Regulation of transcriptional elongation is emerging as an important control mechanism for eukaryotic gene expression. In this essay, we review the basis of the current view of the regulation of elongation in the human c‐myc gene and discuss similarities in elongation control among the c‐myc, Drosophila hsp70 and the HIV‐1 genes. Based upon these similarities, we propose a model for control of expression of these genes at the elongation phase of transcription. This model suggests that distinct promoter elements direct the (...) assembly of RNA polymerase II transcription complexes which differ in their elongation efficiency. (shrink)

In this paper we are going to show that error coping strategies play an essential role in linguistic pragmatics. We study the effect of noisy speaker strategies within a framework of signalling games with feedback loop. We distinguish between cases in which errors occur in message selection and cases in which they occur in signal selection. The first type of errors affects the content of an utterance, and the second type its linguistic expression. The general communication model is inspired by (...) the Shannon–Weaver communication model. We test the model by a number of benchmark examples, including examples of relevance implicatures, quantity implicatures, and presupposition accommodation. (shrink)

Previous research on scalar implicature has primarily relied on meta-linguistic judgment tasks and found varying rates of such inferences depending on the nature of the task and contextual manipulations. This paper introduces a novel interactive paradigm involving both a production and a comprehension side and a precise conversational goal. The main research question is what is reliably communicated by some in this communicative setting, both when the quantifier occurs in unembedded and embedded positions. Our new paradigm involves an action-based task (...) from which participants’ interpretation of utterances can be inferred. It incorporates a game-theoretic design, thereby including a precise model to predict participants’ behaviour in the experimental context. Our study shows that embedded and unembedded implicatures are reliably communicated by some. We propose two cognitive principles that describe what can be left unsaid. In our experimental context, a production strategy based on these principles is more efficient than a strategy based on literal descriptions. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

Recent scholarship has analyzed Hegel’s account of life in the Logic in some detail and has suggested that Hegel provides ways of thinking about organic phenomena that might still be fruitful for us today. However, it failed to clearly distinguish this account from Hegel’s discussion of natural organisms in his Philosophy of Nature and to assess the latter philosophically. In particular, it has not yet been properly discussed that some things that Hegel says about organic phenomena there suggest that his (...) position is objectionably vitalist in that he believes investigating physical and chemical properties of organisms is irrelevant for understanding organic phenomena. I argue that Hegel’s core account of life does not imply this sort of a vitalist position. While some claims Hegel makes suggest that he believed inorganic sciences to be of no relevance for understanding organic phenomena, his core position is that they are merely not sufficient for the full understanding of such phenomena. From this discussion I draw a further consequence that the multi-level structure of nature presented in the Philosophy of Nature points to different properties of natural objects, rather than to distinct domains of objects. (shrink)

This article deals with the question of whether an increased teaching of business ethics can/will have a positive effect on the fight against corruption in companies. It is written from a (South) African perspective. Statistics about the alarming state of corruption in South African businesses are provided in the beginning. A Hegelian approach to the problem, in terms of which theory can and does influence practice, is compared to a Marxist approach, in terms of which theory is only a reflection (...) of practice. The author chooses a position that mediates between these two extremes. In the end, he develops a model that relies heavily on the idea of an ethics of responsibility that draws on Aristotle's idea of phronesis (practical wisdom based on deliberation). The practical implications of these ideas for the utilization of business ethics teaching in companies are consequently spelt out. While more teaching of this discipline cannot guarantee better morals in a company, it can better equip all involved to deal with the ever-increasing moral problems that business people have to deal with. S. Afr. J. Philos. Vol.22(2) 2003: 128–138. (shrink)

The traditional formalism of quantum mechanics is mainly used to describe ensembles of identical systems (with a density-operator formalism) or single isolated systems, but is not capable of describing single open quantum objects with many degrees of freedom showing pure-state stochastic dynamical behaviour. In particular, stochastic 'line-migration' as in single-molecule spectroscopy of defect molecules in a molecular matrix is not adequately described. Starting with the Bohr scenario of stochastic quantum jumps (between strict energy eigenstates), we try to incorporate more general (...) pure-state stochastic dynamical behaviour into the quantum mechanical formalism.Probability distributions of (approximately) pure states, arising through the stochastic pure-state dynamics for long times, give rise to appropriate decompositions of thermal density operators. These decompositions of density operators into pure states mediate between quantum mechanics for ensembles of molecules and quantum theory for single molecules (or single dressed quantum objects). We suggest that such decompositions should be consistent with infinite limits (e.g. the Born-Oppenheimer limit for infinite nuclear masses) in the sense that quantum fluctuations (around classical behaviour in the infinite limit) die out asymptotically. (shrink)

Réflexions sur deux publications récentes en ecclésiologie : «Eclesiología 30 años después de Lumen Gentium. Pueblo de Dios - Cuerpo de Cristo - Templo del Espíritu Santo - Sacramento - Comuniοn», Pedro Rodríguez , Madrid : Rialp, 1994 et François Guillemette, «Théologie des conférences Episcopales. Une herméneutique de Vatican II», Montréal, QC : Médiaspaul, 1994.

Gran parte de los estudios sobre la naturaleza de la cognición social, que también se ha entendido como una perspectiva de se-gunda persona, ha tenido lugar en el marco de la llamada “teoría de la mente”, entendida básicamente como capacidad inferencial de atribución de estados mentales. La fenomenología, por el contrario, advierte la naturaleza corporizada e integrada de la experiencia de sí, lo que permite, consecuentemente, el acceso inmediato a la experiencia vivida del otro. La incorporación de esta comprensión de (...) la cognición social en el ámbito experimental ha planteado un giro interactivo: de perspectivas observacionales y mecanismos individuales a escenarios interactivos y procesos participativos. Este trabajo se propone mostrar tanto el sentido fenomenológico de la cognición social como así también las diversas interpretaciones que han encontrado aplicación en la experimentación neurocientífica en cuanto perspectivas de segunda persona, a fin de evaluar sus aportes y ofrecer posibles tareas aún pendientes.Most of the studies on the nature of social cognition, which has also been understood as second-person perspective, have taken place within the framework of the so-called "theory of mind", basically understood as inferential capacity for attribution of mental states. Phenomenology, on the contrary, shows the embodied and integrated nature of self-experience, which consequently allows immediate access to the lived experience of the other. The incorporation of this understanding of social cognition in the experimental field has proposed an interactive turn: from observational perspectives and individual mechanisms to interactive scenarios and participatory processes. This work aims to show both the phenomenological meaning of social cognition as well as the various interpretations that have found application in neuroscientific experimentation as second-person perspectives, in order to evaluate their contributions and offer possible open tasks. (shrink)

“The inquiry into the foundations of knowledge is a systematic inquiry into the problem of truth. This problem constitutes one of the three main concerns of philosophical analysis, the others being the problem of beauty and the problem of goodness.” Thus Evangelos P. Papanoutsos, Greece’s leading contemporary philosopher, introduces this third book of his “Trilogy of the Mind.” The first two volumes covered aesthetics and ethics; this one is a major work in epistemology. Combining rigorous analysis with thorough-going scholarship, displaying (...) an intimate acquaintance with the physical and humanistic sciences, and drawing on a deep understanding of philosophical method and the history of philosophy, Professor Papanoutsos is held in high esteem by his European colleagues. This translation of his masterpiece will enhance his reputation and influence among readers of English. The themes of The Foundation of Knowledge range over the topics that have been continually challenging to the modern era of philosophers: being and consciousness, experience and reason, common sense and science, and the domains of knowledge, including the nature of philosophical knowledge. Special attention is paid to the analysis of theoretical consciousness, the problems of categorical thinking, the theory of judgment, mathematics and logic, and the limits of historical understanding. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews How Philosophy Uses Its Past. By John Herman Randall, Jr. Foreword by Cornelius Krus~. (The Matehette Lectures, Wesleyan University, 1961; New York and London: Columbia University Press, 1963. Pp. xiv + 106. $3.50.) One could easily characterize this small volume as a minor masterpiece on a major theme. It is an admirable statement from the pen of one of America's leading thinkers in both the history of (...) philosopy and philosophy "proper." Actually the distinction between these two fields of philosophic activity becomes superfluous since Professor Randall has an elaborate theory of his own, whereby to do philosophy and do it well involves, in a serious and inescapable way, competent performance in the history of philosophy. How Philosophy UsesIts Past may have to be read, and I propose here that it should, as the general introduction to Randall's projected three volumes of his monumental The Career of Philosophy, of which only Volume One has been published. The close analyses of specific men and issues presented in the latter work can be seen as the evidence meant to corroborate the thesis asserted in How Philosophy Uses Its Past. In his own words: "It remains true that it is impossible to gain insight into the history of philosophical ideas--into the dimensions of philosophizing--without being led to formulate a philosophy of cultural change" (p. 20). Randall has made in this volume a significant contribution if only by way of focusing his powerful lens on three central issues: (1) how genuine philosophizing is still "metaphysical" thinking; (2) why it is necessary to undertake a thorough investigation of the antecedents leading up to our prevailing philosophies of experience; (3) how to understand the seemingly chaotic situation in our philosophical affairs, under the age-old distinction of the "one and many." In a critical and appreciative article on Lovejoy, Randall stated his reservations toward Lovejoy's "atomistic" conception of intellectual history and proceeded to note that the history of philosophy has a philosophic function iust as philosophy has historical dimensions such that when adequately explored can tell us much about the nature and limits of our own philosophizing.1 A permeative thesis in the volume under review is that to do "history of philosophy" is to do "philosophy." To show how and why Randall believes this to be the case, we must consider in some detail three of his main themes: the redefinition of metaphysics, the broader conception of experience, and the "one and many" aspect of contemporary philosophy. One may go so far as to say that Randall is doing philosophy just as he is formulating a theory of the philosophy, for the sake of responding philosophically to the stated problems. But to respond philosophically is something that one must learn in conjunction with the examination of the historical past of philosophy. Randall thus believes, on the evidence gathered, that philosophy has revealed itself to be "a clarification and criticism of fundamental beliefs involved in all the great enterprises of human culture, science, art, religion, the moral, social and practical activity, when some new idea or some altered experience has impinged upon them and generated intellectual tensions and maladjustments" (pp. 19; 100). This way of understanding philosophy affects his approach to every problem he mentions. Indeed, even the denial of the importance of the history of philosophy is rooted in historical processes which must be understood before the denial can be fully illumined. Without historical knowledge, he argues even our decisions will suffer (p. 14). Randall calls his approach to defining philosophical problems "operational." Accordingly, we do not know whether we have a philosophical problem until a philosophical response has occurred. Looking back from the response to what it was that philosophers responded to, we See Randall's "Arthur O. Lovejoy and the History of Ideas," Philosophy and Phenomenological Research,XXII (1963), 475-479; also book under review, p. 36. [1071 108 HISTORY OF PHILOSOPHY discover that these were problems that emerged "whenever strife of ideas and experiences forced men back to the fundamental assumptions in any field" (p. 18). Briefly put, the response has always been that of analysing, clarifying, criticizing and reconstructing "fundamental assumptions." The problems vary and... (shrink)

L’article traite de la relation entre l’homme et la loi chez Spinoza. Une première partie porte sur la question de savoir si l’individu doit toujours observer les lois. Dans la seconde, sous la conduite du Traité politique, nous passons à une perspective collective et on analyse la pensée de Spinoza sur la puissance de la multitude face aux lois. À la fin, on tire quelques conclusions pour la vie d’aujourd’hui.

Charles R. Kesler, an eminent scholar and prodigious editor, has exerted a profound influence on the study of American politics and the practice of American conservatism. A precocious high-school student, he impressed a visiting William F. Buckley Jr. who, before becoming a life-long friend, wrote him a recommendation letter to Yale. Kesler asked for another--to Harvard, where he completed his undergraduate degree and earned a PhD under the legendary professor Harvey C. Mansfield. An early passion for political journalism, played out (...) largely on the pages of National Review, led Kesler to author an NR cover story on his third great influence, Harry V. Jaffa. Kesler became a faculty colleague of Jaffa's at Claremont McKenna College and Claremont Graduate University and is perhaps best known as the editorial helmsman of the Claremont Review of Books. The author of I Am the Change: Barack Obama and the Crisis of Liberalism and Crisis of the Two Constitutions: The Rise, Decline, and Recovery of American Greatness, Kesler also co-edited (with William F. Buckley Jr.) Keeping the Tablets: Modern American Conservative Thought. His edited volume of The Federalist Papers is the best-selling edition version in the country. In this volume, Kesler's students, friends, and colleagues commemorate his four-decade career as a teacher, mentor, and scholar. (shrink)

El objetivo de este trabajo es identificar el significado del papel de la madre, en el desarrollo social, para tres iniciativas de la Renovación de la Pedagogía: la Institución Libre de Enseñanza, las Escuelas del Ave María y la Escuela Moderna de Barcelona. Las fuentes primarias, analizadas para alcanzar dicho fin, son publicaciones de revistas con fines socioeducativos, en su gran mayoría. Y nos advierten de un discurso dispar entre los tres proyectos. Determinando como conclusión principal que las propuestas examinadas (...) tuvieron sus propios planteamientos sobre el significado de madre, pero todas ellas sabían de su importancia como figura educadora. (shrink)

There seems to be tension between portrayals of Socrates as both a committed philosopher and a pious man. For instance, one might doubt Socrates’ commitment to philosophy since he seems to irrationally defer to a daimonion. On the other hand, the fact that he challenges messages from Oracles and the gods’ role concerning the origin of the pious draws into question Socrates’ piety. In this paper, I argue that Socratic piety and rationality are not only compatible, but they are also (...) symbiotic. Socrates could not be rational without being pious, nor could he be pious without being rational because, for him, care and curiosity are intimately intertwined. In this regard, Socrates’ epistemology, when applied, resembles Karl Popper’s falsificationism. For Socrates, maintaining human wisdom amounts to regular purification of one’s belief-system. In addition, this maintenance is functionally identical to caring for one’s soul, which is morally imperative. (shrink)

Capitalism is in crisis. Is a better world possible and what would it look like? Taking Socialism Seriously breaks important new paths for significant social change by examining detailed questions seriously that had previously been neglected.

In this volume, Baumstark deals with the transmission of Aristotelian philosophy into Syriac and Arabic. Syriac texts with German translations are included, alongside a detailed study of their textual interrelationships.

The volume presented here is a collection of the contributions to an author s colloquium with Walter Burkert, which was held in November 2007 in the Centre for Interdisciplinary Research at the University of Bielefeld. Well known experts looked in detail at the work of the internationally renowned scholar of Greek. In his epochal cultural-scientific studies focusing on the origins of human co-existence in rites, on violence, sacrifice, guilt and horrific scenarios of death, Burkert approached questions of biological behavioural research, (...) anthropology and aggression theory, and developed an enormous intellectual impact that reached beyond classical and religious studies. ". (shrink)

Dans cette contribution, la Comédie Ancienne est associée de manière surprenante au complexe chamanistique, ou respectivement, au schéma du goës ou magos qui existait dans la Grèce archaïque et dans les premiers temps de la Grèce classique. Après un bref aperçu de l’histoire de la recherche concernant le ‘chamanisme’ grec dans les études classiques, l’auteur écarte explicitement les spéculations essentialistes sur l’origine, mais utilise le phénomène religieux au sens d’un procédé de fantaisie mental et théâtral. Le potentiel performatif du goës (...) est à même de traduire la chute soudaine, constitutive du genre, dans des espaces et des modes de jeu grotesques et ataviques, sur la scène comique. En particulier, les thèmes de la guérison et des voyages dans l’Hadès ou au ciel, thèmes qui jusqu’à présent n’ont pas vraiment été traités comme il l’aurait fallu, comme le héros comique ambigu et excessif, et la poétique alogique et non naturaliste de la Comédie Ancienne, peuvent s’expliquer comme repoussoirs d’un goës chamanique. Dans les pièces populaires de la place de marché, un tel théâtre de bouffons et de médecins charlatans perdure à travers l’histoire. À la fin, l’approche théorique est mise en pratique en prenant comme exemple la Paix d’Aristophane. L’intrigue relativement simple, où le héros chevauche jusqu’au ciel pour trouver une sorte de thérapie pour la cité, est enrichie d’une nouvelle signification totalement englobante, au-delà du politique strict. (shrink)

Aparte de los ejemplos añadidos por Miguel Asín Palacios y Luce López-Baralt, en los que se aprecia la presencia del símbolo de castillo interior en la mística islámica, el símil de los siete castillos del alma de los siete castillos del alma se encuentra también en el filósofo persa filósofo persa Shihaboddin Yahya Sohravardi (siglo XII). Por tanto, se trata de un antecedente de Santa Teresa de Ávila en el uso de este símbolo.

This article compares affinities in Walter Benjamin and Rosi Braidotti’s historiographical methodologies, focusing on a monadic/nomadic perception of history. For Benjamin and Braidotti questions on how we remember, write and represent history are critical. Benjamin develops a non-linear representation of history in relation to the microscopic perception of Leibniz monad. Braidotti, in turn, develops a critical nomadic theory in relation to Deleuze’s re-reading of Leibniz’s monad. Can a link be established between these two adaptations of the concept of the monad? (...) Can Benjamin’s historico-philosophical thinking be actualized in relation to the contemporary critical theory, such as post-humanism, queer and feminist theory? (shrink)

The subject of the study is collective trauma and its manifestations in post-war Italy. The definition of collective trauma is given on the basis of the works of sociologists and its characteristics. The purpose and novelty of the work is to explain the "phenomenality" of the journalist and historian Giampaolo Pansa. The contribution he made to the Italian consciousness after the release of the books "Children of the Eagle" and "Blood of the Vanquished", devoted to methods of retaliation against fascist (...) arbitrariness during the Italian Civil War of 1943-1945, consists in explaining the bilateral collective trauma that arose as a consequence of the ideology of fascism, affecting both its supporters and its opponents. The main conclusion of the study is the following. The method of J. Alexander's cultural sociology enriched with the existential grief of A.I. Etkind is analyzed. The meaning of socio-cultural trauma can be determined by answering the questions about what crisis events we are talking about, who is responsible for them, what are the consequences of traumatic actions. Turning these questions into a narrative is the most important problem for anthropology. The meaning of socio-cultural trauma can be determined by answering the questions about what crisis events we are talking about, who is responsible for them, what are the consequences of traumatic actions. Turning these questions into a narrative is the most important problem for anthropology. (shrink)

Heródoto en las primeras líneas de sus Historias decía que las escribía para que "el tiempo no abatiera el recuerdo de las acciones humanas". Antonio Hermosa, catedrático de filosofía en la universidad de Sevilla, quiere traernos a la mente algunos de los hechos principales que narraron los historiadores antiguos. Frente a una historia positivista de datos y fechas, quiere promover una historia reflexiva y que el tiempo no abata los pensamientos de los historiadores clásicos ni los que a partir de (...) ellos podemos formar. (shrink)