Transcription is a potential threat to genome integrity, and transcription‐associated DNA damage must be repaired for proper messenger RNA (mRNA) synthesis and for cells to transmit their genome intact into progeny. For a wide range of structurally diverse DNA lesions, cells employ the highly conserved nucleotide excision repair (NER) pathway to restore their genome back to its native form. Recent evidence suggests that NER factors function, in addition to the canonical DNA repair mechanism, in processes that facilitate mRNA synthesis or (...) shape the 3D chromatin architecture. Here, these findings are critically discussed and a working model that explains the puzzling clinical heterogeneity of NER syndromes highlighting the relevance of physiological, transcription‐associated DNA damage to mammalian development and disease is proposed. (shrink)

(1996). Different concepts and types of nationalism in the Nineteenth and Twentieth centuries. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the study of European Ideas, pp. 453-458.

Since in Heyting Arithmetic all atomic formulas are decidable, a Kripke model for HA may be regarded classically as a collection of classical structures for the language of arithmetic, partially ordered by the submodel relation. The obvious question is then: are these classical structures models of Peano Arithmetic ? And dually: if a collection of models of PA, partially ordered by the submodel relation, is regarded as a Kripke model, is it a model of HA? Some partial answers to these (...) questions were obtained in [6], [3], [1] and [2]. Here we present some results in the same direction, announced in [7]. In particular, it is proved that the classical structures at the nodes of a Kripke model of HA must be models of IΔ1 and that the relation between these classical structures must be that of a Δ1-elementary submodel. MSC: 03F30, 03F55. (shrink)

At the basis of tireless efforts to explain the nature of law lies the question of how judges should decide cases. Therefrom arises a need for a theory that would clarify the role of the courts and, moreover, provide guidance to them on reaching judgments. The history of legal theory abounds with various attempts to offer a generally acceptable answer to the question raised. The fervor of debate and the perpetual dissatisfaction with offered solutions prompted the thought of untamable arbitrariness (...) of judges. In the contemporary debate the significance of argumentation is particularly emphasized as a link of the court procedure which provides reasonableness and therewith justification and persuasiveness of the decision. Before going into the matter, I will indicate in broad strokes which areas of legal theory do argumentation and interpretation belong to. The purpose of setting a conceptual framework is to prevent losing sight of the whole as well as to limit the scope of discourse to a certain section of legal issues. The second part deals with the concept of argumentation in general and some specific features of the argumentation in law. The third part examines the role of legal interpretation and draws a clear distinction between the interpretation as a process and the interpretation as a result. At the end of the discussion I shall put forward a thesis that the interpretation as a process is argumentation, while the interpretation as a result is an argument in the justification of judgment. nema. (shrink)

In the past few decades, a growth in ethical consumerism has led brands to increasingly develop conscientiousness and depict ethical image at a corporate level. However, most of the research studying business ethics in the field of corporate brand management is either conceptual or has been empirically conducted in relation to goods/products contexts. This is surprising because corporate brands are more relevant in services contexts, because of the distinct nature of services and the key role that employees have in the (...) services sector. Accordingly, this article aims at empirically examining the effects of customer perceived ethicality in the context of corporate services brands. Based on data collected for eight service categories using a panel of 2179 customers, the hypothesized structural model is tested using path analysis. The results show that, in addition to a direct effect, customer perceived ethicality has a positive and indirect effect on customer loyalty, through the mediators of customer affective commitment and customer perceived quality. Further, employee empathy positively influences the impact of customer perceived ethicality on customer affective commitment, and customer loyalty positively impacts customer positive word-of-mouth. The first implication of these results is that corporate brand strategy needs to be aligned with human resources policies and practices if brands want to turn ethical strategies into employee behavior. Second, corporate brands should build more authentic communications grounded in their ethical beliefs and supported by evidence from actual employees. (shrink)

Unchosen transformative experiences—transformative experiences that are imposed upon an agent by external circumstances—present a fundamental problem for agency: how does one act intentionally in circumstances that transform oneself as an agent, and that disrupt one’s core projects, cares, or goals? Drawing from William James’s analysis of conversion and Matthew Ratcliffe’s account of grief, I give a phenomenological analysis of transformative experiences as involving the restructuring of systems of practical meaning. On this analysis, an agent’s experience of the world is structured (...) by practically significant possibilities that form organized systems on the basis of the agent’s projects and relationships. Transformative experiences involve shifts to systems of possibility, that is, changes to habitual meanings and to how an agent’s projects are situated in relation to one another. I employ the enactivist notion of sense-making to analyze how an agent rebuilds the meaning structures disrupted by a transformative experience. In an unchosen transformative experience, an agent adjusts to a significant disruption through a process of sense-making in precarious conditions. By establishing new patterns of bodily and social interaction with the world, one alters the practical meanings of one’s surroundings, and thereby reconstitutes oneself as an intentional agent. (shrink)

In this paper, we present a method for introducing law students to the writing of legal documents. The method uses a machine-readable representation of the legal knowledge to support document assembly and to help the students to understand how the assembly is performed. The knowledge base consists of enacted legislation, document templates, and assembly instructions. We propose a system called LEDAS (LEgal Document Assembly System) for the interactive assembly of legal documents. It guides users through the assembly process and provides (...) explanations of the interconnection between input data and claims stated in the document. The system acts as a platform for practicing drafting skills and has great potential as an education tool. It allows teachers to configure the system for the assembly of some particular type of legal document and then enables students to draft the documents by investigating which information is relevant for these documents and how the input data shape the final document. The generated legal document is complemented by a graphical representation of legal arguments expressed in the document. The system is based on existing legal standards to facilitate its introduction in the legal domain. Applicability of the system in the education of future lawyers is positively evaluated by the group of law students and their TA. (shrink)

A Marxist analysis of the role of politics in liberal democracies and fascist and socialist states.

The present study aims to identify contextual and psychological factors of proneness to radicalization and violent extremism operationalized through the Militant Extremist Mindset scale consisting of three distinct aspects: Proviolence, Vile World beliefs, and trust in Divine Power. A community sample of 271 high school students from Belgrade and Sandžak regions in Serbia completed: a 24-item MEM scale; contextual measures including a 6-item scale of family dysfunction and a 4-item composite measure capturing exposure to a harsh school environment and peer (...) abuse ; psychological measures including the 9-item Right-Wing Authoritarianism scale, the 5-item Social Dominance Orientation scale, and the 20-item UCLA Loneliness scale. A path analysis was conducted with contextual factors on the first and psychological factors on the second level of the model predicting the three factors of MEM. LON was positively predicted by FDys and HSE, SDO by HSE only, while RWA was positively predicted by FDys only. Contextual and psychological factors accounted for 27% of the variance in PV, 15% of the variance in VW, and 31% of the variance in DP. Obtained findings reveal a complex interplay of contextual and psychological drivers in the prediction of different aspects of RVE and build upon existing knowledge on risk factors associated with RVE. (shrink)

Business Ethics, the Environment &Responsibility, Volume 32, Issue 2, Page 415-418, April 2023.

Note by editors of Voprosy filosofii: The great transformer of modern natural science, Albert Einstein, was not only a physicist of genius, not merely the discoverer of outstanding scientific discoveries: he was also a remarkable human being, a courageous protagonist of peace and justice on earth. A convinced humanist and antifascist, he spoke out irreconcilably against chauvinism, militarism, and misanthropy, always and everywhere. Defending the principles of humanism and high ideals of citizenship, aware of his responsibility as a scientist, he (...) protested passionately against the use of atomic and hydrogen weapons. Along with Bertrand Russell, Frederic Joliot-Curie, and other major scientists, Einstein signed the widely known manifesto that played an important role in founding the Pugwash movement of scientists. (shrink)

Emotionally arousing events reach awareness more easily and evoke greater visual cortex activation than more mundane events. Recent studies have shown that they are also perceived more vividly and that emotionally enhanced perceptual vividness predicts memory vividness. We propose that affect-biased attention (ABA) – selective attention to emotionally salient events – is an endogenous attentional system tuned by an individual's history of reward and punishment. We present the Biased Attention via Norepinephrine (BANE) model, which unifies genetic, neuromodulatory, neural and behavioural (...) evidence to account for ABA. We review evidence supporting BANE's proposal that a key mechanism of ABA is locus coeruleus–norepinephrine (LC–NE) activity, which interacts with activity in hubs of affective salience networks to modulate visual cortex activation and heighten the subjective vividness of emotionally salient stimuli. We further review literature on biased competition and look at initial evidence for its potential as a neural mechanism behind ABA. We also review evidence supporting the role of the LC–NE system as a driving force of ABA. Finally, we review individual differences in ABA and memory including differences in sensitivity to stimulus category and valence. We focus on differences arising from a variant of the ADRA2b gene, which codes for the alpha2b adrenoreceptor as a way of investigating influences of NE availability on ABA in humans. (shrink)

Anxiety disorders are among the most prevalent mental disorders. Present treatments such as cognitive behavior therapy and pharmacological treatments show only moderate success, which emphasizes the importance for the development of new treatment protocols. Non-invasive brain stimulation methods such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation have been probed as therapeutic option for anxiety disorders in recent years. Mechanistic information about their mode of action, and most efficient protocols is however limited. Here the fear extinction model can (...) serve as a model of exposure therapies for studying therapeutic mechanisms, and development of appropriate intervention protocols. We systematically reviewed 30 research articles that investigated the impact of rTMS and tDCS on fear memory and extinction in animal models and humans, in clinical and healthy populations. The results of these studies suggest that tDCS and rTMS can be efficient methods to modulate fear memory and extinction. Furthermore, excitability-enhancing stimulation applied over the vmPFC showed the strongest potential to enhance fear extinction. We further discuss factors that determine the efficacy of rTMS and tDCS in the context of the fear extinction model and provide future directions to optimize parameters and protocols of stimulation for research and treatment. (shrink)