This article offers an overview of the main first-order ethical questions raised by robots and Artificial Intelligence (RAIs) under five broad rubrics: functionality, inherent significance, rights and responsibilities, side-effects, and threats. The first letter of each rubric taken together conveniently generates the acronym FIRST. Special attention is given to the rubrics of functionality and inherent significance given the centrality of the former and the tendency to neglect the latter in virtue of its somewhat nebulous and contested character. (...) In addition to exploring some illustrative issues arising under each rubric, the article also emphasizes a number of more general themes. These include: the multiplicity of interacting levels on which ethical questions about RAIs arise, the need to recognise that RAIs potentially implicate the full gamut of human values (rather than exclusively or primarily some readily identifiable sub-set of ethical or legal principles), and the need for practically salient ethical reflection on RAIs to be informed by a realistic appreciation of their existing and foreseeable capacities. -/- . (shrink)

We investigate dynamic operations acting over a knowing how logic. Our approach makes use of a recently introduced semantics for the knowing how operator, based on an indistinguishability relation between plans. This semantics is arguably closer to the standard presentation of knowing that modalities in classic epistemic logic. Here, we discuss how the semantics enables us to define dynamic modalities representing different ways in which an agent can learn how to achieve a goal. In this regard, we study two types (...) of updates: ontic updates (for which we provide axiomatizations over a particular class of models), and epistemic updates (for which we investigate some semantic properties). (shrink)

Ivan V. Sarailiev (1887-1969) was a pioneer convert to pragmatism, incorporating the pragmatic viewpoint in his writings as early as 1909. Born in an educated and intellectual family, his father was a lawyer, who graduated from St. Petersburg. Ivan Sarailiev studied in Paris under Bergson and graduated summa cum laude from the Sorbonne in 1909. Although he was fluent in French, English, and German, he wrote almost exclusively in Bulgarian. As a result, his achievements remained largely unknow...

The minimax theorem of matrix game theory is examined from a constructive point of view. It is then shown that the existence of solutions for matrix games cannot be proved constructively, but that a 2-by-2 game with at most one solution has a constructible solution.

A defense of equality for great apes must begin with an understanding of the opposition and an acknowledgement of the most basic point of disagreement. For great apes to gain status as persons in our community, we must begin by determining what the multitude of different definitions of "person" have in common. Finding that great apes fulfill the requirements of any one specific theory of personhood is insufficient, for these theories are highly controversial, and a critique of the theory will (...) undermine the status of great apes as persons. Instead, the first step in the argument for ape equality must be a defense of their self-consciousness. This notion is one thing all plausible theories of personhood have in common. (shrink)

When one looks at the extensive literature on collectivity in philosophy, it may seem that every item in the family of collective states, traits and entities has been examined, but one crucial state has largely been left out of focus: collective intellectual self-trust. In this article I propose a novel conception of collective intellectual self-trust and explain the role of collective intellectual self-trust in groups. I start with a short overview of individual intellectual self-trust, then I introduce what kinds of (...) groups are capable of having collective intellectual self-trust. Against this background I develop the constituents of collective intellectual self-trust. Then I turn to the differences between warranted and unwarranted collective intellectual self-trust and their function in different groups. I close by discussing an objection about the acquisition of collective intellectual self-trust. These are first steps in an epistemology of collective intellectual self-trust that aim to provide the ground for further work in this field. (shrink)

A core symptom of anxiety disorders is the tendency to interpret ambiguous information as threatening. Using EEG and BOLD-MRI, several studies have begun to elucidate brain processes involved in fear-related perceptual biases, but thus far mainly found evidence for general hypervigilance in high fearful individuals. Recently, multi-voxel pattern analysis (MVPA) has become popular for decoding cognitive states from distributed patterns of neural activation. Here, we used this technique to assess whether biased fear generalization, characteristic of clinical fear, is already present (...) during the initial perception and categorization of a stimulus, or emerges during the subsequent interpretation of a stimulus. Individuals with low spider fear (LSF, n = 20) and high spider fear (HSF, n = 18) underwent functional MRI scanning while viewing series of schematic flowers morphing to spiders. In line with previous studies, individuals with high fear of spiders were behaviorally more likely to classify ambiguous morphs as spiders than individuals with low fear of spiders. Univariate analyses of BOLD-MRI data revealed stronger activation towards spider pictures in high fearful individuals compared to low fearful individuals in numerous areas. Yet, neither average activation, nor support vector machine classification (i.e. a form of MVPA) matched the behavioral results - i.e., a biased response towards ambiguous stimuli - in any of the regions of interest. This may point to limitations of the current design, and to challenges associated with classifying emotional and neutral stimuli in groups that differ in their judgment of emotionality. Improvements for future research are suggested. (shrink)

This paper is about Artificial Intelligence (AI) attempts at writing poetry, usually referred to with the term “poetry generation”. Poetry generation started out from Digital Humanities, which developed out of humanities computing; nowadays, however, it is part of Computational Creativity, a field that tackles several areas of art and science. In the paper it is examined, first, why poetry was chosen among other literary genres as a field for experimentation. Mention is made to the characteristics of poetry (namely arbitrariness (...) and absurdity) that make it fertile ground for such endeavors and also to various text- and reader-centered literary approaches that favored experimentation even by human poets. Then, a rough historic look at poetry generation is attempted, followed by a review of the methods employed, either for fun or as academic projects, along Lamb et al.’s (2017) taxonomy which distinguishes between mere poetry generation and result enhancement. Another taxonomy by Gonçalo Oliveira (2017), dividing between form and content issues in poetry generation, is also briefly presented. The results of poetry generators are evaluated as generally poor and the reasons for this failure are examined: inability of computers to understand any word as a sign with a signified, lack of general intelligence, process- (rather than output-) driven attempts, etc. Then, computer-like results from a number of human poetic movements are also presented as a juxtaposition: DADA, stream of consciousness, OuLiPo, LangPo, Flarf, blackout/erasure poetry. The equivalence between (i) human poets that are concerned more with experimentation more than with good results and (ii) computer scientists who are process-driven leads to a discussion of the characteristics of humanness, of the possibility of granting future AI personhood and of the need to see our world in terms of a new, more refined ontology. (shrink)

In section 308 of Philosophical Investigations, Wittgenstein talks of the first step in philosophizing being ‘the one that altogether escapes notice ... that’s just what commits us to a particular way of looking at the matter’. In this essay, Michael Beaney explores some of the connections between conceptual creativity and the kind of first steps of which Wittgenstein spoke. Beaney argues that a good example of such a first step is Frege’s use of function–argument analysis (...) and the associated conception of concepts as functions, which led to almost all his characteristic doctrines. And Beaney shows that, while it is tempting to see the conceptual creativity involved in this case—that is, in Frege’s reconceiving concepts as functions—as originating in some ‘Eureka!’ moment and as catching on when others can exclaim ‘Now I can go on!’, all this needs careful description to avoid mythologization. (shrink)

This is a first course in propositional modal logic, suitable for mathematicians, computer scientists and philosophers. Emphasis is placed on semantic aspects, in the form of labelled transition structures, rather than on proof theory. The book covers all the basic material - propositional languages, semantics and correspondence results, proof systems and completeness results - as well as some topics not usually covered in a modal logic course. It is written from a mathematical standpoint. To help the reader, the material (...) is covered in short chapters, each concentrating on one topic. These are arranged into five parts, each with a common theme. An important feature of the book is the many exercises and an extensive set of solutions is provided. (shrink)

The paper connects two central ethical views, both with a rich tradition, sentimentalism and contractualism. From the former, it also borrows the response-dependentist metaphysics. The idea of combining the two has been sketched before, but not systematically and explicitly; for instance, in various comments on classical authors, especially on Kant and elsewhere, most prominently in Habermas. Here is the kernel of the present proposal. Our initial practical intuitions are emotion-based and the values, when detected, are response-dependent. This is the starting (...) point borrowed from sentimentalism. These intuitions get improved by reflection, and by dialogue that crucially involves perspective taking. If all goes well, this results in insights, in particular into principles that all rational parties can agree about in a kind of “contract.” This brings two traditions, the one of David Hume and Adam Smith, and the other of Kant, together. The resulting theory would be a kind of sentimentalist, response-dependentist contractualism. (shrink)

Witnessing Whiteness invites educators to consider what it means to be white, describes and critiques strategies used to avoid race issues, and identifies the detrimental effect of avoiding race on cross-race collaborations. The author illustrates how racial discomfort leads white educators toward ineffective teaching pedagogy and poor relationships with students and colleagues of color. Questioning the implications our history has for educational institutions, school reform efforts, and diversity initiatives, this book considers political, economic, socio-cultural, and legal histories that shaped the (...) meanings associated with whiteness. Drawing on dialogue with well-known figures within education, race, and multicultural work, the book offers intimate, personal stories of cross-race friendships that address both how a deep understanding of whiteness supports cross-race collaboration and the long-term nature of the work of excising racism from the deep psyche. Concluding chapters offer practical information on building knowledge, skills, capacities, and communities that support anti-racism practices, a hopeful look at our collective future, and a discussion of how to create a culture of witnessing educators who support allies for social and racial justice. (shrink)

Not all categorization is conceptual. Many of the experimental findings concerning infant and animal categorization invite the hypothesis that the subjects form abstract perceptual representations, mental models or cognitive maps that are not composed of concepts. The paper is a reflection upon the idea that conceptual categorization involves the ability to make categorical judgements under the guidance of norms of rationality. These include a norm of truth-seeking and a norm of good evidence. Acceptance of these norms implies willingness to defer (...) to cognitive authorities, unwillingness to commit oneself to contradictions, and knowledge of how to reorganize one's representational system upon discovering that one has made a mistake. It is proposed that the cognitive architecture required for basic rationality is similar to that which underlies pretend-play. The representational system must be able to make room for separate 'mental spaces' in which alternatives to the actual world are entertained. The same feature underlies the ability to understand modalities, time, the appearance-reality distinction, other minds, and ethics. Each area of understanding admits of degrees, and mastery takes years. But rational concept-management, at least in its most rudimentary form, does not require a capacity to form second-order representations. It requires knowledge of how to operate upon, and compare, the contents of different mental spaces.Nem toda categorização é conceitual. Muitas das descobertas experimentais sobre o processo de categorização nas crianças e animais sugerem a hipótese segundo a qual os sujeitos formam representações perceptuais abstratas, modelos mentais ou mapas cognitivos que não são compostos de conceitos. Este artigo é uma reflexão acerca da ideia de que categorização conceitual envolve a habilidade de fazer julgamentos categoriais, tender como guia as normas de racionalidade. Estas incluem uma norma de busca da verdade e uma norma de evidência adequada. A aceitação dessas normas implica boa vontade em respeitar as autoridades cognitivas, o desejo de evitar as contradições e o conhecimento de como reorganizar seu sistema representacional após descobrir que se cometeu um erro. Sugere-se que a arquitetura cognitiva requerida pela racionalidade básica é semelhante àquela subjacente ao jogo do "faz de conta". O sistema representacional deve ser capaz de arrumar lugar para "espaços mentais", nos quais alternativas para o mundo real são consideradas. A mesma característica subjaz à habilidade de compreender modalidades, tempo, a distinção entre aparência e realidade, outras mentes e éticas. Cada área de compreensão admite graus, e o seu domínio leva anos. Contudo a manipulação racional de conceitos, pelo menos na sua forma mais rudimentar, não requer a capacidade de formar representações de segunda ordem. Ela requer conhecimento do procedimento de como operar e comparar os conteúdos dos diferentes espaços mentais. (shrink)

Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...) Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III). (shrink)

The connections of Medicine and Religion are thoroughly documented in the primitive societies, and it comes as no surprise to see them together. Here we describe the true story of a Portuguese physician of the late 19th century whose image today is venerated in such a way as to compare him to a saint and to bestow upon him miraculous powers of healing. We propose that modern day physicians can learn from the example of this man that the role of (...) doctor encompasses not only scientific and technical mastery but, most of all, piety, humanity and compassion. (shrink)

Recently, calls have grown louder for more stakeholder democracy that is, letting stakeholders participate in the process of organizing, decision‐making, and governance in corporations, especially in the area of Corporate Social Responsibility (CSR) activities. Despite the relevance of the subject, the impact of customer involvement in CSR on their company‐related attitudes and behaviors still represents a major research void. The paper at hand develops a conceptual framework of consumer involvement in CSR based on the existing literature, theories of stakeholder democracy, (...) and organizational boundaries as well as drawing from the qualitative focus group interviews (N = 24). The framework is tested on a large scale, two‐time point field‐experimental study (N = 3,397). More specifically, consumer reactions to three degrees of customer involvement (i.e., information, feedback, and dialogue) are tested in two different CSR domains (i.e., company‐internal business process vs. company‐external philanthropic CSR). Results indicate that the customer involvement in CSR has a more beneficial effect in terms of strengthening customer outcomes in CSR domains that directly affect external stakeholders of the company (i.e., philanthropic CSR) than in domains that mainly concern company‐internal stakeholders (i.e., business process CSR). (shrink)

Inspired by the work done by Baaz et al. (Ann Pure Appl Log 147(1–2): 23–47, 2007; Lecture Notes in Computer Science, vol 4790/2007, pp 77–91, 2007) for first-order Gödel logics, we investigate Nilpotent Minimum logic NM. We study decidability and reciprocal inclusion of various sets of first-order tautologies of some subalgebras of the standard Nilpotent Minimum algebra, establishing also a connection between the validity in an NM-chain of certain first-order formulas and its order type. Furthermore, we analyze (...) axiomatizability, undecidability and the monadic fragments. (shrink)

This paper provides an analysis of data collected on the continued prevalence of outdated, marginalizing terms in contemporary cataloguing practices, stemming from the Library of Congress Subject Heading term “Indians” and all its related terms. Using Manitoba Archival Information Network’s (MAIN) list of current LCSH and recommended alternatives as a foundation, we built a dataset from titles published in the last five years. We show a wide distribution of LCSH used to catalogue fiction and non-fiction, with outdated but recognized terms (...) like “Indians of North America-History” appearing the most frequently and ambiguous and offensive terms like “Indian gays” appearing throughout the dataset. We discuss two primary problems with the continued use of current LCSH terms: their ambiguity limits the effectiveness of an institution’s catalog, and they do not reflect the way Indigenous Peoples, Nations, and communities in North America prefer to represent themselves as individuals and collectives. These findings support those of parallel scholarship on knowl­edge organization practices for works on Indigenous topics and provide a foundation for further work. (shrink)

Interdisciplinary research calls together different scientific disciplines in order to answer a research question which cannot be answered by an individual discipline alone. Technology Assessment (TA) is a problem-oriented approach (Bechmann and Frederichs 1996) dealing with the non-technical aspects of technology development, in order to gain knowledge about the (un-)intended consequences, the (un-)desired impacts, the main and side-effects and the chances and risks of (new) technologies. Moreover, by applying TA, scientists can develop potential solutions to solve societal or political problems (...) related to, for example, the “grand challenges” such as “feeding 10 billion people,” demographic change, global health. These societal problems need to be reframed or transformed into research questions to be dealt with by interdisciplinary research. Which scientific disciplines are invited to participate in an interdisciplinary research project is defined with respect to these research questi. (shrink)

In the summer of 1928, Kurt Gödel (1906–1978) embarked on his logical journey that would bring him world fame in a mere three years. By early 1929, he had solved an outstanding problem in logic, namely the question of the completeness of the axioms and rules of quantificational logic. He then went on to extend the result to the axiom system of arithmetic but found, instead of completeness, his famous incompleteness theorem that got published in 1931. It belongs to the (...) most iconic achievements of 20th century science and has been instrumental in the development of theories of formal languages and algorithmic computability – two essential components in the birth of the information society. This book explores Gödel’s way from an exceptional high-school student to a firmly established young logician. Essays in Gödel’s hand from the high school show that his central philosophical and scientific convictions were formed early on, before his university studies. Particular emphasis is laid on the course that made Gödel one of the foremost logicians of all times. The scientific biography of young Gödel is followed by English translations from Gödel’s German Gabelsberger shorthand of all his early preserved notebooks on logic and related topics. (shrink)

Human flourishing is the topic of an increasing number of books and articles in educational philosophy. Flourishing should be regarded as an ideal aim of education. If this is defended, the first step should be to elucidate what is meant by flourishing, and what exactly the concept entails. Listing formal criteria can facilitate reflection on the ideal of flourishing as an aim of education. We took Aristotelian eudaimonia as a prototype to construct two criteria for the concept of (...) human flourishing: human flourishing is regarded as intrinsically worthwhile and flourishing means ‘actualisation of human potential’. The second criterion has three sub-criteria: flourishing is about a whole life, it is a ‘dynamic state’ and flourishing presupposes there being objective goods. (shrink)

Zen Masters of China presents more than 300 traditional Zen stories and koans, far more than any other collection. Retelling them in their proper place in Zen's historical journey, it also tells a larger story: how, in taking the first step east from India to China, Buddhism began to be Zen. The stories of Zen are unlike any other writing, religious or otherwise. Used for centuries by Zen teachers as aids to bring about or deepen the experience of (...) awakening, they have a freshness that goes way beyond religious practice and a mystery and authenticity that appeal to a wide range of readers. The author himself was drawn to Zen through the stories and has been collecting them for forty years. He began this book because he was curious about the relationships between the people you read about in the stories: they are historical figures, masters and students in Zen's long passage from India to China and on to Japan. He realized that, placed in chronological order, the stories tell the story of Zen itself, how it traveled from West to East but also how it was transformed in that journey, from an Indian practice to something different in China (Ch'an) and then more different still in Japan (Zen). The fact that its transmission was so human, from teacher to student in a long chain from West to East, meant that the cultures it passed through inevitably changed it. Zen Masters of China is first and foremost a collection of mind-bending Zen stories and their wisdom. More than that, without academic pretensions or baggage, it recounts the genealogy of Zen Buddhism in China and, through the stories themselves, illuminates how Zen became what it is today. (shrink)

This paper presents an approach to managing knowledge specific to a particular location for complex instruments. The goal is to improve the knowledge communication between experts and end-users of scientific instruments. We propose a computational framework that integrates augmented reality and augmented virtuality as interface for manipulating knowledge. The augmented virtuality-based interface can be produced and distributed without extra costs. It allows knowledge dissemination at a larger scale. The prominent feature of our model is that the knowledge representation is independent (...) from those interfaces. A preliminary version of our framework has been implemented and deployed in customers’ environments. (shrink)

Business activity can be analyzed through a ‘risk awareness’ perspective and a ‘responsibility awareness’ perspective. However, risk and responsibility are actually interdependent. Risk-taking triggers responsibility issues and taking responsibility means risking being asked critical questions. This article suggests some first steps for combining these two perspectives conceptually. After several introductory illustrations showing how risk and responsibility issues are intertwined, the article looks separately each at risk and at responsibility. Then the argument that such perspectives could be usefully combined is (...) elaborated further from a theoretical angle and from a practical angle, by looking at various ethical issues and by presenting paradigmatic examples of balancing or sharing risk and responsibility related to leadership, to ERM and to insurance. (shrink)

In 1956, I decided to apply my experience in microbial genetics to developing analogous systems for human cell lines, including the selection of mutants with either a loss or gain of a biochemical function. For instance, mutants resistant to azahypoxanthine showed a loss of the HPRT enzyme (hypoxanthine phosphoribosyl transferase), whereas gain of the same enzyme was accomplished by blocking de novo purine biosynthesis with aminopterin, while supplying hypoxanthine and thymine (HAT selection). Using HAT selection, we: (i) genetically transformed HPRT− (...) mutant cells to HPRT+ wild type by using DNA extracted from HPRT+ cells, and (ii) selected HPRT+ hybrid cells by fusing HPRT− D98/AH2 cells with skin cells. These approaches, which we dubbed in 1962 as a [first step toward gene therapy], contributed to the later development of (i) cell fusion techniques, (ii) the development of monoclonal antibodies, (iii) routine transformation of mammalian cells with cloned genes, and (iv) methods for creating transgenic organisms. (shrink)

We consider the problem of finding and classifying representations in algebraic logic. This is approached by letting two players build a representation using a game. Homogeneous and universal representations are characterized according to the outcome of certain games. The Lyndon conditions defining representable relation algebras (for the finite case) and a similar schema for cylindric algebras are derived. Finite relation algebras with homogeneous representations are characterized by first order formulas. Equivalence games are defined, and are used to establish whether (...) an algebra is ω-categorical. We have a simple proof that the perfect extension of a representable relation algebra is completely representable. An important open problem from algebraic logic is addressed by devising another two-player game, and using it to derive equational axiomatisations for the classes of all representable relation algebras and representable cylindric algebras. Other instances of this approach are looked at, and include the step by step method. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more (...) fact-oriented and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more (...) fact-oriented and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

_ Source: _Volume 11, Issue 1, pp 46 - 70 In this article, I analyze the idea of “stepping into the void”, which can be traced in the thinking of both Proclus and Damascius, but which sets their perspectives apart. Thus, I show how Proclus warns us that to speak about the absolute principle, taking it as an object of thought, is a negative “stepping into the void” that should be avoided. On the contrary, I show that Damascius starts from (...) this warning and tries to prove that the only adequate manner in which we can trace the absolute principle and approach it is precisely through “stepping into the void,” yet, this time, in a positive sense, as a constant attempt to understand that the principle is an absolute void which reverses our discourse. (shrink)

This essay finds room for scepticism in the context of a Reformed understanding of how we come to know, and participate in, the work of God in the world. To disallow scepticism in the face of the impossible things God has promised is to impede the work of bringing God’s Kingdom to earth as it is in heaven. This work is done only when we step into that which is beyond anything we can ask or imagine. I develop this (...) argument first by considering how we might do a better job of including and conversing with sceptics in our midst. I then explore three theological themes in the Reformed tradition that suggest the potential value of scepticism. Finally, I suggest that scepticism secures a place for wonder in the face of God’s Kingdom, a place from which we can effectively work for God’s impossible promises to come to fruition. (shrink)

Insight problem solving is hindered by automated verbal–conceptual processes. Because mindfulness meditation training aims at “nonconceptual awareness” which involves a reduced influence of habitual verbal–conceptual processes on the interpretation of ongoing experience, mindfulness may facilitate insight problem solving. This hypothesis was examined across two studies . Participants in both studies completed a measure of trait mindfulness and a series of insight and noninsight problems. Further, participants in Study 2 completed measures of positive affect and a mindfulness or control training. The (...) results indicated that trait mindfulness predicts better insight but not noninsight problem solving , this relation is maintained when controlling for positive affect , mindfulness training improves insight but not noninsight problem solving and this improvement is partially mediated by state mindfulness . These findings are the first to document a direct relation between mindfulness and creativity. (shrink)

Ulrike Heuer argues that there can be a reason for a person to perform an action that this person cannot perform, as long as this person can take efficient steps towards performing this action. In this reply, I first argue that Heuer's examples fail to undermine my claim that there cannot be a reason for a person to perform an action if it is impossible that this person will perform this action. I then argue that, on a plausible interpretation (...) of what 'efficient steps' are, Heuer's claim is consistent with my claim. I end by showing that Heuer fails to undermine the arguments I gave for my claim. (shrink)

This chapter discusses Arnold Lobel's story “Cookies,” a story about will‐power, a concept central to moral psychology. The question of whether Frog and Toad both, or one or neither, possess will‐power at the end of the story is a good one to begin a discussion of this interesting philosophical topic with children. The concept of will‐power is linked to an important philosophical concept, weakness of the will. The Greek philosopher Aristotle first identified this phenomenon. This area of philosophical investigation (...) bridges the fields of ethics and philosophy of mind, developing an account of the mental faculties necessary for moral — and immoral — behavior. Moral psychology integrates ethics with the philosophy of mind. While ethics discusses questions of right and wrong, moral psychology focuses on what gives us the ability to do what's right despite the attractions of morally problematic courses of action. (shrink)

Ethical concerns about randomising persons to a no-treatment arm in the context of Ebola epidemic led to consideration of alternative designs. The stepped wedge design, in which participants or clusters are randomised to receive an intervention at different time points, gained popularity. Common arguments in favour of using this design are when an intervention is likely to do more good than harm, all participants should receive the experimental intervention at some time point during the study and the design might be (...) preferable for practical reasons. We examine these assumptions when considering Ebola vaccine research. First, based on the claim that a stepped wedge design is indicated when it is likely that the intervention will do more good than harm, we reviewed published and ongoing SW trials to explore previous use of this design to test experimental drugs or vaccines, and found that SW design has never been used for trials of experimental drugs or vaccines. Given that Ebola vaccines were all experimental with no prior efficacy data, the use of a stepped wedge design would have been unprecedented. Second, we show that it is rarely true that all participants receive the intervention in SW studies, but rather, depending on certain design features, all clusters receive the intervention. Third, we explore whether the SW design is appealing for feasibility reasons and point out that there is significant complexity. In the setting of the Ebola epidemic, spatiotemporal variation may have posed problematic challenges to a stepped wedge design for vaccine research. Finally, we propose a set of points to consider for scientific reviewers and ethics committees regarding proposals for SW designs. (shrink)

As humans, we constantly change our movement strategies to adapt to changes in physical functions and the external environment. We have to walk very slowly in situations with a high risk of falling, such as walking on slippery ice, carrying an overflowing cup of water, or muscle weakness owing to aging or motor deficit. However, previous studies have shown that a normal gait pattern at low speeds results in reduced efficiency and stability in comparison with those at a normal speed. (...) Another possible strategy is to change the gait pattern from normal to step-to gait, in which the other foot is aligned with the first swing foot. However, the efficiency and stability of the step-to gait pattern at low speeds have not been investigated yet. Therefore, in this study, we compared the efficiency and stability of the normal and step-to gait patterns at intermediate, low, and very low speeds. Eleven healthy participants were asked to walk with a normal gait and step-to gait on a treadmill at five different speeds, ranging from very low to normal walking speed. The efficiency parameters and stability parameters were analyzed from the motion capture data and then compared for the two gait patterns. The results suggested that step-to gait had a more efficient gait pattern at very low speeds of 10–30 m/min, with a larger percent recovery, and was more stable at 10–60 m/min in comparison with a normal gait. However, the efficiency of the normal gait was better than that of the step-to gait pattern at 60 m/min. Therefore, step-to gait is effective in improving gait efficiency and stability when faced with situations that force us to walk slowly or hinder quick walking because of muscle weakness owing to aging or motor deficit along with a high risk of falling. (shrink)

Digital photography is sweeping the country, and it’s easy to see why. You can take pictures of anything, do it quickly, see instantly what you got, save only the stuff you like, and share your pictures as prints, on the Web, as a slideshow, or even on things like mugs and mousepads. A digital camera and the appropriate software let you Take wide-angle or closeup shots, indoors or out Know immediately whether you got what you wanted Delete shots you don’t (...) like and retake them Improve your images on your computer Combine images into a montage Customize your pictures by adding special visual effects Digital photography is fun, but whether you’re an old hand at taking digital pictures or still picking out your first camera, there are plenty of times when you know what you want to do and just want to figure out how to do it, right now. That’s exactly what Digital Photography Just the Steps For Dummies helps you do. It’s designed so you can quickly find the task you want to perform and follow step-by-step instructions to get the job done, right now. Loaded with full-color photos to show you what you can do, Digital Photography Just the Steps For Dummies helps you Choose the camera, lenses, and flash equipment that are best for the type of photography you want to do Compose good pictures regardless of your subject Scan and digitize existing photos so you can enhance or repair them Change the size or format of an image Adjust color, brightness, contrast, sharpness, and other attributes of a digital image Repair tears, creases, or scratches in a scanned photo, remove red-eye, and restore a faded image Use layers to alter an image, add text, or change the background Photograph items you want to sell online to show them at their best Sort and organize photos on your computer Print picture albums, make photo T-shirts, create a slideshow, or burn a video CD When you’re looking for a clear set of instructions so you can get results right away, you want a Just the Steps For Dummies book. With Digital Photography Just the Steps For Dummies, you’ll find everything quickly comes into focus! (shrink)

Beloved author of, among many other books, the bestsellers How to Argue and Win Every Time and The Making of a Country Lawyer , Gerry Spence distills a lifetime of wisdom and observation about how we live, and how we ought to live in Seven Simple Steps to Personal Freedom . Here, in seven chapters, he delivers messages that inspire us first to recognize our servitude-to money, possessions, corporations, the status quo, and our own fears-and then shows us how (...) to begin the self-defining process toward liberation. Seven Simple Steps to Personal Freedom is a powerfully affirming, large-hearted, and life-changing book that asks us all to take the greatest risk for the greatest reward-our own freedom. (shrink)

Volume 20, Issue 3, March 2020, Page 6-8.