en effet dans cette doctrine parente que résident les écueils auxquels s'est heurté le travail de l'auteur. C'est aussi là que son système a trouvé sa force et sa simplicité caractéristiques. C'est aussi, semble-t-il, ce qui fait la fécondité de ses idées. (shrink)

Chora – le «cratère à mélanger» maternel, vannant et secouant de Platon – remplit «l’écart explicatif» entre les paradigmes formels «intelligibles et toujours existants» (48E5) et un monde encosmique «généré et visible». Proclus traite la gamme polysémique des termes utilisés par Platon pour chôra : hypodochê (réceptacle), kratêr (cratère à mélanger), etc., comme désignant des forces actives dans un univers où la sympathie cosmique règne, à partir des plus élevées, jusqu’aux plus basses manifestations de l’ «Un» transcendant. L’univers proclusien est (...) un «hénothéisme», dans lequel une «unité» dominante surgit sur la totalité de l’Être et du Devenir. Chôra permet à la fois au monde immatériel et au monde matériel de recevoir, de manière appropriée à chacun, les mêmes dons transcendants que leurs homologues intellectifs‑intelligibles superieurs. Aucun niveau de la réalité n’est dépourvu de cette donation. La réceptivité (hypodochê), indéterminée, mais toujours active, est présente à tous les niveaux. L’âme reçoit l’Intellect, la temporalité reçoit le temps monadique, la matière reçoit la structure géométrique polyédrique, etc. Chôra n’est pas l’equivalent de la matière, mais permet à la matière d’être imprimée par des paradigmes formels. Dans son rôle de «cratère à mélanger», elle protège la matière de sa potentielle itérabilité et dissolution infinie. Dans l’univers proclusien, le Bien atteint la dernière et la plus extrême de ses limites, il est espace et lieu, recevant à la fois l’expansivité et une capacité à donner place à la forme pour qu’elle puisse s’imposer à la matière. Après tout, les dons lui sont accordés depuis la plus haute hypostase, celle de la Limite et de l’Illimité, premier niveau après l’Un lui‑même. Vitale pour la création, la Chôra est alors la «mère» de tout. Il n’est donc pas étonnant que, comme nous le dit Proclus, la chôra soit, en fait, la déesse Rhéa. En hommage à la littérature révélatrice antique, comme les Oracles chaldaïques, Homère et Hésiode, Proclus fournit une élucidation non seulement philosophique, mais aussi théologique, de la chôra. À la différence de Platon, il théologise la Physique. (shrink)

Cette note de recherche prend pour point de départ un certain nombre d’observations empiriques sur les pratiques d’écritures relatives à la « rédaction web ». Son ancrage est celui de l’analyse du discours, envisagée comme discipline interprétative et lecture critique des énoncés mais aussi comme démarche susceptible d’apporter sa contribution à une didactique de l’écrit. Nous y livrons quelques premiers éléments de réflexion pour la caractérisation discursive des textes issus de la rédaction web, prenant en compte pour cela à la (...) fois la composante discursive de ces productions et les discours construisant la rédaction web comme pratique d’écriture. A partir de deux exemples, nous montrons que les normes dominantes de la rédaction web, liées notamment aux contraintes du support et à des enjeux économiques, sont diversement prises en compte suivant la sphère d'activité où sont produits les textes. (shrink)

Many students have experienced the death of a loved one, which increases their risk of grief and mental health problems. Formal and social support can contribute to better coping skills and personal growth in bereaved students. The purpose of this study was to examine the support that students received or wanted to receive and its relation to students’ mental health. We also looked at students’ needs when receiving support and barriers in seeking formal and social support. Participants completed an online (...) survey consisting of questions about their sociodemographic characteristics, the support they received or wanted to receive, and support needs and barriers in seeking support. The survey also included three scales assessing grief, mental health distress, and personal growth. First, we analyzed the data descriptively. Next, we used MANCOVA to examine whether students who did or did not receive or wanted more support differed in terms of their grief, mental health distress, or personal growth. About 30% of students needed more support and experienced more grief and mental health distress than students who had their support needs met. Students who received support experienced more personal growth and grief than students who did not receive support. Students indicated a need for feeling acknowledged and safe. Feeling like a burden to others and perceiving their problems as not serious enough to warrant support were common barriers to seeking support. Our results indicate that support should be provided actively to students after the death of a loved one, and support being available on an ongoing basis. (shrink)

Omniprésent dans les médias, le terme transhumanisme nécessite un éclaircissement académique. En effet, il n'existe pas un, mais des transhumanismes. La parole est ici donnée à des penseurs de diverses disciplines, plus ou moins ouverts à ce courant d'idées parfois taxé d'idéologie, voire de menace pour l'Humanité. Ces craintes sont-elles fondées? Quelles sont les origines de ce mouvement de pensée? Quels en sont les différentes ramifications? Quelles en sont les réalisations, notamment dans le domaine médical? Un encadrement éthique et/ou juridique (...) de ces pratiques est- elle nécessaire? De nouveaux droits fondamentaux méritaient-ils d'être reconnus? La parole est ici donnée tant aux militants transhumanistes qu'aux penseurs critiques afin de croiser leurs regards"--Page 4 of cover. (shrink)

After reviewing the literature on current knowledge about consciousness in humans, we present a state-of-the art discussion on consciousness and related key concepts in animals. Obviously much fewer publications are available on non-human species than on humans, most of them relating to laboratory or wild animal species, and only few to livestock species. Human consciousness is by definition subjective and private. Animal consciousness is usually assessed through behavioural performance. Behaviour involves a wide array of cognitive processes that have to be (...) assessed separately using specific experimental protocols. Accordingly, several processes indicative of the presence of consciousness are discussed: perception and cognition, awareness of the bodily-self, self-related knowledge of the environment (including social environment). When available, specific examples are given in livestock species. Next, we review the existing evidence regarding neuronal correlates of consciousness, and emphasize the difficulty of linking aspects of consciousness to specific neural structures across the phyla because high-level cognitive abilities may have evolved independently along evolution. Several mammalian brain structures (cortex and midbrain) are involved in the manifestations of consciousness, while the equivalent functional structures for birds and fishes would likely be the pallium/tectum and midbrain. Caution is required before excluding consciousness in species not having the same brain structures as the mammalian ones as different neural architectures may mediate comparable processes. Finally, specific neurophysiological mechanisms appear to be strongly linked to the emergence of consciousness, namely neural synchrony and neural feedback. Considering the limited amount of data available and the few animal species studied so far, we conclude that different manifestations of consciousness can be observed in animals but that further refinement is still needed to characterize their level and content in each species. Further research is required to clarify these issues, especially in livestock species. (shrink)

In “A Public Health Ethics Framework for Populations with Limited English Proficiency,” Chipman and colleagues present a valuable framework for addressing health disparities linked to limited Engli...

In recent years, humans’ ability to selectively modify genes has increased dramatically as a result of the development of new, more efficient, and easier genetic modification technology. In this paper, we argue in favor of using this technology to improve the welfare of agricultural animals. We first argue that using animals genetically modified for improved welfare is preferable to the current status quo. Nevertheless, the strongest argument against pursuing gene editing for welfare is that there are alternative approaches to addressing (...) some of the challenges of modern agriculture that may offer ethical advantages over genetic modification; namely, a dramatic shift towards plant-based diets or the development of in vitro meat. Nevertheless, we provide reasons for thinking that despite these possible comparative disadvantages there are important reasons for continuing the pursuit of welfare improvements via genetic modification. (shrink)