The EU Kids Online project aims to enhance knowledge of the experiences and practices of European children and their parents regarding online risks and safety. A crucial research effort by the EU Kids Online network has been a survey in 25 European countries which targeted approximately 1,000 children per country. This article applies a cross-cultural values filter to the data that were gathered on parental mediation and the Internet in this survey. Our intention is to test whether Geert Hofstede’s (...) cross-national research results about national cultural values also apply to the EU Kids Online data on parental mediation. This implies studying collectivism versus individualism, low versus high power distance, masculinity versus femininity and low versus high uncertainty avoidance. We test whether differences between nations on these four dimensions correlate with differences between countries in parental mediation of the Internet and we test which European countries form clusters. (shrink)

This article critically examines the paradigm shift from the attention economy to the intimacy economy—a market system where personal and emotional data are exchanged for customized experiences that cater to individual emotional and psychological needs. It explores how AI transforms these personal and emotional inputs into services, thereby raising essential questions about the authenticity of digital interactions and the potential commodification of intimate experiences. The study delineates the roles of human–computer interaction and AI in deepening personal connections, significantly impacting (...) emotional dynamics, and underscores AI’s role in various applications, from healthcare to grief tech, highlighting both enhancements in emotional connections and potential disruptions to genuine human interactions. An AI-mediated framework (AMIE) is introduced to assess how AI reshapes these connections and the overall digital society through personalized interactions. This framework explores the interplay between human emotions and AI-generated responses within the new Avatar Sphere, emphasizing the necessity for regulatory measures to safeguard digital identities, recognize emotional data as intellectual property, and maintain system transparency. It highlights the critical need for maintaining genuine human interactions and advocates for context-aware consent, continuous monitoring, and cross-cultural considerations to foster ethical AI practices. Leveraging blockchain technology and decentralized autonomous organizations, the framework proposes methods to enhance individual control over emotional data, mitigating the commodification risks. The findings contribute to ongoing discussions on AI ethics, digital privacy, and the future of human-AI interactions, providing valuable insights for cultivating a responsible intimacy economy. (shrink)

A standard view would suggest that research is a neutral apolitical activity. It neutralizes external pressures by its fidelity to robust scientific methods. However, politics is an inevitable part of human knowledge. Our knowledge of the world is always mediated by human priorities. What matters is therefore a contested and political debate rather a neutral accumulation of factual data. How researchers manage this varies. Research paradigms are one way in which research engages with knowledge. They frame knowledge within epistemological and (...) ontological philosophies. In this paper, I will explore this view in relation to neo‐positivism, qualitative research, Foucault and critical realism. I will argue that if nursing knowledge is to be effective it needs to acknowledge the political, particularly in the context of neoliberalism. Healthcare systems are having to cope with a social world increasingly dominated by market fundamentalism, extreme levels of inequality and a rise in xenophobia. These forces are undermining the provision of ethically sound health care, misdirecting research practice and contributing to a discourse of dehumanization. These forces need to be challenged politically and I will argue that epistemologically diverse approaches, alongside a realist ontology can provide a way forward for nursing research. (shrink)

Luthra, Peraza-Santiago, Beeson, Saltzman, Crinnion, and Magnuson (2021) present data from the lexically mediated compensation for coarticulation paradigm that they claim provides conclusive evidence in favor of top-down processing in speech perception. We argue here that this evidence does not support that conclusion. The findings are open to alternative explanations, and we give data in support of one of them (that there is an acoustic confound in the materials). Lexically mediated compensation for coarticulation thus remains elusive, while prior data (...) from the paradigm instead challenge the idea that there is top-down processing in online speech recognition. (shrink)

The philosophical paradigm of world perception has changed the mediator. Humans as body and mind become insufficient to know what the world is or is believed to be. The anthropological, social, and ethical basis of the relationship between humans and the world gains importance in comparison with the previously dominant metaphysical background. The relationship between humans and the world is transformed into a relationship between humans and the human world, as a thought endeavor to encourage and recognize the changes (...) that the world is going through as a result of human intervention. This paper will discuss three main issues. First, perception to know objects: (a) the question of the external world as a perception of changed sensibility, and (b) a new understanding of perception – mediation, as a result of technological development. Second, perception to understand relationships in the human world: (a) how the question of perception becomes a question of communication within the human world (symbolic space of perception as knowledge of relationships), and (b) if the need for an epistemological foundation is overcome by the anthropological and ethical context. Third, perception to change the paradigm of relations with the out-of-human world: (a) how under the influence of technology the “truth about a thing” becomes the “truth of a thing”, or how the subject-object relationship is replaced, and (b) does technology facilitate communication with that which is not “our world”? In conclusion, we will discuss the “truth of things” through the “truth of relationships” to the “truth of principles and responsibilities”. (shrink)

In a society where mobility, globalization and contact with people from other cultures have become its basic descriptors, the enhancement of plurilingualism and intercultural understanding seem to be of the utmost concern. From a Positive Psychology Perspective, agency is the human capacity to affect other people positively or negatively through their actions. This agentic vision can be related to mediation, a concept rooted in the socio-cultural learning theory where social interaction is considered a fundamental cornerstone in the development of (...) cognition. Social interactions in the language learning setting may be facilitated through musical activities due to its social bonding effect. This paper tries to offer insights on how a musical-mediated experience in language learning may develop students’ interpersonal and collaborative competences to become active members of a more inclusive society. Mediation, considered as a paradigm shift in the foreign language classroom and the different out-of-class language learning possibilities, could also provide an environment where learners maximize their emotional intelligence. Our paper focuses on this paradigm shift spearheaded by the CEFR Companion Volume and the considerable repercussions it is bound to have for foreign language didactics, as cooperative tasks become central to foreign language learning. We hypothesize that mediated language learning experiences imply a socioemotional change in learners, focusing on the others, on their needs and interests, by trying to help them understand texts, concepts or facilitating communication with their peers. An intervention with a musical-mediated language learning experience was designed and implemented in the classroom. A self assessment scale with mediation descriptors and the socioemotional expertise scale (SEE) were administered. Results show that students become more mindful of their strengths, of their capacity for collaborating and team working. This leads to more awareness of their mediation skills. Students’ mediation skills correlate significantly with their socio-emotional skills, more concretely with their expressivity. The implementation of a musical-mediated experience also promoted tolerance and enhanced learners’ intrinsic motivation for language learning at the same time as they acknowledged their diversity. (shrink)

Identifying the role of opioids in the mediation of learned sexual behaviors has been complicated by the use of differing methodologies in the investigations. In this review addressing multiple species, techniques, and pharmaceutical manipulations, several features of opioid mediation become apparent. Opioids are differentially involved in conditioned and unconditioned sexual behaviors. The timing of the delivery of a sexual reinforcer during conditioning trials, especially those using male subjects, acutely influences the role that opioids have in learning. Opioids may (...) be particularly important in the maintenance of conditioned sexual behaviors during periods of non-reinforcement. This appears to be true both for probe trials and procedures designed explicitly to extinguish a sexual conditioned response. These features of opioid mediation of learning do not appear to be restricted to sexual conditioning paradigms. This suggests that, as for other aspects of sexual learning that despite distinctive features conform to underlying behavioral principles, the mediation of conditioned sexual behavior by opioids relies on processes common across reinforcement systems. Keywords: opiate; conditioning; extinction; persistence; naloxone; learning (Published: 15 March 2012) Citation: Socioaffective Neuroscience & Psychology 2012, 2 : 14874 - DOI: 10.3402/snp.v2i0.14874. (shrink)

Heterochronic genes control the timing of developmental programs. In C. elegans, two key genes in the heterochronic pathway, lin-4 and let-7, encode small temporally expressed RNAs (stRNAs) that are not translated into protein. These stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3′ untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 family of proteins, which are better known for their (...) roles in RNA interference (RNAi). However, stRNA function appears unrelated to RNAi. Both sequence and temporal regulation of let-7 stRNA is conserved in other animal species suggesting that this is an evolutionarily ancient gene. Indeed, C. elegans, Drosophila and humans encode at least 86 other RNAs with similar structural features to lin-4 and let-7. We postulate that other small non-coding RNAs may function as stRNAs to control temporal identity during development in C. elegans and other organisms. BioEssays 24:119–129, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Many critics view Irigaray's work as an extension or deconstruction of a Lacanian paradigm. Few actually analyse it as a direct challenge to Lacanian concepts of symbolic subjectivity, and the consequent, alternative framework this would envisage. This article discusses a poss ible beyond the phallus, in relation to mediating concepts of the female imaginary and symbolic within her work, and an understanding of the female imaginary and symbolic within different feminist interpretations of the maternal imaginary and symbolic, arguing that (...) the imaginary is crucial in delineating a non-separatist cultural sublimation of female desire. Feminist revisions of the Oedipal by Jessica Benjamin and Kaja Silverman are examined in relation to the question of a maternal imagin ary and symbolic. Irigaray objects to Silverman's privileging of a Lacan ian concept of symbolic castration because it cannot negotiate between the literal relation to the body, and the metaphors and language of our cultural symbolic. Her female imaginary and symbolic provide this mediating link in direct challenge to the overly literal penis of Freud's castration complex and the essentially metaphorical nature of Lacan's phallus. Her mediation is related to the work of diverse psychoanalytic thinkers such as Andrew Samuels, Cornelius Castoriadis and Anthony Elliott. Returning to a feminist reading by Margaret Whitford, this article finally negates a Lacanian understanding of these structures and goes on to explore Irigaray's creative bodily imaginary, within two of her papers on analytic practice. Elaboration of a bodily and creative imaginary within the clinical setting can represent necessary mediation between real and symbolic and between the psyche and culture: this HISTORY OF THE HUMAN SCIENCES Vol. 10 No. 2 @ 1997 SAGE Publications (London, Thousand Oaks and New Delhi) pp. 41-60 [0952-6951(199705)10:2] mediation is personified through the hysteric, not through the Oedipal Law of the Father, which is finally the key question in culturally locat ing female desire, thereby connecting the theory of psychoanalysis with practice and with history. (shrink)

The integrity of the human being made in the image and likeness of God (Genesis 1:26) has been a challenge confronting not just the theologian, but great rulers, politicians, reformers, scientists, poets, artists, composers and novelists over centuries. The Orthodox Tradition might note that our human condition in time and space is shaped and challenged by this journey from likeness to image. Biblically we journey to see the face of God. Less theologically, the human condition is shaped by the tensions (...) and contradictions as we journey to seek 'freedom'. Paradigms of Freedom explores, in the context of the unfolding of modern history, how this challenge has been compounded and enriched by the people and institutions who have sought to find and promote the concept of freedom (and issues of personal liberty) in the face of contrary or oppressive circumstances and systems. Importantly, it will examine the contribution of the artist to various models of freedom, some of which may be identified as vectors of transcendence; when image becomes likeness. The nature of human society, the sense of social harmony and paternalistic control that characterized society for centuries, and especially the emergence of Western culture, began to crumble in the fourteenth century with the cataclysmic onslaught of the Black Death; the challenge to the monolithic power of the Church and the nature of feudalism; the growth of new philosophical and political theories; and overall crumbling of authority. In the fifteenth century new developments like the invention of printing; the standardization of modern languages; and the global expansion of exploration, mercantilism and colonization presented unprecedented horizons of growth and challenges to the place and meaning of humanity in the world. These challenges are embodied in the Renaissance and Reformation, where the very foundations of belief and knowledge were questioned in new processes of discovery in both the world and the cosmos. The nature of freedom to search, to question and to discover new things brought about political and intellectual developments in an ever-expanding series of movements and interrogations. Moved by the annals of the times, individuals have sought to understand and perpetuate the heroic struggles through their own creative power. This in turn can draw us to share in those lost or sorrowful times, and reflect on the sacrifice and vision of those who have been prepared to witness fearlessly to the indomitable spirit of mankind, and his slow but inexorable movement or journey into the light. This exposition will examine various types/paradigms that have proposed and embodied concepts of freedom. These have tried, and often succeeded, in serving as vectors of transcendence, meditating on and mediating human aspiration. Such reflective movements of mind and heart are embodied both contemporaneously and retrospectively in various historical movements, political gestures and artistic creativity that have provoked thoughts on human liberty: political actions, decrees, philosophy, books, pictorial art, novels, poetry, theatre, opera and film. Representatives and examples (in words and imagery) of all these modes are exemplified in the chapters that explore certain iconic movements and personalities in some of the key historical and social events of the past six centuries. The process is of necessity selective. Religious conflict, freedom of thought and denomination, the wars fought over faith and control of the land, the desire for liberty of choice, challenging new discoveries in science and geography, cosmology, colonialism and slavery, Enlightenment, revolution and the search for national identity and independence-these are all areas that have absorbed human thought, knowledge and aspiration, and resulted in inevitable artistic reflection. This is not a history but a consideration of mankind's search to be free, and how this striving is embodied in the poetry of liberation. (shrink)

In this paper we critically review recent developments in policies, practices and philosophies pertaining to the mediation between science and the public within the EU and the UK, focusing in particular on the current paradigm of Public Understanding of Science and Technology (PEST) which seeks to depart from the science information-transmission associated with previous paradigms, and enact a deliberative democracy model. We first outline the features of the current crisis in democracy and discuss deliberative democracy as a response (...) to this crisis. We then map out and critically review the broad outlines of recent policy developments in public-science mediation in the EU and UK contexts, focusing on the shift towards the deliberative-democratic model. We conclude with some critical thoughts on the complex interrelationships between democracy, equality, science and informal pedagogies in public-science mediations. We argue that science and democracy operate within distinct value-spheres that are not necessarily consonant with each other. We also problematize the now common dismissal of information-transmission of science as inimical to democratic engagement, and argue for a reassessment of the role and importance of informal science learning for the lay public, provided within the framework of a deliberative democracy that is not reducible to consensus building or the mere expression of opinions rooted in social and cultural givens. This, we argue, can be delivered by a model of PEST that is creative and experimental, with both educational and democratic functions. (shrink)

This volume proposes an interdisciplinary framework that views attention from a particular angle: as a means of accessing, that is, disclosing the world in a practical and meaningful way. Moreover, it investigates how this access is concretely mediated. The book is structured in the following two parts: 1) Attention and Access The first section is concerned with attention as such. What is attention and what does it do? A common thread between the expected contributions addresses attention as a directional disclosing (...) process, opening up a possibility of access to the world. This section brings contributions from a cognitive psychology/neuroscience into dialogue with phenomenology and philosophy of mind; and links attention research to new paradigms, such as predictive coding, and 4e cognition. 2) Attention and Mediation The second section tackles the question of how this disclosing process may work. Concrete disclosing is always framed by different factors and frames the world. The contributions in this section spell out the different ways in which attention is mediated and shaped by technology, situations, sociality etc., and the ways in which attention mediates our access to the world. (shrink)

This article examines the regulation of nonsteroidal anti-inflammatory drugs, with particular focus on products approved for marketing in the United Kingdom, while denied marketing approval in the United States on safety grounds, and then subsequently withdrawn from the UK market on those grounds. Using international comparison of regulatory data never before accessed outside government and companies, together with interviews with relevant industry scientists and regulators, the article demonstrates the importance of regulatory expectations, deficits and paradigms. It is argued both that (...) these sociological concepts can be enriched by their application to detailed comparative case study of regulatory science, and that they provide an important policy-relevant framework with which to understand discrepant drug regulatory processes in a sociohistorical context. It is found that regulatory expectations and paradigms may be regarded as mediating factors between political culture and structural interests, on the one hand, and the outcomes of regulatory science, on the other. (shrink)

The communicative affordances of the participatory web have opened up new and multifarious channels for the proliferation of hate. In particular, women navigating the cybersphere seem to be the target of a disproportionate amount of hostility. This paper explores the contexts, approaches and conceptual synergies around research on online misogyny within the new communicative paradigm of social media communication. The paper builds on the core principle that online misogyny is demonstrably and inherently a discourse; therefore, the field is envisaged (...) at the intersection of digital media scholarship, discourse theorization and critical feminist explications. As an ever-burgeoning phenomenon, online hate has been approached from a range of disciplinary perspectives but has only been partially mapped at the interface of meaning making contents/processes and new mediation technologies. The paper aims to advance the state of the art by investigating online hate in general, and misogyny in particular, from the vantage point of Social Media Critical Discourse Studies ; an emerging model of theorization and operationalization of research combining tenets from Critical Discourse Studies with scholarship in digital media and technology research. Our SM-CDS approach to online misogyny demarcates itself from insinuation whereby the phenomenon is reduced to digital communicative affordances per se and argues in favor of a double critical contextualization of research findings at both digital participatory as well as social and cultural levels. (shrink)

Chad A Witt, Ramsey R Hachem Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, MO, USA: The role of donor-specific antibodies to human leukocyte antigens and the burden of antibody-mediated rejection in lung transplantation remain enigmatic. Over the past several years, evidence has been emerging that humoral immunity plays an important role in the development of both acute and chronic lung allograft dysfunction. Multiple case reports and case series have identified (...) lung allograft recipients with clinical findings consistent with acute AMR. However, there is currently no widely accepted definition for AMR in lung transplantation, and this has been a significant barrier to furthering our understanding of this form of rejection. Nonetheless, the development of DSA after transplantation has consistently been identified as an independent risk factor for persistent and high-grade acute cellular rejection and CLAD. This has raised the possibility that chronic AMR may be a distinct phenotype of CLAD although evidence supporting this paradigm is still lacking. Additionally, antibodies to lung-restricted self-antigens have been associated with primary graft dysfunction early and the development of CLAD late after transplantation, and emerging evidence underscores significant interactions between autoimmunity and alloimmunity after transplantation. There is currently an active International Society for Heart and Lung Transplantation working group that is developing an operational definition for AMR in lung transplantation. This will be critical to improve our understanding of this form of rejection and conduct clinical trials to identify optimal treatment strategies. This review will summarize the literature on DSA and AMR in lung transplantation and discuss the impact of antibodies to self-antigens on lung allograft dysfunction. Keywords: antibody-mediated rejection, donor-specific antibodies, lung transplantation. (shrink)

Based on Moscovici’s classical study on the cultivation of psychoanalytic ideas in France in the 1950’s and our own research on modern biotechnology, we propose a paradigm for researching social representations. Following a consideration of the nature of representations and of the ‘iconoclastic suspicion’ that haunts them, we propose a model of the emergence of meaning relating three elements: subjects, objects, and projects. The basic unit of analysis is the elongated triangle of mediation : subject 1, object, project, (...) and subject 2, captured in the image of a ‘Toblerone’. Such social units cultivate, that is produce, circulate and receive representation which may be embodied in four modes–habitual behaviour, individual cognition, informal communication and formal communication–and in three mediums–words, visual images or non-linguistic sounds. We propose an operational definition of a ‘social representation’ as the comparison of four characteristics of communication systems: the content structures , the typified processes , and their functions , within the context of segmented social milieus. Seven implications for research on social representations are outlined: content and process; segmentation by social milieus rather than taxonomies; cultivation studies within social milieus; multi-method analysis; time structures and longitudinal data; the crossover of cultural projects and trajectories; the disinterested research attitude. This ideal type paradigm leads to an operational clarification to identify new research questions, and to guide the design and evaluation of studies on social representations. (shrink)

When you enrol as a student you are assigned a ‘place’ in education. This assignment will gradually imply an assessment of you as a human being. We argue that these are processes taking place in educational practice. In our orientation in educational research an orientation towards a theory of action has been inspired by the French philosopher Paul Ricoeur. In our search for an educational practice that could describe what it is that makes the student a capable human being we (...) continue in the spirit of Ricoeur. The text is divided in two parts. In the first part, Basic Capabilities in Education, we are asking: Who is the student if education is the process where the student learns to be a capable human being? We try to answer this with the help of Ricoeur’s phenomenology of the capable human being which is structured around the capacity to speak, to act, to tell and finally to impute. In the second part, Institutional Mediations of Capabilities in Education, we try to show how the transmission of the human capacities to an actualization through education at an institutional level, represented by the teacher, is necessary. If the student shall become a capable human being s/he has to have conditions for actualizations of her capacities. A paradigm for this is found in the process of assigning and assessing in education. (shrink)

I provide a distinctively Wittgensteinian interpretation of Hegel’s Subjective Logic, including the parts on the concept, the judgement and the syllogism. I argue that Wittgenstein implicitly recognised the moments of universality, particularity and individuality; moreover, he was sensitive to Hegel’s crucial distinction between abstract and concrete universals. More specifically, for Wittgenstein the moment of particularity has the status of a paradigmatic sample which mediates between a universal concept and its individual instances. Thus, a concrete universal is a universal that includes (...) every individual via its paradigmatic sample. Next, I provide a generic account of the emergence of concrete universals through a series of negations that follows the basic structure of Hegel’s judgement—“the individual is the universal”—and the syllogism—“the individual is the universal mediated by the particular”. This development is illustrated with examples from Hegel (a plant, Socrates, Caesar, a Stoic sage, Jesus) as well as from Wittgenstein (colour samples, the standard metre, works of art). I take Wittgenstein’s argument against private language as implying that we cannot do without paradigms in our epistemic practices. If the conclusion of the section “Subjectivity” in Hegel’s Science of Logic is that the moment of particularity cannot be ignored or dispensed with, then it would mean that we cannot do without paradigms in our epistemic practices: that is, that private rules are impossible. (shrink)

The research aim of this article is to answer the question of the validity of the dialogical paradigm when confronted with the challenges posed by new digital technologies. The article is a synthetic and selective study of this issue. The research intention is realised in several points. The scope of considerations includes a brief presentation of the issue of paradigm as an important element in contemporary science, the presentation of key issues in the field of philosophy of dialogue (...) and the significance of the dialogical approach for challenges that arise in the context of new technologies. The thesis of this article is that the way of understanding the phenomenon of encounter proposed by dialogicalists makes it possible to assess the directions of the development of new technologies in such aspects as: the experience of the subjectivity of the Other in technological mediation, personal authenticity versus mediality, the limitation of human autonomy. The next part of the article will be a discussion of selected digital technologies which, due to the effects produced on their users, pose a social challenge. In the article, I apply the critical-analytical method, there is also an attempt to reconstruct concepts and an application of own observations. The article ends with conclusions based on the analysis presented. (shrink)

The demonstration that dendritic cell (DC)‐derived exosomes can be exploited for targeted RNAi delivery to the brain after systemic injection provides the first proof‐of‐concept for the potential of these naturally occurring vesicles as vehicles of drug delivery. As well as being amenable to existing in vivo targeting strategies already in use for viruses and liposomes, this novel approach offers the added advantages of in vivo safety and low immunogenicity. Fulfilment of the potential of exosome delivery methods warrants a better understanding (...) of their biology, as well as the development of novel production, characterisation, targeting and cargo‐loading nanotechnologies. Ultimately, exosome‐mediated drug delivery promises to overcome important challenges in the field of therapeutics, such as delivery of drugs across otherwise impermeable biological barriers, such as the blood brain barrier, and using patient‐derived tissue as a source of individualised and biocompatible therapeutic drug delivery vehicles. (shrink)

The The sustainability of social life is based on social values. The manifestation of these values also takes place within the society. On the other hand, the realization of individuals is possible in society because a non-social human being is not a "human" in the philosophical sense. With human-oriented conditions that manifest themselves in the network of social relations, the criteria (moral values) related to the purpose of creation crystallize and become known so that the construction of a social (...) class='Hi'>paradigm becomes possible. However, the society in which individuals live is also surrounded by an external world (material world). For this reason, the social paradigm also indirectly relies on a perception of the outside world. Thus, no matter what period of history, people's endeavor for an ideal society is accompanied by an interpretation of the external world, and with this "cumulative" knowledge, a "reducing" simulation of being is derived (cosmology). In fact, causality, which is the subject of physics, becomes the subject of philosophy in this mediation. As it can be understood, a significant problem here is the correlation between the fixed values (unconditional imperatives) that form the core of the social paradigm and the variable external world knowledge that is culturally effective in the manifestation of these values. Consequently, while determining the rules in the social order, one should act on the basis of values, not as if they have absolute knowledge of the material world. Whether we believe that the universe consists of "seven heavens" and is geocentric or heliocentric; Existential values such as justice, equality, and freedom are essential regardless of time and space. However, as historical facts show, those who have problems with this value system, which is accompanied by an interpretation of the external world, have raised objections through ever-developing knowledge of nature instead of universal values. For this reason, the geocentric perception of the universe, which forms the basis of the political paradigm in the class-based society of medieval Europe, was strongly desired to be maintained by the ruling classes. Ultimately, although this model of the universe collapsed, moral pursuits of human life continued to be sabotaged for the same political reasons, and disinformation began. Thus, scientific studies and the search for the truth (philosophy) were accompanied by endless polemics disguised as "philosophy." In fact, this situation reveals two opposing attitudes that repeat themselves in history, either in the East or the West: paradigmatic attitude (paradigmism) and enigmatic attitude (enigmatism). As a reflection of these two attitudes, the dominant discourse, which categorically accuses even the interest in understanding Western modernization in the Islamic world as heresy, did not occasionally hesitate to refer to some Western references by confirming with a vulgar pragmatism. For instance, Newtonian physics has been ignored. On the other hand, an attempt has been made to jump directly from Aristotelian physics to quantum physics by assuming an overlapping in classical texts. However, facing the new knowledge of nature has more actual consequences than polemics. To face these results and to show the legitimacy of Islamic values in the modern era, which are in conformity with the creation of human beings, the developments in the current knowledge of the universe (modern cosmology) cannot be ignored. This endeavor can be possible only when the philosophical and historical foundations of the subject are examined throughout the Western experience. (shrink)

In light of the pragmatic aspirations of ordinary language philosophy, this essay critically examines the competing grammatical strictures that are often set forth within the theoretical discourse of 'power'. It repudiates both categorically appraisive employments of 'power' and the antithetical urge to fully operationalize the concept. It offers an attenuated defense of the thesis that 'power' is an essentially contestable concept, but rejects the notion that this linguistic fact stems from conflict between antipodal ideological paradigms. Careful attention to the ordinary (...) pragmatics of power-language evinces the prospects for integrating various context-specific aspects of power and mediating between traditionally divergent theoretical frameworks. (shrink)

The multiple activities of the RecA protein in DNA metabolism have inspired over a decade of research in dozens of laboratories around the world. This effort has nevertheless failed to yield an understanding of the mechanism of several RecA protein‐mediated processes, the DNA strand exchange reactions prominent among them. The major factors impeding progress are the invalid constraints placed upon the problem by attempting to understand RecA protein‐mediated DNA strand exchange within the context of an inappropriate biological paradigm – (...) namely, homologous genetic recombination as a mechanism for generating genetic diversity. In this essay I summarize genetic and biochemical data demonstrating that RecA protein evolved as the central component of a recombinational DNA repair system, with the generation of genetic diversity being a sometimes useful byproduct, and review the major in vitro activities of RecA protein from a repair perspective. While models proposed for both recombination and recombinational repair often make use of DNA strand cleavage and transfer steps that appear to be quite similar, the molecular and thermodynamic requirements of the two processes are very different. The recombinational repair function provides a much more logical and informative framework for thinking about the biochemical properties of RecA and the strand exchange reactions it facilitates. (shrink)

Dynamic resilience is a novel concept that aims to quantify how individuals are coping while operating in dynamic and complex task environments. A recently developed dynamic resilience measure, derived through autoregressive modeling, offers an avenue toward dynamic resilience classification that may yield valuable information about working personnel for industries such as defense and elite sport. However, this measure classifies dynamic resilience based upon in-task performance rather than self-regulating cognitive structures; thereby, lacking any supported self-regulating cognitive links to the dynamic resilience (...) framework. Vagally mediated heart rate variability (vmHRV) parameters are potential physiological measures that may offer an opportunity to link self-regulating cognitive structures to dynamic resilience given their supported connection to the self-regulation of stress. This study examines if dynamic resilience classifications reveal significant differences in vagal reactivity between higher, moderate and lower dynamic resilience groups, as participants engage in a dynamic, decision-making task. An amended Three Rs paradigm was implemented that examined vagal reactivity across six concurrent vmHRV reactivity segments consisting of lower and higher task load. Overall, the results supported significant differences between higher and moderate dynamic resilience groups' vagal reactivity but rejected significant differences between the lower dynamic resilience group. Additionally, differences in vagal reactivity across vmHRV reactivity segments within an amended Three Rs paradigm were partially supported. Together, these findings offer support toward linking dynamic resilience to temporal self-regulating cognitive structures that play a role in mediating physiological adaptations during task engagement. (shrink)

Many studies showed that comprehenders monitor changes in protagonists’ emotions and actions. This article reports two experiments that explored how focusing comprehenders’ attention on a particular property of the protagonist dimension affects the accessibility of information about target objects mentioned in the sentence. Furthermore, the present research examined whether participants’ attitudes toward the issues described in the sentence can modulate comprehension processes. To this end, we asked participants to read sentences about environmental issues that focused comprehenders’ attention on different mental (...) and physical attributes of the same entities and then self-report their own thoughts on the topic of environment by responding to the items assessing their environmental awareness. Importantly, we manipulated the task requirements across two experiments by administering a self-report task, which required the participants to rate the seriousness and the frequency of the problem mentioned in a sentence; and administering a sentence-picture verification paradigm, which required the participants to merely indicate if the object depicted in the picture was mentioned in the preceding sentence. The results of these experiments suggest that the focus of a sentence on the environmental problem enhances the accessibility of information about environmental issues ; that the comprehender’s level of environmental awareness influences one’s attention during sentence processing; and that comprehender characteristics significantly modulate comprehension processes only when the measures tap into explicit processes. (shrink)

This paper is inspired by the 1995 dispute between the philosophers Jürgen Habermas and John Rawls in the Journal of Philosophy about the role of the philosopher in the public sphere. I am criticizing Habermas in his attempt to depict Rawls as a kind of justice expert. I am grounding my defence of Rawls in an argument that parallels Quine’s indeterminacy argument.This crossover of argumentative strategies taken from analytic philosophy into moral and political theory maybe can account for the relevance (...) of this paper to post-linguistic-turn philosophy, firstly, because the syncretistic nature of such an attempt bears a certain affinity to postmodern fashions of thinking. Secondly, I believe that a thinker such as Quine who is firmly rooted in the analytic tradition nevertheless surpasses this tradition in a way that in some respects may be seen as paralleling the developments in post-structuralist and postmodern thought.In Quine and some of his contemporaries and disciples, analytic philosophy turns away from the positivist assumptions of its fathers. It no longer stipulates a single way of representing the positive world in the one and only true theory. Truth, in fact, comes to be looked at as relative to a theory of which there can be many. However, if many theories serve the same purpose equally well, then truth, as theory dependent, becomes a pluralistic concept itself.This much I think I should say to guard against the misunderstanding that all analytic philosophy is positivistic and hence that all moral and political theory that avails itself of argumentative strategies from the analytic school is infected by positivism. Analytic philosophy has of course inherited the scepticism of the positivists with respect to classical metaphysics. It refused to tackle metaphysical problems directly because it very often dismissed them as merely a confused way of speaking.In order to assess where the problem is real or where, in fact, there is no problem at all, analytic philosophy turned towards our common way of speaking about the problem in question. Instead of directly asking, for example, whether human beings have a free will, analytic philosophers would ask: how do we talk about freedom? Or: what do we mean by the word 'freedom' in our everyday conversation?Consequently, either the metaphysical problem would go away or it had to be reformulated and clarified in terms of a language that we do understand. Asking these kinds of questions is of course critical of classical metaphysics, but it is not necessarily positivistic.Thus, it seems that we have to distinguish two kinds of philosophical schools both operating under the paradigm of the linguistic turn: the early positivist and the later non-positivist schools of analytic philosophy. Both share the view that reflection upon language is the primary step in philosophical investigation. They differ in their respective monistic and pluralistic conceptions of science and truth.Now, the question arises as to where to place moral and political theory within this paradigm. Until the early seventies when Rawls's Theory of Justice appeared, it was commonly held among analytic philosophers that moral and political theory had no place at all in modern post-metaphysical philosophy. It was either not scientific enough or it would be subsumed under the social sciences.It is Rawls, precisely, who made this view obsolete demonstrating that moral and political theory can operate outside the whole paradigm of post-linguistic-turn analytic philosophy and still not fall prey to the inadequacies of the old-fashioned metaphysics that had been dismissed. I would therefore call Rawls an early post-linguistic-turn philosopher. (shrink)

The environmentally responsive molecular chaperone Hsp90 assists the maturation of many key regulatory proteins. An unexpected consequence of this essential biochemical function is that genetic variation can accumulate in genomes and can remain phenotypically silent until Hsp90 function is challenged. Notably, this variation can be revealed by modest environmental change, establishing an environmentally responsive exposure mechanism. The existence of diverse cryptic polymorphisms with a plausible exposure mechanism in evolutionarily distant lineages has implications for the pace and nature of evolutionary change. (...) Chaperone‐mediated storage and release of genetic variation is undoubtedly rooted in protein‐folding phenomena. As we discuss, proper protein folding crucially affects the trajectory from genotype to phenotype. Indeed, the impact of protein quality‐control mechanisms and other fundamental cellular processes on evolution has heretofore been overlooked. A true understanding of evolutionary processes will require an integration of current evolutionary paradigms with the many new insights accruing in protein science. BioEssays 26:348–362, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This paper selectively reviews the neurophysiological evidence for shared neural circuits (supposedly implemented by mirror neurons) as the mechanism underlying empathy. I will argue that while the mirror neuron system plays a role in motor resonance, it is not possible to conclude that this system is critically involved in emotion recognition, and there is little evidence for its role in empathy and sympathy. In addition, there is modest support from neurological observations that lesion of the regions involved in the mirror (...) neuron system leads to dysfunction in empathy, whereas damage of the ventromedial prefrontal cortex is associated with such impairment. To significantly advance our understanding of the mechanisms underlying empathy, research needs finer conceptualization, better designed paradigms, and integration with knowledge from lesion studies. (shrink)

We examined the role of verbal mediation in planning performance of English–Spanish-speaking bilingual children and monolingual English-speaking children, between the ages of 9 and 12 years. To measure planning, children were administered the Tower of London (ToL) task. In a dual-task paradigm, children completed ToL problems under three conditions: with no secondary task (baseline), with articulatory suppression, and with non-verbal motor suppression. Analyses revealed generally shorter planning times for bilinguals than monolinguals but both groups performed similarly on number (...) of moves and execution times. Additionally, bilingual children were more efficient at planning throughout the duration of the task while monolingual children showed significant gains with more practice. Children’s planning times under articulatory suppression were significantly shorter than under motor suppression as well as the baseline condition, and there was no difference in planning times between monolingual and bilingual children during articulatory suppression. These results demonstrate that bilingualism influences performance on a complex EF measure like planning, and that these effects are not related to verbal mediation. (shrink)

Individuals with anxiety disorders show deficits in the discrimination between a cue that predicts an aversive outcome and a safe stimulus that predicts the absence of that outcome. This impairment has been linked to increased spontaneous recovery of fear following extinction, however it is unknown if there is a link between discrimination and return of fear in a novel context. It is also unknown if impaired discrimination mediates the relationship between trait anxiety and either spontaneous recovery or context renewal. The (...) present study used a differential fear conditioning paradigm to examine the relationships between trait anxiety, discrimination learning, spontaneous recovery and context renewal in healthy volunteers. Fear learning was assessed using continuous ratings of US expectancy and subjective ratings of fear. Discrimination mediated the relationships between trait anxiety and both spontaneous recovery and context renewal such that elevated trait anxiety was associated with poorer discrimination, which in turn was associated with increased fear at test phases. Results are discussed in terms of the genesis and maintenance of anxiety disorders. (shrink)

Long-lasting interference effects in picture naming are induced when objects are presented in categorically related contexts in both continuous and blocked cyclic paradigms. Less consistent context effects have been reported when the task is changed to semantic classification. Experiment 1 confirmed the recent finding of cumulative facilitation in the continuous paradigm with living/non-living superordinate categorization. To avoid a potential confound involving participants responding with the identical superordinate category in related contexts in the blocked cyclic paradigm, we devised a (...) novel set of categorically related objects that also varied in terms of relative age – a core semantic type associated with the adjective word class across languages. Experiment 2 demonstrated the typical interference effect with these stimuli in basic level naming. In Experiment 3, using the identical blocked cyclic paradigm, we failed to observe semantic context effects when the same pictures were classified as younger–older. Overall, the results indicate the semantic context effects in the two paradigms do not share a common origin, with the effect in the continuous paradigm arising at the level of conceptual representations or in conceptual-to-lexical connections while the effect in the blocked cyclic paradigm most likely originates at a lexical level of representation. The implications of these findings for current accounts of long-lasting interference effects in spoken word production are discussed. (shrink)

This article seeks to overcome some of the greatest difficulties in generating a feminist-friendly approach to sacraments by proposing a new paradigm: sacraments as forms of energy. Several factors have hindered feminist theologians in revisioning sacramentality. For the most part sacraments were ‘done to’ women, never ‘done by’ women. A too-literal reading of the Christian scriptures blurs the fact that early Christians developed ritual patterns for Baptism and Eucharist first, and only later wrote them down. To speak of sacraments (...) as mediations may re-inscribe dualism. The static model of reality which explained sacraments in Aristotelian categories of matter and form has given way to dynamic models of matter and energy. A sacramentality of energy can be articulated from three different angles: first, in terms of the action of the Holy Spirit; second, from scientific advances in quantum thinking, and the third from new spirituality. This paradigm applies to both Baptism and Eucharist. (shrink)

This is a response to a short communication on our research presented in Solbrække et al. (Med Health Care Philos 20(1):89–103, 2017), which raises a series of serious allegations. Our article explored the rise of ‘the breast cancer gene’ as a field of medical, cultural and personal knowledge. We used the concept biological citizenship to elucidate representations of, and experiences with, hereditary breast cancer in a Norwegian context, addressing a research deficit. In our response to Møller and Hovig’s (Med Health (...) Care Philos 21(2):239–242, 2018a) opinionated piece, we start by questioning on which scientific grounds they base their knowledge claims and situate their criticism in a pre-determined positivist script, which exposes their incompetency when it comes to establishing a useful critique of our research. We tie this to an attitude of scientific supremacy, which reduces the complexity and specificity of different knowledges into a clichéd divide between ‘hard evidence’ and ‘fiction’—presented in a predictable narrative which seeks to establish research protagonists and antagonists. We elaborate on the rationale of our qualitative approach to analyzing and interpreting situated and mediated aspects of BRCA 1/2. We counter claims that our research does harm to patients. We refer to a medical scandal emerging from Norway where 21 women were wrongfully diagnosed and surgically treated for a mis-interpreted cancer gene mutation. In conclusion, we stand by the integrity of our research as reported in the original paper. Scientific supremacy and pre-scripted criticism impose considerable obstacles for the possibility of establishing interdisciplinary dialogue across knowledge paradigms in health care and medicine. We therefore urge readers to reflect on how we can establish and sustain ethically careful and truthful dialogue—without doing violence to epistemological differences—to protect and advance the interdisciplinarity that constitutes the journal’s scope. (shrink)

SUMMARYPeter Jonkers' paper ‘Justifying Sacrifice’ presents a subtle and nuanced defence of the ethical paradigm of sacrifice as offering up ‘for the sake of’ another item or principle. He employs Hegel and Levinas for this purpose. While Jonkers presents his position as in basic agreement with the position of John Milbank in his paper ‘Midwinter Sacrifice’, I claim that the two positions are, in fact, diametrically opposed. Milbank is proposing a radical critique of the ethical paradigm of sacrifice (...) as the product of, and in collusion with, secular nihilism. Thus there is no justification of sacrifice ‘for the sake of’ for Milbank: certainly not in the forms presented by either Hegel or Levinas. Milbank's motive for such a strident rejection of such theories lies in his overarching theory of the secular as itself an illegitimate alternative theology. I conclude, however, that Jonkers can withstand the challenge of Milbank. Nevertheless, any adequate justification of the model of sacrifice needs to be augmented by an account of both its metaphysical underpinning and its symbolism. (shrink)

The last two decades have witnessed growing interest in the study of social cognition and its multiple facets, including trust. Interpersonal trust is generally understood as the belief that others are not likely to harm you. When meeting strangers, judgments of trustworthiness are mostly based on fast evaluation of facial appearance, unless information about past behavior is available. In the past decade studies have tried to understand the complex relationship between trust and joint visual attention (i.e. attentional orienting following another (...) person’s gaze). This review will focus on the studies that used a gaze-cueing paradigm to explore this relationship. One study found enhanced gaze-following behavior with trustworthy faces; another one found stronger effects of gaze-following with faces associated with undesirable behavior. Notably, the majority of studies failed to observe significant interactions between trust and gaze-following. Overall, the evidence is mixed, and studies have highlighted the complexity of this relationship. Multiple factors seem to play a role, including the type of manipulation to induce trust, the level of trait-anxiety, and gender. We conclude that further investigation is needed to clarify whether an interaction exists between trust and joint visual attention, possibly focusing on the potential role of perceived threat. (shrink)

When two populations of cells within a tissue mass differ from one another in magnitude or type of intercellular adhesions, a boundary can form within the tissue, across which cells will fail to mix. This phenomenon may occur regardless of the identity of the molecules that mediate cell adhesion. If, in addition, a choice between the two adhesive states is regulated by a molecule the concentration of which is periodic in space, or in time, then alternating bands of non‐mixing tissue, (...) or segments, can form. But temporal or spatial periodicities in concentration will tend to arise for any molecule that is positively autoregu‐latory. It is therefore proposed that segmentation is a ‘generic’ property of metazoan organisms, and that metamerism would be expected to have emerged numerous times during evolution. A simple model of segmentation, based solely on differential adhesion and periodic regulation of adhesion, can account for segment properties as disparate as those seen in long and short germ band insects, and for diverse experimental results on boundary regeneration in the chick hind brain and the insect cuticle. It is suggested that the complex, multicom‐ponent segment‐forming systems found in contemporary organisms (e.g., Drosophila) are the products of evolutionary recruitment of molecular cues such as homeobox gene products, that increase the reliability and stability of metameric patterns originally templated by generic self‐organizing properties of tissues. (shrink)

Se propone el uso de la Semiótica como herramienta integradora para investigar los aspectos fundamentales de los seres vivos. Como tal, la Biosemiótica abre nuevas perspectivas metodológicas para integrar un gran numero de fenómenos aparentemente no vinculados o incompatibles entre sí. EI principio básico es que la Biología, desde el nivel molecular al sistemíco, puede ser estudiada como comunicación, y los procesos biológicos como interacciones mediadas por signos. La vida es definida como una propiedad sistemica de la materia. La Biología (...) es, en si misma y en todos sus aspectos, Semiótica Natural próxima al caos determinista. EI paradigma biosemiótico es propuesto como un paso hacia la formulación de una teoría sintética de la vida, que incorpore los componentes mecanistico-moIeculares, interpretaciones semioticas, y Ia historia natural de los sistemas vivientes.Semiotics is introduced as an integrative approach to investigate the intimate features of living systems. As an overarching concept, Biosemiotics offers new methodological perspectives to integrate a vast number of apparently unrelated phenomena. The basic tenet is that Biology, from the molecular to the systemic level, can be investigated as communication, and biological processes as sign-mediated interactions. Life is defined as a systemic property of matter. Biology is then, in all its aspects, Natural Semiotics with a proximity to deterministic chaos. The biosemiotic paradigm is intended as a step toward the establishment of a synthetic theory of life, incorporating the molecular-mechanistic components, the semiotic interpretations, and the natural history of the living systems. (shrink)

Odor and color are strongly associated. Numerous studies demonstrate consistent odor‐color associations, as well as effects of color on odor perception and language. Yet, we know little about how these associations arise. Here, we test whether language is a possible mediator of odor‐color associations, specifically whether odor‐color associations are mediated by implicit odor naming. In two experiments, we used an interference paradigm to prevent the verbalization of odors during an odor‐color matching task. If participants generate color associations subsequent to (...) labeling an odor, interfering with verbalization during the task should affect the ability to make color associations. In Experiment 1, contrary to our hypothesis, verbal interference did not affect odor‐color matches. However, since performance accuracy on the verbal interference task was high, it is possible our task did not sufficiently disrupt verbal processing. In Experiment 2, we, therefore, used an active verbal interference task, and still found no difference across interference conditions. Odor naming accuracy, odor familiarity, and odor pleasantness, however, did predict odor‐color matches. This suggests that although color associations are related to semantic factors, they are not generated by recruiting odor labels in the moment. Overall, our results do not provide evidence that language plays an online role in odor‐color associations, instead, they are consistent with the claim that language may have shaped associations during development. (shrink)

Metamodernism, which is used synonymous with post-postmodernism or neo-modernism, has come forward in response to postmodernism and the emerged crises, instabilities, and uncertainties in all areas of this epoch. Metamodernism is a perspective situated epistemologically with modernism, ontologically between modernism and historically beyond modernism. It seeks an oscillation between modernism and postmodernism with mediating between them and responding to existing cultural modes. Thus, metamodernism is a paradigm beyond modernism and postmodernism, trying to explain today’s cultural and intellectual developments which (...) are not sufficiently criticized by modernism nor postmodernism. This paper questions and discusses the understanding of this paradigm and its reflections on education, school leadership, and schooling in the Nordic countries. By reviewing education related reports, survey reports, books and articles about these countries, comprehending their philosophy of education throughout the years, and analyzing the ongoing educational developments, the main notion of metamodernism and its influences on schooling, leadership implications, classroom activities and research in education are focused on this paper. (shrink)