Graphical AbstractVarious diagnostic methods are available to detect the six human pathogenic Plasmodium species that replicate within host erythrocytes and cause different types of malaria. Every currently available diagnostic method has distinct advantages and disadvantages. There is still a high demand for simple, fast, and highly sensitive alternative diagnostic methods that ideally do not rely on blood drawing and might be applied by the patient at home. In article number 1900138, Brian Gitta and Nicole Kilian discuss the history (...) of Plasmodium detection and assess advantages and disadvantages of diagnostic methods that are currently being applied. (shrink)

Fast and effective detection of the causative agent of malaria in humans, protozoan Plasmodium parasites, is of crucial importance for increasing the effectiveness of treatment and to control a devastating disease that affects millions of people living in endemic areas. The microscopic examination of Giemsa‐stained blood films still remains the gold‐standard in Plasmodium detection today. However, there is a high demand for alternative diagnostic methods that are simple, fast, highly sensitive, ideally do not rely on blood‐drawing and can potentially be (...) conducted by the patients themselves. Here, the history of Plasmodium detection is discussed, and advantages and disadvantages of diagnostic methods that are currently being applied are assessed. (shrink)

A number of authors have commented on the topic of mandated reporting in cases of suspected child maltreatment and the application of this requirement to researchers. Most of these commentaries focus on the interpretation of current legal standards and offer opinions for or against the imposition of mandated reporting laws on research activities. Authors on both sides of the issue offer ethical arguments, although a direct comparison and analysis of these opposing arguments is rare. This article critically examines the ethical (...) arguments made by authors on both sides of the debate. The conclusion is reached that researchers should be mandated reporters of child maltreatment because the current arguments do not justify their exclusion from current ethical and legal standards. The author makes recommendations for the ethically responsible conduct of research in regard to this topic and legal implications are discussed. (shrink)

We critically evaluate arguments in a recent Journal of Law, Medicine & Ethics article by Svoboda, Adler, and Van Howe disputing the 2012 affirmative infant male circumcision policy recommendations of the American Academy of Pediatrics. We provide detailed evidence in explaining why the extensive claims by these opponents are not supported by the current strong scientific evidence. We furthermore show why their legal and ethical arguments are contradicted by a reasonable interpretation of current U.S. and international law and ethics. After (...) all considerations are taken into account it would be logical to conclude that failure to recommend male circumcision early in infancy may be viewed as akin to failure to recommend childhood vaccination to parents. In each case, parental consent is required and the intervention is not compulsory. Our evaluation leads us to dismiss the arguments by Svoboda et al. Instead, based on the evidence, infant male circumcision is both ethical and lawful. (shrink)

A common element of Western theism is a belief in Providence, in the sense of some kind of (perhaps unknown or inscrutable) Divine Plan for creation, especially if it involves Divine intervention in the world to see to it that His will be done. This positioning of God as a behind-the-scenes agent acting so as to bring about some end of His own desire has the flavor of conspiracy theory. Where some secular conspiracy theorists posit a cabal of powerful individuals (...) (bankers, Freemasons, etc.) “pulling the strings” behind current events, belief in Providence posits God in a similar role (or perhaps God in conflict with a powerful, supernatural force of evil). But is this a fair comparison? Prima facie, there are a number of differences between the two cases, for example, God is posited as beneficent, whereas most conspiracy theories involve more self-serving goals or conspiracy theorists believe they have rational reason for their belief, not mere faith. This paper explores the relationship between these two cases in an attempt to more clearly define the epistemological features of each and to help understand how conclusions about the epistemic virtue of one might (or might not) apply to the other. (shrink)

As late as 1948, when he was making his report to the Literae Humaniores Faculty Board on the work he had done as University Lecturer since 1945, Friedrich Waismann listed three text books that he had ready for publication and one book—as it might be “real book”—which he referred to as “Philosophy and Grammar”. That was his fi nal title for a work he had been preparing since 1929 and which was originally to be called “Logik Sprache Philosophie”. In 1948 (...) that work will have consisted physically in a heavily corrected set of galley proofs, printed for Routledge and Kegan Paul . The print was set up in the unhappy year of 1939, the copy reaching the publisher on 25 July of that year. (shrink)

Renin is the rate‐limiting enzyme in a cascade that leads to production of angiotensin II, which is perhaps our most important regulator of salt and water balance and blood pressure. In this personal perspective, I describe how I entered the renin field 33 years ago by discovering that proteases increased the level of renin activity in biological fluids, so revealing the existence of a ‘pro’ form of the molecule. This led me on a journey that encapsulated all of the major (...) milestones in molecular discovery for renin. These included (1) the elucidation of the steps in renin biosynthesis, (2) the cloning of renin cDNA and its gene, (3) demonstration of the structure of the renin protein, (4) using the renin gene in the first genetic studies in hypertension, (5) finding the mechanism by which the major controller, cyclic AMP, regulates the promoter, (6) showing that a strong enhancer and its weak promoter control this physiologically regulatable gene in accord with the variegation (on/off switching) model, and (7) being the first to identify molecules involved in posttranscriptional control. The renin molecule, its gene and molecular control are now very well understood, but more fine details on the topic of renin continue to emerge to delight ‘reninologists’ and others. BioEssays 25:520–527, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This paper explores the role of divine speaking in Christian ethics, critically engaging with the tendency in modern evangelicalism to seek to derive moral principles from Scripture or a biblically-derived ontology, often via deployment of map-making metaphors. The paper sets out the rather different centrality of the divine claim found in biblical accounts of good or righteous human action. Drawing on the criticisms of the anthropologist Tim Ingold of what he calls the “map-making fallacy,” the paper concludes by suggesting the (...) methodological importance of understanding the orientation of the Christian life to be a fundamentally grounded in interpersonal responsivity. (shrink)

This case involves invasive research on captive wild populations of birds to study aggressive animal behavior. The case and associated commentaries raise and examine fundamental issues: whether and under what conditions, such research is ethically justified when the research has no expected, direct application to the human species; the moral status of animals and how one balances concern for the animal’s interests against the value of gains in scientific knowledge. They also emphasize the issue of the importance of a thorough (...) literature search to ensure appropriate research design and experimental design to minimize animal suffering. It raises the issue of circumstances in which such research should be modified or terminated. (shrink)

"This book is based on new work relating gendered assumptions about rationality to men's mental health. It offers the reader a theoretical exploration of a topically and politically sensitive issue and provides a valuable critique of postmodern theory and theorists. It is relevant to practitioners and activists in the mental health field, will be of interest to profeminist theorists, and is essential reading for academics and students of sociology and allied disciplines."--Jacket.

A concept for teaching business ethics and its relationship with business law is developed. Legal regulations form the essential boundaries of the business game. Many students do not realize the degree to which law is dependent upon ethical actors to achieve its objectives. At least three examples are insightful in this regard: First, the interpretive requirements of legal rules often rely on the ethical character of the interpreting business actor to achieve their objectives. Second, law does not prohibit harms from (...) occurring, it only associates costs with behaviors. Third, law cannot compensate society for non-fungible harms. Legal regulations do not sustain the orderly function of society without ethical business actors. (shrink)

One of Śaṅkara's most fundamental claims is that nirguṇa brahman, 'unqualified reality', is the origin of the world of experience. A serious challenge is posed by the Sāṅkhyan philosophers in terms of a principle of material causation, that the properties manifested in the effect are inherited from the material cause. Since nirguṇa brahman and the experienced world are so different, the principle implies that the former cannot be the material cause of the latter. Versions of the principle in relation to (...) alternative kinds of candidates for the role of material cause are discussed, considering the particular cases which motivate both Śaṅkara's and the Sāṅkhyans' metaphysics alike. Śaṅkara seems forced to accept an implausible version of the principle by his own analysis of material causation. (shrink)

This newly edited volume is a significant addition to the study of modern political thought. The volume includes an introduction co-authored by the two editors and 11 chapters covering early modern...

Originally published 1967, this title reveals how the missionaries, so often misguided and short-sighted, were in fact pioneers of modernization, science and freedom. The structure of the book allows for comparative analysis and the volume illustrates how some of the social consequences of action through the schools could be foreseen. In addition light is thrown on the results of Imperial rule during the nineteenth century and on the nature of the impact of Western education in Asia and Africa.

What is the significance of the Protestant Reformation for Christian ethical thinking and action? Can core Protestant commitments and claims still provide for compelling and viable accounts of Christian living. This collection of essays by leading international scholars explores the relevance of the Protestant Reformation and its legacy for contemporary Christian ethics.

Many proponents and opponents of the Corrida de Toros agree in describing the practice as a sacrifice. This surprising agreement is compounded by a further agreement that the sacrificial victim is the bull. In what follows, I contest both points. Beginning with the later, I argue that the victim is not the bull but the torero, especially the matador. Rather than seeing the corrida as the sacrifice of the bull, it is the deferred sacrifice of the torero, and the crowd (...) is on the side of the victim. Moreover, I argue that once the victim status of the matador has been appreciated, it can serve as the foundation for a new interpretation of... (shrink)

There has been a recent surge of interest among economists in developing models of doxastic states that can account for some aspects of human cognitive limitations that are ignored by standard formal models, such as awareness. Epistemologists purport to have a principled reason for ignoring the question of awareness: under the equilibrium conception of doxastic states they favour, a doxastic state comprises the doxastic commitments an agent would recognise were he fully aware, so the question of awareness plays no role. (...) The objective of this paper is to scrutinize this argument. A thesis underlying the argument, which we call the independence of doxastic commitments with respect to awareness, is identified, and examples are given where it appears to be violated. By considering these examples, one can get an idea of the price of accepting this thesis. On the one hand, one can escape the conclusion that the thesis is violated, but only at the expense of another principle espoused by all major formal models of belief, which we call constant doxastic rest; and abandoning this principle necessitates extensive revision of current models of belief. On the other hand, there are epistemologically valid reasons for thinking that the thesis fails to hold in the examples, which have to be rebutted if the thesis, and the equilibrium justification for ignoring the issue of awareness, are to be retained. (shrink)

This study develops a Heideggerian thesis on the significance of Dasein's bodiliness. In Grundbegriffe der aristotelischen Philosophie , Heidegger claims that bodiliness secures the ground for the full being of the human. I situate this thesis squarely within die Sache selbst for Heidegger. Die Sache selbst concerns the issue of how being itself is engendered in human understanding . From as early as 1921, Heidegger explicitly understands his central topic in terms of ki&d12;nh siv . That is, the emergence of (...) being in conjunction with the ontological structure of the human being is ultimately intelligible as a kind of movement. The 1924 thesis makes sense ultimately insofar as bodiliness itself is understood as the ontological movement---the original being-moved or pa&d12;qov ---that allows entities to appear within the domain of human concerns. After examining Heidegger's retrieval of several key Aristotelian concepts , I interpret bodiliness as the always already operative being-pulled-out-ahead-of-itself by its own essential lack. Entities are first able to be present to Dasein because Dasein is opened in this way. Thus, bodiliness on my reading is die Sache selbst. My interpretation of Heidegger's thesis also forms the interpretive starting point for a rereading of Geworfenheit and Gewesenheit as concepts of bodiliness. As Dasein's original pa&d12;qov , bodiliness in Sein und Zeit would go by the name die gewesene Geworfenheit: the a priori or always already operative thrown-open-ness that first allows being to emerge to human understanding. (shrink)