Results for 'Alexei Verkhratsky'

297 found
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  1.  18
    Biology of purinergic signalling: Its ancient evolutionary roots, its omnipresence and its multiple functional significance.Alexei Verkhratsky & Geoffrey Burnstock - 2014 - Bioessays 36 (7):697-705.
    The purinergic signalling system, which utilises ATP, related nucleotides and adenosine as transmitter molecules, appeared very early in evolution: release mechanisms and ATP‐degrading enzymes are operative in bacteria, and the first specific receptors are present in single cell eukaryotic protozoa and algae. Further evolution of the purinergic signalling system resulted in the development of multiple classes of purinoceptors, several pathways for release of nucleotides and adenosine, and a system of ectonucleotidases controlling extracellular levels of purinergic transmitters. The purinergic signalling system (...)
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  2.  12
    How astrocytic chloride modulates brain states.Verena Untiet & Alexei Verkhratsky - 2024 - Bioessays 46 (6):2400004.
    The way the central nervous system (CNS) responds to diverse stimuli is contingent upon the specific brain state of the individual, including sleep and wakefulness. Despite the wealth of readout parameters and data delineating the brain states, the primary mechanisms are yet to be identified. Here we highlight the role of astrocytes, with a specific emphasis on chloride (Cl−) homeostasis as a modulator of brain states. Neuronal activity is regulated by the concentration of ions that determine excitability. Astrocytes, as the (...)
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  3.  42
    Memories with a blind mind: Remembering the past and imagining the future with aphantasia.Alexei J. Dawes, Rebecca Keogh, Sarah Robuck & Joel Pearson - 2022 - Cognition 227 (C):105192.
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  4. A Fiduciary Argument Against Stakeholder Theory.Alexei M. Marcoux - 2003 - Business Ethics Quarterly 13 (1):1-24.
    Critics attack normative ethical stakeholder theory for failing to recognize the special moral status of shareholders that justifiesthe fiduciary duties owed to them at law by managers. Stakeholder theorists reply that there is nothing morally significant about shareholders that can underwrite those fiduciary duties. I advance an argument that seeks to demonstrate both the special moral status of shareholders in a firm and the concomitant moral inadequacy of stakeholder theory. I argue that (i) if some relations morally requirefiduciary duties, and (...)
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  5.  66
    Protosemiosis: Agency with Reduced Representation Capacity.Alexei A. Sharov & Tommi Vehkavaara - 2015 - Biosemiotics 8 (1):103-123.
    Life has semiotic nature; and as life forms differ in their complexity, functionality, and adaptability, we assume that forms of semiosis also vary accordingly. Here we propose a criterion to distinguish between the primitive kind of semiosis, which we call “protosemiosis” from the advanced kind of semiosis, or “eusemiosis”. In protosemiosis, agents associate signs directly with actions without considering objects, whereas in eusemiosis, agents associate signs with objects and only then possibly with actions. Protosemiosis started from the origin of life, (...)
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  6. Reconstructing instead of interpreting quantum theory.Alexei Grinbaum - 2007 - Philosophy of Science 74 (5):761-774.
    A paradigmatic shift in the foundations of quantum mechanics is recorded, from interpreting to reconstructing quantum theory. Examples of reconstruction are analyzed, and conceptual foundations of the information-theoretic reconstruction developed. A concept of intentionally incomplete reconstruction is introduced to mark the novel content of research in the foundation of quantum theory. ‡Many thanks to Lucien Hardy, Jeff Bub and Bill Demopoulos for their comments. This research was supported through the ANR grant ANR-06-BLAN-0348-01. Part of this research was held at the (...)
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  7. Reconstruction of quantum theory.Alexei Grinbaum - 2007 - British Journal for the Philosophy of Science 58 (3):387 - 408.
    What belongs to quantum theory is no more than what is needed for its derivation. Keeping to this maxim, we record a paradigmatic shift in the foundations of quantum mechanics, where the focus has recently moved from interpreting to reconstructing quantum theory. Several historic and contemporary reconstructions are analyzed, including the work of Hardy, Rovelli, and Clifton, Bub and Halvorson. We conclude by discussing the importance of a novel concept of intentionally incomplete reconstruction.
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  8.  32
    How device-independent approaches change the meaning of physical theory.Alexei Grinbaum - 2017 - Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics 58:22-30.
  9.  32
    Role of Utility and Inference in the Evolution of Functional Information.Alexei A. Sharov - 2009 - Biosemiotics 2 (1):101-115.
    Functional information means an encoded network of functions in living organisms from molecular signaling pathways to an organism’s behavior. It is represented by two components: code and an interpretation system, which together form a self-sustaining semantic closure. Semantic closure allows some freedom between components because small variations of the code are still interpretable. The interpretation system consists of inference rules that control the correspondence between the code and the function (phenotype) and determines the shape of the fitness landscape. The utility (...)
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  10.  36
    Evolution of Natural Agents: Preservation, Advance, and Emergence of Functional Information.Alexei A. Sharov - 2016 - Biosemiotics 9 (1):103-120.
    Biological evolution is often viewed narrowly as a change of morphology or allele frequency in a sequence of generations. Here I pursue an alternative informational concept of evolution, as preservation, advance, and emergence of functional information in natural agents. Functional information is a network of signs that are used by agents to preserve and regulate their functions. Functional information is preserved in evolution via complex interplay of copying and construction processes: the digital components are copied, whereas interpreting subagents together with (...)
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  11. Which Fine-Tuning Arguments Are Fine?Alexei Grinbaum - 2012 - Foundations of Physics 42 (5):615-631.
    Fine-tuning arguments are a frequent find in the literature on quantum field theory. They are based on naturalness—an aesthetic criterion that was given a precise definition in the debates on the Higgs mechanism. We follow the history of such definitions and of their application at the scale of electroweak symmetry breaking. They give rise to a special interpretation of probability, which we call Gedankenfrequency. Finally, we show that the argument from naturalness has been extended to comparing different models of the (...)
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  12.  50
    Comprehending the Semiosis of Evolution.Alexei Sharov, Timo Maran & Morten Tønnessen - 2016 - Biosemiotics 9 (1):1-6.
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  13.  29
    Consciousness and Learning from the Biosemiotic Perspective.Alexei A. Sharov - 2022 - Biosemiotics 15 (3):483-490.
  14.  66
    Freeman and Evan.Alexei M. Marcoux - 1999 - Business Ethics Quarterly 9 (2):207-224.
    We argue that the Rawlsian social contract argument advanced for stakeholder theory by R. Edward Freeman, writing alone and with William M. Evan, fails in three main ways. First, it is true to Rawls in neither form, nor purpose, nor the level of knowledge (or ignorance) required to motivate the veil of ignorance. Second, it fails to tailor the veil of ignorance to the fairness conditions that are required to solve the moral problem that Freeman and Evan set out to (...)
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  15.  34
    Evolutionary Biosemiotics and Multilevel Construction Networks.Alexei A. Sharov - 2016 - Biosemiotics 9 (3):399-416.
    In contrast to the traditional relational semiotics, biosemiotics decisively deviates towards dynamical aspects of signs at the evolutionary and developmental time scales. The analysis of sign dynamics requires constructivism to explain how new components such as subagents, sensors, effectors, and interpretation networks are produced by developing and evolving organisms. Semiotic networks that include signs, tools, and subagents are multilevel, and this feature supports the plasticity, robustness, and evolvability of organisms. The origin of life is described here as the emergence of (...)
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  16.  38
    Towards Synthesis of Biology and Semiotics.Alexei Sharov, Timo Maran & Morten Tønnessen - 2015 - Biosemiotics 8 (1):1-7.
    The journal Biosemiotics was envisioned by its founding editor, Marcello Barbieri, as a major periodical for interdisciplinary papers that integrate biology and semiotics. Since 2008 the journal has published 21 issues, including special issues on crucial problems such as the semiotics of perception, origins of mind, code biology, biohermeneutics, biosemiotic analysis of information and chance. The impact factor of the journal does not fully describe the significance of this journal, because the discipline of biosemiotics is young and remains in its (...)
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  17.  40
    Umwelt-theory and pragmatism.Alexei Sharov - 2001 - Semiotica 2001 (134).
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  18. Biosemiotics: A functional-evolutionary approach to the analysis of the sense of information.Alexei A. Sharov - forthcoming - Biosemiotics: The Semiotic Web.
     
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  19.  16
    The Kantian Concept of Human Dignity Today.Alexei N. Krouglov - 2024 - Kantian Journal 43 (1):47-75.
    Although Kant was born three hundred years ago, his practical philosophy is still relevant and helpful for understanding difficult and crucial issues of today. One example is the strange transformation the concept of human dignity has undergone in post-Soviet Russia — in everyday language, in ideological doctrines, and in legal documents. While in ordinary life dignity is increasingly reduced to access to material benefits, in its legal sense — above all in the 1993 Constitution of the Russian Federation — anti-communist (...)
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  20.  24
    La BFM 2022 : un corpus pour les recherches diachroniques en français médiéval et au-delà.Alexei Guillot-Barbance Lavrentiev - 2024 - Corpus 25.
    La Base de français médiéval (BFM) fait partie des corpus de français médiéval (9e-15e s.) les plus anciens et les plus utilisés par les linguistes diachroniciens et plus largement par tous ceux qui s’intéressent à l’histoire du français. Elle est le fruit d’une collaboration entre linguistes-philologues et spécialistes de la méthode textométrique implémentée dans la plateforme TXM. L’article présente un état des lieux du corpus BFM2022 focalisé sur la représentativité et l’interopérabilité des données. Il illustre l’apport des outils numériques pour (...)
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  21.  60
    Recognition and Trust: Hegel and Confucius on the Normative Basis of Ethical Life.Alexei Procyshyn & Mario Wenning - 2019 - Dao: A Journal of Comparative Philosophy 18 (1):1-22.
    This essay offers a comparative analysis of the notion of trust in Hegel and Confucius. It shows that Hegel’s two senses of trust depend upon his theory of recognition and recognitive struggle. The competitive thrust of Hegel’s account of trust, it argues, introduces a series of problems that cannot be adequately resolved within his theory, since it presupposes the kinds of trusting relations—self-, intersubjective- and world-trust—that it purports to explain. This essay then turns to the Confucian notions of xin 心 (...)
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  22.  55
    The Conditions of Immanent Critique.Alexei Procyshyn - 2022 - Critical Horizons 23 (1):22-43.
    ABSTRACT This article contributes to methodological debates in contemporary critical theory regarding the scope and features of immanent critique. I spell out the philosophical commitments presupposed by this approach to criticism and identify its basic features by comparing it with more recognizable argumentative or interpretative strategies. This comparison yields three immanent-critical requirements – for inherence, contradiction, and access – which bring into relief the heuristic and ampliative character of immanent criticism. Yet, these requirements also imply that “immanent critique” is not (...)
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  23.  35
    Narratives of quantum theory in the age of quantum technologies.Alexei Grinbaum - 2017 - Ethics and Information Technology 19 (4):295-306.
    Quantum technologies can be presented to the public with or without introducing a strange trait of quantum theory responsible for their non-classical efficiency. Traditionally the message was centered on the superposition principle, while entanglement and properties such as contextuality have been gaining ground recently. A less theoretical approach is focused on simple protocols that enable technological applications. It results in a pragmatic narrative built with the help of the resource paradigm and principle-based reconstructions. I discuss the advantages and weaknesses of (...)
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  24.  17
    Hegel’s Bellicis View of War. Mature Works.Alexei N. Krouglov & Круглов Алексей Николаевич - 2023 - RUDN Journal of Philosophy 27 (2):390-405.
    In “The Phenomenology of Spirit” and “Philosophy of Right”, Hegel gives a detailed specification of the theses about the war that were claimed in earlier papers and manuscripts, but his position is not fundamentally changed. In the “The Phenomenology of Spirit” Hegel advocates governments’ need and right to initiate a war from time to time in order to prevent both the isolation and atomization, and let individuals feel the death. As in the past, the war, as Hegel says, has a (...)
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  25.  20
    The origin and evolution of signs.Alexei A. Sharov - 1999 - Semiotica 127 (1-4):521-536.
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  26.  66
    Business ethics.Alexei Marcoux - 2008 - Stanford Encyclopedia of Philosophy.
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  27. Ethics in robotics research: CERNA recommendations.Alexei Grinbaum & Raja Chatila - 2017 - IEEE Robotics and Automation Magazine (99):1-8.
    This article summarizes the recommendations concerning robotics as issued by the Commission for the Ethics of Research in Information Sciences and Technologies (CERNA), the French advisory commission for the ethics of information and communication technology (ICT) research. Robotics has numerous applications in which its role can be overwhelming and may lead to unexpected consequences. In this rapidly evolving technological environment, CERNA does not set novel ethical standards but seeks to make ethical deliberation inseparable from scientific activity. Additionally, it provides tools (...)
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  28.  26
    The Hanf number for amalgamation of coloring classes.Alexei Kolesnikov & Chris Lambie-Hanson - 2016 - Journal of Symbolic Logic 81 (2):570-583.
  29. Das Problem der Intersubjektivität bei Husserl und Sartre.Alexei Krioukov - 2004 - Ibidem.
    Alexei Krioukovs Studie widmet sich einem der sowohl interessantesten als auch in theoretischer Hinsicht schwierigsten Themen der zeitgenossischen Philosophie: dem Problem der Intersubjektivität. In praktischem Sinn handelt es sich dabei um die Beziehung zwischen Menschen (Subjekten). Was alltäglich nicht zu beweisen ist, bildet auf theoretischer Ebene ein grundsätzliches Problem: Wer sind die Subjekte der Intersubjektivität? Auf welche Weise, mit welchem Recht und mit welcher Methode kann man einen Bezug zwischen diesen Subjekten rechtfertigen? Alexei Krioukov geht detailliert auf diese (...)
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  30.  55
    The Informational Reality Commentary on Igor Aleksander and Helen Morton's — "Aristotle's Laptop: The Discovery of Our Informational Mind".Alexei V. Samsonovich - 2014 - International Journal of Machine Consciousness 6 (1):49-53.
    Alexei V. Samsonovich, Int. J. Mach. Conscious., 06, 49 (2014). DOI: 10.1142/S1793843014400083.
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  31.  66
    Kant and the Crusians in the Debate on Optimism.Alexei N. Krouglov - 2018 - Kantian Journal 37 (2):7-31.
  32.  62
    Moral Equivalence in the Metaverse.Alexei Grinbaum & Laurynas Adomaitis - 2022 - NanoEthics 16 (3):257-270.
    Are digital subjects in virtual reality morally equivalent to human subjects? We divide this problem into two questions bearing, respectively, on cognitive and emotional equivalence. Typically, cognitive equivalence does not hold due to the lack of substantialist indistinguishability, but emotional equivalence applies: digital subjects endowed with face or language elicit emotional responses on a par with real-world pleasure, desire, horror, or fear. This is sufficient for projecting moral traits on avatars in the metaverse or on dialog systems based on large (...)
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  33.  37
    Two Condemnations of Sergei Bulgakov.Alexei P. Kozyrev - 2022 - Russian Studies in Philosophy 60 (4):322-336.
    This article uses the personal diaries and memoirs of Archpriest Sergius (Sergei) Bulgakov to examine the circumstances of his expulsion from Bolshevik-occupied Crimea in late 1922. At the time, he was rector of the Alexander Nevsky Cathedral in Yalta. The expulsion of Fr. Sergius was part of a large-scale operation to expel the humanist intelligentsia, who did not fit within the ideological contours of the new government. We will examine the political aspects of the condemnations of Fr. Sergius’s doctrine of (...)
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  34.  29
    Composite Agency: Semiotics of Modularity and Guiding Interactions.Alexei A. Sharov - 2017 - Biosemiotics 10 (2):157-178.
    Principles of constructivism are used here to explore how organisms develop tools, subagents, scaffolds, signs, and adaptations. Here I discuss reasons why organisms have composite nature and include diverse subagents that interact in partially cooperating and partially conflicting ways. Such modularity is necessary for efficient and robust functionality, including mutual construction and adaptability at various time scales. Subagents interact via material and semiotic relations, some of which force or prescribe actions of partners. Other interactions, which I call “guiding”, do not (...)
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  35.  48
    The Great War, the Russian Civil War, and the Invention of Big Science.Alexei Kojevnikov - 2002 - Science in Context 15 (2):239-275.
    ArgumentThe revolutionary transformation in Russian science toward the Soviet model of research started even before the revolution of 1917. It was triggered by the crisis of World War I, in response to which Russian academics proposed radical changes in the goals and infrastructure of the country’s scientific effort. Their drafts envisioned the recognition of science as a profession separate from teaching, the creation of research institutes, and the turn toward practical, applied research linked to the military and industrial needs of (...)
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  36.  77
    The nanotechnological golem.Alexei Grinbaum - 2010 - NanoEthics 4 (3):191-198.
    We give reasons for the importance of old narratives, including myths, in ethical thinking about science and technology. On the example of a legend about creating artificial men we explore the side effects of having too much success and the problem of intermediate social status of bioengineered artefacts.
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  37.  16
    Hegel’s Bellicis View of War. Initial State and Early Works.Alexei N. Krouglov - 2022 - RUDN Journal of Philosophy 26 (3):644-657.
    For over a century, Hegel’s view of war is seen as controversial that results in mutually exclusive interpretations. To reach a proper evaluation of Hegel’s views, it is necessary to consider both Hegel’s initial states of philosophical doctrine about war and peace, and the development of his understanding of war from early works to mature ones. In the first part of the paper, I characterize Kant’s position on war, since it was the starting point for Hegel. Contrary to popular representations (...)
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  38.  52
    Tetens und die Deduktion der Kategorien bei Kant.Alexei N. Krouglov - 2013 - Kant Studien 104 (4):466-489.
  39.  92
    Fundamental principles and mechanisms of the conscious self.Alexei V. Samsonovich & Lynn Nadel - 2005 - Cortex. Special Issue 41 (5):669-689.
  40.  19
    Kant and the Problem of Optimism: The Origin of the Debate.Alexei N. Krouglov - 2018 - Kantian Journal 37 (1):9-24.
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  41.  46
    Towards a Biosemiotic Theory of Evolution.Alexei A. Sharov - 2021 - Biosemiotics 14 (1):101-105.
    The target article by Denis Noble is an excellent overview of the illusions of the Modern Synthesis that still remains in textbooks despite of the recent criticism. Overcoming these illusions shows the active role of organisms in the evolutionary process and accounts for additional mechanisms such as plasticity of embryo development, epigenetic heredity, multilevel selection, Baldwin effect, and niche construction, which are components of the Extended Evolutionary Synthesis. Adding these mechanisms is certainly an important step forward, but I argue that (...)
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  42. The Old-New Meaning of Researcher’s Responsibility.Alexei Grinbaum - 2013 - Etica E Politica 15 (1):236-250.
    If the technological situation is unique, the ways to understand the contemporary moral condition are not. We link it to age-old questions: in fact, the power promised by technol-ogy only establishes a new form of human finitude. In the face of this continuity of the fundamental moral condition, we examine a number of alternative ways of thinking about the basis of responsible innovation, exploring the metaphors of quasi-parental and political responsibilities, as well as the place of virtue in innovation and (...)
     
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  43.  28
    n-Simple theories.Alexei S. Kolesnikov - 2005 - Annals of Pure and Applied Logic 131 (1-3):227-261.
    The main topic of this paper is the investigation of generalized amalgamation properties for simple theories. That is, we are trying to answer the question of when a simple theory has the property of n-dimensional amalgamation, where two-dimensional amalgamation is the Independence Theorem for simple theories. We develop the notions of strong n-simplicity and n-simplicity for 1≤n≤ω, where both “1-simple” and “strongly 1-simple” are the same as “simple”. For strong n-simplicity, we present examples of simple unstable theories in each subclass (...)
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  44.  39
    Can social systems theory be used for immanent critique?Alexei Procyshyn - 2017 - Thesis Eleven 143 (1):97-114.
    Two trends have emerged in recent work from the Frankfurt School: the first involves a reconsideration of immanent critique’s basic commitments and viability for critical social theory, while the second involves an effort to introduce temporal considerations for social interaction into critical theorizing to help make sense of the phenomenon of social acceleration. This article contributes to these ongoing discussions by investigating whether social systems theory, in which temporal relations play a primary role, can be integrated with immanent critique. If (...)
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  45.  81
    A Counterintuitive Argument for Résumé Embellishment.Alexei M. Marcoux - 2006 - Journal of Business Ethics 63 (2):183-194.
    Applied ethicists say little about résumé embellishment. Presumably, this is so because résumé embellishment seems obviously wrong; an instance of ordinary lying, familiar moral prohibitions against which cover the case completely. Analysis of résumé embellishment merely as ordinary lying overlooks its collective action aspects. Taking account of those aspects and their implications, I argue on consequentialist grounds that, given some plausible background conditions, a limited form of résumé embellishment is morally permissible. This outcome is a particular instantiation of a more (...)
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  46.  40
    President of Stalin's Academy: The Mask and Responsibility of Sergei Vavilov.Alexei Kojevnikov - 1996 - Isis 87 (1):18-50.
  47.  33
    Toward a semantic general theory of everything.Alexei V. Samsonovich, Rebecca F. Goldin & Giorgio A. Ascoli - 2010 - Complexity 15 (4):NA-NA.
  48. Towards the semiotic paradigm in biology.Alexei A. Sharov - 1998 - Semiotica 120 (3-4):403-19.
     
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  49.  58
    The mental state formalism of gmu-Bica.Alexei V. Samsonovich, Kenneth A. de Jong & Anastasia Kitsantas - 2009 - International Journal of Machine Consciousness 1 (1):111-130.
  50.  36
    Beyond Rasiowan Systems: Unital Deductive Systems.Alexei Y. Muravitsky - 2014 - Logica Universalis 8 (1):83-102.
    We deal with monotone structural deductive systems in an unspecified propositional language \ . These systems fall into several overlapping classes, forming a hierarchy. Along with well-known classes of deductive systems such as those of implicative, Fregean and equivalential systems, we consider new classes of unital and weakly implicative systems. The latter class is auxiliary, while the former is central in our discussion. Our analysis of unital systems leads to the concept of Lindenbaum–Tarski algebra which, under some natural conditions, is (...)
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