Most of the essential cellular components, like nucleic acids, lipids and sugars, are phosphorylated. The phosphate equilibrium in Escherichia coli is regulated by the phosphate (Pi) input from the surrounding medium. Some 90 proteins are synthesized at an increased rate during Pi starvation and the global control of the cellular metabolism requires cross‐talk with other regulatory mechanisms. Since the Pi concentration is normally low in E. coli's natural habitat, these cells have devised a mechanism for synthesis of about 15 proteins (...) to accomplish two specific functions: transport of Pi and its intracellular regulation. The synthesis of these proteins is controlled by two genes (the phoB‐phoR operon), involving both negative and positive functions. PhoR protein is a histidine protein kinase, induced in Pi starvation and is a transmembrane protein. It phosphorylates the regulator protein PhoB which is also Pi starvation‐induced. The PhoB phosphorylated form binds specifically to a DNA sequence of 18 nucleotides (the pho Box), which is part of the promoters of the Pho genes. The genes controlled by phoB constitute the Pho regulon.The repression of phoA (the gene encoding alkaline phosphatase) by high Pi concentrations in the medium requires the presence of an intact Pst operon (pstS, pstC, pstA, pstB and phoU) and phoR. The products of pstA and pstC are membrane bound, whereas the product of pstS is periplasmic and PstB and PhoU proteins are cytoplasmic. The function of the PhoU protein may be regulated by cofactor nucleotides and may be involved in signaling the activation of the regulon via PhoR. (shrink)

How is time framed in corporate social responsibility (CSR) talk? The literature mostly fails to analyze how multiple CSR activities are framed from a temporal perspective. Moreover, those researchers who undertake temporal framing tend to overlook the role of home-country cultural characteristics. Using a mixed-method analysis of 2,720 CSR reports from developing country companies, we show that CSR talk is mostly framed in the future tense when firms communicate complex human rights issues such as slavery or child labor, while the (...) past and present tenses are more frequent when they report on philanthropy and other cause-related activities. We find that these effects are stronger when firms are from countries characterized by greater uncertainty avoidance. We contribute to the CSR communication literature by showing that temporal references in CSR talk tend to differ, depending on the company-level control of CSR activities, and by highlighting uncertainty avoidance’s role as a boundary condition for aspirational talk’s performativity. (shrink)

This paper is a comparative study based on the linguistic evidence in Vedic Sanskrit and Homeric Greek, aimed at reconstructing the space-time cognitive models used in the Proto-Indo-European language in a diachronic perspective. While it has been widely recognized that ancient Indo-European languages construed earlier events as in front of later ones, as predicted in the Time-Reference-Point mapping, it is less clear how in the same languages the passage took place from this ‘archaic’ Time-RP model or non-deictic sequence, in which (...) future events are behind or follow the past ones in a temporal sequence, to the more recent ‘post-archaic’ Ego-RP model that is found only from the classical period onwards, in which the future is located in front and the past in back of a deictic observer. Data from the Rigveda and the Homeric poems show that an Ego-RP mapping with an ego-perspective frame of reference could not have existed yet at an early Indo-European stage. In particular, spatial terms of front and behind turn out to be used with reference not only to temporal events, but also to east and west respectively, thus presupposing the existence of an absolute field-based FoR which the temporal sequence is metaphorically related to. Specifically, sequence is relative position on a path appears to be motivated by what has been called day orientation frame, in which the different positions of the sun during the day motivate the mapping of front onto ‘earlier’ and behind onto ‘later’, without involving ego’s ‘now’. These findings suggest that early Indo-European still had not made use of spatio-temporal deixis based on the tense-related ego-perspective FoR found in modern languages. (shrink)

Since the 1980s, several studies of visual perception have persuasively argued that important aspects of human vision are best accounted for not by recourse to inner mental representations but rather through socially observable actions and behaviors (e.g. Lynch 1985, Latour 1986, Lynch 1990, Goodwin 1994, Goodwin 1997, Sharrock & Coulter 1998). While there are clearly physiological mechanisms required for vision, psychological accounts of perception in terms of inner mental representations have been dislodged from their position as the basic term in (...) the interface between human beings and their environment and replaced with terms such as "social practice," and "vernacular intelligibility." The focus for these .. (shrink)

The collaborative ‹Big Science’ approach prevalent in physics during the mid- and late-20th century is becoming more common in the life sciences. Often computationally mediated, these collaborations challenge researchers’ trust practices. Focusing on the visualisations that are often at the heart of this form of scientific practice, the paper proposes that the aesthetic aspects of these visualisations are themselves a way of securing trust. Kant’s account of aesthetic judgements in the Third Critique is drawn upon in order to show that (...) the image-building capability of imagination, and the sensus communis, both of which are integral parts of aesthetic experience, play an important role in building and sustaining community in these forms of science. Kant’s theory shows that the aesthetic appeal of scientific visualisations is not isolated from two other dimensions of the visualisations: the cognitive-epistemic, aesthetic-stylistic and interpersonal dimensions, and that in virtue of these inter-relationships, visualisations contribute to building up the intersubjectively shared framework of agreement which is basic for trust. (shrink)

Knowledge does not float free of the technologies available for its production and presentation. The intimate connection between ideas and praxis - embodied, technological, social - exemplified in any knowledge practice is, in the terms of Ihde & Selinger (2004), an 'epistemology engine'. This refers to the material-semiotic connections that obtain for any specific rendering of an idea. Often this material-semiotic connection is easier to recognise in the case of art than in that of knowledge, where it appears more-or-less obvious (...) that the rendering of an idea in poetic rather than prose form, in musical rather than linguistic form, in plastic rather than digital form, makes a difference to the idea. However, it is also recognisable (if not always actually recognised) in science, where there is a keen awareness of visual media alongside or instead of discursive media. -/- Ideas on the Internet shift and change as they pass through different networks of meaning production and communication, in different media and modalities. Different disciplines and modes of knowledge have either embraced these possibilities of transmogrification or remained aloof. Philosophy is one of the latter, and seems still steadily rooted to the discursive world. However, as a discipline, it overlaps in interesting ways both with science and with art. What are the epistemology-engines that apply to philosophy, and are there specific philosophy-engines? This is the background against which the applications to e-learning in philosophy will be considered. -/- In previous work, I claimed that the nature of philosophical argument cannot simply be assumed to remain constant even in the use of relatively simple discursive technologies such as discussion boards (Carusi 2006). In the present paper I consider a range of other technologies that form the technological culture of philosophy, or which mediate it. The paper aims to open a line of enquiry into these underlying technologies and the kinds of philosophy-engine that emerge from them, individually or by way of a convergence of a set of technologies. In particular, I focus on text-mining techniques, visualisations, and modeling showing what potential they have for disturbing, derailing, re-shaping or transforming the mode, form or substance of philosophy. -/- . (shrink)

Philologus, founded in 1846, is one of the oldest and most respected periodicals in the field of Classics. It publishes articles on Greek and Latin literature, historiography, philosophy, history of religion, linguistics, reception, and the history of scholarship. The journal aims to contribute to our understanding of Greco-Roman culture and its lasting influence on European civilization. The journal Philologus, conceived as a forum for discussion among different methodological approaches to the study of ancient texts and their reception, publishes original scholarly (...) contributions with a strong international focus. Publications languages are: German, English, Italian, French. As of 2014 the publication of supplementary volumes will be resumed. The series Philologus. Supplemente / Philologus. Supplementary Volumes will publish monographs and edited volumes pertaining to all aspects of the study of ancient literature and its reception, with a special focus on topics concerning literary theory, philosophy and the history of scholarship from an interdisciplinary perspective. (shrink)

Introduction: The actions taken by the government to deal with the consequences of the coronavirus diseases 2019 pandemic caused different levels of restriction on the mobility of the population. The need to continue offering physical exercise to individuals after stroke became an emergency. However, these individuals may have barriers to adhere to the programs delivered remotely. There is a lack of evidence related to adherence, attendance, safety, and satisfaction of remote exercise programs for this population.Objective: The aim was to evaluate (...) adherence and barriers to attend a remote physical exercise program for individuals after stroke. We aimed to identify adherence and attendance rate of the remote physical exercise program ; to identify the safety of a remote physical exercise program ; and to identify the overall experience to participate in a remote program.Materials and methods: This is a longitudinal study, including 36 stroke survivors who already attended a face-to-face physical exercise program prior to the COVID-19 pandemic. The remote physical exercise program included sessions for 2 days/week for a duration of 22 weeks, with a total of 44 sessions, which were delivered asynchrony via recorded video sessions. As outcome measures, we performed two questionnaires to identify attendance, barriers, safety, and overall experience related to the program.Results: The adherence rate was 86. The attendance rate was 19, with a total of 8 sessions. The main barriers for lower attendance rate were as follows: lack of motor skills and physical fitness to workout in 80 reports, followed by no exercise companion in 44 reports. The remote physical program has been shown to be safe, and the overall experience was positive from the perspectives of the participants and the family members.Conclusion: Although the adherence rate was high, the attendance rate was low on the remote physical exercise program. The main barriers to attending the program remotely reflect the need of tailoring individually an asynchrony mode of delivering the sessions to individuals after stroke. Our results also indicate how the COVID-19 impacted the health conditions of stroke survivors. The program was safe, and the overall experience indicated a change in the mental, physical, and social health of individuals after stroke and their family members. (shrink)

In this article I revisit earlier stages of the discussion of personal identity, before Neo-Lockean psychological continuity views became prevalent. In particular, I am interested in Bernard Williams’ initial proposal of bodily identity as a necessary, although not sufficient, criterion of personal identity. It was at this point that psychological continuity views came to the fore arguing that bodily identity was not necessary because brain transplants were logically possible, even if physically impossible. Further proposals by Shoemaker of causal relations between (...) mental states in our memory and Parfit’s discussion of branching causal chains created additional complications. My contention in this paper is that psychological continuity views deflected our attention from what should have remained in the spotlight all the time: the intersubjective character (or not) of criteria proposed to decide personal identity in our language game, and ultimately our form of life concerning ourselves as persons. B. Williams’ emphasis on the body was not just common sense. It was also recognition of the importance of giving priority to criteria that could be kept under intersubjective control. (shrink)

Name der Zeitschrift: Archiv für Geschichte der Philosophie Jahrgang: 99 Heft: 2 Seiten: 129-155.

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we (...) identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies. (shrink)

This paper discusses the fallacies of combination and division as they are presented by Aristotle in chapter 4 of his Sophistici Elenchi. Aristotle's examples are concise, their discussion is unclear, and it is difficult to distinguish the cases of combination from those of division. I analyse the Aristotelian examples and the interpretations offered so far. I show that these interpretations suffer from a major defect: they fail to identify a common characteristic whereby the Aristotelian examples can be classified as instances (...) of combination or division. In my reconstruction of the examples, I repair this deficiency: I give a single pattern of explanation for the fallacy of combination and another (similar) pattern for the fallacy of division. Thus, it is possible to free Aristotle from the following charges: (i) he did not clearly distinguish between combination and division, and (ii) he reduced combination and division to a single fallacy. My explanation of the fallacies uses the notion of scope of an expression: in modern terminology, the fallacy of combination can be described as ?fallacy of the wide scope?, the fallacy of division as ?fallacy of the narrow scope? (shrink)

In clinical practice, decision-making is not performed by individual knowers but by an assemblage of people and instruments in which no one member has full access to every piece of evidence. This is due to decision making teams consisting of members with different kinds of expertise, as well as to organisational and time constraints. This raises important questions for the epistemology of medicine, which is inherently social in this kind of setting, and implies epistemic dependence on others. Trust in these (...) contexts is a highly complex social practice, involving different forms of relationships between trust and reasons for trust: based on reasons, and not based on reasons; based on reasons that are easily accessible to reflection and others that are not. In this paper, we focus on what it means to have reasons to trust colleagues in an established clinical team, collectively supporting or carrying out every day clinical decision-making. We show two important points about these reasons, firstly, they are not sought or given in advance of a situation of epistemic dependence, but are established within these situations; secondly they are implicit in the sense of being contained or nested within other actions that are not directly about trusting another person. The processes of establishing these reasons are directly about accomplishing a task, and indirectly about trusting someone else’s expertise or competence. These processes establish a space of reasons within which what it means to have reasons for trust, or not, gains a meaning and traction in these team-work settings. Based on a qualitative study of decision-making in image assisted diagnosis and treatment of a complex disease called pulmonary hypertension (PH), we show how an intersubjective framework, or ‘space of reasons’ is established through team members forging together a common way of identifying and dealing with evidence. In dealing with images as a central diagnostic tool, this also involves a common way of looking at the images, a common mode or style of perception. These frameworks are developed through many iterations of adjusting and calibrating interpretations in relation to those of others, establishing what counts as evidence, and ranking different kinds of evidence. Implicit trust is at work throughout this process. Trusting the expertise of others in clinical decision-making teams occurs while the members of the team are busy on other tasks, most importantly, building up a framework of common modes of seeing, and common ways of identifying and assessing evidence emerge. It is only in this way that trusting or mistrusting becomes meaningful in these contexts, and that a framework for epistemic dependence is established. (shrink)

Background: Paediatric nurses often face complex situations requiring decisions that sometimes clash with their own values and beliefs, or with the needs of the children they care for and their families. Paediatric nurses often use new technology that changes the way they provide care, but also reduces their direct interaction with the child. This may generate ethical issues, which nurses should be able to address in the full respect of the child. Research question and objectives: The purpose of this review (...) is to describe the main ethical dimensions of paediatric nursing. Our research question was, ‘What are the most common ethical dimensions and competences related to paediatric nursing?’ Research design: A rapid evidence assessment. Method: According to the principles of the rapid evidence assessment, we searched the PubMed, SCOPUS and CINAHL databases for papers published between January 2001 and March 2015. These papers were then independently read by two researchers and analysed according to the inclusion criteria. Ethical considerations: Since this was a rapid evidence assessment, no approval from the ethics committee was required. Findings: Ten papers met our inclusion criteria. Ethical issues in paediatric nursing were grouped into three areas: (a) ethical issues in paediatric care, (b) social responsibility and (c) decision-making process. Conclusion: Few studies investigate the ethical dimensions and aspects of paediatric nursing, and they are mainly qualitative studies conducted in critical care settings based on nurses’ perceptions and experiences. Paediatric nurses require specific educational interventions to help them resolve ethical issues, contribute to the decision-making process and fulfil their role as advocates of a vulnerable population (i.e. sick children and their families). Further research is needed to investigate how paediatric nurses can improve the involvement of children and their families in decision-making processes related to their care plan. (shrink)

Nietzsche presents a challenging conception of aesthetics. One of the most well-known discussions on this issue is presented by Heidegger in Der Wille zur Macht als Kunst. In discussing Nietzsche’s aesthetic theory, Heidegger argues that Nietzsche’s reception of Kantian aesthetics is only ever indirect and necessarily mediated by Schopenhauer. His conclusion hinges on what he considers to be a widespread misinterpretation of Kant’s theory of the beautiful, a misinterpretation that begins with Schopenhauer but characterizes all of Kant’s followers, especially Nietzsche. (...) In this paper, I will consider Nietzsche’s position toward aesthetics from a different perspective, namely in the space between Kant’s and Schopenhauer’s position. The argumentation departs from Nietzsche’s early critique of teleology; his first approaches to aesthetics in Die Geburt der Tragödie ; and his position on the concept of causality and morality. As a careful interpretation of GM III 6 will make clear, Heidegger’s claim that Nietzsche misinterprets Kant is made questionable by the fact that Nietzsche here distinguishes Kant from Schopenhauer’s approach and proposes an artist-based aesthetics in which it is rather Stendhal’s idea of beauty as “une promesse de bonheur” which expresses the human need for illusions in Nietzsche’s conception of aesthetics. (shrink)

The aim of this work is to show how Edgar Morin chose Vico and Hegel as cultural points of reference while elaborating a new method as an alternative to classical scientific knowledge. The French philosopher did this specifically when he tried to re-propose the problem s of history and the event in human sciences. The origins of sociology arose from the explicit extension of the scientific method to the socio-anthropological world; that is, with the intention of studying society as a (...) natural phenomenon to which the laws of physical and biological sciences must be applied. As a tendency against this, at the end of the 1970s Morin began a process of putting sociology into historical context, which led him to a methodological revolution of sociology itself. (shrink)

Pila (2009) has criticised the recommendations made by requirements engineers involved in the design of a grid technology for the support of distributed readings of mammograms made by Jirotka et al. (2005). The disagreement between them turns on the notion of “biographical familiarity” and whether it can be a sound basis for trust for the performances of professionals such as radiologists. In the first two sections, this paper gives an interpretation of the position of each side in this disagreement and (...) their recommendation for the design of technology for distributed reading, and in the third the underlying reasons for this is agreement are discussed. It is argued that Pila, in attempting to make room for mistrust as well as trust, brings to the fore the question of having and reflecting upon reasons for trust or mistrust. Pila holds that biographical familiarity is not a sound reason for trust/mistrust, as it seems to obliterate the possibility of mistrust. In response to her proposal, an analysis is proposed of the forms of trust involved in biographical familiarity. In particular, implicit trust is focused upon — as a form of trust in advance of reasons, and as a form of trust contained (in the logical sense) within other reasons. It is proposed that implicit trust has an important role in establishing an intersubjectively shared world in which what counts as a reason for the acceptability of performances such as readings of X-rays is established. Implicit trust, therefore, is necessary for professionals to enter into a “space of reasons”. To insist upon judgements made in the absence of the form of implicit trust at play in biographical familiarity is to demand that radiologists (and other relevantly similar professionals) make judgements regarding whether to trust or mistrust on the basis of reasons capable of being reflected upon, but at the same time leave them without reasons upon which to reflect. (shrink)

Late archaic lyric poetry tends to obscure all pathetic and tragic elements of Achilles’ destiny present in the Iliad. The offence against his honour, his grief for Patroclus, his yearning for native Phthia, and a painful awareness of being ὠκύμορος – none of these themes play a role in the passages of Pindar, Bacchylides or Simonides where Achilles is mentioned. Yet each of these three poets operates differently with regard to the epic source, and it is worth investigating how they (...) do so. (shrink)

In this paper, Plotinus' treatise On Dialectic I.3 [20] is discussed. In the first part of the paper, I argue that for Plotinus the importance of dialectic stands in the method of division that enables one to grasp the ‘what it is’. I present and examine some passages which contain a description of dialectic and an account of its activity. I then look into the reasons why Plotinus affirms the superiority of dialectic, as he conceived it, over logic, as the (...) Peripatetics and the Stoics conceived it. The second part of the paper explores the relation between dialectic and truth and that between dialectic and soul: in this discussion Plotinus offers some interesting and more original epistemological remarks. (shrink)

O discernimento entre o bem e o mal pode ser considerado a preocupação central da Filosofia, mas seu cultivo requer uma combinação complexa de habilidades cognitivas, linguísticas e sociais complexas. Diferentemente da religião ou da Teologia, espera-se que os filósofos superem a confusão ao apresentarem posições sustentáveis forma puramente lógica, sem apelos à autoridade ou às emoções. Isto deposita altas expectativas sobre o intelecto, a nossa habilidade de usar a razão discursiva. Schopenhauer defendia que a Filosofia seria primariamente teórica ou (...) contemplativa, portanto não orientaria a conduta ou o caráter. Enquanto a Vontade seria ativa, o intelecto seria passivo e instrumental. Nietzsche subordinou o intelecto ao corpo e propôs um critério fisiológico para avaliar filosofias. Piaget investigou o desenvolvimento da inteligência em estádios examinando a interação construtiva da criança com coisas e pessoas. O intelecto permanece em desequilíbrio e deve se adaptar continuamente. (shrink)

É bem sabido que a estética de Kant está estruturada intersubjetivamente, porque ele honra a reivindicação do gosto pela universalidade. No entanto, o fundamento transcendental desta universalidade compartilhada é uma base suprasensível tida por certa, mas que não pode ser trazida diretamente para dentro da experiência comunicativa. O apelo kantiano à estrutura sintética a priori do juízo estético também remove-o da esfera da interação pessoal observável. Esta estratégia argumentativa expõe-no a desafios céticos e gera referências inacessíveis às representações internas (sejam (...) elas intuições, categorias do entendimento ou idéias racionais). Não é suficiente, como faz Kant, propor uma descrição da experiência estética que seja subjetivamente plausível e, a partir disso, reivindicar sua validade intersubjetiva. É indispensável encarnar a intersubjetividade no comportamento e na linguagem. Na intersubjetividade prática, lida-se com as atitudes estéticas em um modo concreto e acessível, sem depender de pressupostos mentalistas como fundamento. Termos conceituais como 'agradável', 'belo', 'sublime', 'feio', 'universalidade' adquirem novo significado em um contexto interativo e reivindicações estéticas são testadas em um modelo dialógico de jogo semântico. (shrink)

As data-intensive and computational science become increasingly established as the dominant mode of conducting scientific research, visualisations of data and of the outcomes of science become increasingly prominent in mediating knowledge in the scientific arena. This position piece advocates that more attention should be paid to the epistemological role of visualisations beyond their being a cognitive aid to understanding, but as playing a crucial role in the formation of evidence for scientific claims. The new generation of computational and informational visualisations (...) and imaging techniques challenges the philosophy of science to re-think its position on three key distinctions: the qualitative/quantitative distinction, the subjective/objective distinction, and the causal/non-causal distinction. (shrink)

In recent years, the contribution of various disciplines and professionals (i.e. from marketing, computer science, psychology and pedagogy) to museum management has encouraged the development of a new conception of museology. Specifically, psychology has affected the overall conception of museum and the visitors towards a more holistic vision of the museum experience as a complexity of memory, personal drives, group identity, meaning-making process, as well as leisure preferences. In this regard, psychological research contributes to advance the scientific knowledge about psychological (...) and social phenomena related to the visitor experience, as well as to design innovative technologies and future tourism services. The present contribution discusses the Socio-Cultural Activity Theory as a theoretical framework to conceptualize the museum visit as an activity mediated by the technology, and to better identify the factors shaping the interaction between the visitors and the technologies. To do so, a case study is presented: a qualitative research performed at the Ara Pacis Museum in Rome (Italy) to analyze the visitor experience of a tour that integrates augmented and virtual reality. Information derived from applying Activity Theory on visitors’ experience highlight the value of technology as mediating tool between the museum mission and the visitor experience, considering the interaction between visitors’ characteristics, museum environmental dimensions and technology’s features. (shrink)

In this issue, Pila (2009) has criticised the recommendations made by requirements engineers involved in the design of a grid technology for the support of distributed readings of mammograms made by Jirotka et al. (2005). The disagreement between them turns on the notion of “biographical familiarity” and whether it can be a sound basis for trust for the performances of professionals such as radiologists. In the first two sections, this paper gives an interpretation of the position of each side in (...) this disagreement and their recommendation for the design of technology for distributed reading, and in the third the underlying reasons for this disagreement are discussed. It is argued that Pila, in attempting to make room for mistrust as well as trust, brings to the fore the question of having and reflecting upon reasons for trust or mistrust. Pila holds that biographical familiarity is not a sound reason for trust/mistrust, as it seems to obliterate the possibility of mistrust. In response to her proposal, an analysis is proposed of the forms of trust involved in biographical familiarity. In particular, implicit trust is focused upon—as a form of trust in advance of reasons, and as a form of trust contained (in the logical sense) within other reasons. It is proposed that implicit trust has an important role in establishing an intersubjectively shared world in which what counts as a reason for the acceptability of performances such as readings of X-rays is established. Implicit trust, therefore, is necessary for professionals to enter into a “space of reasons”. To insist upon judgements made in the absence of the form of implicit trust at play in biographical familiarity is to demand that radiologists (and other relevantly similar professionals) make judgements regarding whether to trust or mistrust on the basis of reasons capable of being reflected upon, but at the same time leave them without reasons upon which to reflect. (shrink)

The borders between the physical and the virtual are ever-more porous in the daily lives of those of us who live in Internet enabled societies. An increasing number of our daily interactions and transactions take place on the Internet. Social, economic, educational, medical, scientific and other activities are all permeated by the digital in one or other kind of virtual environment. Hand in hand with the ever-increasing reach of the Internet, the digital and the virtual, go concerns about trust. In (...) the increasing numbers of cross-disciplinary attempts to understand the way that the Internet is changing our societies, ‘trust’ is a truly cross-boundary word, used just as frequently by computer scientists as it is by economists, sociologists and philosophers. Concerns in the name of trust are articulated about the objects and artefacts found, accessed or bought on the Internet, about the people with whom we interact on the interact, and about the technological systems and infrastructures that enable us to carry out activities of different types. -/- This paper reflects on the implications for trust of the way we shape our technologies and they in turn shape us, for example, in the way we trust and the extent to which we can trust ourselves as trusters. The account I am working towards is an ecological and co-evolutionary view of trust and technologies, which attempts to hold in view the complex inter-relationships between the agents and other entities within and across environments. First, I consider the ways in which problems of justifying trust are analogous to problems of justifying knowledge, and claim that trust, like knowledge, cannot be justified from an external position. Second, I outline an account of internal relations drawn from phenomenology. This is followed by a discussion of three aspects of trust which are internally related to it: value, reason and morality. (shrink)