Despite advances in treatments over the last decades, a uniformly reliable and free of side effects therapy of human cancers remains to be achieved. During chromosome replication, a premature halt of two converging DNA replication forks would cause incomplete replication and a cytotoxic chromosome nondisjunction during mitosis. In contrast to normal cells, most cancer cells bear numerous DNA deletions. A homozygous deletion permanently marks a cell and its descendants. Here, we propose an approach to cancer therapy in which a pair (...) of sequence‐specific roadblocks is placed solely at two cancer‐confined deletion sites that are located ahead of two converging replication forks. We describe this method, termed “replication blocks specific for deletions” (RBSD), and another deletions‐based approach as well. RBSD can be expanded by placing pairs of replication roadblocks on several different chromosomes. The resulting simultaneous nondisjunctions of these chromosomes in cancer cells would further increase the cancer‐specific toxicity of RBSD. (shrink)

The following statement is a report of the Committee on Philosophy in Education of the American Philosophical Association and was approved by the Association's Board of Officers in September, 1959. The Committee was composed of the following: C. W. Hendel, Chairman, H. G. Alexander, R. M. Chisholm, Max Fisch, Lucius Garvin, Douglas Morgan, A. E. Murphy, Charner Perry, and R. G. Turnbull. Primary responsibility for the preparation of this report belonged to a subcommittee composed of Roderick M. Chisholm, Chairman, (...) H. G. Alexander, Lewis Hahn, Paul C. Hayner, and Charles W. Hendel. (shrink)

According to David Lewis's extreme modal realism, every waythat a world could be is a way that some concretely existingphysical world really is. But if the worlds are physicalentities, then there should be a set of all worlds, whereasI show that in fact the collection of all possible worlds is nota set. The latter conclusion remains true even outside of theLewisian framework.

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Most donated organs in the United States come from brain dead donors, while a small percentage come from patients who die in “controlled,” or expected, circumstances, typically after the family or surrogate makes a decision to withdraw life support. The number of organs available for transplant could be substantially if donations were permitted in “uncontrolled” circumstances–that is, from people who die unexpectedly, often outside the hospital. According to projections from the Institute of Medicine, establishing programs permitting “uncontrolled donation after circulatory (...) determination of death,” or uDCDD, throughout the United States has the potential to provide 22,000 more donation opportunities annually. In contrast, U.S. controlled donation after circulatory determination of death, or cDCDD, cases have increased progressively over the past decade from 87 to 848 donors, but currently account for only 10.6 percent of all deceased donors. Following the IOM recommendations, several projects exploring the feasibility of uDCDD were funded by the federal government, including a grant from the Health Resources and Services Administration that supported a pilot project in New York City in which the authors of this article participated.A key feature of our protocol, and indeed of many uDCDD protocols, is the initiation of preservation methods such as chest compressions and extracorporeal membrane oxygenation shortly after death in order to perfuse and preserve the donor's organs. Critics of uDCDD argue that the means of determining death deviates from generally ascribed principles. They assert that reinstituting circulation in order to preserve organs has the effect of “undoing” the prior determination of death. The result is that cDCDD is widely accepted and practiced routinely even though it only marginally increases the number of organs available for transplantation, and uDCDD is widely considered unacceptable despite being ethically embraced and proven to significantly increase organ donation opportunities in other countries. This article explores the evolution of this counterintuitive state of affairs and calls for a policy that, in line with the IOM report, allows for both cDCDD and uDCDD protocols. (shrink)

I argue for the claim that if Lewis’s regularity theory of laws were true, we could not know any positive law statement to be true. Premise 1: According to that theory, for any law statement true of the actual world, there is always a nearby world where the law statement is false (a world that differs with respect to one matter of particular fact). Premise 2: One cannot know a proposition to be true if it is false in a (...) nearby world (the epistemological safety principle). The conclusion that no law statement can be known to be true follows immediately from the two premises. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Remembering Lewis E. HahnGeorge C. H. Sun, President, John Howie, Professor Emeritus, Thomas Alexander, Professor and Director of Graduate Studies, Kenneth W. Stikkers, Professor and Chair, Randall Auxier, Professor, Robert Hahn, Professor, Joseph Wu, Professor Emeritus, Elizabeth R. Eames, Professor Emeritus, Martin Lu, Professor of Philosophy, George Kimball Plochmann, Professor Emeritus, Matt Sronkoski, Philosophy Graduate and Academic Adviser, Dave Clarke, Professor Emeritus, Eugenie Gatens-Robinson, Professor Emerita, Hans (...) H. Rudnick, Professor Emeritus, Stephen Bickham, Professor EmeritusPresident, and Don Mikula (bio)The following testimonials were offered on the occasion of a memorial gathering for Dr. Lewis E. Hahn held on February 19, 2005, and were compiled for presentation here by Sharon (Hahn) Crowell.A Tribute to Dr. Lewis E. Hahn (1908-2004) from a Global PerspectiveGeorge C. H. Sun President, Thomé H. Fang Institute, Inc., Mobile, AlabamaAmong the philosophical community in both the East and the West, no word of introduction is needed for our beloved Master, who was the recipient of numerous distinctions and honors, with titles that included "Man of the Year in Philosophy" and "Award of Lifetime Achievement." The very name "Lewis E. Hahn" itself already stands now for genuineness, dedication, and fulfillment.A great work is a dialogue with eternity; a great person is such a work. In less than thirty years he succeeded in developing Carbondale from what had been a small college town in the Midwest into the Mecca of American philosophy. His most important achievements were the Dewey Center and the Pepper Archives that he helped install at SIUC These, among other such institutions, will remain a unique contribution, a glory of American philosophy, and a monument in the history of human thought.For posterity Lewis E. Hahn will remain an object of wonder and amazement. How is it possible for one human being to have accomplished so much, so well, and in so short a span of time—less than one century—in breadth, depth, and diversity? Some one hundred years ago, by bridging the gap between the New World and the Old, William James was hailed as the great genius of international friendship among philosophical thinkers, but we now find a greater genius in Lewis E. Hahn, who succeeded in bringing together the peoples of East and West from at least four continents: Europe, Australia, America (both North and Latin America), and Asia. To my knowledge, few of his predecessors and contemporaries have been half so widely read and liberal-minded as he was, in view of the range and scope of the Library of Living Philosophers that he helped continue after the passing of its founder, Dr. Paul A. Schilpp.What type of man was Hahn, our younger generation will wonder? Only a pluralist approach can help us understand the true character of such a legendary pluralist-contextualist. In short, he was "a full personality." As I recall, while working on my dissertation with him in the 1970s, we had a brief discussion on Confucius, the sage of ancient China. "A full personality!" was his laconic assessment. Suddenly I realized, to quote the Analects: "The Master is talking about himself!" For, as the Buddhists put it, only a Buddha can understand a Buddha. Or, as William James put it, only one who has philosophy can appreciate philosophy. Many friends [End Page 1] of my generation admire him so much; Te Chen of Hong Kong calls him "a great Confucian in America." Those who regret the loss of many precious Confucian virtues in China today have now rediscovered them in the person of Lewis E. Hahn! If Nietzsche called Kant "a great Chinese in Königsberg," it is simply because he had not encountered our own Master.A paradigm of academic leadership, Dr. Hahn is simply irreplaceable—this is a tribute I personally heard in Carbondale in the late 1960s. It is not an exaggeration to say that he was a superb administrator, and he could have been the best Secretary of the State we ever had, for he possessed more in the way of philosophical wisdom than all his predecessors put together! As a great teacher, he was no less "serene, good, learned, wise, and ardent" than... (shrink)

_ Source: _Volume 10, Issue 3, pp 349 - 369 A theory of causation suitable for historiography must accommodate the many types of causal claims historians make. In this paper, I examine the advantages of applying D. K. Lewis’s counterfactual theory of causation to the philosophy of historiography. I contend that Lewis’s possible world semantics offers a superior framework for making sense of historical causation, and that it lays the foundation for historians to look at history as causal (...) series of events, remaining agnostic as to whether there may be historical regularities or laws. Lewis’s theory can also accommodate important notions often used by historians, such as absences as causes, historical necessity and contingency, and the role they play in the formulation of historical counterfactuals. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

David Lewis (1979) has argued that according to his possible worlds analysis of counterfactuals, “backtracking” counterfactuals of the form “If event A were to happen at tA, then event B would happen at tB” where tB precedes tA, are usually false if B does not actually happen at tB. On the other..

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Christ in the Life and Teaching of Gregory of Nazianzus by Andrew Hofer, O.P.Lewis AyresChrist in the Life and Teaching of Gregory of Nazianzus. By Andrew Hofer, O.P. Oxford: Oxford University Press, 2013. Pp. xi + 270. $105.00 (cloth). ISBN 978-0-19-968194-5.Fr. Andrew Hofer has written a cleverly conceived treatise on Gregory Nazianzen, one whose main focus is Gregory’s vision of his own life (and the life of (...) Christians more generally) as both imitatio Christi and participatio Christi. Hofer grounds his account of this imitatio and participatio in Gregory’s core dogmatic account of the person of Christ. The book thus offers us a study, focusing on one central author, of the ways in which a Nicene Christology could shape and stimulate (as well as be shaped and stimulated by) an account of the Christian life.The first chapter is an extended meditation on the nature of the “word” in Gregory. Here, Hofer begins by exploring how Gregory situates himself in the ancient battle—or at least the ancient literary topos of such a battle—between philosophy and rhetoric. Not surprisingly, Hofer emphasizes that Gregory sees himself as a philosopher, but one for whom the Christian life offers the true form of a philosophical life. The discussion then turns toward ways in which Gregory sees the Scriptures as providing a basis for discussing and modeling virtually all aspects of the Christian life. Hofer offers a little discussion of the manner in which Gregory adapts ancient rhetorical traditions of, for example, the paradeigma (see 44), but these debts are acknowledged mostly en passant.The second chapter takes us to the heart of the book and does an excellent job of setting up the author’s theme. Considering Gregory’s poetic auto-biographical [End Page 314] writing, Hofer argues that Gregory not only “blends Christ into the troubles, fears, and joys of his own life” but that he also “makes present the baptismal mysteries of one’s life immersed in Christ’s life” (56). In chapter 5, this extra dimension will receive a foundation in an account of the ways in which Gregory sees Christians drawn into the very events of Christ’s life (156-60, commenting particularly on Gregory’s Or. 40). There, Hofer emphasizes that Christ’s life is itself “a mimesis of ours” (160), creating realities that may be models for ours, models into which we are then drawn. But, in chapter 2 itself, Hofer’s main concern is to show the sheer variety of ways in which Gregory interweaves the scriptural account of Christ’s life and ministry with his own. This complex set of reference styles is termed Gregory’s “autobiographical Christology.”Chapter 3 pursues this agenda by turning to the ways in which Gregory uses the terminology of “mixture” to describe Christ—and to describe Christ’s relationship to Christians. It is this chapter that Stanley Hauerwas, were he endorsing the book, would say is “worth the price of the book alone.” Two things are particularly noteworthy. The first is the helpful discussion of the philosophical traditions that lie behind the terms Gregory uses. Hofer wishes us to take seriously traditions of thought on this theme that run between Aristotle and Alexander of Aphrodisias, rather than to place most weight on the Stoic tradition. Hofer advocates for his thesis in a sensitive fashion, emphasizing the difficulty in distinguishing distinct traditions in late antiquity. Second, there is much to be learned from the manner in which Hofer stretches discussion of Christ himself as “mixture” so that it provides insight into Gregory’s account of the Christian’s relationship with Christ.Chapter 4 follows a similar pattern, showing that a discussion of Christ’s person in Gregory’s writings (in this case, the famous sequence epp. 101, 102, and 202) has repercussions for wider themes. This chapter is less successful, in large part because of the sheer scale of the exercise attempted by Hofer. The largest section of the chapter (123-47) offers an extended discussion of Gregory’s ep. 101. This famous letter gives an extended critique of Christological error. Hofer begins by situating... (shrink)

The need to find an intrinsic characterization of what makes a relation between events causal arises not only in local theories of causation like Salmon's process theory but also in global approaches like Lewis' counterfactual theory. According to the localist intuition, whether a process connecting two events is causal should depend only on what goes on between the events, not on conditions that hold elsewhere in the world. If such intrinsic characterizations could be found, an identification of the causal (...) relation in the actual world (though not in other possible worlds) with physical processes may be feasible (the a posteriori identification). I consider recent proposals made for intrinsic characterizations of causality and conclude that none of them is able to deliver the intended result. (shrink)

In ‘Finkish Dispositions’1 David Lewis proposes an analysis of dispositions which improves on the simple conditional analysis. In this paper I show that Lewis’ analysis still fails. I also argue that repairs are of no avail, and suggest why this is so.

In my 'Dispositions and Antidotes', The Philosophical Quarterly, 48 (1998), I raise an objection to the conditional analysis of dispositions, both in its simple formulation and in a more sophisticated version due to David Lewis, The Philosophical Quarterly, 47 (1997). The objection suggests that a disposition may be continuously present and the appropriate stimulus occur without the manifestation occurring, because some outside influence, an antidote, interferes. Gundersen in The Philosophical Quarterly, 50 (2000), argues that my objection rests on an (...) equivocation about which object possesses the disposition and more particularly on an equivocation about the context in which the events referred to take place, and that when the equivocation is resolved the counter-example disappears. I respond by showing that the counter-example does remain if we take contextual and mereological issues into account, and I conclude by remarking that the difference with Lewisdepends on whether certain features are seen as significant for the semanticsand metaphysics of dispositions or as merely characteristic of the pragmaticsof common usage. (shrink)

Paul Boghossian has recently argued against reductive dispositionalism concerning mental content. However, there is a powerful version of reductive dispositionalism—based on work by Ramsey and Lewis—that Boghossian does not consider. In this paper I argue that Boghossian's arguments can be adapted to apply even to this stronger version of reductionism.

In ‘Ramseyan Humility’ David Lewis argues that a particular view about fundamental properties, quidditism, leads to the position that we are irredeemably ignorant of the identities of fundamental properties. We are ignorant of the identities of fundamental properties since we can never know which properties play which causal roles, and we have no other way of identifying fundamental properties other than by the causal roles they play. It has been suggested in the philosophical literature that Lewis’ argument for (...) Humility is merely an instance of traditional scepticism, to which traditional responses to scepticism are applicable. I agree that in ‘Ramseyan Humility’ Lewis does present an argument to which it is appropriate to consider the applicability of responses to traditional scepticism—he argues that we irredeemably lack the evidence to rule out possibilities in which different properties occupy the causal roles described by our best physical theory. And prima facie this is just the kind of argument responses to traditional scepticism are designed to tackle. However, I will argue that Lewis bolsters this argument with a second. This second argument serves to deepen Lewis’ case and cannot be met with a response to traditional scepticism. For Lewis argues that not only do we lack evidence for which properties play which roles, we lack the ability to grasp any such proposition about role-occupancy. And if we cannot grasp any such proposition we cannot know it. (shrink)

This paper concerns Kripke’s puzzle about belief. I have two goals in this paper. The first is to argue that two leading approaches to Kripke’s puzzle, those of Lewis and Chalmers, are inadequate as they stand. Both approaches require the world to supply an object that the relevant intentional attitudes pick out. The problem is that there are cases which, I argue, exhibit the very same puzzling phenomenon in which the world does not supply an object in the required (...) way. The second goal is to draw out a more general lesson about Kripke’s puzzle. I argue that Kripke’s puzzle should be understood as intimately related to a phenomenon known as ‘intentional identity’, and that an adequate account of Kripke’s puzzle should be extensible to cases in which the relevant attitudes are empty. (shrink)

John Divers and Joseph Melia have argued that Lewis's modal realism is extensionally inadequate. This paper explains why their argument does not succeed.

It is shown that one common formulation of Stalnaker's semantics for conditionals is incomplete: it has no sound and (strongly) complete proof system. At first, this seems to conflict with well-known completeness results for this semantics (e.g., Stalnaker and Thomason 1967; Stalnaker 1970 and Lewis 1973, ch. 6). As it turns out, it does not: these completeness results rely on another closely-related formulation of the semantics that is provably complete. Specifically, the difference comes down to how the Limit Assumption (...) is stated. I close with some remarks about what this means for the logic of conditionals. (shrink)

In this paper I bring together and discuss claims that David Lewis has made in Counterfactuals, and in “Causation,” and explore a number of difficulties which the views of these two works make for each other. If these difficulties are as serious as I suggest, they will require revision or rejection of the view of causation that Lewis defends.

Fine is widely thought to have refuted the simple modal account of essence, which takes the essential properties of a thing to be those it cannot exist without exemplifying. Yet, a number of philosophers have suggested resuscitating the simple modal account by appealing to distinctions akin to the distinction Lewis draws between sparse and abundant properties, treating only those in the former class as candidates for essentiality. I argue that ‘sparse modalism’ succumbs to counterexamples similar to those originally posed (...) by Fine, and fails to capture paradigmatic instances of essence involving abundant properties and relations. (shrink)

This thesis examines the alethic modal concepts of possibility and necessity. It is argued that one cannot do justice to all our modal talk without possible worlds, i.e., complete ways that a cosmos might have been. I argue that not all of the proposed applications of possible worlds succeed but enough remain to give one good theoretical reason to posit them. The two central problems now are: What feature of reality makes correct alethic modal claims true and What are possible (...) worlds? ;David Lewis makes possible worlds be concretely existing universes. Unfortunately, I show Lewis's account involves set-theoretic, ethical, inductive and probabilistic paradoxes, and commits Lewis to an objectionable form of primitive modality that governs the choice of the counterpart relation. The most promising contemporary alternatives to Lewis's theory have been the worlds of Adams and Plantinga constructed out of Platonic entities such as maximal collections of consistent propositions. However, these approaches fail to provide a satisfactory answer to the question of what makes true modal claims true. I also criticize some alternative accounts. ;Finally, I discuss and combine two historical approaches. The first is an Aristotelian approach that says a non-actual event is possible is to say that some actual substances could have initiated a causal chain that could lead up to the event in question. However, it can be shown that some plausible global possibility claims can be made true on this account only if there is a necessarily existent first cause capable of initiating very different universes. On the other hand, Leibniz made possible worlds be ideas in the mind of an omniscient necessarily existent deity. Leibniz fails to explain what it is that makes these possible worlds possible, but if we were willing to combine his story with the conclusion drawn from the Aristotelian one, we could get the following story: Possible worlds are ideas in the mind of an omniscient deity and what makes them possible is that this deity has the Aristotelian capability of initiating causal chains that can lead to them being actualized. (shrink)

A counteridentical is a counterfactual with an identity statement in the antecedent. While counteridenticals generally seem non-trivial, most semantic theories for counterfactuals, when combined with the necessity of identity and distinctness, attribute vacuous truth conditions to such counterfactuals. In light of this, one could try to save the orthodox theories either by appealing to pragmatics or by denying that the antecedents of alleged counteridenticals really contain identity claims. Or one could reject the orthodox theory of counterfactuals in favor of a (...) hyperintensional semantics that accommodates non-trivial counterpossibles. In this paper, I argue that none of these approaches can account for all the peculiar features of counteridenticals. Instead, I propose a modified version of Lewis’s counterpart theory, which rejects the necessity of identity, and show that it can explain all the peculiar features of counteridenticals in a satisfactory way. I conclude by defending the plausibility of contingent identity from objections. (shrink)

A central theme of Cheryl Misak’s important new history is that there are two markedly different strands of the pragmatist tradition. One pragmatism traces back to Peirce, she thinks, and it takes seriously the ideals of logical precision, truth, and objectivity. This tradition had its insights carried through later analytic philosophy by figures like C. I. Lewis, Quine, and Davidson, among others. The second pragmatism has its roots in James’s (allegedly) more subjectivistic outlook and after Dewey’s death was revived (...) by Goodman, Rorty, and other so-called “neo-pragmatists.”Misak recommends the Peircean strain because it is “committed to doing justice to the objective dimension of human inquiry” (Misak 2013: 3)... (shrink)

Conventional wisdom has it that truth is always evaluated using our actual linguistic conventions, even when considering counterfactual scenarios in which different conventions are adopted. This principle has been invoked in a number of philosophical arguments, including Kripke’s defense of the necessity of identity and Lewy’s objection to modal conventionalism. But it is false. It fails in the presence of what Einheuser (2006) calls c-monsters, or convention-shifting expressions (on analogy with Kaplan’s monsters, or context-shifting expressions). We show that c-monsters naturally (...) arise in contexts, such as metalinguistic negotiations, where speakers entertain alternative conventions. We develop an expressivist theory—inspired by Barker (2002) and MacFarlane (2016) on vague predications and Einheuser (2006) on counterconventionals—to model these shifts in convention. Using this framework, we reassess the philosophical arguments that invoked the conventional wisdom. (shrink)

Near the end of 'Naming the Colours', Lewis (1997) makes an interesting claim about the relationship between linguistic and mental content; we are typically unable to read the content of a belief off the content of a sentence used to express that belief or vice versa. I call this view autonomism. I motivate and defend autonomism and discuss its importance in the philosophy of mind and language. In a nutshell, I argue that the different theoretical roles that mental and (...) linguistic content play suggest these kinds of content should be understood as sensitive to different things. (shrink)

The current interest in bioregionalism, stimulated in part by Kirkpatrick Sale’s Dwellers in the Land, shows that people are looking for a form of political praxis which addresses the importance of region. In this paper, I argue that much of the bioregional literature written to date mystifies the concept of region, discounting the role of subjectivity and culture in shaping regional boundaries and veers toward asimplistic view of “nature knows best.” Bioregionalism can be rehabilitated, provided we treat it not as (...) a “revealed wisdom” for the reconstruction of human society, but as a sensibility and environmental ethic that can infuse our work even as we make use of the functional regionalisms that increasingly shape people’s consciousness. I conclude by citing Lewis Mumford’s concept of a region as capturing the dialectical interplay of natural and cultural elements. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Remembering Lewis E. HahnGeorge C. H. Sun, President, John Howie, Professor Emeritus, Thomas Alexander, Professor and Director of Graduate Studies, Kenneth W. Stikkers, Professor and Chair, Randall Auxier, Professor, Robert Hahn, Professor, Joseph Wu, Professor Emeritus, Elizabeth R. Eames, Professor Emeritus, Martin Lu, Professor of Philosophy, George Kimball Plochmann, Professor Emeritus, Matt Sronkoski, Philosophy Graduate and Academic Adviser, Dave Clarke, Professor Emeritus, Eugenie Gatens-Robinson, Professor Emerita, Hans (...) H. Rudnick, Professor Emeritus, Stephen Bickham, Professor EmeritusPresident, and Don Mikula (bio)The following testimonials were offered on the occasion of a memorial gathering for Dr. Lewis E. Hahn held on February 19, 2005, and were compiled for presentation here by Sharon (Hahn) Crowell.A Tribute to Dr. Lewis E. Hahn (1908-2004) from a Global PerspectiveGeorge C. H. Sun President, Thomé H. Fang Institute, Inc., Mobile, AlabamaAmong the philosophical community in both the East and the West, no word of introduction is needed for our beloved Master, who was the recipient of numerous distinctions and honors, with titles that included "Man of the Year in Philosophy" and "Award of Lifetime Achievement." The very name "Lewis E. Hahn" itself already stands now for genuineness, dedication, and fulfillment.A great work is a dialogue with eternity; a great person is such a work. In less than thirty years he succeeded in developing Carbondale from what had been a small college town in the Midwest into the Mecca of American philosophy. His most important achievements were the Dewey Center and the Pepper Archives that he helped install at SIUC These, among other such institutions, will remain a unique contribution, a glory of American philosophy, and a monument in the history of human thought.For posterity Lewis E. Hahn will remain an object of wonder and amazement. How is it possible for one human being to have accomplished so much, so well, and in so short a span of time—less than one century—in breadth, depth, and diversity? Some one hundred years ago, by bridging the gap between the New World and the Old, William James was hailed as the great genius of international friendship among philosophical thinkers, but we now find a greater genius in Lewis E. Hahn, who succeeded in bringing together the peoples of East and West from at least four continents: Europe, Australia, America (both North and Latin America), and Asia. To my knowledge, few of his predecessors and contemporaries have been half so widely read and liberal-minded as he was, in view of the range and scope of the Library of Living Philosophers that he helped continue after the passing of its founder, Dr. Paul A. Schilpp.What type of man was Hahn, our younger generation will wonder? Only a pluralist approach can help us understand the true character of such a legendary pluralist-contextualist. In short, he was "a full personality." As I recall, while working on my dissertation with him in the 1970s, we had a brief discussion on Confucius, the sage of ancient China. "A full personality!" was his laconic assessment. Suddenly I realized, to quote the Analects: "The Master is talking about himself!" For, as the Buddhists put it, only a Buddha can understand a Buddha. Or, as William James put it, only one who has philosophy can appreciate philosophy. Many friends [End Page 1] of my generation admire him so much; Te Chen of Hong Kong calls him "a great Confucian in America." Those who regret the loss of many precious Confucian virtues in China today have now rediscovered them in the person of Lewis E. Hahn! If Nietzsche called Kant "a great Chinese in Königsberg," it is simply because he had not encountered our own Master.A paradigm of academic leadership, Dr. Hahn is simply irreplaceable—this is a tribute I personally heard in Carbondale in the late 1960s. It is not an exaggeration to say that he was a superb administrator, and he could have been the best Secretary of the State we ever had, for he possessed more in the way of philosophical wisdom than all his predecessors put together! As a great teacher, he was no less "serene, good, learned, wise, and ardent" than... (shrink)

Is the nature of explanation a metaphysical issue? Or has it more to do with psychology and pragmatics? To put things in a different way: what are primary relata in an explanation? What sorts of thing explain what other sorts of thing? David Lewis identifies two senses of ‘explanation’ (Lewis 1986, 217–218). In the first sense, an explanation is an act of explaining. I shall call this the subjectivist sense, since its existence depends on some subject doing the (...) explaining. Hence it is people who, in this sense, explain things. In the second of his two senses, Lewis says, quoting Sylvain Bromberger, that one may properly ask of an explanation “Does anyone know it? Who thought of it first? Is it very complicated?” (Lewis 1986, 218; Bromberger 1965). In this second sense, no subject is needed, the explanation can remain unknown, perhaps for ever. So I call this the objectivist sense. (shrink)

Sender–receiver games, first introduced by David Lewis ([1969]), have received increased attention in recent years as a formal model for the emergence of communication. Skyrms ([2010]) showed that simple models of reinforcement learning often succeed in forming efficient, albeit not necessarily minimal, signalling systems for a large family of games. Later, Alexander et al. ([2012]) showed that reinforcement learning, combined with forgetting, frequently produced both efficient and minimal signalling systems. In this article, I define a ‘dynamic’ sender–receiver game (...) in which the state–action pairs are not held constant over time and show that neither of these two models of learning learn to signal in this environment. However, a model of reinforcement learning with discounting of the past does learn to signal; it also gives rise to the phenomenon of linguistic drift. 1 Introduction2 Dynamic Signalling Games with Reinforcement Learning2.1 Introducing new states2.2 Swapping state–action pairs3 Discounting the Past3.1 Learning to signal in a dynamic world3.2 An unexpected outcome: linguistic drift4 ConclusionAppendix: A Markov Chain Analysis. (shrink)

The history of ancient chemistry has been virtually ignored. I examine the foundations of the chemical theories of the Peripatetics and Stoics, in an attempt to glean the motivations for their chemical theories, and how these theories relate to their greater natural philosophies. This involves a detailed examination of ancient theories of mixture. I attempt to relate Aristotle's theory of mixture to his theories of substantial change, the elements and matter. This entails a rejection of the notion of prime matter, (...) and a reevaluation of the status of the contrarieties. I also look at the understudied fourth book of the Meteorologica, which sheds new light on Aristotle's theory of matter. I then turn to Alexander of Aphrodisias, and his development of Aristotle's theory. Next I consider the Stoic theory of body, and how doxographers have misinterpreted this theory. While offering a radically new interpretation of the Stoic theory of mixture, much of Stoic natural philosophy is reconstructed, including their theory of categories and qualities. In the end a Stoic theory free from obvious paradox is presented. (shrink)

Following David Lewis, Ted Sider has famously argued that unrestricted first-order quantification cannot be vague. His argument was intended as a type of reductio: its strategy was to show that the mere hypothesis of unrestricted quantifier vagueness collapses into the claim that unrestricted quantification is precise. However, this short article considers two natural reconstructions of the argument, and shows that each can be resisted. The theme will be that each reconstruction of the argument involves assumptions which advocates of vague (...) quantification have independent reason to reject. (shrink)

Craig Callender, Jonathan Cohen and Markus Schrenk have recently argued for an amended version of the best system account of laws – the better best system account (BBSA). This account of lawhood is supposed to account for laws in the special sciences, among other desiderata. Unlike David Lewis's original best system account of laws, the BBSA does not rely on a privileged class of natural predicates, in terms of which the best system is formulated. According to the BBSA, a (...) contingently true generalization is a law of a special science S iff the generalization is an axiom (or a theorem) of the best system relative to the set of predicates used by special science S. We argue that the BBSA is, at best, an incomplete theory of special science laws, as it does not account for typical features of special science laws, such as attached ceteris paribus conditions and the idealized character of law statements in these disciplines. (shrink)

ABSTRACT. May scientists rely on substantive, a priori presuppositions? Quinean naturalists say "no," but Michael Friedman and others claim that such a view cannot be squared with the actual history of science. To make his case, Friedman offers Newton's universal law of gravitation and Einstein's theory of relativity as examples of admired theories that both employ presuppositions (usually of a mathematical nature), presuppositions that do not face empirical evidence directly. In fact, Friedman claims that the use of such presuppositions is (...) a hallmark of "science as we know it." But what should we say about the special sciences, which typically do not rely on the abstruse formalisms one finds in the exact sciences? I identify a type of a priori presupposition that plays an especially striking role in the development of empirical psychology. These are ontological presuppositions about the type of object a given science purports to study. I show how such presuppositions can be both a priori and rational by investigating their role in an early flap over psychology's contested status as a natural science. The flap focused on one of the field's earliest textbooks, William James's Principles of Psychology. The work was attacked precisely for its reliance on a priori presuppositions about what James had called the "mental state," psychology's (alleged) proper object. I argue that the specific presuppositions James packed into his definition of the "mental state" were not directly responsible to empirical evidence, and so in that sense were a priori; but the presuppositions were rational in that they were crafted to help overcome philosophical objections (championed by neo-Hegelians) to the very idea that there can be a genuine science of mind. Thus, my case study gives an example of substantive, a priori presuppositions being put to use—to rational use—in the special sciences. In addition to evaluating James's use of presuppositions, my paper also offers historical reflections on two different strands of pragmatist philosophy of science. One strand, tracing back through Quine to C. S. Peirce, is more naturalistic, eschewing the use of a priori elements in science. The other strand, tracing back through Kuhn and C. I. Lewis to James, is more friendly to such presuppositions, and to that extent bears affinity with the positivist tradition Friedman occupies. (shrink)

This chapter contains sections titled: Introduction Two Interrelated Problems Lewis's Solution Inductive Paradox Identity versus Counterpart Theory Platonism: The Main Realist Alternative to Lewis An Aristotelian Alternative Leibniz's Account A Combined Account.

Essentialism as applied to individuals is the claim that for at least some individuals there are properties that those individuals possess essentially. What it is to possess a property essentially is a matter of debate. To possess a property essentially is often taken to be akin to possessing a property necessarily, but stronger, although this is not a feature of Aristotle’s essentialism, according to which essential properties are those thing could not lose without ceasing to exist. Kit Fine (1994) takes (...) essential properties to be those that an object has in virtue of its identity, while other essentialists refer (as Fine also does) to the nature of an object as the source of its essential properties. It is sometimes important to distinguish the essential properties of a thing and the ‘full’ essence of a thing. The latter is the set of the essential properties of a thing, when that set necessarily suffices to determine the thing’s identity. One might hold that something has essential properties without agreeing that it has an identity-determining essence. Essentialism was largely in abeyance during the first two thirds of the twentieth century thanks to the domination of analytic philosophy by anti-metaphysical logical empiricism and the linguistic turn. The rehabilitation of essentialism owes much to the development of a formal apparatus for the understanding of modality more generally, thanks to C. I. Lewis, Ruth Barcan Marcus, and Saul Kripke. Kripke’s discussion of essentialism both about individuals and also about about natural kinds brought essentialism to wider philosophical prominence. Natural kind essentialism, which finds its modern genesis also in the work of Hilary Putnam, claims that natural kinds have essential properties: to say that possession of property P is is part of the essence of the kind K implies that, necessarily, every member or sample of the kind K possesses P. Essentialism about individuals has been linked to thinking about natural kinds by the contentious claim that one of the essential properties of any entity is that it belongs to the natural kind (or kinds) it actually belongs to. In this chapter I shall first outline certain claims and arguments concerning essentialism concerning individuals (Section 2).. (shrink)

Consider the reasonable axioms of subjunctive conditionals if p → q1 and p → q2 at some world, then p → at that world, and if p1 → q and p2 → q at some world, then → q at that world, where p → q is the subjunctive conditional. I show that a Lewis-style semantics for subjunctive conditionals satisfies these axioms if and only if one makes a certain technical assumption about the closeness relation, an assumption that is (...) probably false. I will then show how Lewisian semantics can be modified so as to assure and even when the technical assumption fails, and in fact in one sense the semantics actually becomes simpler then. (shrink)